PMC:539297 / 445-1018
Annnotations
craft-ca-core-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T71 | 11-15 | PR:000005591 | denotes | Cln3 |
T72 | 31-35 | NCBITaxon:10088 | denotes | mice |
T73 | 79-86 | GO:0010467 | denotes | express |
T74 | 94-102 | PR:000005591 | denotes | battenin |
T75 | 206-220 | CL:0000540 | denotes | neuronal cells |
T76 | 242-247 | NCBITaxon:10088 | denotes | mouse |
T77 | 248-257 | UBERON:0002037 | denotes | cerebella |
T78 | 298-300 | UBERON:0002037 | denotes | Cb |
T79 | 300-304 | PR:000005591 | denotes | Cln3 |
T80 | 345-353 | CL:0000540 | denotes | neuronal |
T81 | 409-414 | PR:000010124 | denotes | MAP-2 |
T82 | 419-423 | PR:000006252 | denotes | NeuN |
T83 | 434-440 | CL:0000540 | denotes | neuron |
T84 | 464-466 | UBERON:0002037 | denotes | Cb |
T85 | 466-470 | PR:000005591 | denotes | Cln3 |
T86 | 493-500 | GO:0010467 | denotes | express |
T87 | 522-530 | PR:000005591 | denotes | battenin |
craft-sa-dev
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T244 | 1-10 | VBD | denotes | generated |
T246 | 11-19 | NN | denotes | Cln3Δex7 |
T247 | 31-35 | NNS | denotes | mice |
T248 | 19-20 | HYPH | denotes | / |
T249 | 20-21 | CD | denotes | 8 |
T250 | 22-27 | VB | denotes | knock |
T251 | 27-28 | HYPH | denotes | - |
T252 | 28-30 | RP | denotes | in |
T253 | 35-37 | , | denotes | , |
T254 | 37-42 | WDT | denotes | which |
T255 | 43-52 | VBP | denotes | replicate |
T256 | 53-56 | DT | denotes | the |
T257 | 69-77 | NN | denotes | mutation |
T258 | 57-63 | JJ | denotes | common |
T259 | 64-68 | NN | denotes | JNCL |
T260 | 77-79 | , | denotes | , |
T261 | 79-86 | VBP | denotes | express |
T262 | 87-93 | NN | denotes | mutant |
T263 | 94-102 | NN | denotes | battenin |
T264 | 103-106 | CC | denotes | and |
T265 | 107-114 | VBP | denotes | display |
T266 | 115-119 | NN | denotes | JNCL |
T267 | 120-124 | JJ | denotes | like |
T268 | 119-120 | HYPH | denotes | - |
T269 | 125-134 | NN | denotes | pathology |
T270 | 134-135 | . | denotes | . |
T271 | 135-144 | sentence | denotes | Results |
T272 | 137-144 | NNS | denotes | Results |
T273 | 144-452 | sentence | denotes | To elucidate the consequences of the common JNCL mutation in neuronal cells, we used P4 knock-in mouse cerebella to establish conditionally immortalized CbCln3 wild-type, heterozygous, and homozygous neuronal precursor cell lines, which can be differentiated into MAP-2 and NeuN-positive, neuron-like cells. |
T274 | 145-147 | TO | denotes | To |
T275 | 148-157 | VB | denotes | elucidate |
T276 | 225-229 | VBD | denotes | used |
T277 | 158-161 | DT | denotes | the |
T278 | 162-174 | NNS | denotes | consequences |
T279 | 175-177 | IN | denotes | of |
T280 | 178-181 | DT | denotes | the |
T281 | 194-202 | NN | denotes | mutation |
T282 | 182-188 | JJ | denotes | common |
T283 | 189-193 | NN | denotes | JNCL |
T284 | 203-205 | IN | denotes | in |
T285 | 206-214 | JJ | denotes | neuronal |
