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PMC:548520 / 19477-24923 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
15676071-7207866-12933281 233-235 7207866 denotes 36
15676071-9020854-12933282 254-256 9020854 denotes 29
15676071-6715580-12933283 800-802 6715580 denotes 30
15676071-2144827-12933284 1020-1022 2144827 denotes 37
15676071-6771304-12933285 1261-1263 6771304 denotes 38
15676071-8943002-12933286 1485-1487 8943002 denotes 39
15676071-9020854-12933287 1488-1490 9020854 denotes 29
15676071-10802659-12933288 1562-1564 10802659 denotes 40
15676071-10581037-12933289 1793-1795 10581037 denotes 34
15676071-10744971-12933290 1811-1813 10744971 denotes 10
15676071-11733058-12933291 1863-1865 11733058 denotes 35
15676071-1418997-12933292 2199-2201 1418997 denotes 41
15676071-8575336-12933293 2582-2584 8575336 denotes 42
15676071-9020854-12933294 2638-2640 9020854 denotes 29
15676071-9245510-12933295 2685-2687 9245510 denotes 43
15676071-9570804-12933296 3479-3481 9570804 denotes 44
15676071-8575625-12933297 3983-3985 8575625 denotes 45
15676071-11733058-12933298 4246-4248 11733058 denotes 35
15676071-15324661-12933299 4971-4973 15324661 denotes 46
15676071-11850625-12933300 5070-5072 11850625 denotes 47
15676071-12915475-12933301 5213-5215 12915475 denotes 48

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T4469 0-3 PR_EXT:000005904 denotes Crx
T4470 3-4 SO_EXT:sequence_nullness_or_absence denotes -
T4471 5-6 SO_EXT:sequence_nullness_or_absence denotes -
T4472 7-21 CL:0000210 denotes photoreceptors
T4473 38-51 GO:0001750 denotes outer segment
T4474 52-65 GO:0009653 denotes morphogenesis
T4475 66-75 SO_EXT:sequence_alteration_entity_or_process denotes Mutations
T4476 79-82 PR_EXT:000005904 denotes Crx
T4477 116-120 SO_EXT:0000704 denotes gene
T4478 121-130 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T4479 147-160 GO:0001750 denotes outer segment
T4480 190-194 SO_EXT:sequence_nullness denotes null
T4481 195-204 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T4482 212-222 PR_EXT:peripherin denotes peripherin
T4483 223-226 PR_EXT:000013290 denotes RDS
T4484 227-231 SO_EXT:0000704 denotes gene
T4485 243-252 PR_EXT:000001245 denotes rhodopsin
T4486 279-292 GO:0001750 denotes outer segment
T4487 320-330 PR_EXT:peripherin denotes peripherin
T4488 330-331 SO_EXT:sequence_nullness_or_absence denotes -
T4489 332-333 SO_EXT:sequence_nullness_or_absence denotes -
T4490 338-341 PR_EXT:000005904 denotes Crx
T4491 341-342 SO_EXT:sequence_nullness_or_absence denotes -
T4492 343-344 SO_EXT:sequence_nullness_or_absence denotes -
T4493 345-358 CL:0000210 denotes photoreceptor
T4494 345-372 GO:0008594 denotes photoreceptor morphogenesis
T4495 404-413 GO:0031982 denotes Vesicular
T4496 428-431 PR_EXT:000005904 denotes Crx
T4497 431-432 SO_EXT:sequence_nullness_or_absence denotes -
T4498 433-434 SO_EXT:sequence_nullness_or_absence denotes -
T4499 435-449 CL:0000210 denotes photoreceptors
T4500 515-518 PR_EXT:000013290 denotes rds
T4501 519-529 PR_EXT:peripherin denotes peripherin
T4502 529-530 SO_EXT:sequence_nullness_or_absence denotes -
T4503 531-532 SO_EXT:sequence_nullness_or_absence denotes -
T4504 533-538 NCBITaxon:10088 denotes mouse
T4505 577-585 GO:0031982 denotes vesicles
T4506 602-614 _FRAGMENT denotes breakdown of
T4507 629-638 GO:0030397 denotes membranes
T4508 615-638 GO:0042622 denotes outer segment membranes
T4509 662-671 GO_EXT:biological_recruitment denotes recruited
T4510 679-693 GO:0001750 denotes outer segments
T4511 712-722 PR_EXT:peripherin denotes peripherin
T4512 772-782 GO:0005902 denotes microvilli
T4513 786-798 CL:0000636 denotes Müller cells
T4514 793-798 CL_GO_EXT:cell denotes cells
T4515 923-932 PR_EXT:000001245 denotes rhodopsin
T4516 933-940 CHEBI_PR_EXT:protein denotes protein
T4517 950-958 GO:0031982 denotes vesicles
T4518 1001-1010 PR_EXT:000001245 denotes rhodopsin
T4519 1011-1018 CHEBI_SO_EXT:epitope denotes epitope
T4520 1053-1061 GO:0031982 denotes vesicles
T4521 1085-1099 GO:0001917 denotes inner segments
T4522 1126-1140 CL:0000210 denotes photoreceptors
T4523 1159-1165 GO_EXT:biological_growth_entity_or_process denotes growth
T4524 1193-1206 GO:0001750 denotes outer segment
T4525 1237-1254 GO:0032391 denotes connecting cilium
T4526 1290-1300 PR_EXT:peripherin denotes Peripherin
T4527 1301-1304 PR_EXT:000013290 denotes RDS
T4528 1309-1314 PR_EXT:000014157 denotes ROM-1
T4529 1315-1323 CHEBI_PR_EXT:protein denotes proteins
T4530 1325-1334 GO_PATO_EXT:biological_localization_process_or_quality denotes localized
T4531 1357-1362 PR_EXT:000001119 denotes opsin
T4532 1363-1371 CHEBI_PR_EXT:protein denotes proteins
T4533 1373-1382 GO_PATO_EXT:biological_localization_process_or_quality denotes localized
T4534 1464-1478 GO:0001750 denotes outer segments
T4535 1494-1499 PR_EXT:000014157 denotes ROM-1
T4536 1499-1500 SO_EXT:sequence_nullness_or_absence denotes -
T4537 1501-1502 SO_EXT:sequence_nullness_or_absence denotes -
T4538 1503-1507 NCBITaxon:10088 denotes mice
T4539 1529-1543 GO:0001750 denotes outer segments
T4540 1567-1570 PR_EXT:000005904 denotes Crx
T4541 1593-1606 GO_EXT:transcription denotes transcription
T4542 1593-1613 GO_EXT:transcription_factor denotes transcription factor
T4543 1626-1634 GO:0065007 denotes controls
T4544 1635-1640 SO_EXT:0000704 denotes genes
T4545 1710-1723 GO:0001750 denotes outer segment
T4546 1745-1754 PR_EXT:000001245 denotes rhodopsin
T4547 1759-1769 PR_EXT:peripherin denotes peripherin
T4548 1839-1843 SO_EXT:0000704 denotes gene
T4549 1839-1854 GO:0010467 denotes gene expression
T4550 1902-1907 SO_EXT:0000704 denotes genes
T4551 1934-1944 GO:0010467 denotes expression
T4552 1954-1957 PR_EXT:000005904 denotes Crx
T4553 1957-1958 SO_EXT:sequence_nullness_or_absence denotes -
T4554 1959-1960 SO_EXT:sequence_nullness_or_absence denotes -
T4555 1961-1965 NCBITaxon:10088 denotes mice
T4556 1981-1990 PR_EXT:000001245 denotes rhodopsin
T4557 1991-2001 GO:0010467 denotes expression
T4558 2029-2032 PR_EXT:000005904 denotes Crx
T4559 2032-2033 SO_EXT:sequence_nullness_or_absence denotes -
T4560 2034-2035 SO_EXT:sequence_nullness_or_absence denotes -
T4561 2036-2043 NCBITaxon:33208 denotes animals
T4562 2049-2059 PR_EXT:peripherin denotes peripherin
T4563 2060-2064 CHEBI_SO_EXT:mRNA denotes mRNA
T4564 2099-2109 SO_EXT:transgenic_entity denotes Transgenic
T4565 2110-2114 NCBITaxon:10088 denotes mice
T4566 2139-2149 GO:0010467 denotes expression
T4567 2153-2162 SO_EXT:wild_type_entity_or_quality denotes wild type
T4568 2163-2172 PR_EXT:000001245 denotes rhodopsin
T4569 2181-2184 CL:0000604 denotes rod
T4570 2246-2255 PR_EXT:000001245 denotes rhodopsin
T4571 2256-2266 GO:0010467 denotes expression
T4572 2295-2304 PR_EXT:000001245 denotes rhodopsin
T4573 2305-2315 GO:0010467 denotes expression
T4574 2366-2376 NCBITaxon:7215 denotes Drosophila
T4575 2381-2391 NCBITaxon:7215 denotes Drosophila
T4576 2393-2402 PR_EXT:000001245 denotes rhodopsin
T4577 2404-2409 PR_EXT:P06002 denotes ninaE
T4578 2414-2423 GO:0010467 denotes expressed
T4579 2427-2444 CL:0000687 denotes photoreceptors R1
T4580 2427-2441 _FRAGMENT denotes photoreceptors
T4581 2445-2447 CL:0000705 denotes R6
T4582 2452-2457 PR_EXT:P06002 denotes ninaE
T4583 2458-2462 SO_EXT:sequence_nullness denotes null
T4584 2463-2470 SO_EXT:sequence_altered_entity denotes mutants
T4585 2476-2486 GO:0016028 denotes rhabdomere
T4586 2513-2523 NCBITaxon:7742 denotes vertebrate
T4587 2524-2538 GO:0001750 denotes outer segments
T4588 2560-2562 _FRAGMENT denotes R1
T4589 2566-2580 CL:0000687 denotes photoreceptors
T4590 2563-2580 CL:0000705 denotes R6 photoreceptors
T4591 2619-2628 PR_EXT:000001245 denotes rhodopsin
T4592 2628-2629 SO_EXT:sequence_nullness_or_absence denotes -
T4593 2630-2631 SO_EXT:sequence_nullness_or_absence denotes -
T4594 2632-2636 NCBITaxon:10088 denotes mice
T4595 2729-2738 PR_EXT:000001245 denotes rhodopsin
T4596 2739-2749 GO:0010467 denotes expression
T4597 2757-2767 GO:0016028 denotes rhabdomere
T4598 2757-2779 GO:0042052 denotes rhabdomere development
T4599 2784-2789 PR_EXT:P06002 denotes ninaE
T4600 2790-2794 SO_EXT:sequence_nullness denotes null
T4601 2795-2800 NCBITaxon:7147 denotes flies
T4602 2804-2809 PR_EXT:P06002 denotes ninaE
T4603 2810-2819 SO_EXT:0000902 denotes transgene
T4604 2830-2837 GO:0065007 denotes control
T4605 2854-2862 SO_EXT:0000167 denotes promoter
T4606 2964-2973 PR_EXT:000001245 denotes rhodopsin
T4607 3021-3027 SO_EXT:sequence_rescue_process denotes rescue
T4608 3031-3044 CL:0000210 denotes photoreceptor
T4609 3069-3075 SO_EXT:sequence_rescue_process denotes rescue
T4610 3079-3092 CL:0000210 denotes photoreceptor
T4611 3093-3103 GO_PATO_EXT:physiological_process_or_quality denotes physiology
T4612 3114-3124 GO:0010467 denotes expression
T4613 3180-3186 SO_EXT:sequence_rescue_process denotes rescue
T4614 3204-3213 PR_EXT:000001245 denotes rhodopsin
T4615 3214-3224 GO:0010467 denotes expression
T4616 3297-3307 GO:0016028 denotes rhabdomere
T4617 3297-3321 GO:0061541 denotes rhabdomere morphogenesis
T4618 3374-3377 NCBITaxon:10114 denotes rat
T4619 3386-3395 PR_EXT:000001245 denotes rhodopsin
T4620 3465-3469 CL:0000604 denotes rods
T4621 3502-3512 GO:0065007 denotes regulation
T4622 3516-3525 PR_EXT:000001245 denotes rhodopsin
T4623 3553-3560 GO:0065007 denotes control
T4624 3584-3597 GO_EXT:positive_regulation denotes up-regulation
T4625 3601-3610 PR_EXT:000001245 denotes rhodopsin
T4626 3634-3637 PR_EXT:000005904 denotes Crx
T4627 3645-3655 GO:0065007 denotes regulating
T4628 3656-3669 GO:0001750 denotes outer segment
T4629 3670-3683 GO:0009653 denotes morphogenesis
T4630 3760-3763 PR_EXT:000005904 denotes Crx
T4631 3776-3786 NCBITaxon:7215 denotes Drosophila
T4632 3790-3793 PR_EXT:P22810 denotes Otd
T4633 3840-3845 SO_EXT:0000704 denotes genes
T4634 3855-3858 PR_EXT:000005904 denotes Crx
T4635 3902-3908 SO_EXT:0001023 denotes allele
T4636 3912-3922 NCBITaxon:7215 denotes Drosophila
T4637 3923-3926 PR_EXT:P22810 denotes otd
T4638 3928-3931 PR_EXT:P22810 denotes otd
T4639 3936-3949 CL:0000210 denotes photoreceptor
T4640 3936-3963 GO:0008594 denotes photoreceptor morphogenesis
T4641 4023-4028 SO_EXT:0000704 denotes genes
T4642 4053-4056 PR_EXT:000005904 denotes Crx
T4643 4073-4082 GO:0010467 denotes expressed
T4644 4107-4110 PR_EXT:000005904 denotes Crx
T4645 4110-4111 SO_EXT:sequence_nullness_or_absence denotes -
T4646 4112-4113 SO_EXT:sequence_nullness_or_absence denotes -
T4647 4114-4120 UBERON:0000966 denotes retina
T4648 4130-4139 PR_EXT:000001245 denotes rhodopsin
T4649 4144-4154 PR_EXT:peripherin denotes peripherin
T4650 4210-4224 CL:0000210 denotes photoreceptors
T4651 4234-4244 GO:0010467 denotes expression
T4652 4264-4271 CHEBI_GO_SO_EXT:enzyme denotes enzymes
T4653 4294-4299 CHEBI:18059 denotes lipid
T4654 4294-4310 GO:0006629 denotes lipid metabolism
T4655 4312-4319 CHEBI_PR_EXT:protein denotes protein
T4656 4312-4327 GO:0006457 denotes protein folding
T4657 4332-4341 GO_EXT:biological_routing_or_transport denotes transport
T4658 4452-4465 GO:0001750 denotes outer segment
T4659 4475-4488 GO:0097617 denotes hybridization
T4660 4495-4501 CHEBI_SO_EXT:molecular_probe denotes probes
T4661 4526-4531 SO_EXT:0000704 denotes genes
T4662 4574-4577 CHEBI_SO_EXT:RNA denotes RNA
T4663 4578-4587 GO_PATO_EXT:biological_localization_process_or_quality denotes localized
T4664 4595-4608 GO:0001917 denotes inner segment
T4665 4632-4640 CHEBI_PR_EXT:protein denotes proteins
T4666 4641-4649 GO_EXT:biological_routing_or_transport denotes targeted
T4667 4657-4670 GO:0001750 denotes outer segment
T4668 4713-4718 SO_EXT:0000704 denotes genes
T4669 4746-4759 GO:0001750 denotes outer segment
T4670 4760-4770 GO_EXT:biogenesis_or_biosynthesis denotes biogenesis
T4671 4797-4811 CL:0000210 denotes photoreceptors
T4672 4851-4863 GO:0042384 denotes ciliogenesis
T4673 4877-4881 SO_EXT:0000704 denotes gene
T4674 4883-4887 PR_EXT:000005848 denotes CRB1
