PMC:539297 / 1680-4162 JSONTXT

{"project":"craft-ca-core-dev","denotations":[{"id":"T535","span":{"begin":364,"end":368},"obj":"SO:0000704"},{"id":"T536","span":{"begin":387,"end":392},"obj":"SO:0000147"},{"id":"T537","span":{"begin":417,"end":425},"obj":"SO:0000188"},{"id":"T538","span":{"begin":567,"end":580},"obj":"GO:0044754"},{"id":"T539","span":{"begin":602,"end":614},"obj":"_FRAGMENT"},{"id":"T540","span":{"begin":619,"end":653},"obj":"PR:000022190"},{"id":"T541","span":{"begin":619,"end":653},"obj":"GO:0005753"},{"id":"T542","span":{"begin":710,"end":713},"obj":"UBERON:0001017"},{"id":"T543","span":{"begin":710,"end":721},"obj":"CL:0000117"},{"id":"T544","span":{"begin":751,"end":759},"obj":"CL:0000540"},{"id":"T545","span":{"begin":781,"end":795},"obj":"UBERON:0001016"},{"id":"T546","span":{"begin":817,"end":826},"obj":"PR:000022190"},{"id":"T547","span":{"begin":899,"end":907},"obj":"CL:0000540"},{"id":"T548","span":{"begin":965,"end":969},"obj":"PR:000005591"},{"id":"T549","span":{"begin":987,"end":995},"obj":"PR:000005591"},{"id":"T550","span":{"begin":1009,"end":1013},"obj":"PR:000005591"},{"id":"T551","span":{"begin":1017,"end":1023},"obj":"PR:000005591"},{"id":"T552","span":{"begin":1061,"end":1070},"obj":"GO:0010467"},{"id":"T553","span":{"begin":1083,"end":1091},"obj":"GO:0016020"},{"id":"T554","span":{"begin":1126,"end":1134},"obj":"GO:0005764"},{"id":"T555","span":{"begin":1145,"end":1154},"obj":"GO:0031982"},{"id":"T556","span":{"begin":1175,"end":1183},"obj":"PR:000005591"},{"id":"T557","span":{"begin":1239,"end":1243},"obj":"PR:Q9US09"},{"id":"T558","span":{"begin":1255,"end":1259},"obj":"PR:000005591"},{"id":"T559","span":{"begin":1260,"end":1268},"obj":"SO:0000855"},{"id":"T560","span":{"begin":1286,"end":1294},"obj":"PR:000005591"},{"id":"T561","span":{"begin":1298,"end":1307},"obj":"GO:0005764"},{"id":"T562","span":{"begin":1308,"end":1322},"obj":"GO:0006885"},{"id":"T563","span":{"begin":1327,"end":1347},"obj":"GO:0006865"},{"id":"T564","span":{"begin":1390,"end":1398},"obj":"PR:000005591"},{"id":"T565","span":{"begin":1435,"end":1446},"obj":"SO:0000704"},{"id":"T566","span":{"begin":1460,"end":1465},"obj":"NCBITaxon:10088"},{"id":"T567","span":{"begin":1473,"end":1477},"obj":"PR:000005591"},{"id":"T568","span":{"begin":1493,"end":1497},"obj":"NCBITaxon:10088"},{"id":"T569","span":{"begin":1540,"end":1547},"obj":"GO:0010467"},{"id":"T570","span":{"begin":1571,"end":1579},"obj":"PR:000005591"},{"id":"T571","span":{"begin":1580,"end":1587},"obj":"SO:0001060"},{"id":"T572","span":{"begin":1612,"end":1622},"obj":"GO:0042571"},{"id":"T573","span":{"begin":1667,"end":1671},"obj":"PR:000005591"},{"id":"T574","span":{"begin":1687,"end":1691},"obj":"NCBITaxon:10088"},{"id":"T575","span":{"begin":1738,"end":1747},"obj":"UBERON:0012101"},{"id":"T576","span":{"begin":1742,"end":1747},"obj":"GO:0007567"},{"id":"T577","span":{"begin":1757,"end":1766},"obj":"PR:000022190"},{"id":"T578","span":{"begin":1816,"end":1824},"obj":"CL:0000540"},{"id":"T579","span":{"begin":1947,"end":1960},"obj":"GO:0005739"},{"id":"T580","span":{"begin":1947,"end":1970},"obj":"PR:000022190"},{"id":"T581","span":{"begin":2013,"end":2016},"obj":"UBERON:0001017"},{"id":"T582","span":{"begin":2013,"end":2024},"obj":"CL:0000117"},{"id":"T583","span":{"begin":2058,"end":2071},"obj":"CL:0000540"},{"id":"T584","span":{"begin":2136,"end":2156},"obj":"GO:0008150"},{"id":"T585","span":{"begin":2189,"end":2199},"obj":"UBERON:0002037"},{"id":"T586","span":{"begin":2189,"end":2208},"obj":"CL:1001611"},{"id":"T587","span":{"begin":2235,"end":2239},"obj":"PR:000005591"},{"id":"T588","span":{"begin":2255,"end":2259},"obj":"NCBITaxon:10088"},{"id":"T589","span":{"begin":2272,"end":2274},"obj":"UBERON:0002037"},{"id":"T590","span":{"begin":2274,"end":2278},"obj":"PR:000005591"},{"id":"T591","span":{"begin":2354,"end":2373},"obj":"GO:0043227"},{"id":"T592","span":{"begin":2383,"end":2391},"obj":"GO:0016020"},{"id":"T593","span":{"begin":2383,"end":2403},"obj":"GO:0055085"},{"id":"T594","span":{"begin":2416,"end":2429},"obj":"GO:0005739"},{"id":"T595","span":{"begin":2463,"end":2465},"obj":"UBERON:0002037"},{"id":"T529","span":{"begin":20,"end":28},"obj":"CL:0000540"},{"id":"T530","span":{"begin":208,"end":217},"obj":"GO:0050890"},{"id":"T531","span":{"begin":237,"end":242},"obj":"GO:0016265"},{"id":"T532","span":{"begin":260,"end":267},"obj":"SO:0000704"},{"id":"T533","span":{"begin":331,"end":338},"obj":"SO:0001026"},{"id":"T534","span":{"begin":359,"end":363},"obj":"PR:000005591"}],"relations":[{"id":"R264","pred":"_lexicallyChainedTo","subj":"T540","obj":"T539"}],"text":"Background\nJuvenile neuronal ceroid lipofuscinosis (JNCL), or Batten disease, is a recessively inherited childhood-onset neurodegenerative disorder characterized by progressive blindness, seizures, motor and cognitive decline, and early death [1]. The primary genetic defect (\u003e80% disease chromosomes) leading to JNCL is a 1.02 kb genomic DNA deletion in the CLN3 gene, which eliminates exons 7 and 8 and surrounding intronic DNA, predicting a non-functional protein product [2].