T286 | 215-220 | NNS | denotes | cells |
T287 | 220-222 | , | denotes | , |
T288 | 222-224 | PRP | denotes | we |
T289 | 230-232 | NN | denotes | P4 |
T290 | 248-257 | NNS | denotes | cerebella |
T291 | 233-238 | VB | denotes | knock |
T292 | 238-239 | HYPH | denotes | - |
T293 | 239-241 | RP | denotes | in |
T294 | 242-247 | NN | denotes | mouse |
T295 | 258-260 | TO | denotes | to |
T296 | 261-270 | VB | denotes | establish |
T297 | 271-284 | RB | denotes | conditionally |
T298 | 285-297 | VBN | denotes | immortalized |
T299 | 369-374 | NNS | denotes | lines |
T300 | 298-304 | NN | denotes | CbCln3 |
T301 | 305-309 | JJ | denotes | wild |
T302 | 310-314 | NN | denotes | type |
T303 | 309-310 | HYPH | denotes | - |
T304 | 314-316 | , | denotes | , |
T305 | 316-328 | JJ | denotes | heterozygous |
T306 | 328-330 | , | denotes | , |
T307 | 330-333 | CC | denotes | and |
T308 | 334-344 | JJ | denotes | homozygous |
T309 | 345-353 | JJ | denotes | neuronal |
T310 | 354-363 | NN | denotes | precursor |
T311 | 364-368 | NN | denotes | cell |
T312 | 374-376 | , | denotes | , |
T313 | 376-381 | WDT | denotes | which |
T314 | 389-403 | VBN | denotes | differentiated |
T315 | 382-385 | MD | denotes | can |
T316 | 386-388 | VB | denotes | be |
T317 | 404-408 | IN | denotes | into |
T318 | 409-412 | NN | denotes | MAP |
T319 | 424-432 | JJ | denotes | positive |
T320 | 412-413 | HYPH | denotes | - |
T321 | 413-414 | CD | denotes | 2 |
T322 | 415-418 | CC | denotes | and |
T323 | 419-423 | NN | denotes | NeuN |
T324 | 423-424 | HYPH | denotes | - |
T325 | 446-451 | NNS | denotes | cells |
T326 | 432-434 | , | denotes | , |
T327 | 434-440 | NN | denotes | neuron |
T328 | 441-445 | JJ | denotes | like |
T329 | 440-441 | HYPH | denotes | - |
T330 | 451-452 | . | denotes | . |
T332 | 453-463 | JJ | denotes | Homozygous |
T333 | 487-492 | NNS | denotes | cells |
T334 | 464-474 | NN | denotes | CbCln3Δex7 |
T335 | 474-475 | HYPH | denotes | / |
T336 | 475-476 | CD | denotes | 8 |
T337 | 477-486 | NN | denotes | precursor |
T338 | 493-500 | VBP | denotes | express |
T339 | 501-504 | JJ | denotes | low |
T340 | 505-511 | NNS | denotes | levels |
T341 | 512-514 | IN | denotes | of |
T342 | 515-521 | NN | denotes | mutant |
T343 | 522-530 | NN | denotes | battenin |
T344 | 531-534 | CC | denotes | and |
T345 | 534-536 | , | denotes | , |
T346 | 536-540 | WRB | denotes | when |
T347 | 541-545 | VBN | denotes | aged |
T348 | 561-571 | VBP | denotes | accumulate |
T349 | 546-548 | IN | denotes | at |
T350 | 549-559 | NN | denotes | confluency |
T351 | 559-561 | , | denotes | , |
R85 | T264 | T261 | cc | and,express |
R86 | T265 | T261 | conj | display,express |
R84 | T263 | T261 | dobj | battenin,express |
R67 | T246 | T247 | nmod | Cln3Δex7,mice |
R68 | T247 | T244 | dobj | mice,generated |
R69 | T248 | T246 | punct | /,Cln3Δex7 |
R70 | T249 | T246 | nummod | 8,Cln3Δex7 |