T4675 4903-4907 SO_EXT:0000704 denotes gene
T4676 4908-4912 PR_EXT:000005850 denotes CRB3
T4677 4938-4950 GO:0042384 denotes ciliogenesis
T4678 4980-4990 NCBITaxon:7215 denotes Drosophila
T4679 4991-5000 SO_EXT:0000853 denotes homologue
T4680 5004-5008 PR_EXT:000005848 denotes CRB1
T4681 5010-5016 PR_EXT:P10040 denotes Crumbs
T4682 5041-5054 CL:0000210 denotes photoreceptor
T4683 5041-5068 GO:0008594 denotes photoreceptor morphogenesis
T4684 5112-5117 NCBITaxon:10088 denotes mouse
T4685 5118-5124 SO_EXT:sequence_altered_entity denotes mutant
T4686 5128-5132 PR_EXT:000005848 denotes CRB1
T4687 5142-5147 NCBITaxon:10088 denotes mouse
T4688 5168-5182 GO:0001750 denotes outer segments
T4689 5234-5247 CL:0000210 denotes photoreceptor
T4690 5265-5279 GO:0007416 denotes synaptogenesis
T4691 5299-5305 SO_EXT:sequence_altered_entity denotes mutant
T4692 5313-5317 PR_EXT:000005848 denotes CRB1
T4693 5322-5325 PR_EXT:000005904 denotes Crx
T4694 5426-5433 UBERON:0000966 denotes retinal
T4695 5426-5445 GO:0060041 denotes retinal development
R2521 T4507 T4506 _lexicallyChainedTo membranes,breakdown of
R2522 T4581 T4580 _lexicallyChainedTo R6,photoreceptors
R2523 T4589 T4588 _lexicallyChainedTo photoreceptors,R1

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T4307 0-3 PR:000005904 denotes Crx
T4308 7-21 CL:0000210 denotes photoreceptors
T4309 38-51 GO:0001750 denotes outer segment
T4310 52-65 GO:0009653 denotes morphogenesis
T4311 79-82 PR:000005904 denotes Crx
T4312 116-120 SO:0000704 denotes gene
T4313 147-160 GO:0001750 denotes outer segment
T4314 223-226 PR:000013290 denotes RDS
T4315 227-231 SO:0000704 denotes gene
T4316 243-252 PR:000001245 denotes rhodopsin
T4317 279-292 GO:0001750 denotes outer segment
T4318 338-341 PR:000005904 denotes Crx
T4319 345-358 CL:0000210 denotes photoreceptor
T4320 345-372 GO:0008594 denotes photoreceptor morphogenesis
T4321 404-413 GO:0031982 denotes Vesicular
T4322 428-431 PR:000005904 denotes Crx
T4323 435-449 CL:0000210 denotes photoreceptors
T4324 515-518 PR:000013290 denotes rds
T4325 533-538 NCBITaxon:10088 denotes mouse
T4326 577-585 GO:0031982 denotes vesicles
T4327 602-614 _FRAGMENT denotes breakdown of
T4328 629-638 GO:0030397 denotes membranes
T4329 615-638 GO:0042622 denotes outer segment membranes
T4330 679-693 GO:0001750 denotes outer segments
T4331 772-782 GO:0005902 denotes microvilli
T4332 786-798 CL:0000636 denotes Müller cells
T4333 923-932 PR:000001245 denotes rhodopsin
T4334 950-958 GO:0031982 denotes vesicles
T4335 1001-1010 PR:000001245 denotes rhodopsin
T4336 1053-1061 GO:0031982 denotes vesicles
T4337 1085-1099 GO:0001917 denotes inner segments
T4338 1126-1140 CL:0000210 denotes photoreceptors
T4339 1193-1206 GO:0001750 denotes outer segment
T4340 1237-1254 GO:0032391 denotes connecting cilium
T4341 1301-1304 PR:000013290 denotes RDS
T4342 1309-1314 PR:000014157 denotes ROM-1
T4343 1357-1362 PR:000001119 denotes opsin
T4344 1464-1478 GO:0001750 denotes outer segments
T4345 1494-1499 PR:000014157 denotes ROM-1
T4346 1503-1507 NCBITaxon:10088 denotes mice
T4347 1529-1543 GO:0001750 denotes outer segments
T4348 1567-1570 PR:000005904 denotes Crx
T4349 1626-1634 GO:0065007 denotes controls
T4350 1635-1640 SO:0000704 denotes genes
T4351 1710-1723 GO:0001750 denotes outer segment
T4352 1745-1754 PR:000001245 denotes rhodopsin
T4353 1839-1843 SO:0000704 denotes gene
T4354 1839-1854 GO:0010467 denotes gene expression
T4355 1902-1907 SO:0000704 denotes genes
T4356 1934-1944 GO:0010467 denotes expression
T4357 1954-1957 PR:000005904 denotes Crx
T4358 1961-1965 NCBITaxon:10088 denotes mice
T4359 1981-1990 PR:000001245 denotes rhodopsin
T4360 1991-2001 GO:0010467 denotes expression
T4361 2029-2032 PR:000005904 denotes Crx
T4362 2036-2043 NCBITaxon:33208 denotes animals
T4363 2110-2114 NCBITaxon:10088 denotes mice
T4364 2139-2149 GO:0010467 denotes expression
T4365 2163-2172 PR:000001245 denotes rhodopsin
T4366 2181-2184 CL:0000604 denotes rod
T4367 2246-2255 PR:000001245 denotes rhodopsin
T4368 2256-2266 GO:0010467 denotes expression
T4369 2295-2304 PR:000001245 denotes rhodopsin
T4370 2305-2315 GO:0010467 denotes expression
T4371 2366-2376 NCBITaxon:7215 denotes Drosophila
T4372 2381-2391 NCBITaxon:7215 denotes Drosophila
T4373 2393-2402 PR:000001245 denotes rhodopsin
T4374 2404-2409 PR:P06002 denotes ninaE
T4375 2414-2423 GO:0010467 denotes expressed
T4376 2427-2444 CL:0000687 denotes photoreceptors R1
T4377 2427-2441 _FRAGMENT denotes photoreceptors
T4378 2445-2447 CL:0000705 denotes R6
T4379 2452-2457 PR:P06002 denotes ninaE
T4380 2476-2486 GO:0016028 denotes rhabdomere
T4381 2513-2523 NCBITaxon:7742 denotes vertebrate
T4382 2524-2538 GO:0001750 denotes outer segments
T4383 2560-2562 _FRAGMENT denotes R1
T4384 2566-2580 CL:0000687 denotes photoreceptors
T4385 2563-2580 CL:0000705 denotes R6 photoreceptors
T4386 2619-2628 PR:000001245 denotes rhodopsin
T4387 2632-2636 NCBITaxon:10088 denotes mice
T4388 2729-2738 PR:000001245 denotes rhodopsin
T4389 2739-2749 GO:0010467 denotes expression
T4390 2757-2767 GO:0016028 denotes rhabdomere
T4391 2757-2779 GO:0042052 denotes rhabdomere development
T4392 2784-2789 PR:P06002 denotes ninaE
T4393 2795-2800 NCBITaxon:7147 denotes flies
T4394 2804-2809 PR:P06002 denotes ninaE
T4395 2810-2819 SO:0000902 denotes transgene
T4396 2830-2837 GO:0065007 denotes control
T4397 2854-2862 SO:0000167 denotes promoter
T4398 2964-2973 PR:000001245 denotes rhodopsin
T4399 3031-3044 CL:0000210 denotes photoreceptor
T4400 3079-3092 CL:0000210 denotes photoreceptor
T4401 3114-3124 GO:0010467 denotes expression
T4402 3204-3213 PR:000001245 denotes rhodopsin
T4403 3214-3224 GO:0010467 denotes expression
T4404 3297-3307 GO:0016028 denotes rhabdomere
T4405 3297-3321 GO:0061541 denotes rhabdomere morphogenesis
T4406 3374-3377 NCBITaxon:10114 denotes rat
T4407 3386-3395 PR:000001245 denotes rhodopsin
T4408 3465-3469 CL:0000604 denotes rods
T4409 3502-3512 GO:0065007 denotes regulation
T4410 3516-3525 PR:000001245 denotes rhodopsin
T4411 3553-3560 GO:0065007 denotes control
T4412 3601-3610 PR:000001245 denotes rhodopsin
T4413 3634-3637 PR:000005904 denotes Crx
T4414 3645-3655 GO:0065007 denotes regulating
T4415 3656-3669 GO:0001750 denotes outer segment
T4416 3670-3683 GO:0009653 denotes morphogenesis
T4417 3760-3763 PR:000005904 denotes Crx
T4418 3776-3786 NCBITaxon:7215 denotes Drosophila
T4419 3790-3793 PR:P22810 denotes Otd
T4420 3840-3845 SO:0000704 denotes genes
T4421 3855-3858 PR:000005904 denotes Crx
T4422 3902-3908 SO:0001023 denotes allele
T4423 3912-3922 NCBITaxon:7215 denotes Drosophila
T4424 3923-3926 PR:P22810 denotes otd
T4425 3928-3931 PR:P22810 denotes otd
T4426 3936-3949 CL:0000210 denotes photoreceptor
T4427 3936-3963 GO:0008594 denotes photoreceptor morphogenesis
T4428 4023-4028 SO:0000704 denotes genes
T4429 4053-4056 PR:000005904 denotes Crx
T4430 4073-4082 GO:0010467 denotes expressed
T4431 4107-4110 PR:000005904 denotes Crx
T4432 4114-4120 UBERON:0000966 denotes retina
T4433 4130-4139 PR:000001245 denotes rhodopsin
T4434 4210-4224 CL:0000210 denotes photoreceptors
T4435 4234-4244 GO:0010467 denotes expression
T4436 4294-4299 CHEBI:18059 denotes lipid
T4437 4294-4310 GO:0006629 denotes lipid metabolism
T4438 4312-4327 GO:0006457 denotes protein folding
T4439 4452-4465 GO:0001750 denotes outer segment
T4440 4475-4488 GO:0097617 denotes hybridization
T4441 4526-4531 SO:0000704 denotes genes
T4442 4595-4608 GO:0001917 denotes inner segment
T4443 4657-4670 GO:0001750 denotes outer segment
T4444 4713-4718 SO:0000704 denotes genes
T4445 4746-4759 GO:0001750 denotes outer segment
T4446 4797-4811 CL:0000210 denotes photoreceptors
T4447 4851-4863 GO:0042384 denotes ciliogenesis
T4448 4877-4881 SO:0000704 denotes gene
T4449 4883-4887 PR:000005848 denotes CRB1
T4450 4903-4907 SO:0000704 denotes gene
T4451 4908-4912 PR:000005850 denotes CRB3
T4452 4938-4950 GO:0042384 denotes ciliogenesis
T4453 4980-4990 NCBITaxon:7215 denotes Drosophila
T4454 4991-5000 SO:0000853 denotes homologue
T4455 5004-5008 PR:000005848 denotes CRB1
T4456 5010-5016 PR:P10040 denotes Crumbs
T4457 5041-5054 CL:0000210 denotes photoreceptor
T4458 5041-5068 GO:0008594 denotes photoreceptor morphogenesis
T4459 5112-5117 NCBITaxon:10088 denotes mouse
T4460 5128-5132 PR:000005848 denotes CRB1
T4461 5142-5147 NCBITaxon:10088 denotes mouse
T4462 5168-5182 GO:0001750 denotes outer segments
T4463 5234-5247 CL:0000210 denotes photoreceptor
T4464 5265-5279 GO:0007416 denotes synaptogenesis
T4465 5313-5317 PR:000005848 denotes CRB1
T4466 5322-5325 PR:000005904 denotes Crx
T4467 5426-5433 UBERON:0000966 denotes retinal
T4468 5426-5445 GO:0060041 denotes retinal development
R2518 T4328 T4327 _lexicallyChainedTo membranes,breakdown of
R2519 T4378 T4377 _lexicallyChainedTo R6,photoreceptors
R2520 T4384 T4383 _lexicallyChainedTo photoreceptors,R1

craft-sa-dev

Id Subject Object Predicate Lexical cue
T4696 0-3 NN denotes Crx
T4697 7-21 NNS denotes photoreceptors
T4698 3-4 SYM denotes -
T4699 4-5 HYPH denotes /
T4700 5-6 SYM denotes -
T4701 29-37 VB denotes complete
T4702 22-25 MD denotes can
T4703 25-28 RB denotes not
T4704 38-43 JJ denotes outer
T4705 44-51 NN denotes segment
T4706 52-65 NN denotes morphogenesis
T4707 65-178 sentence denotes Mutations in Crx represent one of a collection of gene mutations that lead to an outer segment formation defect.
T4708 66-75 NNS denotes Mutations
T4709 83-92 VBP denotes represent
T4710 76-78 IN denotes in
T4711 79-82 NN denotes Crx
T4712 93-96 CD denotes one
T4713 97-99 IN denotes of
T4714 100-101 DT denotes a
T4715 102-112 NN denotes collection
T4716 113-115 IN denotes of
T4717 116-120 NN denotes gene
T4718 121-130 NNS denotes mutations
T4719 131-135 WDT denotes that
T4720 136-140 VBP denotes lead
T4721 141-143 IN denotes to
T4722 144-146 DT denotes an
T4723 171-177 NN denotes defect
T4724 147-152 JJ denotes outer
T4725 153-160 NN denotes segment
T4726 161-170 NN denotes formation
T4727 177-178 . denotes .
T4728 178-303 sentence denotes Homozygous null mutations in the peripherin/RDS gene [36] or in rhodopsin [29] lead to a failure of outer segment formation.
T4729 179-189 JJ denotes Homozygous
T4730 195-204 NNS denotes mutations
T4731 190-194 JJ denotes null
T4732 258-262 VBP denotes lead
T4733 205-207 IN denotes in
T4734 208-211 DT denotes the
T4735 227-231 NN denotes gene
T4736 212-222 NN denotes peripherin
T4737 223-226 NN denotes RDS
T4738 222-223 HYPH denotes /
T4739 232-233 -LRB- denotes [
T4740 233-235 CD denotes 36
T4741 235-236 -RRB- denotes ]
T4742 237-239 CC denotes or
T4743 240-242 IN denotes in
T4744 243-252 NN denotes rhodopsin
T4745 253-254 -LRB- denotes [
T4746 254-256 CD denotes 29
T4747 256-257 -RRB- denotes ]
T4748 263-265 IN denotes to
T4749 266-267 DT denotes a
T4750 268-275 NN denotes failure
T4751 276-278 IN denotes of
T4752 279-284 JJ denotes outer
T4753 285-292 NN denotes segment
T4754 293-302 NN denotes formation
T4755 302-303 . denotes .
T4756 303-403 sentence denotes The deficits in peripherin-/- and Crx-/- photoreceptor morphogenesis were found to be very similar.
T4757 304-307 DT denotes The
T4758 308-316 NNS denotes deficits
T4759 378-383 VBN denotes found
T4760 317-319 IN denotes in
T4761 320-330 NN denotes peripherin
T4762 359-372 NN denotes morphogenesis
T4763 330-331 SYM denotes -
T4764 331-332 HYPH denotes /
T4765 332-333 SYM denotes -
T4766 334-337 CC denotes and
T4767 338-341 NN denotes Crx
T4768 341-342 SYM denotes -
T4769 342-343 HYPH denotes /
T4770 343-344 SYM denotes -
T4771 345-358 NN denotes photoreceptor
T4772 373-377 VBD denotes were
T4773 384-386 TO denotes to
T4774 387-389 VB denotes be
T4775 390-394 RB denotes very
T4776 395-402 JJ denotes similar
T4777 402-403 . denotes .
T4778 403-539 sentence denotes Vesicular structures in Crx-/- photoreceptors were observed that were similar to those previously noted in the rds/peripherin-/- mouse.