\nThe pathological hallmark of JNCL is autofluorescent ceroid lipofuscin deposits within autolysosomes that are enriched in subunit c of the mitochondrial ATP synthase complex [3-5]. Remarkably, these deposits are not only found in CNS neurons but are also abundant in non-neuronal cells outside of the nervous system. The relationship of subunit c deposits to the JNCL disease process, and the underlying reason for the neuronal specificity of the disease remain poorly understood.\nThe CLN3-encoded protein (battenin, also called CLN3 or cln3 p) is a highly conserved, ubiquitously expressed, multi-pass membrane protein [6] that localizes to the lysosome and other vesicular compartments [7-9]. Battenin function remains to be elucidated, although studies of btn1, the yeast CLN3 ortholog, have implicated battenin in lysosomal pH homeostasis and amino acid transport [10,11].\nTo explore JNCL pathogenesis and battenin function, we previously generated a genetically precise JNCL mouse model. Cln3Δex7/8 knock-in mice harbor the ~1 kb common JNCL mutation and express a non-truncated mutant battenin isoform that is detectable with antibodies recognizing C-terminal epitopes. Homozygous Cln3Δex7/8 knock-in mice exhibit a progressive JNCL-like disease, with perinatal onset of subunit c deposition in many cell types and later onset of neuronal dysfunction and behavioral deficits [12]. These findings suggest that the major JNCL defect leads to abnormal turnover of mitochondrial subunit c, in a manner that selectively compromises CNS neurons.\nCurrently, there is no suitable neuronal cell system to investigate the impact of the common JNCL mutation on biological processes. Therefore, we have established cerebellar neuronal precursor cell lines from Cln3Δex7/8 knock-in mice. Homozygous CbCln3Δex7/8 cells exhibit pathological hallmarks of the disease, and a survey of membrane organelles revealed membrane trafficking defects and mitochondrial dysfunction in homozygous mutant CbCln3Δex7/8 cells."}

{"project":"craft-sa-dev","denotations":[{"id":"T696","span":{"begin":11,"end":19},"obj":"JJ"},{"id":"T697","span":{"begin":36,"end":50},"obj":"NN"},{"id":"T698","span":{"begin":20,"end":28},"obj":"JJ"},{"id":"T699","span":{"begin":29,"end":35},"obj":"NN"},{"id":"T700","span":{"begin":78,"end":80},"obj":"VBZ"},{"id":"T701","span":{"begin":51,"end":52},"obj":"-LRB-"},{"id":"T702","span":{"begin":52,"end":56},"obj":"NN"},{"id":"T703","span":{"begin":56,"end":57},"obj":"-RRB-"},{"id":"T704","span":{"begin":57,"end":59},"obj":","},{"id":"T705","span":{"begin":59,"end":61},"obj":"CC"},{"id":"T706","span":{"begin":62,"end":68},"obj":"NNP"},{"id":"T707","span":{"begin":69,"end":76},"obj":"NN"},{"id":"T708","span":{"begin":76,"end":78},"obj":","},{"id":"T709","span":{"begin":81,"end":82},"obj":"DT"},{"id":"T710","span":{"begin":139,"end":147},"obj":"NN"},{"id":"T711","span":{"begin":83,"end":94},"obj":"RB"},{"id":"T712","span":{"begin":95,"end":104},"obj":"VBN"},{"id":"T713","span":{"begin":105,"end":114},"obj":"NN"},{"id":"T714","span":{"begin":114,"end":115},"obj":"HYPH"},{"id":"T715","span":{"begin":115,"end":120},"obj":"JJ"},{"id":"T716","span":{"begin":121,"end":138},"obj":"JJ"},{"id":"T717","span":{"begin":148,"end":161},"obj":"VBN"},{"id":"T718","span":{"begin":162,"end":164},"obj":"IN"},{"id":"T719","span":{"begin":165,"end":176},"obj":"JJ"},{"id":"T720","span":{"begin":177,"end":186},"obj":"NN"},{"id":"T721","span":{"begin":186,"end":188},"obj":","},{"id":"T722","span":{"begin":188,"end":196},"obj":"NNS"},{"id":"T723","span":{"begin":196,"end":198},"obj":","},{"id":"T724","span":{"begin":198,"end":203},"obj":"NN"},{"id":"T725","span":{"begin":218,"end":225},"obj":"NN"},{"id":"T726","span":{"begin":204,"end":207},"obj":"CC"},{"id":"T727","span":{"begin":208,"end":217},"obj":"JJ"},{"id":"T728","span":{"begin":225,"end":227},"obj":","},{"id":"T729","span":{"begin":227,"end":230},"obj":"CC"},{"id":"T730","span":{"begin":231,"end":236},"obj":"JJ"},{"id":"T731","span":{"begin":237,"end":242},"obj":"NN"},{"id":"T732","span":{"begin":243,"end":244},"obj":"-LRB-"},{"id":"T733","span":{"begin":244,"end":245},"obj":"CD"},{"id":"T734","span":{"begin":245,"end":246},"obj":"-RRB-"},{"id":"T735","span":{"begin":246,"end":247},"obj":"."},{"id":"T736","span":{"begin":247,"end":479},"obj":"sentence"},{"id":"T737","span":{"begin":248,"end":251},"obj":"DT"},{"id":"T738","span":{"begin":268,"end":274},"obj":"NN"},{"id":"T739","span":{"begin":252,"end":259},"obj":"JJ"},{"id":"T740","span":{"begin":260,"end":267},"obj":"JJ"},{"id":"T741","span":{"begin":318,"end":320},"obj":"VBZ"},{"id":"T742","span":{"begin":275,"end":276},"obj":"-LRB-"},{"id":"T743","span":{"begin":289,"end":300},"obj":"NNS"},{"id":"T744","span":{"begin":276,"end":277},"obj":"SYM"},{"id":"T745","span":{"begin":277,"end":279},"obj":"CD"},{"id":"T746","span":{"begin":279,"end":280},"obj":"NN"},{"id":"T747","span":{"begin":281,"end":288},"obj":"NN"},{"id":"T748","span":{"begin":300,"end":301},"obj":"-RRB-"},{"id":"T749","span":{"begin":302,"end":309},"obj":"VBG"},{"id":"T750","span":{"begin":310,"end":312},"obj":"IN"},{"id":"T751","span":{"begin":313,"end":317},"obj":"NN"},{"id":"T752","span":{"begin":321,"end":322},"obj":"DT"},{"id":"T753","span":{"begin":343,"end":351},"obj":"NN"},{"id":"T754","span":{"begin":323,"end":327},"obj":"CD"},{"id":"T755","span":{"begin":328,"end":330},"obj":"NN"},{"id":"T756","span":{"begin":331,"end":338},"obj":"JJ"},{"id":"T757","span":{"begin":339,"end":342},"obj":"NN"},{"id":"T758","span":{"begin":352,"end