PMC:549712 / 49124-49649
Annnotations
craft-sa-dev
{"project":"craft-sa-dev","denotations":[{"id":"T14475","span":{"begin":0,"end":9},"obj":"NN"},{"id":"T14476","span":{"begin":10,"end":16},"obj":"NN"},{"id":"T14477","span":{"begin":16,"end":239},"obj":"sentence"},{"id":"T14478","span":{"begin":17,"end":18},"obj":"DT"},{"id":"T14479","span":{"begin":74,"end":79},"obj":"NN"},{"id":"T14480","span":{"begin":19,"end":24},"obj":"NN"},{"id":"T14481","span":{"begin":25,"end":35},"obj":"VBG"},{"id":"T14482","span":{"begin":24,"end":25},"obj":"HYPH"},{"id":"T14483","span":{"begin":36,"end":45},"obj":"JJ"},{"id":"T14484","span":{"begin":57,"end":67},"obj":"NN"},{"id":"T14485","span":{"begin":46,"end":56},"obj":"JJ"},{"id":"T14486","span":{"begin":68,"end":69},"obj":"-LRB-"},{"id":"T14487","span":{"begin":69,"end":72},"obj":"NN"},{"id":"T14488","span":{"begin":72,"end":73},"obj":"-RRB-"},{"id":"T14489","span":{"begin":133,"end":141},"obj":"VBN"},{"id":"T14490","span":{"begin":80,"end":81},"obj":"-LRB-"},{"id":"T14491","span":{"begin":116,"end":118},"obj":"NN"},{"id":"T14492","span":{"begin":81,"end":88},"obj":"NNP"},{"id":"T14493","span":{"begin":106,"end":114},"obj":"NN"},{"id":"T14494","span":{"begin":89,"end":98},"obj":"NN"},{"id":"T14495","span":{"begin":99,"end":105},"obj":"NN"},{"id":"T14496","span":{"begin":114,"end":115},"obj":":"},{"id":"T14497","span":{"begin":118,"end":119},"obj":"HYPH"},{"id":"T14498","span":{"begin":119,"end":121},"obj":"CD"},{"id":"T14499","span":{"begin":121,"end":122},"obj":"HYPH"},{"id":"T14500","span":{"begin":122,"end":127},"obj":"CD"},{"id":"T14501","span":{"begin":127,"end":128},"obj":"-RRB-"},{"id":"T14502","span":{"begin":129,"end":132},"obj":"VBD"},{"id":"T14503","span":{"begin":142,"end":144},"obj":"IN"},{"id":"T14504","span":{"begin":145,"end":153},"obj":"NN"},{"id":"T14505","span":{"begin":154,"end":162},"obj":"NN"},{"id":"T14506","span":{"begin":163,"end":167},"obj":"IN"},{"id":"T14507","span":{"begin":168,"end":169},"obj":"DT"},{"id":"T14508","span":{"begin":191,"end":198},"obj":"NN"},{"id":"T14509","span":{"begin":170,"end":175},"obj":"NN"},{"id":"T14510","span":{"begin":176,"end":178},"obj":"NN"},{"id":"T14511","span":{"begin":175,"end":176},"obj":"HYPH"},{"id":"T14512","span":{"begin":179,"end":186},"obj":"JJ"},{"id":"T14513","span":{"begin":187,"end":190},"obj":"NN"},{"id":"T14514","span":{"begin":199,"end":200},"obj":"-LRB-"},{"id":"T14515","span":{"begin":214,"end":223},"obj":"NNS"},{"id":"T14516","span":{"begin":200,"end":202},"obj":"NN"},{"id":"T14517","span":{"begin":202,"end":203},"obj":"HYPH"},{"id":"T14518","span":{"begin":203,"end":205},"obj":"CD"},{"id":"T14519","span":{"begin":205,"end":206},"obj":":"},{"id":"T14520","span":{"begin":207,"end":213},"obj":"NN"},{"id":"T14521","span":{"begin":223,"end":225},"obj":","},{"id":"T14522","span":{"begin":225,"end":232},"obj":"NNP"},{"id":"T14523","span":{"begin":232,"end":234},"obj":","},{"id":"T14524","span":{"begin":234,"end":237},"obj":"NNP"},{"id":"T14525","span":{"begin":237,"end":238},"obj":"-RRB-"},{"id":"T14526","span":{"begin":238,"end":239},"obj":"."