T4779 404-413 JJ denotes Vesicular
T4780 414-424 NNS denotes structures
T4781 455-463 VBN denotes observed
T4782 425-427 IN denotes in
T4783 428-431 NN denotes Crx
T4784 435-449 NNS denotes photoreceptors
T4785 431-432 SYM denotes -
T4786 432-433 HYPH denotes /
T4787 433-434 SYM denotes -
T4788 450-454 VBD denotes were
T4789 464-468 WDT denotes that
T4790 469-473 VBD denotes were
T4791 474-481 JJ denotes similar
T4792 482-484 IN denotes to
T4793 485-490 DT denotes those
T4794 491-501 RB denotes previously
T4795 502-507 VBN denotes noted
T4796 508-510 IN denotes in
T4797 511-514 DT denotes the
T4798 533-538 NN denotes mouse
T4799 515-518 NN denotes rds
T4800 519-529 NN denotes peripherin
T4801 518-519 HYPH denotes /
T4802 529-530 SYM denotes -
T4803 530-531 HYPH denotes /
T4804 531-532 SYM denotes -
T4805 538-539 . denotes .
T4806 539-804 sentence denotes It was initially proposed that these vesicles were due to the breakdown of outer segment membranes that were not properly recruited to the outer segments in the absence of peripherin, or were from the result of the breakdown of the microvilli of Müller cells [30].
T4807 540-542 PRP denotes It
T4808 557-565 VBN denotes proposed
T4809 543-546 VBD denotes was
T4810 547-556 RB denotes initially
T4811 566-570 IN denotes that
T4812 586-590 VBD denotes were
T4813 571-576 DT denotes these
T4814 577-585 NNS denotes vesicles
T4815 591-594 IN denotes due
T4816 595-597 IN denotes to
T4817 598-601 DT denotes the
T4818 602-611 NN denotes breakdown
T4819 612-614 IN denotes of
T4820 615-620 JJ denotes outer
T4821 621-628 NN denotes segment
T4822 629-638 NNS denotes membranes
T4823 639-643 WDT denotes that
T4824 662-671 VBN denotes recruited
T4825 644-648 VBD denotes were
T4826 649-652 RB denotes not
T4827 653-661 RB denotes properly
T4828 672-674 IN denotes to
T4829 675-678 DT denotes the
T4830 685-693 NNS denotes segments
T4831 679-684 JJ denotes outer
T4832 694-696 IN denotes in
T4833 697-700 DT denotes the
T4834 701-708 NN denotes absence
T4835 709-711 IN denotes of
T4836 712-722 NN denotes peripherin
T4837 722-724 , denotes ,
T4838 724-726 CC denotes or
T4839 727-731 VBD denotes were
T4840 732-736 IN denotes from
T4841 737-740 DT denotes the
T4842 741-747 NN denotes result
T4843 748-750 IN denotes of
T4844 751-754 DT denotes the
T4845 755-764 NN denotes breakdown
T4846 765-767 IN denotes of
T4847 768-771 DT denotes the
T4848 772-782 NNS denotes microvilli
T4849 783-785 IN denotes of
T4850 786-792 NN denotes Müller
T4851 793-798 NNS denotes cells
T4852 799-800 -LRB- denotes [
T4853 800-802 CD denotes 30
T4854 802-803 -RRB- denotes ]
T4855 803-804 . denotes .
T4856 804-1024 sentence denotes Strong support in favor of the former explanation was provided by Nir and colleagues who demonstrated the presence of rhodopsin protein in these vesicles using immunoelectron microscopy against a rhodopsin epitope [37].
T4857 805-811 JJ denotes Strong
T4858 812-819 NN denotes support
T4859 859-867 VBN denotes provided
T4860 820-822 IN denotes in
T4861 823-828 NN denotes favor
T4862 829-831 IN denotes of
T4863 832-835 DT denotes the
T4864 843-854 NN denotes explanation
T4865 836-842 JJ denotes former
T4866 855-858 VBD denotes was
T4867 868-870 IN denotes by
T4868 871-874 NN denotes Nir
T4869 875-878 CC denotes and
T4870 879-889 NNS denotes colleagues
T4871 890-893 WP denotes who
T4872 894-906 VBD denotes demonstrated
T4873 907-910 DT denotes the
T4874 911-919 NN denotes presence
T4875 920-922 IN denotes of
T4876 923-932 NN denotes rhodopsin
T4877 933-940 NN denotes protein
T4878 941-943 IN denotes in
T4879 944-949 DT denotes these
T4880 950-958 NNS denotes vesicles
T4881 959-964 VBG denotes using
T4882 965-979 NN denotes immunoelectron
T4883 980-990 NN denotes microscopy
T4884 991-998 IN denotes against
T4885 999-1000 DT denotes a
T4886 1011-1018 NN denotes epitope
T4887 1001-1010 NN denotes rhodopsin
T4888 1019-1020 -LRB- denotes [
T4889 1020-1022 CD denotes 37
T4890 1022-1023 -RRB- denotes ]
T4891 1023-1024 . denotes .
T4892 1024-1111 sentence denotes Further, as shown here, the vesicles appear to bud from the inner segments themselves.
T4893 1025-1032 RB denotes Further
T4894 1062-1068 VBP denotes appear
T4895 1032-1034 , denotes ,
T4896 1034-1036 IN denotes as
T4897 1037-1042 VBN denotes shown
T4898 1043-1047 RB denotes here
T4899 1047-1049 , denotes ,
T4900 1049-1052 DT denotes the
T4901 1053-1061 NNS denotes vesicles
T4902 1069-1071 TO denotes to
T4903 1072-1075 VB denotes bud
T4904 1076-1080 IN denotes from
T4905 1081-1084 DT denotes the
T4906 1091-1099 NNS denotes segments
T4907 1085-1090 JJ denotes inner
T4908 1100-1110 PRP denotes themselves
T4909 1110-1111 . denotes .
T4910 1111-1289 sentence denotes In developing photoreceptors, an extraordinary growth process occurs whereby the outer segment is generated from the nascent connecting cilium (see [38] and references therein).
T4911 1112-1114 IN denotes In
T4912 1174-1180 VBZ denotes occurs
T4913 1115-1125 VBG denotes developing
T4914 1126-1140 NNS denotes photoreceptors
T4915 1140-1142 , denotes ,
T4916 1142-1144 DT denotes an
T4917 1166-1173 NN denotes process
T4918 1145-1158 JJ denotes extraordinary
T4919 1159-1165 NN denotes growth
T4920 1181-1188 WRB denotes whereby
T4921 1210-1219 VBN denotes generated
T4922 1189-1192 DT denotes the
T4923 1199-1206 NN denotes segment
T4924 1193-1198 JJ denotes outer
T4925 1207-1209 VBZ denotes is
T4926 1220-1224 IN denotes from
T4927 1225-1228 DT denotes the
T4928 1248-1254 NN denotes cilium
T4929 1229-1236 JJ denotes nascent
T4930 1237-1247 VBG denotes connecting
T4931 1255-1256 -LRB- denotes (
T4932 1256-1259 VB denotes see
T4933 1260-1261 -LRB- denotes [
T4934 1261-1263 CD denotes 38
T4935 1263-1264 -RRB- denotes ]
T4936 1265-1268 CC denotes and
T4937 1269-1279 NNS denotes references
T4938 1280-1287 RB denotes therein
T4939 1287-1288 -RRB- denotes )
T4940 1288-1289 . denotes .
T4941 1289-1493 sentence denotes Peripherin/RDS and ROM-1 proteins (localized in disc rims) and the opsin proteins (localized throughout the discs) have important roles in the structural integrity of mature outer segments (see [39,29]).
T4942 1290-1300 NN denotes Peripherin
T4943 1301-1304 NN denotes RDS
T4944 1300-1301 HYPH denotes /
T4945 1315-1323 NN denotes proteins
T4946 1305-1308 CC denotes and
T4947 1309-1312 NN denotes ROM
T4948 1312-1313 HYPH denotes -
T4949 1313-1314 CD denotes 1
T4950 1405-1409 VBP denotes have
T4951 1324-1325 -LRB- denotes (
T4952 1325-1334 VBN denotes localized
T4953 1335-1337 IN denotes in
T4954 1338-1342 NN denotes disc
T4955 1343-1347 NNS denotes rims
T4956 1347-1348 -RRB- denotes )
T4957 1349-1352 CC denotes and
T4958 1353-1356 DT denotes the
T4959 1363-1371 NN denotes proteins
T4960 1357-1362 NN denotes opsin
T4961 1372-1373 -LRB- denotes (
T4962 1373-1382 VBN denotes localized
T4963 1383-1393 IN denotes throughout
T4964 1394-1397 DT denotes the
T4965 1398-1403 NNS denotes discs
T4966 1403-1404 -RRB- denotes )
T4967 1410-1419 JJ denotes important
T4968 1420-1425 NNS denotes roles
T4969 1426-1428 IN denotes in
T4970 1429-1432 DT denotes the
T4971 1444-1453 NN denotes integrity
T4972 1433-1443 JJ denotes structural
T4973 1454-1456 IN denotes of
T4974 1457-1463 JJ denotes mature
T4975 1470-1478 NNS denotes segments
T4976 1464-1469 JJ denotes outer
T4977 1479-1480 -LRB- denotes (
T4978 1480-1483 VB denotes see
T4979 1484-1485 -LRB- denotes [
T4980 1485-1487 CD denotes 39
T4981 1488-1490 CD denotes 29
T4982 1487-1488 , denotes ,
T4983 1490-1491 -RRB- denotes ]
T4984 1491-1492 -RRB- denotes )
T4985 1492-1493 . denotes .
T4986 1493-1566 sentence denotes ROM-1-/- mice produce disorganized outer segments with large disks [40].
T4987 1494-1497 NN denotes ROM
T4988 1503-1507 NNS denotes mice
T4989 1497-1498 HYPH denotes -
T4990 1498-1499 CD denotes 1
T4991 1499-1500 SYM denotes -
T4992 1500-1501 HYPH denotes /
T4993 1501-1502 SYM denotes -
T4994 1508-1515 VBP denotes produce
T4995 1516-1528 VBN denotes disorganized
T4996 1535-1543 NNS denotes segments
T4997 1529-1534 JJ denotes outer
T4998 1544-1548 IN denotes with
T4999 1549-1554 JJ denotes large
T5000 1555-1560 NNS denotes disks
T5001 1561-1562 -LRB- denotes [
T5002 1562-1564 CD denotes 40
T5003 1564-1565 -RRB- denotes ]
T5004 1565-1566 . denotes .
T5005 1566-1770 sentence denotes Crx, by virtue of being a transcription factor, presumably controls genes that are responsible for the building and perhaps maintenance of the outer segment structure, including rhodopsin and peripherin.
T5006 1567-1570 NN denotes Crx
T5007 1626-1634 VBZ denotes controls
T5008 1570-1572 , denotes ,
T5009 1572-1574 IN denotes by
T5010 1575-1581 NN denotes virtue
T5011 1582-1584 IN denotes of
T5012 1585-1590 VBG denotes being
T5013 1591-1592 DT denotes a
T5014 1607-1613 NN denotes factor
T5015 1593-1606 NN denotes transcription
T5016 1613-1615 , denotes ,
T5017 1615-1625 RB denotes presumably
T5018 1635-1640 NNS denotes genes
T5019 1641-1645 WDT denotes that
T5020 1646-1649 VBP denotes are
T5021 1650-1661 JJ denotes responsible
T5022 1662-1665 IN denotes for
T5023 1666-1669 DT denotes the
T5024 1670-1678 NN denotes building
T5025 1679-1682 CC denotes and
T5026 1683-1690 RB denotes perhaps
T5027 1691-1702 NN denotes maintenance
T5028 1703-1705 IN denotes of
T5029 1706-1709 DT denotes the
T5030 1724-1733 NN denotes structure
T5031 1710-1715 JJ denotes outer
T5032 1716-1723 NN denotes segment
T5033 1733-1735 , denotes ,
T5034 1735-1744 VBG denotes including
T5035 1745-1754 NN denotes rhodopsin
T5036 1755-1758 CC denotes and
T5037 1759-1769 NN denotes peripherin
T5038 1769-1770 . denotes .
T5039 1770-1966 sentence denotes Using northern blots [34], microarrays [10], and serial analysis of gene expression (SAGE) [35], we have defined a large number of genes that are altered in their expression level in Crx-/- mice.
T5040 1771-1776 VBG denotes Using
T5041 1876-1883 VBN denotes defined
T5042 1777-1785 NNP denotes northern
T5043 1786-1791 NNS denotes blots
T5044 1792-1793 -LRB- denotes [
T5045 1793-1795 CD denotes 34
T5046 1795-1796 -RRB- denotes ]
T5047 1796-1798 , denotes ,
T5048 1798-1809 NNS denotes microarrays
T5049 1810-1811 -LRB- denotes [
T5050 1811-1813 CD denotes 10
T5051 1813-1814 -RRB- denotes ]
T5052 1814-1816 , denotes ,
T5053 1816-1819 CC denotes and
T5054 1820-1826 JJ denotes serial
T5055 1827-1835 NN denotes analysis
T5056 1836-1838 IN denotes of
T5057 1839-1843 NN denotes gene
T5058 1844-1854 NN denotes expression
T5059 1855-1856 -LRB- denotes (
T5060 1856-1860 NN denotes SAGE
T5061 1860-1861 -RRB- denotes )
T5062 1862-1863 -LRB- denotes [
T5063 1863-1865 CD denotes 35
T5064 1865-1866 -RRB- denotes ]
T5065 1866-1868 , denotes ,
T5066 1868-1870 PRP denotes we
T5067 1871-1875 VBP denotes have
T5068 1884-1885 DT denotes a
T5069 1892-1898 NN denotes number
T5070 1886-1891 JJ denotes large
T5071 1899-1901 IN denotes of
T5072 1902-1907 NNS denotes genes
T5073 1908-1912 WDT denotes that
T5074 1917-1924 VBN denotes altered
T5075 1913-1916 VBP denotes are
T5076 1925-1927 IN denotes in
T5077 1928-1933 PRP$ denotes their
T5078 1945-1950 NN denotes level
T5079 1934-1944 NN denotes expression
T5080 1951-1953 IN denotes in
T5081 1954-1957 NN denotes Crx
T5082 1961-1965 NNS denotes mice
T5083 1957-1958 SYM denotes -
T5084 1958-1959 HYPH denotes /
T5085 1959-1960 SYM denotes -
T5086 1965-1966 . denotes .
T5087 1966-2098 sentence denotes We found that rhodopsin expression was severely diminished in Crx-/- animals, and peripherin mRNA was reduced by approximately 30%.
T5088 1967-1969 PRP denotes We
T5089 1970-1975 VBD denotes found
T5090 1976-1980 IN denotes that
T5091 2015-2025 VBN denotes diminished
T5092 1981-1990 NN denotes rhodopsin
T5093 1991-2001 NN denotes expression
T5094 2002-2005 VBD denotes was
T5095 2006-2014 RB denotes severely
T5096 2026-2028 IN denotes in
T5097 2029-2032 NN denotes Crx
T5098 2036-2043 NNS denotes animals
T5099 2032-2033 SYM denotes -
T5100 2033-2034 HYPH denotes /
T5101 2034-2035 SYM denotes -
T5102 2043-2045 , denotes ,
T5103 2045-2048 CC denotes and
T5104 2049-2059 NN denotes peripherin
T5105 2060-2064 NN denotes mRNA
T5106 2069-2076 VBN denotes reduced
T5107 2065-2068 VBD denotes was
T5108 2077-2079 IN denotes by
T5109 2080-2093 RB denotes approximately
T5110 2094-2096 CD denotes 30
T5111 2096-2097 NN denotes %
T5112 2097-2098 . denotes .
T5113 2098-2267 sentence denotes Transgenic mice with variable levels of expression of wild type rhodopsin exhibit rod degeneration [41], indicating the importance of the level of rhodopsin expression.