":354},"obj":"IN"},{"id":"T759","span":{"begin":355,"end":358},"obj":"DT"},{"id":"T760","span":{"begin":364,"end":368},"obj":"NN"},{"id":"T761","span":{"begin":359,"end":363},"obj":"NN"},{"id":"T762","span":{"begin":368,"end":370},"obj":","},{"id":"T763","span":{"begin":370,"end":375},"obj":"WDT"},{"id":"T764","span":{"begin":376,"end":386},"obj":"VBZ"},{"id":"T765","span":{"begin":387,"end":392},"obj":"NNS"},{"id":"T766","span":{"begin":393,"end":394},"obj":"CD"},{"id":"T767","span":{"begin":395,"end":398},"obj":"CC"},{"id":"T768","span":{"begin":399,"end":400},"obj":"CD"},{"id":"T769","span":{"begin":401,"end":404},"obj":"CC"},{"id":"T770","span":{"begin":405,"end":416},"obj":"JJ"},{"id":"T771","span":{"begin":426,"end":429},"obj":"NN"},{"id":"T772","span":{"begin":417,"end":425},"obj":"JJ"},{"id":"T773","span":{"begin":429,"end":431},"obj":","},{"id":"T774","span":{"begin":431,"end":441},"obj":"VBG"},{"id":"T775","span":{"begin":442,"end":443},"obj":"DT"},{"id":"T776","span":{"begin":467,"end":474},"obj":"NN"},{"id":"T777","span":{"begin":444,"end":458},"obj":"JJ"},{"id":"T778","span":{"begin":459,"end":466},"obj":"NN"},{"id":"T779","span":{"begin":475,"end":476},"obj":"-LRB-"},{"id":"T780","span":{"begin":476,"end":477},"obj":"CD"},{"id":"T781","span":{"begin":477,"end":478},"obj":"-RRB-"},{"id":"T782","span":{"begin":478,"end":479},"obj":"."},{"id":"T783","span":{"begin":479,"end":660},"obj":"sentence"},{"id":"T784","span":{"begin":480,"end":483},"obj":"DT"},{"id":"T785","span":{"begin":497,"end":505},"obj":"NN"},{"id":"T786","span":{"begin":484,"end":496},"obj":"JJ"},{"id":"T787","span":{"begin":514,"end":516},"obj":"VBZ"},{"id":"T788","span":{"begin":506,"end":508},"obj":"IN"},{"id":"T789","span":{"begin":509,"end":513},"obj":"NN"},{"id":"T790","span":{"begin":517,"end":532},"obj":"JJ"},{"id":"T791","span":{"begin":551,"end":559},"obj":"NNS"},{"id":"T792","span":{"begin":533,"end":539},"obj":"NN"},{"id":"T793","span":{"begin":540,"end":550},"obj":"NN"},{"id":"T794","span":{"begin":560,"end":566},"obj":"IN"},{"id":"T795","span":{"begin":567,"end":580},"obj":"NNS"},{"id":"T796","span":{"begin":581,"end":585},"obj":"WDT"},{"id":"T797","span":{"begin":586,"end":589},"obj":"VBP"},{"id":"T798","span":{"begin":590,"end":598},"obj":"JJ"},{"id":"T799","span":{"begin":599,"end":601},"obj":"IN"},{"id":"T800","span":{"begin":602,"end":609},"obj":"NN"},{"id":"T801","span":{"begin":610,"end":611},"obj":"NN"},{"id":"T802","span":{"begin":612,"end":614},"obj":"IN"},{"id":"T803","span":{"begin":615,"end":618},"obj":"DT"},{"id":"T804","span":{"begin":646,"end":653},"obj":"NN"},{"id":"T805","span":{"begin":619,"end":632},"obj":"JJ"},{"id":"T806","span":{"begin":637,"end":645},"obj":"NN"},{"id":"T807","span":{"begin":633,"end":636},"obj":"NN"},{"id":"T808","span":{"begin":654,"end":655},"obj":"-LRB-"},{"id":"T809","span":{"begin":655,"end":656},"obj":"CD"},{"id":"T810","span":{"begin":656,"end":657},"obj":"SYM"},{"id":"T811","span":{"begin":657,"end":658},"obj":"CD"},{"id":"T812","span":{"begin":658,"end":659},"obj":"-RRB-"},{"id":"T813","span":{"begin":659,"end":660},"obj":"."},{"id":"T814","span":{"begin":660,"end":796},"obj":"sentence"},{"id":"T815","span":{"begin":661,"end":671},"obj":"RB"},{"id":"T816","span":{"begin":701,"end":706},"obj":"VBN"},{"id":"T817","span":{"begin":671,"end":673},"obj":","},{"id":"T818","span":{"begin":673,"end":678},"obj":"DT"},{"id":"T819","span":{"begin":679,"end":687},"obj":"NNS"},{"id":"T820","span":{"begin":688,"end":691},"obj":"VBP"},{"id":"T821","span":{"begin":692,"end":695},"obj":"RB"},{"id":"T822","span":{"begin":696,"end":700},"obj":"RB"},{"id":"T823","span":{"begin":707,"end":709},"obj":"IN"},{"id":"T824","span":{"begin":710,"end":713},"obj":"NN"},{"id":"T825","span":{"begin":714,"end":721},"obj":"NNS"},{"id":"T826","span":{"begin":722,"end":725},"obj":"CC"},{"id":"T827","span":{"begin":726,"end":729},"obj":"VBP"},{"id":"T828","span":{"begin":730,"end":734},"obj":"RB"},{"id":"T829","span":{"begin":735,"end":743},"obj":"JJ"},{"id":"T830","span":{"begin":744,"end":746},"obj":"IN"},{"id":"T831","span":{"begin":747,"end":759},"obj":"JJ"},{"id":"T832","span":{"begin":760,"end":765},"obj":"NNS"},{"id":"T833","span":{"begin":766,"end":773},"obj":"IN"},{"id":"T834","span":{"begin":774,"end":776},"obj":"IN"},{"id":"T835","span":{"begin":777,"end":780},"obj":"DT"},{"id":"T836","span":{"begin":789,"end":795},"obj":"NN"},{"id":"T837","span":{"begin":781,"end":788},"obj":"JJ"},{"id":"T838","span":{"begin":795,"end":796},"obj":"."},{"id":"T839","span":{"begin":796,"end":960},"obj":"sentence"},{"id":"T840","span":{"begin":797,"end":800},"obj":"DT"},{"id":"T841","span":{"begin":801,"end":813},"obj":"NN"},{"id":"T842","span":{"begin":935,"end":941},"obj":"VBP"},{"id":"T843","span":{"begin":814,"end":816},"obj":"IN"},{"id":"T844","span":{"begin":817,"end":824},"obj":"NN"},{"id":"T845","span":{"begin":825,"end":826},"obj":"NN"},{"id":"T846","span":{"begin":827,"end":835},"obj":"NNS"},{"id":"T847","span":{"begin":836,"end":838},"obj":"IN"},{"id":"T848","span":{"begin":839,"end":842},"obj":"DT"},{"id":"T849","span":{"begin":856,"end":863},"obj":"NN"},{"id":"T850","span":{"begin":843,"end":847},"obj":"NN"},{"id":"T851","span":{"begin":848,"end":855},"obj":"NN"},{"id":"T852","span":{"begin":863,"end":865},"obj":","},{"id":"T853","span":{"begin":865,"end":868},"obj":"CC"},{"id":"T854","span":{"begin":869,"end":872},"obj":"DT"},{"id":"T855","span":{"begin":884,"end":890},"obj":"NN"},{"id":"T856","span":{"begin":873,"end":883},"obj":"JJ"},{"id":"T857","span":{"begin":891,"end":894},"obj":"IN"},{"id":"T858","span":{"begin":895,"end":898},"obj":"DT"},{"id":"T859","span":{"begin":908,"end":919},"obj":"NN"},{"id":"T860","span":{"begin":899,"end":907},"obj":"JJ"},{"id":"T861","span":{"begin":920,"end":922},"obj":"IN"},{"id":"T862","span":{"begin":923,"end":926},"obj":"DT"},{"id":"T863","span":{"begin":927,"end":934},"obj":"NN"},{"id":"T864","span":{"begin":942,"end":948},"obj":"RB"},{"id":"T865","span":{"begin":949,"end":959},"obj":"VBN"},{"id":"T866","span":{"begin":959,"end":960},"obj":"."