},{"id":"T14527","span":{"begin":239,"end":525},"obj":"sentence"},{"id":"T14528","span":{"begin":240,"end":241},"obj":"DT"},{"id":"T14529","span":{"begin":261,"end":269},"obj":"NN"},{"id":"T14530","span":{"begin":242,"end":246},"obj":"CD"},{"id":"T14531","span":{"begin":247,"end":249},"obj":"NN"},{"id":"T14532","span":{"begin":250,"end":254},"obj":"NN"},{"id":"T14533","span":{"begin":255,"end":260},"obj":"NN"},{"id":"T14534","span":{"begin":254,"end":255},"obj":"HYPH"},{"id":"T14535","span":{"begin":339,"end":348},"obj":"VBN"},{"id":"T14536","span":{"begin":270,"end":280},"obj":"VBG"},{"id":"T14537","span":{"begin":281,"end":284},"obj":"DT"},{"id":"T14538","span":{"begin":298,"end":303},"obj":"NN"},{"id":"T14539","span":{"begin":285,"end":291},"obj":"JJ"},{"id":"T14540","span":{"begin":292,"end":297},"obj":"NN"},{"id":"T14541","span":{"begin":304,"end":307},"obj":"CC"},{"id":"T14542","span":{"begin":308,"end":309},"obj":"CD"},{"id":"T14543","span":{"begin":327,"end":334},"obj":"NNS"},{"id":"T14544","span":{"begin":309,"end":310},"obj":"SYM"},{"id":"T14545","span":{"begin":311,"end":314},"obj":"CC"},{"id":"T14546","span":{"begin":315,"end":316},"obj":"CD"},{"id":"T14547","span":{"begin":316,"end":317},"obj":"SYM"},{"id":"T14548","span":{"begin":318,"end":326},"obj":"NN"},{"id":"T14549","span":{"begin":335,"end":338},"obj":"VBD"},{"id":"T14550","span":{"begin":349,"end":353},"obj":"IN"},{"id":"T14551","span":{"begin":354,"end":358},"obj":"DT"},{"id":"T14552","span":{"begin":363,"end":368},"obj":"NN"},{"id":"T14553","span":{"begin":359,"end":362},"obj":"NN"},{"id":"T14554","span":{"begin":369,"end":372},"obj":"CC"},{"id":"T14555","span":{"begin":373,"end":374},"obj":"DT"},{"id":"T14556","span":{"begin":394,"end":402},"obj":"NN"},{"id":"T14557","span":{"begin":375,"end":378},"obj":"CD"},{"id":"T14558","span":{"begin":379,"end":381},"obj":"NN"},{"id":"T14559","span":{"begin":382,"end":387},"obj":"NN"},{"id":"T14560","span":{"begin":388,"end":393},"obj":"NN"},{"id":"T14561","span":{"begin":387,"end":388},"obj":"HYPH"},{"id":"T14562","span":{"begin":451,"end":459},"obj":"VBN"},{"id":"T14563","span":{"begin":403,"end":413},"obj":"VBG"},{"id":"T14564","span":{"begin":414,"end":419},"obj":"NNS"},{"id":"T14565","span":{"begin":420,"end":421},"obj":"CD"},{"id":"T14566","span":{"begin":422,"end":425},"obj":"CC"},{"id":"T14567","span":{"begin":426,"end":428},"obj":"CD"},{"id":"T14568","span":{"begin":429,"end":431},"obj":"IN"},{"id":"T14569","span":{"begin":432,"end":435},"obj":"DT"},{"id":"T14570","span":{"begin":442,"end":446},"obj":"NN"},{"id":"T14571","span":{"begin":436,"end":441},"obj":"NN"},{"id":"T14572","span":{"begin":447,"end":450},"obj":"VBD"},{"id":"T14573","span":{"begin":460,"end":462},"obj":"IN"},{"id":"T14574","span":{"begin":463,"end":464},"obj":"DT"},{"id":"T14575","span":{"begin":510,"end":518},"obj":"NN"},{"id":"T14576","span":{"begin":465,"end":468},"obj":"CD"},{"id":"T14577","span":{"begin":469,"end":471},"obj":"NN"},{"id":"T14578","span":{"begin":472,"end":476},"obj":"NN"},{"id":"T14579","span":{"begin":477,"end":484},"obj":"VBN"},{"id":"T14580","span