T5114 2099-2109 JJ denotes Transgenic
T5115 2110-2114 NNS denotes mice
T5116 2173-2180 VBP denotes exhibit
T5117 2115-2119 IN denotes with
T5118 2120-2128 JJ denotes variable
T5119 2129-2135 NNS denotes levels
T5120 2136-2138 IN denotes of
T5121 2139-2149 NN denotes expression
T5122 2150-2152 IN denotes of
T5123 2153-2157 JJ denotes wild
T5124 2158-2162 NN denotes type
T5125 2163-2172 NN denotes rhodopsin
T5126 2181-2184 NN denotes rod
T5127 2185-2197 NN denotes degeneration
T5128 2198-2199 -LRB- denotes [
T5129 2199-2201 CD denotes 41
T5130 2201-2202 -RRB- denotes ]
T5131 2202-2204 , denotes ,
T5132 2204-2214 VBG denotes indicating
T5133 2215-2218 DT denotes the
T5134 2219-2229 NN denotes importance
T5135 2230-2232 IN denotes of
T5136 2233-2236 DT denotes the
T5137 2237-2242 NN denotes level
T5138 2243-2245 IN denotes of
T5139 2246-2255 NN denotes rhodopsin
T5140 2256-2266 NN denotes expression
T5141 2266-2267 . denotes .
T5142 2267-2377 sentence denotes In addition, the timing of rhodopsin expression may be very important, as indicated by studies in Drosophila.
T5143 2268-2270 IN denotes In
T5144 2320-2322 VB denotes be
T5145 2271-2279 NN denotes addition
T5146 2279-2281 , denotes ,
T5147 2281-2284 DT denotes the
T5148 2285-2291 NN denotes timing
T5149 2292-2294 IN denotes of
T5150 2295-2304 NN denotes rhodopsin
T5151 2305-2315 NN denotes expression
T5152 2316-2319 MD denotes may
T5153 2323-2327 RB denotes very
T5154 2328-2337 JJ denotes important
T5155 2337-2339 , denotes ,
T5156 2339-2341 IN denotes as
T5157 2342-2351 VBN denotes indicated
T5158 2352-2354 IN denotes by
T5159 2355-2362 NNS denotes studies
T5160 2363-2365 IN denotes in
T5161 2366-2376 NNP denotes Drosophila
T5162 2376-2377 . denotes .
T5163 2377-2448 sentence denotes In Drosophila, rhodopsin (ninaE) is expressed in photoreceptors R1–R6.
T5164 2378-2380 IN denotes In
T5165 2414-2423 VBN denotes expressed
T5166 2381-2391 NNP denotes Drosophila
T5167 2391-2393 , denotes ,
T5168 2393-2402 NN denotes rhodopsin
T5169 2403-2404 -LRB- denotes (
T5170 2404-2409 NN denotes ninaE
T5171 2409-2410 -RRB- denotes )
T5172 2411-2413 VBZ denotes is
T5173 2424-2426 IN denotes in
T5174 2427-2441 NNS denotes photoreceptors
T5175 2442-2444 NN denotes R1
T5176 2444-2445 SYM denotes –
T5177 2445-2447 NN denotes R6
T5178 2447-2448 . denotes .
T5179 2448-2642 sentence denotes In ninaE null mutants, the rhabdomere, a structure analogous to vertebrate outer segments, fails to develop in R1–R6 photoreceptors [42], reminiscent of the situation in rhodopsin-/- mice [29].
T5180 2449-2451 IN denotes In
T5181 2540-2545 VBZ denotes fails
T5182 2452-2457 NN denotes ninaE
T5183 2458-2462 JJ denotes null
T5184 2463-2470 NNS denotes mutants
T5185 2470-2472 , denotes ,
T5186 2472-2475 DT denotes the
T5187 2476-2486 NN denotes rhabdomere
T5188 2486-2488 , denotes ,
T5189 2488-2489 DT denotes a
T5190 2490-2499 NN denotes structure
T5191 2500-2509 JJ denotes analogous
T5192 2510-2512 IN denotes to
T5193 2513-2523 NN denotes vertebrate
T5194 2530-2538 NNS denotes segments
T5195 2524-2529 JJ denotes outer
T5196 2538-2540 , denotes ,
T5197 2546-2548 TO denotes to
T5198 2549-2556 VB denotes develop
T5199 2557-2559 IN denotes in
T5200 2560-2562 NN denotes R1
T5201 2566-2580 NNS denotes photoreceptors
T5202 2562-2563 SYM denotes –
T5203 2563-2565 NN denotes R6
T5204 2581-2582 -LRB- denotes [
T5205 2582-2584 CD denotes 42
T5206 2584-2585 -RRB- denotes ]
T5207 2585-2587 , denotes ,
T5208 2587-2598 JJ denotes reminiscent
T5209 2599-2601 IN denotes of
T5210 2602-2605 DT denotes the
T5211 2606-2615 NN denotes situation
T5212 2616-2618 IN denotes in
T5213 2619-2628 NN denotes rhodopsin
T5214 2632-2636 NNS denotes mice
T5215 2628-2629 SYM denotes -
T5216 2629-2630 HYPH denotes /
T5217 2630-2631 SYM denotes -
T5218 2637-2638 -LRB- denotes [
T5219 2638-2640 CD denotes 29
T5220 2640-2641 -RRB- denotes ]
T5221 2641-2642 . denotes .
T5222 2642-2780 sentence denotes An intriguing experiment by Kumar et al. [43] demonstrated a temporal requirement for rhodopsin expression during rhabdomere development.
T5223 2643-2645 DT denotes An
T5224 2657-2667 NN denotes experiment
T5225 2646-2656 JJ denotes intriguing
T5226 2689-2701 VBD denotes demonstrated
T5227 2668-2670 IN denotes by
T5228 2671-2676 NNP denotes Kumar
T5229 2677-2679 FW denotes et
T5230 2680-2683 FW denotes al.
T5231 2684-2685 -LRB- denotes [
T5232 2685-2687 CD denotes 43
T5233 2687-2688 -RRB- denotes ]
T5234 2702-2703 DT denotes a
T5235 2713-2724 NN denotes requirement
T5236 2704-2712 JJ denotes temporal
T5237 2725-2728 IN denotes for
T5238 2729-2738 NN denotes rhodopsin
T5239 2739-2749 NN denotes expression
T5240 2750-2756 IN denotes during
T5241 2757-2767 NN denotes rhabdomere
T5242 2768-2779 NN denotes development
T5243 2779-2780 . denotes .
T5244 2780-2926 sentence denotes In ninaE null flies, a ninaE transgene under the control of a heat shock promoter was subjected to various temperature shifts during development.
T5245 2781-2783 IN denotes In
T5246 2867-2876 VBN denotes subjected
T5247 2784-2789 NN denotes ninaE
T5248 2790-2794 JJ denotes null
T5249 2795-2800 NNS denotes flies
T5250 2800-2802 , denotes ,
T5251 2802-2803 DT denotes a
T5252 2810-2819 NN denotes transgene
T5253 2804-2809 NN denotes ninaE
T5254 2820-2825 IN denotes under
T5255 2826-2829 DT denotes the
T5256 2830-2837 NN denotes control
T5257 2838-2840 IN denotes of
T5258 2841-2842 DT denotes a
T5259 2854-2862 NN denotes promoter
T5260 2843-2847 NN denotes heat
T5261 2848-2853 NN denotes shock
T5262 2863-2866 VBD denotes was
T5263 2877-2879 IN denotes to
T5264 2880-2887 JJ denotes various
T5265 2900-2906 NNS denotes shifts
T5266 2888-2899 NN denotes temperature
T5267 2907-2913 IN denotes during
T5268 2914-2925 NN denotes development
T5269 2925-2926 . denotes .
T5270 2926-3104 sentence denotes Heat shock during the normal time of rhodopsin onset resulted in substantial and long-lasting rescue of photoreceptor structure and transient rescue of photoreceptor physiology.
T5271 2927-2931 NN denotes Heat
T5272 2932-2937 NN denotes shock
T5273 2980-2988 VBD denotes resulted
T5274 2938-2944 IN denotes during
T5275 2945-2948 DT denotes the
T5276 2956-2960 NN denotes time
T5277 2949-2955 JJ denotes normal
T5278 2961-2963 IN denotes of
T5279 2964-2973 NN denotes rhodopsin
T5280 2974-2979 NN denotes onset
T5281 2989-2991 IN denotes in
T5282 2992-3003 JJ denotes substantial
T5283 3021-3027 NN denotes rescue
T5284 3004-3007 CC denotes and
T5285 3008-3012 RB denotes long
T5286 3013-3020 VBG denotes lasting
T5287 3012-3013 HYPH denotes -
T5288 3028-3030 IN denotes of
T5289 3031-3044 NN denotes photoreceptor
T5290 3045-3054 NN denotes structure
T5291 3055-3058 CC denotes and
T5292 3059-3068 JJ denotes transient
T5293 3069-3075 NN denotes rescue
T5294 3076-3078 IN denotes of
T5295 3079-3092 NN denotes photoreceptor
T5296 3093-3103 NN denotes physiology
T5297 3103-3104 . denotes .
T5298 3104-3322 sentence denotes However, expression shortly before or after this critical period failed to rescue, suggesting that rhodopsin expression during a discrete window of time in development is essential for proper rhabdomere morphogenesis.
T5299 3105-3112 RB denotes However
T5300 3170-3176 VBD denotes failed
T5301 3112-3114 , denotes ,
T5302 3114-3124 NN denotes expression
T5303 3125-3132 RB denotes shortly
T5304 3133-3139 IN denotes before
T5305 3140-3142 CC denotes or
T5306 3143-3148 IN denotes after
T5307 3149-3153 DT denotes this
T5308 3163-3169 NN denotes period
T5309 3154-3162 JJ denotes critical
T5310 3177-3179 TO denotes to
T5311 3180-3186 VB denotes rescue
T5312 3186-3188 , denotes ,
T5313 3188-3198 VBG denotes suggesting
T5314 3199-3203 IN denotes that
T5315 3273-3275 VBZ denotes is
T5316 3204-3213 NN denotes rhodopsin
T5317 3214-3224 NN denotes expression
T5318 3225-3231 IN denotes during
T5319 3232-3233 DT denotes a
T5320 3243-3249 NN denotes window
T5321 3234-3242 JJ denotes discrete
T5322 3250-3252 IN denotes of
T5323 3253-3257 NN denotes time
T5324 3258-3260 IN denotes in
T5325 3261-3272 NN denotes development
T5326 3276-3285 JJ denotes essential
T5327 3286-3289 IN denotes for
T5328 3290-3296 JJ denotes proper
T5329 3308-3321 NN denotes morphogenesis
T5330 3297-3307 JJ denotes rhabdomere
T5331 3321-3322 . denotes .
T5332 3322-3483 sentence denotes This result is consistent with observations in the rat wherein rhodopsin onset occurs with strict timing in the developmental history of most rods in vivo [44].
T5333 3323-3327 DT denotes This
T5334 3328-3334 NN denotes result
T5335 3335-3337 VBZ denotes is
T5336 3338-3348 JJ denotes consistent
T5337 3349-3353 IN denotes with
T5338 3354-3366 NNS denotes observations
T5339 3367-3369 IN denotes in
T5340 3370-3373 DT denotes the
T5341 3374-3377 NN denotes rat
T5342 3378-3385 IN denotes wherein
T5343 3402-3408 VBZ denotes occurs
T5344 3386-3395 NN denotes rhodopsin
T5345 3396-3401 NN denotes onset
T5346 3409-3413 IN denotes with
T5347 3414-3420 JJ denotes strict
T5348 3421-3427 NN denotes timing
T5349 3428-3430 IN denotes in
T5350 3431-3434 DT denotes the
T5351 3449-3456 NN denotes history
T5352 3435-3448 JJ denotes developmental
T5353 3457-3459 IN denotes of
T5354 3460-3464 JJS denotes most
T5355 3465-3469 NNS denotes rods
T5356 3470-3472 FW denotes in
T5357 3473-3477 FW denotes vivo
T5358 3478-3479 -LRB- denotes [
T5359 3479-3481 CD denotes 44
T5360 3481-3482 -RRB- denotes ]
T5361 3482-3483 . denotes .
T5362 3483-3684 sentence denotes Thus, through its regulation of rhodopsin levels, or perhaps through control of the kinetics of the up-regulation of rhodopsin beginning at about P6, Crx may be regulating outer segment morphogenesis.
T5363 3484-3488 RB denotes Thus
T5364 3645-3655 VBG denotes regulating
T5365 3488-3490 , denotes ,
T5366 3490-3497 IN denotes through
T5367 3498-3501 PRP$ denotes its
T5368 3502-3512 NN denotes regulation
T5369 3513-3515 IN denotes of
T5370 3516-3525 NN denotes rhodopsin
T5371 3526-3532 NNS denotes levels
T5372 3532-3534 , denotes ,
T5373 3534-3536 CC denotes or
T5374 3537-3544 RB denotes perhaps
T5375 3545-3552 IN denotes through
T5376 3553-3560 NN denotes control
T5377 3561-3563 IN denotes of
T5378 3564-3567 DT denotes the
T5379 3568-3576 NN denotes kinetics
T5380 3577-3579 IN denotes of
T5381 3580-3583 DT denotes the
T5382 3587-3597 NN denotes regulation
T5383 3584-3586 JJ denotes up
T5384 3586-3587 HYPH denotes -
T5385 3598-3600 IN denotes of
T5386 3601-3610 NN denotes rhodopsin
T5387 3611-3620 VBG denotes beginning
T5388 3621-3623 IN denotes at
T5389 3624-3629 RB denotes about
T5390 3630-3632 NN denotes P6
T5391 3632-3634 , denotes ,
T5392 3634-3637 NN denotes Crx
T5393 3638-3641 MD denotes may
T5394 3642-3644 VB denotes be
T5395 3656-3661 JJ denotes outer
T5396 3662-3669 NN denotes segment
T5397 3670-3683 NN denotes morphogenesis
T5398 3683-3684 . denotes .
T5399 3684-3735 sentence denotes The similarty of the two cases may extend further.
T5400 3685-3688 DT denotes The
T5401 3689-3698 NN denotes similarty
T5402 3720-3726 VB denotes extend
T5403 3699-3701 IN denotes of
T5404 3702-3705 DT denotes the
T5405 3710-3715 NNS denotes cases
T5406 3706-3709 CD denotes two
T5407 3716-3719 MD denotes may
T5408 3727-3734 RB denotes further
T5409 3734-3735 . denotes .
T5410 3735-3867 sentence denotes At present, the closest Crx relative in Drosophila is Otd, the founding member of the class of homeobox genes to which Crx belongs.
T5411 3736-3738 IN denotes At
T5412 3787-3789 VBZ denotes is
T5413 3739-3746 JJ denotes present
T5414 3746-3748 , denotes ,
T5415 3748-3751 DT denotes the
T5416 3760-3763 NN denotes Crx
T5417 3752-3759 JJS denotes closest
T5418 3764-3772 JJ denotes relative
T5419 3773-3775 IN denotes in
T5420 3776-3786 NNP denotes Drosophila
T5421 3790-3793 NN denotes Otd
T5422 3793-3795 , denotes ,
T5423 3795-3798 DT denotes the
T5424 3808-3814 NN denotes member
T5425 3799-3807 JJ denotes founding
T5426 3815-3817 IN denotes of
T5427 3818-3821 DT denotes the
T5428 3822-3827 NN denotes class
T5429 3828-3830 IN denotes of
T5430 3831-3839 NN denotes homeobox
T5431 3840-3845 NNS denotes genes
T5432 3846-3848 IN denotes to
T5433 3859-3866 VBZ denotes belongs
T5434 3849-3854 WDT denotes which
T5435 3855-3858 NN denotes Crx
T5436 3866-3867 . denotes .