},{"id":"T867","span":{"begin":960,"end":1174},"obj":"sentence"},{"id":"T868","span":{"begin":961,"end":964},"obj":"DT"},{"id":"T869","span":{"begin":978,"end":985},"obj":"NN"},{"id":"T870","span":{"begin":965,"end":969},"obj":"NN"},{"id":"T871","span":{"begin":970,"end":977},"obj":"VBN"},{"id":"T872","span":{"begin":969,"end":970},"obj":"HYPH"},{"id":"T873","span":{"begin":1025,"end":1027},"obj":"VBZ"},{"id":"T874","span":{"begin":986,"end":987},"obj":"-LRB-"},{"id":"T875","span":{"begin":987,"end":995},"obj":"NN"},{"id":"T876","span":{"begin":995,"end":997},"obj":","},{"id":"T877","span":{"begin":997,"end":1001},"obj":"RB"},{"id":"T878","span":{"begin":1002,"end":1008},"obj":"VBN"},{"id":"T879","span":{"begin":1009,"end":1013},"obj":"NN"},{"id":"T880","span":{"begin":1014,"end":1016},"obj":"CC"},{"id":"T881","span":{"begin":1017,"end":1021},"obj":"NN"},{"id":"T882","span":{"begin":1022,"end":1023},"obj":"NN"},{"id":"T883","span":{"begin":1023,"end":1024},"obj":"-RRB-"},{"id":"T884","span":{"begin":1028,"end":1029},"obj":"DT"},{"id":"T885","span":{"begin":1092,"end":1099},"obj":"NN"},{"id":"T886","span":{"begin":1030,"end":1036},"obj":"RB"},{"id":"T887","span":{"begin":1037,"end":1046},"obj":"JJ"},{"id":"T888","span":{"begin":1046,"end":1048},"obj":","},{"id":"T889","span":{"begin":1048,"end":1060},"obj":"RB"},{"id":"T890","span":{"begin":1061,"end":1070},"obj":"VBN"},{"id":"T891","span":{"begin":1070,"end":1072},"obj":","},{"id":"T892","span":{"begin":1072,"end":1082},"obj":"NN"},{"id":"T893","span":{"begin":1083,"end":1091},"obj":"NN"},{"id":"T894","span":{"begin":1100,"end":1101},"obj":"-LRB-"},{"id":"T895","span":{"begin":1101,"end":1102},"obj":"CD"},{"id":"T896","span":{"begin":1102,"end":1103},"obj":"-RRB-"},{"id":"T897","span":{"begin":1104,"end":1108},"obj":"WDT"},{"id":"T898","span":{"begin":1109,"end":1118},"obj":"VBZ"},{"id":"T899","span":{"begin":1119,"end":1121},"obj":"IN"},{"id":"T900","span":{"begin":1122,"end":1125},"obj":"DT"},{"id":"T901","span":{"begin":1126,"end":1134},"obj":"NN"},{"id":"T902","span":{"begin":1135,"end":1138},"obj":"CC"},{"id":"T903","span":{"begin":1139,"end":1144},"obj":"JJ"},{"id":"T904","span":{"begin":1155,"end":1167},"obj":"NNS"},{"id":"T905","span":{"begin":1145,"end":1154},"obj":"JJ"},{"id":"T906","span":{"begin":1168,"end":1169},"obj":"-LRB-"},{"id":"T907","span":{"begin":1169,"end":1170},"obj":"CD"},{"id":"T908","span":{"begin":1170,"end":1171},"obj":"SYM"},{"id":"T909","span":{"begin":1171,"end":1172},"obj":"CD"},{"id":"T910","span":{"begin":1172,"end":1173},"obj":"-RRB-"},{"id":"T911","span":{"begin":1173,"end":1174},"obj":"."},{"id":"T912","span":{"begin":1174,"end":1356},"obj":"sentence"},{"id":"T913","span":{"begin":1175,"end":1183},"obj":"NN"},{"id":"T914","span":{"begin":1184,"end":1192},"obj":"NN"},{"id":"T915","span":{"begin":1193,"end":1200},"obj":"VBZ"},{"id":"T916","span":{"begin":1201,"end":1203},"obj":"TO"},{"id":"T917","span":{"begin":1207,"end":1217},"obj":"VBN"},{"id":"T918","span":{"begin":1204,"end":1206},"obj":"VB"},{"id":"T919","span":{"begin":1217,"end":1219},"obj":","},{"id":"T920","span":{"begin":1219,"end":1227},"obj":"IN"},{"id":"T921","span":{"begin":1275,"end":1285},"obj":"VBN"},{"id":"T922","span":{"begin":1228,"end":1235},"obj":"NNS"},{"id":"T923","span":{"begin":1236,"end":1238},"obj":"IN"},{"id":"T924","span":{"begin":1239,"end":1243},"obj":"NN"},{"id":"T925","span":{"begin":1243,"end":1245},"obj":","},{"id":"T926","span":{"begin":1245,"end":1248},"obj":"DT"},{"id":"T927","span":{"begin":1260,"end":1268},"obj":"NN"},{"id":"T928","span":{"begin":1249,"end":1254},"obj":"NN"},{"id":"T929","span":{"begin":1255,"end":1259},"obj":"NN"},{"id":"T930","span":{"begin":1268,"end":1270},"obj":","},{"id":"T931","span":{"begin":1270,"end":1274},"obj":"VBP"},{"id":"T932","span":{"begin":1286,"end":1294},"obj":"NN"},{"id":"T933","span":{"begin":1295,"end":1297},"obj":"IN"},{"id":"T934","span":{"begin":1298,"end":1307},"obj":"JJ"},{"id":"T935","span":{"begin":1311,"end":1322},"obj":"NN"},{"id":"T936","span":{"begin":1308,"end":1310},"obj":"NN"},{"id":"T937","span":{"begin":1323,"end":1326},"obj":"CC"},{"id":"T938","span":{"begin":1327,"end":1332},"obj":"NN"},{"id":"T939","span":{"begin":1333,"end":1337},"obj":"NN"},{"id":"T940","span":{"begin":1338,"end":1347},"obj":"NN"},{"id":"T941","span":{"begin":1348,"end":1349},"obj":"-LRB-"},{"id":"T942","span":{"begin":1352,"end":1354},"obj":"CD"},{"id":"T943","span":{"begin":1349,"end":1351},"obj":"CD"},{"id":"T944","span":{"begin":1351,"end":1352},"obj":","},{"id":"T945","span":{"begin":1354,"end":1355},"obj":"-RRB-"},{"id":"T946","span":{"begin":1355,"end":1356},"obj":"."