":{"begin":476,"end":477},"obj":"HYPH"},{"id":"T14581","span":{"begin":485,"end":493},"obj":"NN"},{"id":"T14582","span":{"begin":494,"end":504},"obj":"NN"},{"id":"T14583","span":{"begin":493,"end":494},"obj":"HYPH"},{"id":"T14584","span":{"begin":505,"end":509},"obj":"NN"},{"id":"T14585","span":{"begin":519,"end":520},"obj":"-LRB-"},{"id":"T14586","span":{"begin":520,"end":523},"obj":"NN"},{"id":"T14587","span":{"begin":523,"end":524},"obj":"-RRB-"},{"id":"T14588","span":{"begin":524,"end":525},"obj":"."}],"relations":[{"id":"R8632","pred":"compound","subj":"T14475","obj":"T14476"},{"id":"R8633","pred":"det","subj":"T14478","obj":"T14479"},{"id":"R8634","pred":"nsubjpass","subj":"T14479","obj":"T14489"},{"id":"R8635","pred":"npadvmod","subj":"T14480","obj":"T14481"},{"id":"R8636","pred":"amod","subj":"T14481","obj":"T14479"},{"id":"R8637","pred":"punct","subj":"T14482","obj":"T14481"},{"id":"R8638","pred":"amod","subj":"T14483","obj":"T14484"},{"id":"R8639","pred":"nmod","subj":"T14484","obj":"T14479"},{"id":"R8640","pred":"amod","subj":"T14485","obj":"T14484"},{"id":"R8641","pred":"punct","subj":"T14486","obj":"T14484"},{"id":"R8642","pred":"appos","subj":"T14487","obj":"T14484"},{"id":"R8643","pred":"punct","subj":"T14488","obj":"T14479"},{"id":"R8644","pred":"punct","subj":"T14490","obj":"T14491"},{"id":"R8645","pred":"parataxis","subj":"T14491","obj":"T14479"},{"id":"R8646","pred":"compound","subj":"T14492","obj":"T14493"},{"id":"R8647","pred":"dep","subj":"T14493","obj":"T14491"},{"id":"R8648","pred":"compound","subj":"T14494","obj":"T14493"},{"id":"R8649","pred":"compound","subj":"T14495","obj":"T14493"},{"id":"R8650","pred":"punct","subj":"T14496","obj":"T14491"},{"id":"R8651","pred":"punct","subj":"T14497","obj":"T14491"},{"id":"R8652","pred":"nummod","subj":"T14498","obj":"T14491"},{"id":"R8653","pred":"punct","subj":"T14499","obj":"T14491"},{"id":"R8654","pred":"nummod","subj":"T14500","obj":"T14491"},{"id":"R8655","pred":"punct","subj":"T14501","obj":"T14491"},{"id":"R8656","pred":"auxpass","subj":"T14502","obj":"T14489"},{"id":"R8657","pred":"prep","subj":"T14503","obj":"T14489"},{"id":"R8658","pred":"compound","subj":"T14504","obj":"T14505"},{"id":"R8659","pred":"pobj","subj":"T14505","obj":"T14503"},{"id":"R8660","pred":"prep","subj":"T14506","obj":"T14505"},{"id":"R8661","pred":"det","subj":"T14507","obj":"T14508"},{"id":"R8662","pred":"pobj","subj":"T14508","obj":"T14506"},{"id":"R8663","pred":"nmod","subj":"T14509","obj":"T14510"},{"id":"R8664","pred":"nmod","subj":"T14510","obj":"T14508"},{"id":"R8665","pred":"punct","subj":"T14511","obj":"T14510"},{"id":"R8666","pred":"amod","subj":"T14512","obj":"T14508"},{"id":"R8667","pred":"compound","subj":"T14513","obj":"T14508"},{"id":"R8668","pred":"punct","subj":"T14514","obj":"T14515"},{"id":"R8669","pred":"parataxis","subj":"T14515","obj":"T14508"},{"id":"R8670","pred":"dep","subj":"T14516","obj":"T14515"},{"id":"R8671","pred":"punct","subj":"T14517","obj":"T14516"},{"id":"R8672","pred":"nummod","subj":"T14518","obj":"T14516"},{"id":"R8673","pred":"punct","subj":"T14519","obj":"T14515"},{"id":