T5437 3867-3987 sentence denotes Interestingly, in one hypomorphic allele of Drosophila otd, otduvi, photoreceptor morphogenesis is also disrupted [45].
T5438 3868-3881 RB denotes Interestingly
T5439 3972-3981 VBN denotes disrupted
T5440 3881-3883 , denotes ,
T5441 3883-3885 IN denotes in
T5442 3886-3889 CD denotes one
T5443 3902-3908 NN denotes allele
T5444 3890-3901 JJ denotes hypomorphic
T5445 3909-3911 IN denotes of
T5446 3912-3922 NNP denotes Drosophila
T5447 3923-3926 NN denotes otd
T5448 3926-3928 , denotes ,
T5449 3928-3934 NN denotes otduvi
T5450 3934-3936 , denotes ,
T5451 3936-3949 NN denotes photoreceptor
T5452 3950-3963 NN denotes morphogenesis
T5453 3964-3966 VBZ denotes is
T5454 3967-3971 RB denotes also
T5455 3982-3983 -LRB- denotes [
T5456 3983-3985 CD denotes 45
T5457 3985-3986 -RRB- denotes ]
T5458 3986-3987 . denotes .
T5459 3987-4057 sentence denotes We found that there are many other genes that are dependent upon Crx.
T5460 3988-3990 PRP denotes We
T5461 3991-3996 VBD denotes found
T5462 3997-4001 IN denotes that
T5463 4008-4011 VBP denotes are
T5464 4002-4007 EX denotes there
T5465 4012-4016 JJ denotes many
T5466 4023-4028 NNS denotes genes
T5467 4017-4022 JJ denotes other
T5468 4029-4033 WDT denotes that
T5469 4034-4037 VBP denotes are
T5470 4038-4047 JJ denotes dependent
T5471 4048-4052 IN denotes upon
T5472 4053-4056 NN denotes Crx
T5473 4056-4057 . denotes .
T5474 4057-4250 sentence denotes Those that are expressed at a lower level in the Crx-/- retina, such as rhodopsin and peripherin, comprise many that are either enriched or specific to photoreceptors in their expression [35].
T5475 4058-4063 DT denotes Those
T5476 4156-4164 VBP denotes comprise
T5477 4064-4068 WDT denotes that
T5478 4073-4082 VBN denotes expressed
T5479 4069-4072 VBP denotes are
T5480 4083-4085 IN denotes at
T5481 4086-4087 DT denotes a
T5482 4094-4099 NN denotes level
T5483 4088-4093 JJR denotes lower
T5484 4100-4102 IN denotes in
T5485 4103-4106 DT denotes the
T5486 4114-4120 NN denotes retina
T5487 4107-4110 NN denotes Crx
T5488 4110-4111 SYM denotes -
T5489 4111-4112 HYPH denotes /
T5490 4112-4113 SYM denotes -
T5491 4120-4122 , denotes ,
T5492 4122-4126 JJ denotes such
T5493 4127-4129 IN denotes as
T5494 4130-4139 NN denotes rhodopsin
T5495 4140-4143 CC denotes and
T5496 4144-4154 NN denotes peripherin
T5497 4154-4156 , denotes ,
T5498 4165-4169 JJ denotes many
T5499 4170-4174 WDT denotes that
T5500 4175-4178 VBP denotes are
T5501 4179-4185 RB denotes either
T5502 4186-4194 VBN denotes enriched
T5503 4195-4197 CC denotes or
T5504 4198-4206 JJ denotes specific
T5505 4207-4209 IN denotes to
T5506 4210-4224 NNS denotes photoreceptors
T5507 4225-4227 IN denotes in
T5508 4228-4233 PRP$ denotes their
T5509 4234-4244 NN denotes expression
T5510 4245-4246 -LRB- denotes [
T5511 4246-4248 CD denotes 35
T5512 4248-4249 -RRB- denotes ]
T5513 4249-4250 . denotes .
T5514 4250-4466 sentence denotes They include enzymes that are important in lipid metabolism, protein folding and transport, as well as in other processes that one might envision would be important in building a structure such as the outer segment.
T5515 4251-4255 PRP denotes They
T5516 4256-4263 VBP denotes include
T5517 4264-4271 NNS denotes enzymes
T5518 4272-4276 WDT denotes that
T5519 4277-4280 VBP denotes are
T5520 4281-4290 JJ denotes important
T5521 4291-4293 IN denotes in
T5522 4294-4299 NN denotes lipid
T5523 4300-4310 NN denotes metabolism
T5524 4310-4312 , denotes ,
T5525 4312-4319 NN denotes protein
T5526 4320-4327 NN denotes folding
T5527 4328-4331 CC denotes and
T5528 4332-4341 NN denotes transport
T5529 4341-4343 , denotes ,
T5530 4343-4345 RB denotes as
T5531 4351-4353 IN denotes as
T5532 4346-4350 RB denotes well
T5533 4354-4356 IN denotes in
T5534 4357-4362 JJ denotes other
T5535 4363-4372 NNS denotes processes
T5536 4373-4377 WDT denotes that
T5537 4388-4396 VB denotes envision
T5538 4378-4381 PRP denotes one
T5539 4382-4387 MD denotes might
T5540 4397-4402 MD denotes would
T5541 4403-4405 VB denotes be
T5542 4406-4415 JJ denotes important
T5543 4416-4418 IN denotes in
T5544 4419-4427 VBG denotes building
T5545 4428-4429 DT denotes a
T5546 4430-4439 NN denotes structure
T5547 4440-4444 JJ denotes such
T5548 4445-4447 IN denotes as
T5549 4448-4451 DT denotes the
T5550 4458-4465 NN denotes segment
T5551 4452-4457 JJ denotes outer
T5552 4465-4466 . denotes .
T5553 4466-4671 sentence denotes In situ hybridization using probes from this collection of genes has revealed that some of them have their RNA localized to the inner segment, a finding typical for proteins targeted to the outer segment.
T5554 4467-4469 FW denotes In
T5555 4470-4474 FW denotes situ
T5556 4475-4488 NN denotes hybridization
T5557 4536-4544 VBN denotes revealed
T5558 4489-4494 VBG denotes using
T5559 4495-4501 NNS denotes probes
T5560 4502-4506 IN denotes from
T5561 4507-4511 DT denotes this
T5562 4512-4522 NN denotes collection
T5563 4523-4525 IN denotes of
T5564 4526-4531 NNS denotes genes
T5565 4532-4535 VBZ denotes has
T5566 4545-4549 IN denotes that
T5567 4563-4567 VBP denotes have
T5568 4550-4554 DT denotes some
T5569 4555-4557 IN denotes of
T5570 4558-4562 PRP denotes them
T5571 4568-4573 PRP$ denotes their
T5572 4574-4577 NN denotes RNA
T5573 4578-4587 VBN denotes localized
T5574 4588-4590 IN denotes to
T5575 4591-4594 DT denotes the
T5576 4601-4608 NN denotes segment
T5577 4595-4600 JJ denotes inner
T5578 4608-4610 , denotes ,
T5579 4610-4611 DT denotes a
T5580 4612-4619 NN denotes finding
T5581 4620-4627 JJ denotes typical
T5582 4628-4631 IN denotes for
T5583 4632-4640 NN denotes proteins
T5584 4641-4649 VBN denotes targeted
T5585 4650-4652 IN denotes to
T5586 4653-4656 DT denotes the
T5587 4663-4670 NN denotes segment
T5588 4657-4662 JJ denotes outer
T5589 4670-4671 . denotes .
T5590 4671-4771 sentence denotes Future analyses of the function of these genes might reveal their role in outer segment biogenesis.
T5591 4672-4678 JJ denotes Future
T5592 4679-4687 NNS denotes analyses
T5593 4725-4731 VB denotes reveal
T5594 4688-4690 IN denotes of
T5595 4691-4694 DT denotes the
T5596 4695-4703 NN denotes function
T5597 4704-4706 IN denotes of
T5598 4707-4712 DT denotes these
T5599 4713-4718 NNS denotes genes
T5600 4719-4724 MD denotes might
T5601 4732-4737 PRP$ denotes their
T5602 4738-4742 NN denotes role
T5603 4743-4745 IN denotes in
T5604 4746-4751 JJ denotes outer
T5605 4752-4759 NN denotes segment
T5606 4760-4770 NN denotes biogenesis
T5607 4770-4771 . denotes .
T5608 4771-4864 sentence denotes Finally, polarization of photoreceptors was found to be largely intact, as was ciliogenesis.
T5609 4772-4779 RB denotes Finally
T5610 4816-4821 VBN denotes found
T5611 4779-4781 , denotes ,
T5612 4781-4793 NN denotes polarization
T5613 4794-4796 IN denotes of
T5614 4797-4811 NNS denotes photoreceptors
T5615 4812-4815 VBD denotes was
T5616 4822-4824 TO denotes to
T5617 4825-4827 VB denotes be
T5618 4828-4835 RB denotes largely
T5619 4836-4842 JJ denotes intact
T5620 4842-4844 , denotes ,
T5621 4844-4846 IN denotes as
T5622 4847-4850 VBD denotes was
T5623 4851-4863 NN denotes ciliogenesis
T5624 4863-4864 . denotes .
T5625 4864-4975 sentence denotes Another LCA gene, CRB1, and a related gene CRB3, have been implicated in ciliogenesis in in vitro models [46].
T5626 4865-4872 DT denotes Another
T5627 4877-4881 NN denotes gene
T5628 4873-4876 NN denotes LCA
T5629 4924-4934 VBN denotes implicated
T5630 4881-4883 , denotes ,
T5631 4883-4887 NN denotes CRB1
T5632 4887-4889 , denotes ,
T5633 4889-4892 CC denotes and
T5634 4893-4894 DT denotes a
T5635 4903-4907 NN denotes gene
T5636 4895-4902 JJ denotes related
T5637 4908-4912 NN denotes CRB3
T5638 4912-4914 , denotes ,
T5639 4914-4918 VBP denotes have
T5640 4919-4923 VBN denotes been
T5641 4935-4937 IN denotes in
T5642 4938-4950 NN denotes ciliogenesis
T5643 4951-4953 IN denotes in
T5644 4954-4956 FW denotes in
T5645 4957-4962 FW denotes vitro
T5646 4963-4969 NNS denotes models
T5647 4970-4971 -LRB- denotes [
T5648 4971-4973 CD denotes 46
T5649 4973-4974 -RRB- denotes ]
T5650 4974-4975 . denotes .
T5651 4975-5074 sentence denotes The Drosophila homologue of CRB1, Crumbs, has been implicated in photoreceptor morphogenesis [47].
T5652 4976-4979 DT denotes The
T5653 4991-5000 NN denotes homologue
T5654 4980-4990 NNP denotes Drosophila
T5655 5027-5037 VBN denotes implicated
T5656 5001-5003 IN denotes of
T5657 5004-5008 NN denotes CRB1
T5658 5008-5010 , denotes ,
T5659 5010-5016 NNP denotes Crumbs
T5660 5016-5018 , denotes ,
T5661 5018-5021 VBZ denotes has
T5662 5022-5026 VBN denotes been
T5663 5038-5040 IN denotes in
T5664 5041-5054 NN denotes photoreceptor
T5665 5055-5068 NN denotes morphogenesis
T5666 5069-5070 -LRB- denotes [
T5667 5070-5072 CD denotes 47
T5668 5072-5073 -RRB- denotes ]
T5669 5073-5074 . denotes .
T5670 5074-5306 sentence denotes However, the spontaneously occurring mouse mutant in CRB1, the Rd8 mouse, develops shortened outer segments that subsequently degenerate [48], suggesting that photoreceptor polarization and synaptogenesis are intact in this mutant.
T5671 5075-5082 RB denotes However
T5672 5149-5157 VBZ denotes develops
T5673 5082-5084 , denotes ,
T5674 5084-5087 DT denotes the
T5675 5118-5124 NN denotes mutant
T5676 5088-5101 RB denotes spontaneously
T5677 5102-5111 VBG denotes occurring
T5678 5112-5117 NN denotes mouse
T5679 5125-5127 IN denotes in
T5680 5128-5132 NN denotes CRB1
T5681 5132-5134 , denotes ,
T5682 5134-5137 DT denotes the
T5683 5142-5147 NN denotes mouse
T5684 5138-5141 NN denotes Rd8
T5685 5147-5149 , denotes ,
T5686 5158-5167 VBN denotes shortened
T5687 5174-5182 NNS denotes segments
T5688 5168-5173 JJ denotes outer
T5689 5183-5187 WDT denotes that
T5690 5201-5211 VBP denotes degenerate
T5691 5188-5200 RB denotes subsequently
T5692 5212-5213 -LRB- denotes [
T5693 5213-5215 CD denotes 48
T5694 5215-5216 -RRB- denotes ]
T5695 5216-5218 , denotes ,
T5696 5218-5228 VBG denotes suggesting
T5697 5229-5233 IN denotes that
T5698 5280-5283 VBP denotes are
T5699 5234-5247 NN denotes photoreceptor
T5700 5248-5260 NN denotes polarization
T5701 5261-5264 CC denotes and
T5702 5265-5279 NN denotes synaptogenesis
T5703 5284-5290 JJ denotes intact
T5704 5291-5293 IN denotes in
T5705 5294-5298 DT denotes this
T5706 5299-5305 NN denotes mutant
T5707 5305-5306 . denotes .
T5708 5306-5446 sentence denotes While CRB1 and Crx have been both linked to LCA, further work is necessary to determine if their function is linked in retinal development.
T5709 5307-5312 IN denotes While
T5710 5341-5347 VBN denotes linked
T5711 5313-5317 NN denotes CRB1
T5712 5318-5321 CC denotes and
T5713 5322-5325 NN denotes Crx
T5714 5326-5330 VBP denotes have
T5715 5331-5335 VBN denotes been
T5716 5336-5340 RB denotes both
T5717 5369-5371 VBZ denotes is
T5718 5348-5350 IN denotes to
T5719 5351-5354 NN denotes LCA
T5720 5354-5356 , denotes ,
T5721 5356-5363 JJ denotes further
T5722 5364-5368 NN denotes work
T5723 5372-5381 JJ denotes necessary
T5724 5382-5384 TO denotes to
T5725 5385-5394 VB denotes determine
T5726 5395-5397 IN denotes if
T5727 5416-5422 VBN denotes linked
T5728 5398-5403 PRP$ denotes their
T5729 5404-5412 NN denotes function
T5730 5413-5415 VBZ denotes is
T5731 5423-5425 IN denotes in
T5732 5426-5433 JJ denotes retinal
T5733 5434-5445 NN denotes development
T5734 5445-5446 . denotes .