},{"id":"T947","span":{"begin":1356,"end":1472},"obj":"sentence"},{"id":"T948","span":{"begin":1357,"end":1359},"obj":"TO"},{"id":"T949","span":{"begin":1360,"end":1367},"obj":"VB"},{"id":"T950","span":{"begin":1423,"end":1432},"obj":"VBD"},{"id":"T951","span":{"begin":1368,"end":1372},"obj":"NN"},{"id":"T952","span":{"begin":1373,"end":1385},"obj":"NN"},{"id":"T953","span":{"begin":1386,"end":1389},"obj":"CC"},{"id":"T954","span":{"begin":1390,"end":1398},"obj":"NN"},{"id":"T955","span":{"begin":1399,"end":1407},"obj":"NN"},{"id":"T956","span":{"begin":1407,"end":1409},"obj":","},{"id":"T957","span":{"begin":1409,"end":1411},"obj":"PRP"},{"id":"T958","span":{"begin":1412,"end":1422},"obj":"RB"},{"id":"T959","span":{"begin":1433,"end":1434},"obj":"DT"},{"id":"T960","span":{"begin":1466,"end":1471},"obj":"NN"},{"id":"T961","span":{"begin":1435,"end":1446},"obj":"RB"},{"id":"T962","span":{"begin":1447,"end":1454},"obj":"JJ"},{"id":"T963","span":{"begin":1455,"end":1459},"obj":"NN"},{"id":"T964","span":{"begin":1460,"end":1465},"obj":"NN"},{"id":"T965","span":{"begin":1471,"end":1472},"obj":"."},{"id":"T966","span":{"begin":1472,"end":1655},"obj":"sentence"},{"id":"T967","span":{"begin":1473,"end":1481},"obj":"NN"},{"id":"T968","span":{"begin":1493,"end":1497},"obj":"NNS"},{"id":"T969","span":{"begin":1481,"end":1482},"obj":"HYPH"},{"id":"T970","span":{"begin":1482,"end":1483},"obj":"CD"},{"id":"T971","span":{"begin":1484,"end":1489},"obj":"VB"},{"id":"T972","span":{"begin":1489,"end":1490},"obj":"HYPH"},{"id":"T973","span":{"begin":1490,"end":1492},"obj":"RP"},{"id":"T974","span":{"begin":1498,"end":1504},"obj":"VBP"},{"id":"T975","span":{"begin":1505,"end":1508},"obj":"DT"},{"id":"T976","span":{"begin":1527,"end":1535},"obj":"NN"},{"id":"T977","span":{"begin":1509,"end":1510},"obj":"SYM"},{"id":"T978","span":{"begin":1510,"end":1511},"obj":"CD"},{"id":"T979","span":{"begin":1512,"end":1514},"obj":"NN"},{"id":"T980","span":{"begin":1515,"end":1521},"obj":"JJ"},{"id":"T981","span":{"begin":1522,"end":1526},"obj":"NN"},{"id":"T982","span":{"begin":1536,"end":1539},"obj":"CC"},{"id":"T983","span":{"begin":1540,"end":1547},"obj":"VBP"},{"id":"T984","span":{"begin":1548,"end":1549},"obj":"DT"},{"id":"T985","span":{"begin":1580,"end":1587},"obj":"NN"},{"id":"T986","span":{"begin":1550,"end":1563},"obj":"JJ"},{"id":"T987","span":{"begin":1564,"end":1570},"obj":"NN"},{"id":"T988","span":{"begin":1571,"end":1579},"obj":"NN"},{"id":"T989","span":{"begin":1588,"end":1592},"obj":"WDT"},{"id":"T990","span":{"begin":1593,"end":1595},"obj":"VBZ"},{"id":"T991","span":{"begin":1596,"end":1606},"obj":"JJ"},{"id":"T992","span":{"begin":1607,"end":1611},"obj":"IN"},{"id":"T993","span":{"begin":1612,"end":1622},"obj":"NNS"},{"id":"T994","span":{"begin":1623,"end":1634},"obj":"VBG"},{"id":"T995","span":{"begin":1635,"end":1636},"obj":"NN"},{"id":"T996","span":{"begin":1637,"end":1645},"obj":"JJ"},{"id":"T997","span":{"begin":1636,"end":1637},"obj":"HYPH"},{"id":"T998","span":{"begin":1646,"end":1654},"obj":"NNS"},{"id":"T999","span":{"begin":1654,"end":1655},"obj":"."},{"id":"T1000","span":{"begin":1655,"end":1866},"obj":"sentence"},{"id":"T1001","span":{"begin":1656,"end":1666},"obj":"JJ"},{"id":"T1002","span":{"begin":1687,"end":1691},"obj":"NNS"},{"id":"T1003","span":{"begin":1667,"end":1675},"obj":"NN"},{"id":"T1004","span":{"begin":1675,"end":1676},"obj":"HYPH"},{"id":"T1005","span":{"begin":1676,"end":1677},"obj":"CD"},{"id":"T1006","span":{"begin":1678,"end":1683},"obj":"VB"},{"id":"T1007","span":{"begin":1683,"end":1684},"obj":"HYPH"},{"id":"T1008","span":{"begin":1684,"end":1686},"obj":"RP"},{"id":"T1009","span":{"begin":1692,"end":1699},"obj":"VBP"},{"id":"T1010","span":{"begin":1700,"end":1701},"obj":"DT"},{"id":"T1011","span":{"begin":1724,"end":1731},"obj":"NN"},{"id":"T1012","span":{"begin":1702,"end":1713},"obj":"JJ"},{"id":"T1013","span":{"begin":1714,"end":1718},"obj":"NN"},{"id":"T1014","span":{"begin":1719,"end":1723},"obj":"JJ"},{"id":"T1015","span":{"begin":1718,"end":1719},"obj":"HYPH"},{"id":"T1016","span":{"begin":1731,"end":1733},"obj":","},{"id":"T1017","span":{"begin":1733,"end":1737},"obj":"IN"},{"id":"T1018","span":{"begin":1738,"end":1747},"obj":"JJ"},{"id":"T1019","span":{"begin":1748,"end":1753},"obj":"NN"},{"id":"T1020","span":{"begin":1754,"end":1756},"obj":"IN"},{"id":"T1021","span":{"begin":1757,"end":1764},"obj":"NN"},{"id":"T1022","span":{"begin":1765,"end":1766},"obj":"NN"},{"id":"T1023","span":{"begin":1767,"end":1777},"obj":"NN"},{"id":"T1024","span":{"begin":1778,"end":1780},"obj":"IN"},{"id":"T1025","span":{"begin":1781,"end":1785},"obj":"JJ"},{"id":"T1026","span":{"begin":1791,"end":1796},"obj":"NNS"},{"id":"T1027","span":{"begin":1786,"end":1790},"obj":"NN"},{"id":"T1028","span":{"begin":1797,"end":1800},"obj":"CC"},{"id":"T1029","span":{"begin":1801,"end":1806},"obj":"JJ"},{"id":"T1030","span":{"begin":1807,"end":1812},"obj":"NN"},{"id":"T1031","span":{"begin":1813,"end":1815},"obj":"IN"},{"id":"T1032","span":{"begin":1816,"end":1824},"obj":"JJ"},{"id":"T1033","span":{"begin":1825,"end":1836},"obj":"NN"},{"id":"T1034","span":{"begin":1837,"end":1840},"obj":"CC"},{"id":"T1035","span":{"begin":1841,"end":1851},"obj":"JJ"},{"id":"T1061","span":{"begin":1977,"end":1983},"obj":"NN"},{"id":"T1036","span":{"begin":1852,"end":1860},"obj":"NNS"},{"id":"T1037","span":{"begin":1861,"end":1862},"obj":"-LRB-"},{"id":"T1038","span":{"begin":1862,"end":1864},"obj":"CD"},{"id":"T1039","span":{"begin":1864,"end":1865},"obj":"-RRB-"},{"id":"T1040","span":{"begin":1865,"end":1866},"obj":"."