PMC:5491911 / 20506-21621
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/5491911","sourcedb":"PMC","sourceid":"5491911","source_url":"https://www.ncbi.nlm.nih.gov/pmc/5491911","text":"The present study also evaluated a neuroprotective agent; i.e., CUR, to avoid the changes in the SD rats. Several researchers have clarified that CUR could recover learning and memory abilities in rats in different conditions. Indeed, Guo et al. (2013[10]) indicated that CUR had a protective effect on HIV-neurotoxicity by reducing microglial inflammation and preventing neuronal apoptosis (Guo et al., 2013[10]). Pan et al. (2008[21]) also reported that CUR could facilitate learning and memory function by diminishing or preventing lipid peroxidation in the brain region of aged rats. In general, CUR is a well-known oxygen free radical scavenger (Pan et al., 2008[21]). Sun et al. (2013[25]) disclosed that CUR could also recover learning and memory in senescence-accelerated mice. Similarly, our previous studies revealed that CUR could play protective roles in rat prefrontal cortical neurons in different pathological conditions (Noorafshan et al., 2015[20]). SD could diminish the spatial memories and affect the mPFC structure. However, CUR could preserve the behavioral and structural changes of the mPFC.","tracks":[{"project":"2_test","denotations":[{"id":"28694754-23936448-29827939","span":{"begin":252,"end":254},"obj":"23936448"},{"id":"28694754-23936448-29827940","span":{"begin":409,"end":411},"obj":"23936448"},{"id":"28694754-18701050-29827941","span":{"begin":432,"end":434},"obj":"18701050"},{"id":"28694754-18701050-29827942","span":{"begin":668,"end":670},"obj":"18701050"},{"id":"28694754-23402943-29827943","span":{"begin":691,"end":693},"obj":"23402943"},{"id":"28694754-25909877-29827944","span":{"begin":961,"end":963},"obj":"25909877"}],"attributes":[{"subj":"28694754-23936448-29827939","pred":"source","obj":"2_test"},{"subj":"28694754-23936448-29827940","pred":"source","obj":"2_test"},{"subj":"28694754-18701050-29827941","pred":"source","obj":"2_test"},{"subj":"28694754-18701050-29827942","pred":"source","obj":"2_test"},{"subj":"28694754-23402943-29827943","pred":"source","obj":"2_test"},{"subj":"28694754-25909877-29827944","pred":"source","obj":"2_test"}]},{"project":"MyTest","denotations":[{"id":"28694754-23936448-29827939","span":{"begin":252,"end":254},"obj":"23936448"},{"id":"28694754-23936448-29827940","span":{"begin":409,"end":411},"obj":"23936448"},{"id":"28694754-18701050-29827941","span":{"begin":432,"end":434},"obj":"18701050"},{"id":"28694754-18701050-29827942","span":{"begin":668,"end":670},"obj":"18701050"},{"id":"28694754-23402943-29827943","span":{"begin":691,"end":693},"obj":"23402943"},{"id":"28694754-25909877-29827944","span":{"begin":961,"end":963},"obj":"25909877"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"28694754-23936448-29827939","pred":"source","obj":"MyTest"},{"subj":"28694754-23936448-29827940","pred":"source","obj":"MyTest"},{"subj":"28694754-18701050-29827941","pred":"source","obj":"MyTest"},{"subj":"28694754-18701050-29827942","pred":"source","obj":"MyTest"},{"subj":"28694754-23402943-29827943","pred":"source","obj":"MyTest"},{"subj":"28694754-25909877-29827944","pred":"source","obj":"MyTest"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93aaec","default":true},{"id":"MyTest","color":"#c4ec93"}]}]}}