R2524 T4696 T4697 nmod Crx,photoreceptors
R2525 T4697 T4701 nsubj photoreceptors,complete
R2526 T4698 T4696 punct -,Crx
R2527 T4699 T4696 punct /,Crx
R2528 T4700 T4696 punct -,Crx
R2529 T4702 T4701 aux can,complete
R2530 T4703 T4701 neg not,complete
R2531 T4704 T4705 amod outer,segment
R2532 T4705 T4706 compound segment,morphogenesis
R2533 T4706 T4701 dobj morphogenesis,complete
R2534 T4708 T4709 nsubj Mutations,represent
R2535 T4710 T4708 prep in,Mutations
R2536 T4711 T4710 pobj Crx,in
R2537 T4712 T4709 dobj one,represent
R2538 T4713 T4712 prep of,one
R2539 T4714 T4715 det a,collection
R2540 T4715 T4713 pobj collection,of
R2541 T4716 T4715 prep of,collection
R2542 T4717 T4718 compound gene,mutations
R2543 T4718 T4716 pobj mutations,of
R2544 T4719 T4720 dep that,lead
R2545 T4720 T4718 relcl lead,mutations
R2546 T4721 T4720 prep to,lead
R2547 T4722 T4723 det an,defect
R2548 T4723 T4721 pobj defect,to
R2549 T4724 T4725 amod outer,segment
R2550 T4725 T4723 compound segment,defect
R2551 T4726 T4723 compound formation,defect
R2552 T4727 T4709 punct .,represent
R2553 T4729 T4730 amod Homozygous,mutations
R2554 T4730 T4732 nsubj mutations,lead
R2555 T4731 T4730 amod null,mutations
R2556 T4733 T4730 prep in,mutations
R2557 T4734 T4735 det the,gene
R2558 T4735 T4733 pobj gene,in
R2559 T4736 T4737 compound peripherin,RDS
R2560 T4737 T4735 compound RDS,gene
R2561 T4738 T4737 punct /,RDS
R2562 T4739 T4740 punct [,36
R2563 T4740 T4735 parataxis 36,gene
R2564 T4741 T4740 punct ],36
R2565 T4742 T4733 cc or,in
R2566 T4743 T4733 conj in,in
R2567 T4744 T4743 pobj rhodopsin,in
R2568 T4745 T4746 punct [,29
R2569 T4746 T4744 parataxis 29,rhodopsin
R2570 T4747 T4746 punct ],29
R2571 T4748 T4732 prep to,lead
R2572 T4749 T4750 det a,failure
R2573 T4750 T4748 pobj failure,to
R2574 T4751 T4750 prep of,failure
R2575 T4752 T4753 amod outer,segment
R2576 T4753 T4754 compound segment,formation
R2577 T4754 T4751 pobj formation,of
R2578 T4755 T4732 punct .,lead
R2579 T4757 T4758 det The,deficits
R2580 T4758 T4759 nsubjpass deficits,found
R2581 T4760 T4758 prep in,deficits
R2582 T4761 T4762 nmod peripherin,morphogenesis
R2583 T4762 T4760 pobj morphogenesis,in
R2584 T4763 T4761 punct -,peripherin
R2585 T4764 T4761 punct /,peripherin
R2586 T4765 T4761 punct -,peripherin
R2587 T4766 T4761 cc and,peripherin
R2588 T4767 T4761 conj Crx,peripherin
R2589 T4768 T4767 punct -,Crx
R2590 T4769 T4767 punct /,Crx
R2591 T4770 T4767 punct -,Crx
R2592 T4771 T4762 compound photoreceptor,morphogenesis
R2593 T4772 T4759 auxpass were,found
R2594 T4773 T4774 aux to,be
R2595 T4774 T4759 xcomp be,found
R2596 T4775 T4776 advmod very,similar
R2597 T4776 T4774 acomp similar,be
R2598 T4777 T4759 punct .,found
R2599 T4779 T4780 amod Vesicular,structures
R2600 T4780 T4781 nsubjpass structures,observed
R2601 T4782 T4780 prep in,structures
R2602 T4783 T4784 nmod Crx,photoreceptors
R2603 T4784 T4782 pobj photoreceptors,in
R2604 T4785 T4783 punct -,Crx
R2605 T4786 T4783 punct /,Crx
R2606 T4787 T4783 punct -,Crx
R2607 T4788 T4781 auxpass were,observed
R2608 T4789 T4790 dep that,were
R2609 T4790 T4781 ccomp were,observed
R2610 T4791 T4790 acomp similar,were
R2611 T4792 T4791 prep to,similar
R2612 T4793 T4792 pobj those,to
R2613 T4794 T4795 advmod previously,noted
R2614 T4795 T4793 acl noted,those
R2615 T4796 T4795 prep in,noted
R2616 T4797 T4798 det the,mouse
R2617 T4798 T4796 pobj mouse,in
R2618 T4799 T4800 nmod rds,peripherin
R2619 T4800 T4798 nmod peripherin,mouse
R2620 T4801 T4800 punct /,peripherin
R2621 T4802 T4800 punct -,peripherin
R2622 T4803 T4800 punct /,peripherin
R2623 T4804 T4800 punct -,peripherin
R2624 T4805 T4781 punct .,observed
R2625 T4807 T4808 nsubjpass It,proposed
R2626 T4809 T4808 auxpass was,proposed
R2627 T4810 T4808 advmod initially,proposed
R2628 T4811 T4812 mark that,were
R2629 T4812 T4808 ccomp were,proposed
R2630 T4813 T4814 det these,vesicles
R2631 T4814 T4812 nsubj vesicles,were
R2632 T4815 T4812 prep due,were
R2633 T4816 T4815 pcomp to,due
R2634 T4817 T4818 det the,breakdown
R2635 T4818 T4815 pobj breakdown,due
R2636 T4819 T4818 prep of,breakdown
R2637 T4820 T4821 amod outer,segment
R2638 T4821 T4822 compound segment,membranes
R2639 T4822 T4819 pobj membranes,of
R2640 T4823 T4824 dep that,recruited
R2641 T4824 T4822 relcl recruited,membranes
R2642 T4825 T4824 auxpass were,recruited
R2643 T4826 T4824 neg not,recruited
R2644 T4827 T4824 advmod properly,recruited
R2645 T4828 T4824 prep to,recruited
R2646 T4829 T4830 det the,segments
R2647 T4830 T4828 pobj segments,to
R2648 T4831 T4830 amod outer,segments
R2649 T4832 T4824 prep in,recruited
R2650 T4833 T4834 det the,absence
R2651 T4834 T4832 pobj absence,in
R2652 T4835 T4834 prep of,absence
R2653 T4836 T4835 pobj peripherin,of
R2654 T4837 T4812 punct ", ",were
R2655 T4838 T4812 cc or,were
R2656 T4839 T4812 conj were,were
R2657 T4840 T4839 prep from,were
R2658 T4841 T4842 det the,result
R2659 T4842 T4840 pobj result,from
R2660 T4843 T4842 prep of,result
R2661 T4844 T4845 det the,breakdown
R2662 T4845 T4843 pobj breakdown,of
R2663 T4846 T4845 prep of,breakdown
R2664 T4847 T4848 det the,microvilli
R2665 T4848 T4846 pobj microvilli,of
R2666 T4849 T4848 prep of,microvilli
R2667 T4850 T4851 compound Müller,cells
R2668 T4851 T4849 pobj cells,of
R2669 T4852 T4853 punct [,30
R2670 T4853 T4839 parataxis 30,were
R2671 T4854 T4853 punct ],30
R2672 T4855 T4808 punct .,proposed
R2673 T4857 T4858 amod Strong,support
R2674 T4858 T4859 nsubjpass support,provided
R2675 T4860 T4858 prep in,support
R2676 T4861 T4860 pobj favor,in
R2677 T4862 T4861 prep of,favor
R2678 T4863 T4864 det the,explanation
R2679 T4864 T4862 pobj explanation,of
R2680 T4865 T4864 amod former,explanation
R2681 T4866 T4859 auxpass was,provided
R2682 T4867 T4859 agent by,provided
R2683 T4868 T4867 pobj Nir,by
R2684 T4869 T4868 cc and,Nir
R2685 T4870 T4868 conj colleagues,Nir
R2686 T4871 T4872 dep who,demonstrated
R2687 T4872 T4868 relcl demonstrated,Nir
R2688 T4873 T4874 det the,presence
R2689 T4874 T4872 dobj presence,demonstrated
R2690 T4875 T4874 prep of,presence
R2691 T4876 T4877 compound rhodopsin,protein
R2692 T4877 T4875 pobj protein,of
R2693 T4878 T4874 prep in,presence
R2694 T4879 T4880 det these,vesicles
R2695 T4880 T4878 pobj vesicles,in
R2696 T4881 T4872 advcl using,demonstrated
R2697 T4882 T4883 compound immunoelectron,microscopy
R2698 T4883 T4881 dobj microscopy,using
R2699 T4884 T4881 prep against,using
R2700 T4885 T4886 det a,epitope
R2701 T4886 T4884 pobj epitope,against
R2702 T4887 T4886 compound rhodopsin,epitope
R2703 T4888 T4889 punct [,37
R2704 T4889 T4872 parataxis 37,demonstrated
R2705 T4890 T4889 punct ],37
R2706 T4891 T4859 punct .,provided
R2707 T4893 T4894 advmod Further,appear
R2708 T4895 T4894 punct ", ",appear
R2709 T4896 T4897 mark as,shown
R2710 T4897 T4894 advcl shown,appear
R2711 T4898 T4897 advmod here,shown
R2712 T4899 T4894 punct ", ",appear
R2713 T4900 T4901 det the,vesicles
R2714 T4901 T4894 nsubj vesicles,appear
R2715 T4902 T4903 aux to,bud
R2716 T4903 T4894 xcomp bud,appear
R2717 T4904 T4903 prep from,bud
R2718 T4905 T4906 det the,segments
R2719 T4906 T4904 pobj segments,from
R2720 T4907 T4906 amod inner,segments
R2721 T4908 T4906 appos themselves,segments
R2722 T4909 T4894 punct .,appear
R2723 T4911 T4912 prep In,occurs
R2724 T4913 T4914 amod developing,photoreceptors
R2725 T4914 T4911 pobj photoreceptors,In
R2726 T4915 T4912 punct ", ",occurs
R2727 T4916 T4917 det an,process
R2728 T4917 T4912 nsubj process,occurs
R2729 T4918 T4917 amod extraordinary,process
R2730 T4919 T4917 compound growth,process
R2731 T4920 T4921 advmod whereby,generated
R2732 T4921 T4912 ccomp generated,occurs
R2733 T4922 T4923 det the,segment
R2734 T4923 T4921 nsubjpass segment,generated
R2735 T4924 T4923 amod outer,segment
R2736 T4925 T4921 auxpass is,generated
R2737 T4926 T4921 prep from,generated
R2738 T4927 T4928 det the,cilium
R2739 T4928 T4926 pobj cilium,from
R2740 T4929 T4928 amod nascent,cilium
R2741 T4930 T4928 amod connecting,cilium
R2742 T4931 T4932 punct (,see
R2743 T4932 T4912 parataxis see,occurs
R2744 T4933 T4934 punct [,38
R2745 T4934 T4932 dobj 38,see
R2746 T4935 T4934 punct ],38
R2747 T4936 T4934 cc and,38
R2748 T4937 T4934 conj references,38
R2749 T4938 T4937 advmod therein,references
R2750 T4939 T4932 punct ),see
R2751 T4940 T4912 punct .,occurs
R2752 T4942 T4943 nmod Peripherin,RDS
R2753 T4943 T4945 nmod RDS,proteins
R2754 T4944 T4943 punct /,RDS
R2755 T4945 T4950 nsubj proteins,have
R2756 T4946 T4943 cc and,RDS
R2757 T4947 T4943 conj ROM,RDS
R2758 T4948 T4947 punct -,ROM
R2759 T4949 T4947 nummod 1,ROM
R2760 T4951 T4945 punct (,proteins
R2761 T4952 T4945 acl localized,proteins
R2762 T4953 T4952 prep in,localized
R2763 T4954 T4955 compound disc,rims
R2764 T4955 T4953 pobj rims,in
R2765 T4956 T4945 punct ),proteins
R2766 T4957 T4945 cc and,proteins
R2767 T4958 T4959 det the,proteins
R2768 T4959 T4945 conj proteins,proteins
R2769 T4960 T4959 compound opsin,proteins
R2770 T4961 T4959 punct (,proteins
R2771 T4962 T4959 acl localized,proteins
R2772 T4963 T4962 prep throughout,localized
R2773 T4964 T4965 det the,discs
R2774 T4965 T4963 pobj discs,throughout
R2775 T4966 T4950 punct ),have
R2776 T4967 T4968 amod important,roles
R2777 T4968 T4950 dobj roles,have
R2778 T4969 T4968 prep in,roles
R2779 T4970 T4971 det the,integrity
R2780 T4971 T4969 pobj integrity,in
R2781 T4972 T4971 amod structural,integrity
R2782 T4973 T4971 prep of,integrity
R2783 T4974 T4975 amod mature,segments
R2784 T4975 T4973 pobj segments,of
R2785 T4976 T4975 amod outer,segments
R2786 T4977 T4978 punct (,see
R2787 T4978 T4950 parataxis see,have
R2788 T4979 T4978 punct [,see
R2789 T4980 T4981 nummod 39,29
R2790 T4981 T4978 dobj 29,see
R2791 T4982 T4981 punct ",",29
R2792 T4983 T4978 punct ],see
R2793 T4984 T4978 punct ),see
R2794 T4985 T4950 punct .,have
R2795 T4987 T4988 nmod ROM,mice
R2796 T4988 T4994 nsubj mice,produce
R2797 T4989 T4987 punct -,ROM
R2798 T4990 T4987 nummod 1,ROM
R2799 T4991 T4987 punct -,ROM
R2800 T4992 T4987 punct /,ROM
R2801 T4993 T4987 punct -,ROM
R2802 T4995 T4996 amod disorganized,segments
R2803 T4996 T4994 dobj segments,produce
R2804 T4997 T4996 amod outer,segments
R2805 T4998 T4996 prep with,segments
R2806 T4999 T5000 amod large,disks
R2807 T5000 T4998 pobj disks,with
R2808 T5001 T5002 punct [,40
R2809 T5002 T4994 parataxis 40,produce
R2810 T5003 T5002 punct ],40
R2811 T5004 T4994 punct .,produce
R2812 T5006 T5007 nsubj Crx,controls
R2813 T5008 T5007 punct ", ",controls
R2814 T5009 T5007 prep by,controls
R2815 T5010 T5009 pobj virtue,by
R2816 T5011 T5010 prep of,virtue
R2817 T5012 T5011 pcomp being,of
R2818 T5013 T5014 det a,factor
R2819 T5014 T5012 attr factor,being
R2820 T5015 T5014 compound transcription,factor
R2821 T5016 T5007 punct ", ",controls
R2822 T5017 T5007 advmod presumably,controls
R2823 T5018 T5007 dobj genes,controls
R2824 T5019 T5020 dep that,are
R2825 T5020 T5018 relcl are,genes
R2826 T5021 T5020 acomp responsible,are
R2827 T5022 T5021 prep for,responsible
R2828 T5023 T5024 det the,building
R2829 T5024 T5022 pobj building,for
R2830 T5025 T5024 cc and,building
R2831 T5026 T5027 advmod perhaps,maintenance
R2832 T5027 T5024 conj maintenance,building
R2833 T5028 T5024 prep of,building
R2834 T5029 T5030 det the,structure
R2835 T5030 T5028 pobj structure,of
R2836 T5031 T5032 amod outer,segment
R2837 T5032 T5030 compound segment,structure
R2838 T5033 T5018 punct ", ",genes
R2839 T5034 T5018 prep including,genes
R2840 T5035 T5034 pobj rhodopsin,including
R2841 T5036 T5035 cc and,rhodopsin
R2842 T5037 T5035 conj peripherin,rhodopsin
R2843 T5038 T5007 punct .,controls
R2844 T5040 T5041 advcl Using,defined
R2845 T5042 T5043 compound northern,blots
R2846 T5043 T5040 dobj blots,Using
R2847 T5044 T5045 punct [,34