},{"id":"T1041","span":{"begin":1866,"end":2025},"obj":"sentence"},{"id":"T1042","span":{"begin":1867,"end":1872},"obj":"DT"},{"id":"T1043","span":{"begin":1873,"end":1881},"obj":"NNS"},{"id":"T1044","span":{"begin":1882,"end":1889},"obj":"VBP"},{"id":"T1045","span":{"begin":1890,"end":1894},"obj":"IN"},{"id":"T1046","span":{"begin":1917,"end":1922},"obj":"VBZ"},{"id":"T1047","span":{"begin":1895,"end":1898},"obj":"DT"},{"id":"T1048","span":{"begin":1910,"end":1916},"obj":"NN"},{"id":"T1049","span":{"begin":1899,"end":1904},"obj":"JJ"},{"id":"T1050","span":{"begin":1905,"end":1909},"obj":"NN"},{"id":"T1051","span":{"begin":1923,"end":1925},"obj":"IN"},{"id":"T1052","span":{"begin":1926,"end":1934},"obj":"JJ"},{"id":"T1053","span":{"begin":1935,"end":1943},"obj":"NN"},{"id":"T1054","span":{"begin":1944,"end":1946},"obj":"IN"},{"id":"T1055","span":{"begin":1947,"end":1960},"obj":"JJ"},{"id":"T1056","span":{"begin":1969,"end":1970},"obj":"NN"},{"id":"T1057","span":{"begin":1961,"end":1968},"obj":"NN"},{"id":"T1058","span":{"begin":1970,"end":1972},"obj":","},{"id":"T1059","span":{"begin":1972,"end":1974},"obj":"IN"},{"id":"T1060","span":{"begin":1975,"end":1976},"obj":"DT"},{"id":"T1062","span":{"begin":1984,"end":1988},"obj":"WDT"},{"id":"T1063","span":{"begin":2001,"end":2012},"obj":"VBZ"},{"id":"T1064","span":{"begin":1989,"end":2000},"obj":"RB"},{"id":"T1065","span":{"begin":2013,"end":2016},"obj":"NN"},{"id":"T1066","span":{"begin":2017,"end":2024},"obj":"NNS"},{"id":"T1067","span":{"begin":2024,"end":2025},"obj":"."},{"id":"T1068","span":{"begin":2025,"end":2157},"obj":"sentence"},{"id":"T1069","span":{"begin":2026,"end":2035},"obj":"RB"},{"id":"T1070","span":{"begin":2043,"end":2045},"obj":"VBZ"},{"id":"T1071","span":{"begin":2035,"end":2037},"obj":","},{"id":"T1072","span":{"begin":2037,"end":2042},"obj":"EX"},{"id":"T1073","span":{"begin":2046,"end":2048},"obj":"DT"},{"id":"T1074","span":{"begin":2072,"end":2078},"obj":"NN"},{"id":"T1075","span":{"begin":2049,"end":2057},"obj":"JJ"},{"id":"T1076","span":{"begin":2058,"end":2066},"obj":"JJ"},{"id":"T1077","span":{"begin":2067,"end":2071},"obj":"NN"},{"id":"T1078","span":{"begin":2079,"end":2081},"obj":"TO"},{"id":"T1079","span":{"begin":2082,"end":2093},"obj":"VB"},{"id":"T1080","span":{"begin":2094,"end":2097},"obj":"DT"},{"id":"T1081","span":{"begin":2098,"end":2104},"obj":"NN"},{"id":"T1082","span":{"begin":2105,"end":2107},"obj":"IN"},{"id":"T1083","span":{"begin":2108,"end":2111},"obj":"DT"},{"id":"T1084","span":{"begin":2124,"end":2132},"obj":"NN"},{"id":"T1085","span":{"begin":2112,"end":2118},"obj":"JJ"},{"id":"T1086","span":{"begin":2119,"end":2123},"obj":"NN"},{"id":"T1087","span":{"begin":2133,"end":2135},"obj":"IN"},{"id":"T1088","span":{"begin":2136,"end":2146},"obj":"JJ"},{"id":"T1089","span":{"begin":2147,"end":2156},"obj":"NNS"},{"id":"T1090","span":{"begin":2156,"end":2157},"obj":"."},{"id":"T1091","span":{"begin":2157,"end":2260},"obj":"sentence"},{"id":"T1092","span":{"begin":2158,"end":2167},"obj":"RB"},{"id":"T1093","span":{"begin":2177,"end":2188},"obj":"VBN"},{"id":"T1094","span":{"begin":2167,"end":2169},"obj":","},{"id":"T1095","span":{"begin":2169,"end":2171},"obj":"PRP"},{"id":"T1096","span":{"begin":2172,"end":2176},"obj":"VBP"},{"id":"T1097","span":{"begin":2189,"end":2199},"obj":"JJ"},{"id":"T1098","span":{"begin":2224,"end":2229},"obj":"NNS"},{"id":"T1099","span":{"begin":2200,"end":2208},"obj":"JJ"},{"id":"T1100","span":{"begin":2209,"end":2218},"obj":"NN"},{"id":"T1101","span":{"begin":2219,"end":2223},"obj":"NN"},{"id":"T1102","span":{"begin":2230,"end":2234},"obj":"IN"},{"id":"T1103","span":{"begin":2235,"end":2243},"obj":"NN"},{"id":"T1104","span":{"begin":2255,"end":2259},"obj":"NNS"},{"id":"T1105","span":{"begin":2243,"end":2244},"obj":"HYPH"},{"id":"T1106","span":{"begin":2244,"end":2245},"obj":"CD"},{"id":"T1107","span":{"begin":2246,"end":2251},"obj":"VB"},{"id":"T1108","span":{"begin":2251,"end":2252},"obj":"HYPH"},{"id":"T1109","span":{"begin":2252,"end":2254},"obj":"RP"},{"id":"T1110","span":{"begin":2259,"end":2260},"obj":"."},{"id":"T1111","span":{"begin":2260,"end":2482},"obj":"sentence"},{"id":"T1112","span":{"begin":2261,"end":2271},"obj":"JJ"},{"id":"T1113","span":{"begin":2285,"end":2290},"obj":"NNS"},{"id":"T1114","span":{"begin":2272,"end":2282},"obj":"NN"},{"id":"T1115","span":{"begin":2282,"end":2283},"obj":"HYPH"},{"id":"T1116","span":{"begin":2283,"end":2284},"obj":"CD"},{"id":"T1117","span":{"begin":2291,"end":2298},"obj":"VBP"},{"id":"T1118","span":{"begin":2299,"end":2311},"obj":"JJ"},{"id":"T1119","span":{"begin":2312,"end":2321},"obj":"NNS"},{"id":"T1120","span":{"begin":2322,"end":2324},"obj":"IN"},{"id":"T1121","span":{"begin":2325,"end":2328},"obj":"DT"},{"id":"T1122","span":{"begin":2329,"end":2336},"obj":"NN"},{"id":"T1123","span":{"begin":2336,"end":2338},"obj":","},{"id":"T1124","span":{"begin":2338,"end":2341},"obj":"CC"},{"id":"T1125","span":{"begin":2342,"end":2343