"R8674","pred":"compound","subj":"T14520","obj":"T14515"},{"id":"R8675","pred":"punct","subj":"T14521","obj":"T14515"},{"id":"R8676","pred":"npadvmod","subj":"T14522","obj":"T14515"},{"id":"R8677","pred":"punct","subj":"T14523","obj":"T14515"},{"id":"R8678","pred":"npadvmod","subj":"T14524","obj":"T14515"},{"id":"R8679","pred":"punct","subj":"T14525","obj":"T14515"},{"id":"R8680","pred":"punct","subj":"T14526","obj":"T14489"},{"id":"R8681","pred":"det","subj":"T14528","obj":"T14529"},{"id":"R8682","pred":"nsubjpass","subj":"T14529","obj":"T14535"},{"id":"R8683","pred":"nummod","subj":"T14530","obj":"T14531"},{"id":"R8684","pred":"compound","subj":"T14531","obj":"T14529"},{"id":"R8685","pred":"compound","subj":"T14532","obj":"T14533"},{"id":"R8686","pred":"compound","subj":"T14533","obj":"T14529"},{"id":"R8687","pred":"punct","subj":"T14534","obj":"T14533"},{"id":"R8688","pred":"acl","subj":"T14536","obj":"T14529"},{"id":"R8689","pred":"det","subj":"T14537","obj":"T14538"},{"id":"R8690","pred":"dobj","subj":"T14538","obj":"T14536"},{"id":"R8691","pred":"amod","subj":"T14539","obj":"T14538"},{"id":"R8692","pred":"compound","subj":"T14540","obj":"T14538"},{"id":"R8693","pred":"cc","subj":"T14541","obj":"T14538"},{"id":"R8694","pred":"nummod","subj":"T14542","obj":"T14543"},{"id":"R8695","pred":"conj","subj":"T14543","obj":"T14538"},{"id":"R8696","pred":"punct","subj":"T14544","obj":"T14542"},{"id":"R8697","pred":"cc","subj":"T14545","obj":"T14542"},{"id":"R8698","pred":"conj","subj":"T14546","obj":"T14542"},{"id":"R8699","pred":"punct","subj":"T14547","obj":"T14546"},{"id":"R8700","pred":"compound","subj":"T14548","obj":"T14543"},{"id":"R8701","pred":"auxpass","subj":"T14549","obj":"T14535"},{"id":"R8702","pred":"prep","subj":"T14550","obj":"T14535"},{"id":"R8703","pred":"det","subj":"T14551","obj":"T14552"},{"id":"R8704","pred":"pobj","subj":"T14552","obj":"T14550"},{"id":"R8705","pred":"compound","subj":"T14553","obj":"T14552"},{"id":"R8706","pred":"cc","subj":"T14554","obj":"T14535"},{"id":"R8707","pred":"det","subj":"T14555","obj":"T14556"},{"id":"R8708","pred":"nsubjpass","subj":"T14556","obj":"T14562"},{"id":"R8709","pred":"nummod","subj":"T14557","obj":"T14558"},{"id":"R8710","pred":"compound","subj":"T14558","obj":"T14556"},{"id":"R8711","pred":"compound","subj":"T14559","obj":"T14560"},{"id":"R8712","pred":"compound","subj":"T14560","obj":"T14556"},{"id":"R8713","pred":"punct","subj":"T14561","obj":"T14560"},{"id":"R8714","pred":"conj","subj":"T14562","obj":"T14535"},{"id":"R8715","pred":"acl","subj":"T14563","obj":"T14556"},{"id":"R8716","pred":"nmod","subj":"T14564","obj":"T14565"},{"id":"R8717","pred":"dobj","subj":"T14565","obj":"T14563"},{"id":"R8718","pred":"cc","subj":"T14566","obj":"T14565"},{"id":"R8719","pred":"conj","subj":"T14567","obj":"T14565"},{"id":"R8720","pred":"prep","subj":"T14568","obj":"T14565"},{"id":"R8721","pred":"det","subj":"T14569","obj":"T14570"},{"id":"R8722","pred":"pobj","subj":"T14570","obj":"T14568"},{"id":"R8723","pred":"compound","subj":"T14571","obj":"T14570"},{"id":"R8724","pred":"auxpass","subj":"T14572","obj":"