R2848 T5045 T5043 parataxis 34,blots
R2849 T5046 T5045 punct ],34
R2850 T5047 T5043 punct ", ",blots
R2851 T5048 T5043 conj microarrays,blots
R2852 T5049 T5050 punct [,10
R2853 T5050 T5048 parataxis 10,microarrays
R2854 T5051 T5050 punct ],10
R2855 T5052 T5048 punct ", ",microarrays
R2856 T5053 T5048 cc and,microarrays
R2857 T5054 T5055 amod serial,analysis
R2858 T5055 T5048 conj analysis,microarrays
R2859 T5056 T5055 prep of,analysis
R2860 T5057 T5058 compound gene,expression
R2861 T5058 T5056 pobj expression,of
R2862 T5059 T5055 punct (,analysis
R2863 T5060 T5055 appos SAGE,analysis
R2864 T5061 T5055 punct ),analysis
R2865 T5062 T5063 punct [,35
R2866 T5063 T5055 parataxis 35,analysis
R2867 T5064 T5063 punct ],35
R2868 T5065 T5041 punct ", ",defined
R2869 T5066 T5041 nsubj we,defined
R2870 T5067 T5041 aux have,defined
R2871 T5068 T5069 det a,number
R2872 T5069 T5041 dobj number,defined
R2873 T5070 T5069 amod large,number
R2874 T5071 T5069 prep of,number
R2875 T5072 T5071 pobj genes,of
R2876 T5073 T5074 dep that,altered
R2877 T5074 T5072 relcl altered,genes
R2878 T5075 T5074 auxpass are,altered
R2879 T5076 T5074 prep in,altered
R2880 T5077 T5078 poss their,level
R2881 T5078 T5076 pobj level,in
R2882 T5079 T5078 compound expression,level
R2883 T5080 T5074 prep in,altered
R2884 T5081 T5082 nmod Crx,mice
R2885 T5082 T5080 pobj mice,in
R2886 T5083 T5081 punct -,Crx
R2887 T5084 T5081 punct /,Crx
R2888 T5085 T5081 punct -,Crx
R2889 T5086 T5041 punct .,defined
R2890 T5088 T5089 nsubj We,found
R2891 T5090 T5091 mark that,diminished
R2892 T5091 T5089 ccomp diminished,found
R2893 T5092 T5093 compound rhodopsin,expression
R2894 T5093 T5091 nsubjpass expression,diminished
R2895 T5094 T5091 auxpass was,diminished
R2896 T5095 T5091 advmod severely,diminished
R2897 T5096 T5091 prep in,diminished
R2898 T5097 T5098 nmod Crx,animals
R2899 T5098 T5096 pobj animals,in
R2900 T5099 T5097 punct -,Crx
R2901 T5100 T5097 punct /,Crx
R2902 T5101 T5097 punct -,Crx
R2903 T5102 T5091 punct ", ",diminished
R2904 T5103 T5091 cc and,diminished
R2905 T5104 T5105 compound peripherin,mRNA
R2906 T5105 T5106 nsubjpass mRNA,reduced
R2907 T5106 T5091 conj reduced,diminished
R2908 T5107 T5106 auxpass was,reduced
R2909 T5108 T5106 prep by,reduced
R2910 T5109 T5110 advmod approximately,30
R2911 T5110 T5111 nummod 30,%
R2912 T5111 T5108 pobj %,by
R2913 T5112 T5089 punct .,found
R2914 T5114 T5115 amod Transgenic,mice
R2915 T5115 T5116 nsubj mice,exhibit
R2916 T5117 T5115 prep with,mice
R2917 T5118 T5119 amod variable,levels
R2918 T5119 T5117 pobj levels,with
R2919 T5120 T5119 prep of,levels
R2920 T5121 T5120 pobj expression,of
R2921 T5122 T5121 prep of,expression
R2922 T5123 T5124 amod wild,type
R2923 T5124 T5125 compound type,rhodopsin
R2924 T5125 T5122 pobj rhodopsin,of
R2925 T5126 T5127 compound rod,degeneration
R2926 T5127 T5116 dobj degeneration,exhibit
R2927 T5128 T5129 punct [,41
R2928 T5129 T5116 parataxis 41,exhibit
R2929 T5130 T5129 punct ],41
R2930 T5131 T5116 punct ", ",exhibit
R2931 T5132 T5116 advcl indicating,exhibit
R2932 T5133 T5134 det the,importance
R2933 T5134 T5132 dobj importance,indicating
R2934 T5135 T5134 prep of,importance
R2935 T5136 T5137 det the,level
R2936 T5137 T5135 pobj level,of
R2937 T5138 T5137 prep of,level
R2938 T5139 T5140 compound rhodopsin,expression
R2939 T5140 T5138 pobj expression,of
R2940 T5141 T5116 punct .,exhibit
R2941 T5143 T5144 prep In,be
R2942 T5145 T5143 pobj addition,In
R2943 T5146 T5144 punct ", ",be
R2944 T5147 T5148 det the,timing
R2945 T5148 T5144 nsubj timing,be
R2946 T5149 T5148 prep of,timing
R2947 T5150 T5151 compound rhodopsin,expression
R2948 T5151 T5149 pobj expression,of
R2949 T5152 T5144 aux may,be
R2950 T5153 T5154 advmod very,important
R2951 T5154 T5144 acomp important,be
R2952 T5155 T5144 punct ", ",be
R2953 T5156 T5157 mark as,indicated
R2954 T5157 T5144 advcl indicated,be
R2955 T5158 T5157 agent by,indicated
R2956 T5159 T5158 pobj studies,by
R2957 T5160 T5159 prep in,studies
R2958 T5161 T5160 pobj Drosophila,in
R2959 T5162 T5144 punct .,be
R2960 T5164 T5165 prep In,expressed
R2961 T5166 T5164 pobj Drosophila,In
R2962 T5167 T5165 punct ", ",expressed
R2963 T5168 T5165 nsubjpass rhodopsin,expressed
R2964 T5169 T5170 punct (,ninaE
R2965 T5170 T5168 parataxis ninaE,rhodopsin
R2966 T5171 T5170 punct ),ninaE
R2967 T5172 T5165 auxpass is,expressed
R2968 T5173 T5165 prep in,expressed
R2969 T5174 T5175 compound photoreceptors,R1
R2970 T5175 T5173 pobj R1,in
R2971 T5176 T5177 punct –,R6
R2972 T5177 T5175 prep R6,R1
R2973 T5178 T5165 punct .,expressed
R2974 T5180 T5181 prep In,fails
R2975 T5182 T5183 npadvmod ninaE,null
R2976 T5183 T5184 amod null,mutants
R2977 T5184 T5180 pobj mutants,In
R2978 T5185 T5181 punct ", ",fails
R2979 T5186 T5187 det the,rhabdomere
R2980 T5187 T5181 nsubj rhabdomere,fails
R2981 T5188 T5187 punct ", ",rhabdomere
R2982 T5189 T5190 det a,structure
R2983 T5190 T5187 appos structure,rhabdomere
R2984 T5191 T5190 amod analogous,structure
R2985 T5192 T5191 prep to,analogous
R2986 T5193 T5194 nmod vertebrate,segments
R2987 T5194 T5192 pobj segments,to
R2988 T5195 T5194 amod outer,segments
R2989 T5196 T5181 punct ", ",fails
R2990 T5197 T5198 aux to,develop
R2991 T5198 T5181 xcomp develop,fails
R2992 T5199 T5198 prep in,develop
R2993 T5200 T5201 nmod R1,photoreceptors
R2994 T5201 T5199 pobj photoreceptors,in
R2995 T5202 T5203 punct –,R6
R2996 T5203 T5200 prep R6,R1
R2997 T5204 T5205 punct [,42
R2998 T5205 T5198 parataxis 42,develop
R2999 T5206 T5205 punct ],42
R3000 T5207 T5198 punct ", ",develop
R3001 T5208 T5198 advcl reminiscent,develop
R3002 T5209 T5208 prep of,reminiscent
R3003 T5210 T5211 det the,situation
R3004 T5211 T5209 pobj situation,of
R3005 T5212 T5211 prep in,situation
R3006 T5213 T5214 nmod rhodopsin,mice
R3007 T5214 T5212 pobj mice,in
R3008 T5215 T5213 punct -,rhodopsin
R3009 T5216 T5213 punct /,rhodopsin
R3010 T5217 T5213 punct -,rhodopsin
R3011 T5218 T5219 punct [,29
R3012 T5219 T5208 parataxis 29,reminiscent
R3013 T5220 T5219 punct ],29
R3014 T5221 T5181 punct .,fails
R3015 T5223 T5224 det An,experiment
R3016 T5224 T5226 nsubj experiment,demonstrated
R3017 T5225 T5224 amod intriguing,experiment
R3018 T5227 T5224 prep by,experiment
R3019 T5228 T5227 pobj Kumar,by
R3020 T5229 T5230 advmod et,al.
R3021 T5230 T5228 advmod al.,Kumar
R3022 T5231 T5232 punct [,43
R3023 T5232 T5228 parataxis 43,Kumar
R3024 T5233 T5232 punct ],43
R3025 T5234 T5235 det a,requirement
R3026 T5235 T5226 dobj requirement,demonstrated
R3027 T5236 T5235 amod temporal,requirement
R3028 T5237 T5235 prep for,requirement
R3029 T5238 T5239 compound rhodopsin,expression
R3030 T5239 T5237 pobj expression,for
R3031 T5240 T5235 prep during,requirement
R3032 T5241 T5242 compound rhabdomere,development
R3033 T5242 T5240 pobj development,during
R3034 T5243 T5226 punct .,demonstrated
R3035 T5245 T5246 prep In,subjected
R3036 T5247 T5248 npadvmod ninaE,null
R3037 T5248 T5249 amod null,flies
R3038 T5249 T5245 pobj flies,In
R3039 T5250 T5246 punct ", ",subjected
R3040 T5251 T5252 det a,transgene
R3041 T5252 T5246 nsubjpass transgene,subjected
R3042 T5253 T5252 compound ninaE,transgene
R3043 T5254 T5252 prep under,transgene
R3044 T5255 T5256 det the,control
R3045 T5256 T5254 pobj control,under
R3046 T5257 T5256 prep of,control
R3047 T5258 T5259 det a,promoter
R3048 T5259 T5257 pobj promoter,of
R3049 T5260 T5261 compound heat,shock
R3050 T5261 T5259 compound shock,promoter
R3051 T5262 T5246 auxpass was,subjected
R3052 T5263 T5246 prep to,subjected
R3053 T5264 T5265 amod various,shifts
R3054 T5265 T5263 pobj shifts,to
R3055 T5266 T5265 compound temperature,shifts
R3056 T5267 T5246 prep during,subjected
R3057 T5268 T5267 pobj development,during
R3058 T5269 T5246 punct .,subjected
R3059 T5271 T5272 compound Heat,shock
R3060 T5272 T5273 nsubj shock,resulted
R3061 T5274 T5272 prep during,shock
R3062 T5275 T5276 det the,time
R3063 T5276 T5274 pobj time,during
R3064 T5277 T5276 amod normal,time
R3065 T5278 T5276 prep of,time
R3066 T5279 T5280 compound rhodopsin,onset
R3067 T5280 T5278 pobj onset,of
R3068 T5281 T5273 prep in,resulted
R3069 T5282 T5283 amod substantial,rescue
R3070 T5283 T5281 pobj rescue,in
R3071 T5284 T5282 cc and,substantial
R3072 T5285 T5286 advmod long,lasting
R3073 T5286 T5282 conj lasting,substantial
R3074 T5287 T5286 punct -,lasting
R3075 T5288 T5283 prep of,rescue
R3076 T5289 T5290 compound photoreceptor,structure
R3077 T5290 T5288 pobj structure,of
R3078 T5291 T5283 cc and,rescue
R3079 T5292 T5293 amod transient,rescue
R3080 T5293 T5283 conj rescue,rescue
R3081 T5294 T5293 prep of,rescue
R3082 T5295 T5296 compound photoreceptor,physiology
R3083 T5296 T5294 pobj physiology,of
R3084 T5297 T5273 punct .,resulted
R3085 T5299 T5300 advmod However,failed
R3086 T5301 T5300 punct ", ",failed
R3087 T5302 T5300 nsubj expression,failed
R3088 T5303 T5304 advmod shortly,before
R3089 T5304 T5302 prep before,expression
R3090 T5305 T5304 cc or,before
R3091 T5306 T5304 conj after,before
R3092 T5307 T5308 det this,period
R3093 T5308 T5306 pobj period,after
R3094 T5309 T5308 amod critical,period
R3095 T5310 T5311 aux to,rescue
R3096 T5311 T5300 xcomp rescue,failed
R3097 T5312 T5300 punct ", ",failed
R3098 T5313 T5300 advcl suggesting,failed
R3099 T5314 T5315 mark that,is
R3100 T5315 T5313 ccomp is,suggesting
R3101 T5316 T5317 compound rhodopsin,expression
R3102 T5317 T5315 nsubj expression,is
R3103 T5318 T5317 prep during,expression
R3104 T5319 T5320 det a,window
R3105 T5320 T5318 pobj window,during
R3106 T5321 T5320 amod discrete,window
R3107 T5322 T5320 prep of,window
R3108 T5323 T5322 pobj time,of
R3109 T5324 T5320 prep in,window
R3110 T5325 T5324 pobj development,in
R3111 T5326 T5315 acomp essential,is
R3112 T5327 T5326 prep for,essential
R3113 T5328 T5329 amod proper,morphogenesis
R3114 T5329 T5327 pobj morphogenesis,for
R3115 T5330 T5329 amod rhabdomere,morphogenesis
R3116 T5331 T5300 punct .,failed
R3117 T5333 T5334 det This,result
R3118 T5334 T5335 nsubj result,is
R3119 T5336 T5335 acomp consistent,is
R3120 T5337 T5336 prep with,consistent
R3121 T5338 T5337 pobj observations,with
R3122 T5339 T5338 prep in,observations
R3123 T5340 T5341 det the,rat
R3124 T5341 T5339 pobj rat,in
R3125 T5342 T5343 prep wherein,occurs
R3126 T5343 T5338 relcl occurs,observations
R3127 T5344 T5345 compound rhodopsin,onset
R3128 T5345 T5343 nsubj onset,occurs
R3129 T5346 T5343 prep with,occurs
R3130 T5347 T5348 amod strict,timing
R3131 T5348 T5346 pobj timing,with
R3132 T5349 T5343 prep in,occurs
R3133 T5350 T5351 det the,history
R3134 T5351 T5349 pobj history,in
R3135 T5352 T5351 amod developmental,history
R3136 T5353 T5351 prep of,history
R3137 T5354 T5355 amod most,rods
R3138 T5355 T5353 pobj rods,of
R3139 T5356 T5357 advmod in,vivo
R3140 T5357 T5343 advmod vivo,occurs
R3141 T5358 T5359 punct [,44
R3142 T5359 T5338 parataxis 44,observations
R3143 T5360 T5359 punct ],44
R3144 T5361 T5335 punct .,is
R3145 T5363 T5364 advmod Thus,regulating
R3146 T5365 T5364 punct ", ",regulating
R3147 T5366 T5364 prep through,regulating
R3148 T5367 T5368 poss its,regulation
R3149 T5368 T5366 pobj regulation,through
R3150 T5369 T5368 prep of,regulation
R3151 T5370 T5371 compound rhodopsin,levels
R3152 T5371 T5369 pobj levels,of
R3153 T5372 T5366 punct ", ",through
R3154 T5373 T5366 cc or,through
R3155 T5374 T5375 advmod perhaps,through
R3156 T5375 T5366 conj through,through
R3157 T5376 T5375 pobj control,through
R3158 T5377 T5376 prep of,control
R3159 T5378 T5379 det the,kinetics
R3160 T5379 T5377 pobj kinetics,of
R3161 T5380 T5379 prep of,kinetics
R3162 T5381 T5382 det the,regulation
R3163 T5382 T5380 pobj regulation,of
R3164 T5383 T5382 amod up,regulation
R3165 T5384 T5382 punct -,regulation
R3166 T5385 T5382 prep of,regulation