},"obj":"DT"},{"id":"T1126","span":{"begin":2344,"end":2350},"obj":"NN"},{"id":"T1127","span":{"begin":2374,"end":2382},"obj":"VBD"},{"id":"T1128","span":{"begin":2351,"end":2353},"obj":"IN"},{"id":"T1129","span":{"begin":2354,"end":2362},"obj":"NN"},{"id":"T1130","span":{"begin":2363,"end":2373},"obj":"NNS"},{"id":"T1131","span":{"begin":2383,"end":2391},"obj":"NN"},{"id":"T1132","span":{"begin":2392,"end":2403},"obj":"VBG"},{"id":"T1133","span":{"begin":2404,"end":2411},"obj":"NNS"},{"id":"T1134","span":{"begin":2412,"end":2415},"obj":"CC"},{"id":"T1135","span":{"begin":2416,"end":2429},"obj":"JJ"},{"id":"T1136","span":{"begin":2430,"end":2441},"obj":"NN"},{"id":"T1137","span":{"begin":2442,"end":2444},"obj":"IN"},{"id":"T1138","span":{"begin":2445,"end":2455},"obj":"JJ"},{"id":"T1139","span":{"begin":2456,"end":2462},"obj":"NN"},{"id":"T1140","span":{"begin":2476,"end":2481},"obj":"NNS"},{"id":"T1141","span":{"begin":2463,"end":2473},"obj":"NN"},{"id":"T1142","span":{"begin":2473,"end":2474},"obj":"HYPH"},{"id":"T1143","span":{"begin":2474,"end":2475},"obj":"CD"},{"id":"T1144","span":{"begin":2481,"end":2482},"obj":"."}],"relations":[{"id":"R266","pred":"amod","subj":"T696","obj":"T697"},{"id":"R267","pred":"nsubj","subj":"T697","obj":"T700"},{"id":"R268","pred":"amod","subj":"T698","obj":"T697"},{"id":"R269","pred":"compound","subj":"T699","obj":"T697"},{"id":"R270","pred":"punct","subj":"T701","obj":"T697"},{"id":"R271","pred":"appos","subj":"T702","obj":"T697"},{"id":"R272","pred":"punct","subj":"T703","obj":"T697"},{"id":"R273","pred":"punct","subj":"T704","obj":"T697"},{"id":"R274","pred":"cc","subj":"T705","obj":"T697"},{"id":"R275","pred":"compound","subj":"T706","obj":"T707"},{"id":"R276","pred":"conj","subj":"T707","obj":"T697"},{"id":"R277","pred":"punct","subj":"T708","obj":"T700"},{"id":"R278","pred":"det","subj":"T709","obj":"T710"},{"id":"R279","pred":"attr","subj":"T710","obj":"T700"},{"id":"R280","pred":"advmod","subj":"T711","obj":"T712"},{"id":"R281","pred":"amod","subj":"T712","obj":"T710"},{"id":"R282","pred":"nmod","subj":"T713","obj":"T710"},{"id":"R283","pred":"punct","subj":"T714","obj":"T713"},{"id":"R284","pred":"amod","subj":"T715","obj":"T713"},{"id":"R285","pred":"amod","subj":"T716","obj":"T710"},{"id":"R286","pred":"acl","subj":"T717","obj":"T710"},{"id":"R287","pred":"agent","subj":"T718","obj":"T717"},{"id":"R288","pred":"amod","subj":"T719","obj":"T720"},{"id":"R289","pred":"pobj","subj":"T720","obj":"T718"},{"id":"R290","pred":"punct","subj":"T721","obj":"T720"},{"id":"R291","pred":"conj","subj":"T722","obj":"T720"},{"id":"R292","pred":"punct","subj":"T723","obj":"T722"},{"id":"R293","pred":"nmod","subj":"T724","obj":"T725"},{"id":"R294","pred":"conj","subj":"T725","obj":"T722"},{"id":"R295","pred":"cc","subj":"T726","obj":"T724"},{"id":"R296","pred":"conj","subj":"T727","obj":"T724"},{"id":"R297","pred":"punct","subj":"T728","obj":"T725"},{"id":"R298","pred":"cc","subj":"T729","obj":"T725"},{"id":"R299","pred":"amod","subj":"T730","obj":"T731"},{"id":"R300","pred":"conj","subj":"T731","obj":"T725"},{"id":"R301","pred":"punct","subj":"T732","obj":"T733"},{"id":"R302","pred":"parataxis","subj":"T733","obj":"T717"},{"id":"R303","pred":"punct","subj":"T734","obj":"T733"},{"id":"R304","pred":"punct","subj":"T735","obj":"T700"},{"id":"R305","pred":"det","subj":"T737","obj":"T738"},{"id":"R306","pred":"nsubj","subj":"T738","obj":"T741"},{"id":"R307","pred":"amod","subj":"T739","obj":"T738"},{"id":"R308","pred":"amod","subj":"T740","obj":"T738"},{"id":"R309","pred":"punct","subj":"T742","obj":"T743"},{"id":"R311","pred":"punct","subj":"T744","obj":"T745"},{"id":"R312","pred":"nummod","subj":"T745","obj":"T746"},{"id":"R313","pred":"compound","subj":"T746","obj":"T743"},{"id":"R314","pred":"compound","subj":"T747","obj":"T743"},{"id":"R315","pred":"punct","subj":"T748","obj":"T743"},{"id":"R316","pred":"acl","subj":"T749","obj":"T738"},{"id":"R317","pred":"prep","subj":"T750","obj":"T749"},{"id":"R318","pred":"pobj","subj":"T751","obj":"T750"},{"id":"R319","pred":"det","subj":"T752","obj":"T753"},{"id":"R321","pred":"nummod","subj":"T754","obj":"T755"},{"id":"R322","pred":"nmod","subj":"T755","obj":"T753"},{"id":"R323","pred":"amod","subj":"T756","obj":"T753"},{"id":"R324","pred":"compound","subj":"T757","obj":"T753"},{"id":"R325","pred":"prep","subj":"T758","obj":"T753"},{"id":"R326","pred":"det","subj":"T759","obj":"T760"},{"id":"R327","pred":"pobj","subj":"T760","obj":"T758"},{"id":"R328","pred":"compound","subj":"T761","obj":"T760"},{"id":"R329","pred":"punct","subj":"T762","obj":"T753"},{"id":"R330","pred":"dep","subj":"T763","obj":"T764"},{"id":"R331","pred":"relcl","subj":"T764","obj":"T753"},{"id":"R332","pred":"nmod","subj":"T765","obj":"T766"},{"id":"R333","pred":"dobj","subj":"T766","obj":"T764"},{"id":"R334","pred":"cc","subj":"T767","obj":"T766"},{"id":"R335","pred":"conj","subj":"T768","obj":"T766"},{"id":"R336","pred":"cc","subj":"T769","obj":"T766"},{"id":"R337","pred":"amod","subj":"T770","obj":"T771"},{"id":"R338","pred":"conj","subj":"T771","obj":"T766"},{"id":"R339","pred":"amod","subj":"T772","obj":"T771"},{"id":"R340","pred":"punct","subj":"T773","obj":"T741"},{"id":"R341","pred":"advcl","subj":"T774","obj":"T741"},{"id":"R342","pred":"det","subj":"T775","obj":"T776"},{"id":"R343","pred