T14562"},{"id":"R8725","pred":"prep","subj":"T14573","obj":"T14562"},{"id":"R8726","pred":"det","subj":"T14574","obj":"T14575"},{"id":"R8727","pred":"pobj","subj":"T14575","obj":"T14573"},{"id":"R8728","pred":"nummod","subj":"T14576","obj":"T14577"},{"id":"R8729","pred":"nmod","subj":"T14577","obj":"T14575"},{"id":"R8730","pred":"npadvmod","subj":"T14578","obj":"T14579"},{"id":"R8731","pred":"amod","subj":"T14579","obj":"T14575"},{"id":"R8732","pred":"punct","subj":"T14580","obj":"T14579"},{"id":"R8733","pred":"compound","subj":"T14581","obj":"T14582"},{"id":"R8734","pred":"compound","subj":"T14582","obj":"T14575"},{"id":"R8735","pred":"punct","subj":"T14583","obj":"T14582"},{"id":"R8736","pred":"compound","subj":"T14584","obj":"T14575"},{"id":"R8737","pred":"punct","subj":"T14585","obj":"T14586"},{"id":"R8738","pred":"parataxis","subj":"T14586","obj":"T14575"},{"id":"R8739","pred":"punct","subj":"T14587","obj":"T14586"},{"id":"R8740","pred":"punct","subj":"T14588","obj":"T14562"}],"text":"Targeting vector\nA Ptdsr-containing bacterial artificial chromosome (BAC) clone (GenBank accession number AC091694; RP-23-316F3) was isolated by sequence homology from a C57BL/6J genomic BAC library (RP-23; BACPAC Resources, Oakland, USA). A 14.5 kb KpnI/BamHI fragment containing the entire Ptdsr locus and 5' and 3' flanking regions was subcloned from this BAC clone and a 1.9 kb RsrII/AatII fragment containing exons I and II of the Ptdsr gene was replaced by a 1.2 kb loxP-flanked neomycin-resistance gene cassette (neo)."}
craft-ca-core-ex-dev
{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T14366","span":{"begin":0,"end":16},"obj":"SO_EXT:0001644"},{"id":"T14367","span":{"begin":19,"end":24},"obj":"PR_EXT:000009218"},{"id":"T14368","span":{"begin":36,"end":45},"obj":"NCBITaxon:2"},{"id":"T14369","span":{"begin":36,"end":67},"obj":"SO_EXT:0000153"},{"id":"T14370","span":{"begin":57,"end":67},"obj":"GO_SO_EXT:chromosome"},{"id":"T14371","span":{"begin":69,"end":72},"obj":"SO_EXT:0000153"},{"id":"T14372","span":{"begin":74,"end":79},"obj":"SO_EXT:sequence_cloned_entity"},{"id":"T14373","span":{"begin":145,"end":153},"obj":"SO_EXT:biological_sequence"},{"id":"T14374","span":{"begin":179,"end":186},"obj":"SO_EXT:0001026"},{"id":"T14375","span":{"begin":187,"end":190},"obj":"SO_EXT:0000153"},{"id":"T14376","span":{"begin":248,"end":249},"obj":"CHEBI_SO_EXT:base"},{"id":"T14377","span":{"begin":255,"end":260},"obj":"PR_EXT:P23940"},{"id":"T14378","span":{"begin":292,"end":297},"obj":"PR_EXT:000009218"},{"id":"T14379","span":{"begin":308,"end":310},"obj":"_FRAGMENT"},{"id":"T14380","span":{"begin":318,"end":334},"obj":"SO_EXT:0001416"},{"id":"T14381","span":{"begin":315,"end":334},"obj":"SO_EXT:0001417"},{"id":"T14382","span":{"begin":359,"end":362},"obj":"SO_EXT:0000153"},{"id":"T14383","span":{"begin":363,"end":368},"obj":"SO_EXT:sequence_cloned_entity"},{"id":"T14384","span":{"begin":380,"end":381},"obj":"CHEBI_SO_EXT:base"},{"id":"T14385","span":{"begin":414,"end":419},"obj":"SO_EXT:0000147"},{"id":"T14386","span":{"begin":436,"end":441},"obj":"PR_EXT:000009218"},{"id