R3167 T5386 T5385 pobj rhodopsin,of
R3168 T5387 T5382 acl beginning,regulation
R3169 T5388 T5387 prep at,beginning
R3170 T5389 T5390 advmod about,P6
R3171 T5390 T5388 pobj P6,at
R3172 T5391 T5364 punct ", ",regulating
R3173 T5392 T5364 nsubj Crx,regulating
R3174 T5393 T5364 aux may,regulating
R3175 T5394 T5364 aux be,regulating
R3176 T5395 T5396 amod outer,segment
R3177 T5396 T5397 compound segment,morphogenesis
R3178 T5397 T5364 dobj morphogenesis,regulating
R3179 T5398 T5364 punct .,regulating
R3180 T5400 T5401 det The,similarty
R3181 T5401 T5402 nsubj similarty,extend
R3182 T5403 T5401 prep of,similarty
R3183 T5404 T5405 det the,cases
R3184 T5405 T5403 pobj cases,of
R3185 T5406 T5405 nummod two,cases
R3186 T5407 T5402 aux may,extend
R3187 T5408 T5402 advmod further,extend
R3188 T5409 T5402 punct .,extend
R3189 T5411 T5412 prep At,is
R3190 T5413 T5411 amod present,At
R3191 T5414 T5412 punct ", ",is
R3192 T5415 T5416 det the,Crx
R3193 T5416 T5412 nsubj Crx,is
R3194 T5417 T5416 amod closest,Crx
R3195 T5418 T5416 amod relative,Crx
R3196 T5419 T5416 prep in,Crx
R3197 T5420 T5419 pobj Drosophila,in
R3198 T5421 T5412 attr Otd,is
R3199 T5422 T5421 punct ", ",Otd
R3200 T5423 T5424 det the,member
R3201 T5424 T5421 appos member,Otd
R3202 T5425 T5424 amod founding,member
R3203 T5426 T5424 prep of,member
R3204 T5427 T5428 det the,class
R3205 T5428 T5426 pobj class,of
R3206 T5429 T5428 prep of,class
R3207 T5430 T5431 compound homeobox,genes
R3208 T5431 T5429 pobj genes,of
R3209 T5432 T5433 prep to,belongs
R3210 T5433 T5431 relcl belongs,genes
R3211 T5434 T5432 pobj which,to
R3212 T5435 T5433 nsubj Crx,belongs
R3213 T5436 T5412 punct .,is
R3214 T5438 T5439 advmod Interestingly,disrupted
R3215 T5440 T5439 punct ", ",disrupted
R3216 T5441 T5439 prep in,disrupted
R3217 T5442 T5443 nummod one,allele
R3218 T5443 T5441 pobj allele,in
R3219 T5444 T5443 amod hypomorphic,allele
R3220 T5445 T5443 prep of,allele
R3221 T5446 T5447 compound Drosophila,otd
R3222 T5447 T5445 pobj otd,of
R3223 T5448 T5443 punct ", ",allele
R3224 T5449 T5443 appos otduvi,allele
R3225 T5450 T5439 punct ", ",disrupted
R3226 T5451 T5452 compound photoreceptor,morphogenesis
R3227 T5452 T5439 nsubjpass morphogenesis,disrupted
R3228 T5453 T5439 auxpass is,disrupted
R3229 T5454 T5439 advmod also,disrupted
R3230 T5455 T5456 punct [,45
R3231 T5456 T5439 parataxis 45,disrupted
R3232 T5457 T5456 punct ],45
R3233 T5458 T5439 punct .,disrupted
R3234 T5460 T5461 nsubj We,found
R3235 T5462 T5463 mark that,are
R3236 T5463 T5461 ccomp are,found
R3237 T5464 T5463 expl there,are
R3238 T5465 T5466 amod many,genes
R3239 T5466 T5463 attr genes,are
R3240 T5467 T5466 amod other,genes
R3241 T5468 T5469 dep that,are
R3242 T5469 T5466 relcl are,genes
R3243 T5470 T5469 acomp dependent,are
R3244 T5471 T5470 prep upon,dependent
R3245 T5472 T5471 pobj Crx,upon
R3246 T5473 T5461 punct .,found
R3247 T5475 T5476 nsubj Those,comprise
R3248 T5477 T5478 dep that,expressed
R3249 T5478 T5475 relcl expressed,Those
R3250 T5479 T5478 auxpass are,expressed
R3251 T5480 T5478 prep at,expressed
R3252 T5481 T5482 det a,level
R3253 T5482 T5480 pobj level,at
R3254 T5483 T5482 amod lower,level
R3255 T5484 T5478 prep in,expressed
R3256 T5485 T5486 det the,retina
R3257 T5486 T5484 pobj retina,in
R3258 T5487 T5486 nmod Crx,retina
R3259 T5488 T5487 punct -,Crx
R3260 T5489 T5487 punct /,Crx
R3261 T5490 T5487 punct -,Crx
R3262 T5491 T5475 punct ", ",Those
R3263 T5492 T5493 amod such,as
R3264 T5493 T5475 prep as,Those
R3265 T5494 T5493 pobj rhodopsin,as
R3266 T5495 T5494 cc and,rhodopsin
R3267 T5496 T5494 conj peripherin,rhodopsin
R3268 T5497 T5476 punct ", ",comprise
R3269 T5498 T5476 dobj many,comprise
R3270 T5499 T5500 dep that,are
R3271 T5500 T5498 relcl are,many
R3272 T5501 T5502 advmod either,enriched
R3273 T5502 T5500 acomp enriched,are
R3274 T5503 T5502 cc or,enriched
R3275 T5504 T5502 conj specific,enriched
R3276 T5505 T5504 prep to,specific
R3277 T5506 T5505 pobj photoreceptors,to
R3278 T5507 T5500 prep in,are
R3279 T5508 T5509 poss their,expression
R3280 T5509 T5507 pobj expression,in
R3281 T5510 T5511 punct [,35
R3282 T5511 T5476 parataxis 35,comprise
R3283 T5512 T5511 punct ],35
R3284 T5513 T5476 punct .,comprise
R3285 T5515 T5516 nsubj They,include
R3286 T5517 T5516 dobj enzymes,include
R3287 T5518 T5519 dep that,are
R3288 T5519 T5517 relcl are,enzymes
R3289 T5520 T5519 acomp important,are
R3290 T5521 T5520 prep in,important
R3291 T5522 T5523 compound lipid,metabolism
R3292 T5523 T5521 pobj metabolism,in
R3293 T5524 T5523 punct ", ",metabolism
R3294 T5525 T5526 compound protein,folding
R3295 T5526 T5523 appos folding,metabolism
R3296 T5527 T5526 cc and,folding
R3297 T5528 T5526 conj transport,folding
R3298 T5529 T5521 punct ", ",in
R3299 T5530 T5531 advmod as,as
R3300 T5531 T5521 cc as,in
R3301 T5532 T5531 advmod well,as
R3302 T5533 T5521 conj in,in
R3303 T5534 T5535 amod other,processes
R3304 T5535 T5533 pobj processes,in
R3305 T5536 T5537 dep that,envision
R3306 T5537 T5535 relcl envision,processes
R3307 T5538 T5537 nsubj one,envision
R3308 T5539 T5537 aux might,envision
R3309 T5540 T5541 aux would,be
R3310 T5541 T5537 xcomp be,envision
R3311 T5542 T5541 acomp important,be
R3312 T5543 T5541 prep in,be
R3313 T5544 T5543 pcomp building,in
R3314 T5545 T5546 det a,structure
R3315 T5546 T5544 dobj structure,building
R3316 T5547 T5548 amod such,as
R3317 T5548 T5546 prep as,structure
R3318 T5549 T5550 det the,segment
R3319 T5550 T5548 pobj segment,as
R3320 T5551 T5550 amod outer,segment
R3321 T5552 T5516 punct .,include
R3322 T5554 T5555 advmod In,situ
R3323 T5555 T5556 amod situ,hybridization
R3324 T5556 T5557 nsubj hybridization,revealed
R3325 T5558 T5556 acl using,hybridization
R3326 T5559 T5558 dobj probes,using
R3327 T5560 T5559 prep from,probes
R3328 T5561 T5562 det this,collection
R3329 T5562 T5560 pobj collection,from
R3330 T5563 T5562 prep of,collection
R3331 T5564 T5563 pobj genes,of
R3332 T5565 T5557 aux has,revealed
R3333 T5566 T5567 mark that,have
R3334 T5567 T5557 ccomp have,revealed
R3335 T5568 T5567 nsubj some,have
R3336 T5569 T5568 prep of,some
R3337 T5570 T5569 pobj them,of
R3338 T5571 T5572 poss their,RNA
R3339 T5572 T5573 nsubj RNA,localized
R3340 T5573 T5567 ccomp localized,have
R3341 T5574 T5573 prep to,localized
R3342 T5575 T5576 det the,segment
R3343 T5576 T5574 pobj segment,to
R3344 T5577 T5576 amod inner,segment
R3345 T5578 T5557 punct ", ",revealed
R3346 T5579 T5580 det a,finding
R3347 T5580 T5557 npadvmod finding,revealed
R3348 T5581 T5580 amod typical,finding
R3349 T5582 T5581 prep for,typical
R3350 T5583 T5582 pobj proteins,for
R3351 T5584 T5583 acl targeted,proteins
R3352 T5585 T5584 prep to,targeted
R3353 T5586 T5587 det the,segment
R3354 T5587 T5585 pobj segment,to
R3355 T5588 T5587 amod outer,segment
R3356 T5589 T5557 punct .,revealed
R3357 T5591 T5592 amod Future,analyses
R3358 T5592 T5593 nsubj analyses,reveal
R3359 T5594 T5592 prep of,analyses
R3360 T5595 T5596 det the,function
R3361 T5596 T5594 pobj function,of
R3362 T5597 T5596 prep of,function
R3363 T5598 T5599 det these,genes
R3364 T5599 T5597 pobj genes,of
R3365 T5600 T5593 aux might,reveal
R3366 T5601 T5602 poss their,role
R3367 T5602 T5593 dobj role,reveal
R3368 T5603 T5602 prep in,role
R3369 T5604 T5605 amod outer,segment
R3370 T5605 T5606 compound segment,biogenesis
R3371 T5606 T5603 pobj biogenesis,in
R3372 T5607 T5593 punct .,reveal
R3373 T5609 T5610 advmod Finally,found
R3374 T5611 T5610 punct ", ",found
R3375 T5612 T5610 nsubjpass polarization,found
R3376 T5613 T5612 prep of,polarization
R3377 T5614 T5613 pobj photoreceptors,of
R3378 T5615 T5610 auxpass was,found
R3379 T5616 T5617 aux to,be
R3380 T5617 T5610 xcomp be,found
R3381 T5618 T5619 advmod largely,intact
R3382 T5619 T5617 acomp intact,be
R3383 T5620 T5617 punct ", ",be
R3384 T5621 T5622 mark as,was
R3385 T5622 T5617 advcl was,be
R3386 T5623 T5622 nsubj ciliogenesis,was
R3387 T5624 T5610 punct .,found
R3388 T5626 T5627 det Another,gene
R3389 T5627 T5629 nsubjpass gene,implicated
R3390 T5628 T5627 compound LCA,gene
R3391 T5630 T5627 punct ", ",gene
R3392 T5631 T5627 appos CRB1,gene
R3393 T5632 T5627 punct ", ",gene
R3394 T5633 T5627 cc and,gene
R3395 T5634 T5635 det a,gene
R3396 T5635 T5627 conj gene,gene
R3397 T5636 T5635 amod related,gene
R3398 T5637 T5635 appos CRB3,gene
R3399 T5638 T5629 punct ", ",implicated
R3400 T5639 T5629 aux have,implicated
R3401 T5640 T5629 auxpass been,implicated
R3402 T5641 T5629 prep in,implicated
R3403 T5642 T5641 pobj ciliogenesis,in
R3404 T5643 T5629 prep in,implicated
R3405 T5644 T5645 advmod in,vitro
R3406 T5645 T5646 amod vitro,models
R3407 T5646 T5643 pobj models,in
R3408 T5647 T5648 punct [,46
R3409 T5648 T5629 parataxis 46,implicated
R3410 T5649 T5648 punct ],46
R3411 T5650 T5629 punct .,implicated
R3412 T5652 T5653 det The,homologue
R3413 T5653 T5655 nsubjpass homologue,implicated
R3414 T5654 T5653 compound Drosophila,homologue
R3415 T5656 T5653 prep of,homologue
R3416 T5657 T5656 pobj CRB1,of
R3417 T5658 T5653 punct ", ",homologue
R3418 T5659 T5653 appos Crumbs,homologue
R3419 T5660 T5655 punct ", ",implicated
R3420 T5661 T5655 aux has,implicated
R3421 T5662 T5655 auxpass been,implicated
R3422 T5663 T5655 prep in,implicated
R3423 T5664 T5665 compound photoreceptor,morphogenesis
R3424 T5665 T5663 pobj morphogenesis,in
R3425 T5666 T5667 punct [,47
R3426 T5667 T5655 parataxis 47,implicated
R3427 T5668 T5667 punct ],47
R3428 T5669 T5655 punct .,implicated
R3429 T5671 T5672 advmod However,develops
R3430 T5673 T5672 punct ", ",develops
R3431 T5674 T5675 det the,mutant
R3432 T5675 T5672 nsubj mutant,develops
R3433 T5676 T5677 advmod spontaneously,occurring
R3434 T5677 T5675 amod occurring,mutant
R3435 T5678 T5675 compound mouse,mutant
R3436 T5679 T5675 prep in,mutant
R3437 T5680 T5679 pobj CRB1,in
R3438 T5681 T5675 punct ", ",mutant
R3439 T5682 T5683 det the,mouse
R3440 T5683 T5675 appos mouse,mutant
R3441 T5684 T5683 compound Rd8,mouse
R3442 T5685 T5672 punct ", ",develops
R3443 T5686 T5687 amod shortened,segments
R3444 T5687 T5672 dobj segments,develops
R3445 T5688 T5687 amod outer,segments
R3446 T5689 T5690 dep that,degenerate
R3447 T5690 T5687 relcl degenerate,segments
R3448 T5691 T5690 advmod subsequently,degenerate
R3449 T5692 T5693 punct [,48
R3450 T5693 T5672 parataxis 48,develops
R3451 T5694 T5693 punct ],48
R3452 T5695 T5672 punct ", ",develops
R3453 T5696 T5672 advcl suggesting,develops
R3454 T5697 T5698 mark that,are
R3455 T5698 T5696 ccomp are,suggesting
R3456 T5699 T5700 compound photoreceptor,polarization
R3457 T5700 T5698 nsubj polarization,are
R3458 T5701 T5700 cc and,polarization
R3459 T5702 T5700 conj synaptogenesis,polarization
R3460 T5703 T5698 acomp intact,are
R3461 T5704 T5698 prep in,are
R3462 T5705 T5706 det this,mutant
R3463 T5706 T5704 pobj mutant,in
R3464 T5707 T5672 punct .,develops
R3465 T5709 T5710 mark While,linked
R3466 T5710 T5717 advcl linked,is
R3467 T5711 T5710 nsubjpass CRB1,linked
R3468 T5712 T5711 cc and,CRB1
R3469 T5713 T5711 conj Crx,CRB1
R3470 T5714 T5710 aux have,linked
R3471 T5715 T5710 auxpass been,linked
R3472 T5716 T5710 advmod both,linked
R3473 T5718 T5710 prep to,linked
R3474 T5719 T5718 pobj LCA,to
R3475 T5720 T5717 punct ", ",is
R3476 T5721 T5722 amod further,work
R3477 T5722 T5717 nsubj work,is
R3478 T5723 T5717 acomp necessary,is
R3479 T5724 T5725 aux to,determine
R3480 T5725 T5723 xcomp determine,necessary
R3481 T5726 T5727 mark if,linked
R3482 T5727 T5725 ccomp linked,determine
R3483 T5728 T5729 poss their,function
R3484 T5729 T5727 nsubjpass function,linked
R3485 T5730 T5727 auxpass is,linked
R3486 T5731 T5727 prep in,linked
R3487 T5732 T5733 amod retinal,development
R3488 T5733 T5731 pobj development,in
R3489 T5734 T5717 punct .,is