R71 | T250 | T247 | amod | knock,mice |
R72 | T251 | T250 | punct | -,knock |
R73 | T252 | T250 | prt | in,knock |
R74 | T253 | T247 | punct | ", ",mice |
R75 | T254 | T255 | dep | which,replicate |
R76 | T255 | T247 | relcl | replicate,mice |
R77 | T256 | T257 | det | the,mutation |
R78 | T257 | T255 | dobj | mutation,replicate |
R79 | T258 | T257 | amod | common,mutation |
R80 | T259 | T257 | compound | JNCL,mutation |
R81 | T260 | T255 | punct | ", ",replicate |
R82 | T261 | T255 | conj | express,replicate |
R83 | T262 | T263 | compound | mutant,battenin |
R87 | T266 | T267 | npadvmod | JNCL,like |
R89 | T268 | T267 | punct | -,like |
R90 | T269 | T265 | dobj | pathology,display |
R91 | T270 | T244 | punct | .,generated |
R92 | T274 | T275 | aux | To,elucidate |
R93 | T275 | T276 | advcl | elucidate,used |
R94 | T277 | T278 | det | the,consequences |
R95 | T278 | T275 | dobj | consequences,elucidate |
R96 | T279 | T278 | prep | of,consequences |
R97 | T280 | T281 | det | the,mutation |
R98 | T281 | T279 | pobj | mutation,of |
R99 | T282 | T281 | amod | common,mutation |
R100 | T283 | T281 | compound | JNCL,mutation |
R101 | T284 | T278 | prep | in,consequences |
R102 | T285 | T286 | amod | neuronal,cells |
R103 | T286 | T284 | pobj | cells,in |
R104 | T287 | T276 | punct | ", ",used |
R105 | T288 | T276 | nsubj | we,used |
R106 | T289 | T290 | nmod | P4,cerebella |
R107 | T290 | T276 | dobj | cerebella,used |
R108 | T291 | T290 | amod | knock,cerebella |
R109 | T292 | T291 | punct | -,knock |
R110 | T293 | T291 | prt | in,knock |
R111 | T294 | T290 | compound | mouse,cerebella |
R112 | T295 | T296 | aux | to,establish |
R113 | T296 | T276 | advcl | establish,used |
R114 | T297 | T298 | advmod | conditionally,immortalized |
R115 | T298 | T299 | amod | immortalized,lines |
R116 | T299 | T296 | dobj | lines,establish |
R117 | T300 | T299 | nmod | CbCln3,lines |
R118 | T301 | T302 | amod | wild,type |
R119 | T302 | T299 | nmod | type,lines |
R120 | T303 | T302 | punct | -,type |
R121 | T304 | T302 | punct | ", ",type |
R122 | T305 | T302 | conj | heterozygous,type |
R123 | T306 | T305 | punct | ", ",heterozygous |
R124 | T307 | T305 | cc | and,heterozygous |
R125 | T308 | T305 | conj | homozygous,heterozygous |
R126 | T309 | T310 | amod | neuronal,precursor |
R127 | T310 | T299 | compound | precursor,lines |
R128 | T311 | T299 | compound | cell,lines |
R129 | T312 | T299 | punct | ", ",lines |
R130 | T313 | T314 | dep | which,differentiated |
R131 | T314 | T299 | relcl | differentiated,lines |
R132 | T315 | T314 | aux | can,differentiated |
R133 | T316 | T314 | auxpass | be,differentiated |
R134 | T317 | T314 | prep | into,differentiated |
R135 | T318 | T319 | npadvmod | MAP,positive |
R136 | T319 | T325 | amod | positive,cells |
R137 | T320 | T318 | punct | -,MAP |
R138 | T321 | T318 | nummod | 2,MAP |
R139 | T322 | T318 | cc | and,MAP |
R140 | T323 | T318 | conj | NeuN,MAP |