":"T14387","span":{"begin":442,"end":446},"obj":"SO_EXT:0000704"},{"id":"T14388","span":{"begin":451,"end":459},"obj":"SO_EXT:sequence_substitution_process"},{"id":"T14389","span":{"begin":470,"end":471},"obj":"CHEBI_SO_EXT:base"},{"id":"T14390","span":{"begin":472,"end":484},"obj":"SO:0000359"},{"id":"T14391","span":{"begin":485,"end":493},"obj":"CHEBI:7507"},{"id":"T14392","span":{"begin":505,"end":518},"obj":"SO_EXT:0005853"},{"id":"T14393","span":{"begin":520,"end":523},"obj":"CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase"}],"relations":[{"id":"R8616","pred":"_lexicallyChainedTo","subj":"T14380","obj":"T14379"}],"text":"Targeting vector\nA Ptdsr-containing bacterial artificial chromosome (BAC) clone (GenBank accession number AC091694; RP-23-316F3) was isolated by sequence homology from a C57BL/6J genomic BAC library (RP-23; BACPAC Resources, Oakland, USA). A 14.5 kb KpnI/BamHI fragment containing the entire Ptdsr locus and 5' and 3' flanking regions was subcloned from this BAC clone and a 1.9 kb RsrII/AatII fragment containing exons I and II of the Ptdsr gene was replaced by a 1.2 kb loxP-flanked neomycin-resistance gene cassette (neo)."}
craft-ca-core-dev
{"project":"craft-ca-core-dev","denotations":[{"id":"T14307","span":{"begin":0,"end":16},"obj":"SO:0001644"},{"id":"T14308","span":{"begin":19,"end":24},"obj":"PR:000009218"},{"id":"T14309","span":{"begin":36,"end":45},"obj":"NCBITaxon:2"},{"id":"T14310","span":{"begin":36,"end":67},"obj":"SO:0000153"},{"id":"T14311","span":{"begin":69,"end":72},"obj":"SO:0000153"},{"id":"T14312","span":{"begin":179,"end":186},"obj":"SO:0001026"},{"id":"T14313","span":{"begin":187,"end":190},"obj":"SO:0000153"},{"id":"T14314","span":{"begin":255,"end":260},"obj":"PR:P23940"},{"id":"T14315","span":{"begin":292,"end":297},"obj":"PR:000009218"},{"id":"T14316","span":{"begin":308,"end":310},"obj":"_FRAGMENT"},{"id":"T14317","span":{"begin":318,"end":334},"obj":"SO:0001416"},{"id":"T14318","span":{"begin":315,"end":334},"obj":"SO:0001417"},{"id":"T14319","span":{"begin":359,"end":362},"obj":"SO:0000153"},{"id":"T14320","span":{"begin":414,"end":419},"obj":"SO:0000147"},{"id":"T14321","span":{"begin":436,"end":441},"obj":"PR:000009218"},{"id":"T14322","span":{"begin":442,"end":446},"obj":"SO:0000704"},{"id":"T14323","span":{"begin":472,"end":484},"obj":"SO:0000359"},{"id":"T14324","span":{"begin":485,"end":493},"obj":"CHEBI:7507"},{"id":"T14325","span":{"begin":505,"end":518},"obj":"SO:0005853"}],"relations":[{"id":"R8615","pred":"_lexicallyChainedTo","subj":"T14317","obj":"T14316"}],"text":"Targeting vector\nA Ptdsr-containing bacterial artificial chromosome (BAC) clone (GenBank accession number AC091694; RP-23-316F3) was isolated by sequence homology from a C57BL/6J genomic BAC library (RP-23; BACPAC Resources, Oakland, USA). A 14.5 kb KpnI/BamHI fragment containing the entire Ptdsr locus and 5' and 3' flanking regions was subcloned from this BAC clone and a 1.9 kb RsrII/AatII fragment containing exons I and II of the Ptdsr gene was replaced by a 1.2 kb loxP-flanked neomycin-resistance gene cassette (neo)."}