R141 | T324 | T319 | punct | -,positive |
R142 | T325 | T317 | pobj | cells,into |
R143 | T326 | T325 | punct | ", ",cells |
R144 | T327 | T328 | npadvmod | neuron,like |
R145 | T328 | T325 | amod | like,cells |
R146 | T329 | T328 | punct | -,like |
R147 | T330 | T276 | punct | .,used |
R148 | T332 | T333 | amod | Homozygous,cells |
R149 | T333 | T338 | nsubj | cells,express |
R150 | T334 | T333 | nmod | CbCln3Δex7,cells |
R151 | T335 | T334 | punct | /,CbCln3Δex7 |
R152 | T336 | T334 | nummod | 8,CbCln3Δex7 |
R153 | T337 | T333 | compound | precursor,cells |
R154 | T339 | T340 | amod | low,levels |
R155 | T340 | T338 | dobj | levels,express |
R156 | T341 | T340 | prep | of,levels |
R157 | T342 | T343 | compound | mutant,battenin |
R158 | T343 | T341 | pobj | battenin,of |
R159 | T344 | T338 | cc | and,express |
R160 | T345 | T338 | punct | ", ",express |
R161 | T346 | T347 | advmod | when,aged |
R162 | T347 | T348 | advcl | aged,accumulate |
R163 | T348 | T338 | conj | accumulate,express |
R164 | T349 | T347 | prep | at,aged |
R165 | T350 | T349 | pobj | confluency,at |
R166 | T351 | T348 | punct | ", ",accumulate |
R88 | T267 | T269 | amod | like,pathology |
craft-ca-core-ex-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T120 | 11-15 | PR_EXT:000005591 | denotes | Cln3 |
T121 | 31-35 | NCBITaxon:10088 | denotes | mice |
T122 | 69-77 | SO_EXT:sequence_alteration_entity_or_process | denotes | mutation |
T123 | 79-86 | GO:0010467 | denotes | express |
T124 | 87-93 | SO_EXT:sequence_altered_entity_or_alteration_process | denotes | mutant |
T125 | 94-102 | PR_EXT:000005591 | denotes | battenin |
T126 | 194-202 | SO_EXT:sequence_alteration_entity_or_process | denotes | mutation |
T127 | 206-220 | CL:0000540 | denotes | neuronal cells |
T128 | 215-220 | CL_GO_EXT:cell | denotes | cells |
T129 | 242-247 | NCBITaxon:10088 | denotes | mouse |
T130 | 248-257 | UBERON:0002037 | denotes | cerebella |
T131 | 298-300 | UBERON:0002037 | denotes | Cb |
T132 | 300-304 | PR_EXT:000005591 | denotes | Cln3 |
T133 | 305-314 | SO_EXT:wild_type_entity_or_quality | denotes | wild-type |
T134 | 345-353 | CL:0000540 | denotes | neuronal |
T135 | 364-368 | CL_GO_EXT:cell | denotes | cell |
T136 | 389-403 | GO_PATO_RO_EXT:developmental_differentiation_process_or_quality | denotes | differentiated |
T137 | 409-414 | PR_EXT:000010124 | denotes | MAP-2 |
T138 | 419-423 | PR_EXT:000006252 | denotes | NeuN |
T139 | 434-440 | CL:0000540 | denotes | neuron |
T140 | 446-451 | CL_GO_EXT:cell | denotes | cells |
T141 | 464-466 | UBERON:0002037 | denotes | Cb |
T142 | 466-470 | PR_EXT:000005591 | denotes | Cln3 |
T143 | 487-492 | CL_GO_EXT:cell | denotes | cells |
T144 | 493-500 | GO:0010467 | denotes | express |
T145 | 515-521 | SO_EXT:sequence_altered_entity_or_alteration_process | denotes | mutant |
T146 | 522-530 | PR_EXT:000005591 | denotes | battenin |
T147 | 541-545 | GO_PATO_EXT:aging_or_agedness | denotes | aged |