":"dobj","subj":"T776","obj":"T774"},{"id":"R344","pred":"amod","subj":"T777","obj":"T776"},{"id":"R345","pred":"compound","subj":"T778","obj":"T776"},{"id":"R346","pred":"punct","subj":"T779","obj":"T780"},{"id":"R347","pred":"parataxis","subj":"T780","obj":"T741"},{"id":"R348","pred":"punct","subj":"T781","obj":"T780"},{"id":"R349","pred":"punct","subj":"T782","obj":"T741"},{"id":"R350","pred":"det","subj":"T784","obj":"T785"},{"id":"R351","pred":"nsubj","subj":"T785","obj":"T787"},{"id":"R352","pred":"amod","subj":"T786","obj":"T785"},{"id":"R353","pred":"prep","subj":"T788","obj":"T785"},{"id":"R354","pred":"pobj","subj":"T789","obj":"T788"},{"id":"R355","pred":"amod","subj":"T790","obj":"T791"},{"id":"R356","pred":"attr","subj":"T791","obj":"T787"},{"id":"R357","pred":"compound","subj":"T792","obj":"T791"},{"id":"R358","pred":"compound","subj":"T793","obj":"T791"},{"id":"R359","pred":"prep","subj":"T794","obj":"T791"},{"id":"R360","pred":"pobj","subj":"T795","obj":"T794"},{"id":"R361","pred":"dep","subj":"T796","obj":"T797"},{"id":"R362","pred":"relcl","subj":"T797","obj":"T791"},{"id":"R363","pred":"acomp","subj":"T798","obj":"T797"},{"id":"R364","pred":"prep","subj":"T799","obj":"T797"},{"id":"R365","pred":"compound","subj":"T800","obj":"T801"},{"id":"R366","pred":"pobj","subj":"T801","obj":"T799"},{"id":"R367","pred":"prep","subj":"T802","obj":"T801"},{"id":"R368","pred":"det","subj":"T803","obj":"T804"},{"id":"R369","pred":"pobj","subj":"T804","obj":"T802"},{"id":"R370","pred":"amod","subj":"T805","obj":"T806"},{"id":"R371","pred":"compound","subj":"T806","obj":"T804"},{"id":"R372","pred":"compound","subj":"T807","obj":"T806"},{"id":"R373","pred":"punct","subj":"T808","obj":"T809"},{"id":"R374","pred":"parataxis","subj":"T809","obj":"T787"},{"id":"R375","pred":"punct","subj":"T810","obj":"T811"},{"id":"R376","pred":"prep","subj":"T811","obj":"T809"},{"id":"R377","pred":"punct","subj":"T812","obj":"T809"},{"id":"R378","pred":"punct","subj":"T813","obj":"T787"},{"id":"R379","pred":"advmod","subj":"T815","obj":"T816"},{"id":"R380","pred":"punct","subj":"T817","obj":"T816"},{"id":"R381","pred":"det","subj":"T818","obj":"T819"},{"id":"R382","pred":"nsubjpass","subj":"T819","obj":"T816"},{"id":"R383","pred":"auxpass","subj":"T820","obj":"T816"},{"id":"R384","pred":"preconj","subj":"T821","obj":"T816"},{"id":"R385","pred":"advmod","subj":"T822","obj":"T821"},{"id":"R386","pred":"prep","subj":"T823","obj":"T816"},{"id":"R387","pred":"compound","subj":"T824","obj":"T825"},{"id":"R388","pred":"pobj","subj":"T825","obj":"T823"},{"id":"R389","pred":"cc","subj":"T826","obj":"T816"},{"id":"R390","pred":"conj","subj":"T827","obj":"T816"},{"id":"R391","pred":"advmod","subj":"T828","obj":"T827"},{"id":"R392","pred":"acomp","subj":"T829","obj":"T827"},{"id":"R393","pred":"prep","subj":"T830","obj":"T827"},{"id":"R394","pred":"amod","subj":"T831","obj":"T832"},{"id":"R395","pred":"pobj","subj":"T832","obj":"T830"},{"id":"R396","pred":"prep","subj":"T833","obj":"T832"},{"id":"R397","pred":"prep","subj":"T834","obj":"T833"},{"id":"R398","pred":"det","subj":"T835","obj":"T836"},{"id":"R399","pred":"pobj","subj":"T836","obj":"T834"},{"id":"R400","pred":"amod","subj":"T837","obj":"T836"},{"id":"R401","pred":"punct","subj":"T838","obj":"T816"},{"id":"R402","pred":"det","subj":"T840","obj":"T841"},{"id":"R403","pred":"nsubj","subj":"T841","obj":"T842"},{"id":"R404","pred":"prep","subj":"T843","obj":"T841"},{"id":"R405","pred":"compound","subj":"T844","obj":"T845"},{"id":"R406","pred":"compound","subj":"T845","obj":"T846"},{"id":"R407","pred":"pobj","subj":"T846","obj":"T843"},{"id":"R408","pred":"prep","subj":"T847","obj":"T841"},{"id":"R409","pred":"det","subj":"T848","obj":"T849"},{"id":"R410","pred":"pobj","subj":"T849","obj":"T847"},{"id":"R411","pred":"compound","subj":"T850","obj":"T851"},{"id":"R412","pred":"compound","subj":"T851","obj":"T849"},{"id":"R413","pred":"punct","subj":"T852","obj":"T841"},{"id":"R414","pred":"cc","subj":"T853","obj":"T841"},{"id":"R415","pred":"det","subj":"T854","obj":"T855"},{"id":"R416","pred":"conj","subj":"T855","obj":"T841"},{"id":"R417","pred":"amod","subj":"T856","obj":"T855"},{"id":"R418","pred":"prep","subj":"T857","obj":"T855"},{"id":"R419","pred":"det","subj":"T858","obj":"T859"},{"id":"R420","pred":"pobj","subj":"T859","obj":"T857"},{"id":"R421","pred":"amod","subj":"T860","obj":"T859"},{"id":"R422","pred":"prep","subj":"T861","obj":"T859"},{"id":"R423","pred":"det","subj":"T862","obj":"T863"},{"id":"R424","pred":"pobj","subj":"T863","obj":"T861"},{"id":"R425","pred":"advmod","subj":"T864","obj":"T865"},{"id":"R426","pred":"acomp","subj":"T865","obj":"T842"},{"id":"R427","pred":"punct","subj":"T866","obj":"T842"},{"id":"R428","pred":"det","subj":"T868","obj":"T869"},{"id":"R429","pred":"nsubj","subj":"T869","obj":"T873"},{"id":"R430","pred":"npadvmod","subj":"T870","obj":"T871"},{"id":"R431","pred":"amod","subj":"T871","obj":"T869"},{"id":"R432","pred":"punct","subj":"T872","obj":"T871"},{"id":"R433","pred":"punct","subj":"T874","obj":"T869"},{"id":"R434","pred":"appos","subj":"T875","obj":"T869"},{"id":"R435","pred":"punct","subj":"T876","obj":"T875"},{"id":"R436","pred":"advmod","subj":"T877","obj":"T878"},{"id":"R437","pred":"acl","subj":"T878","obj":"T875"},{"id":"R438","pred":"oprd","subj":"T879","obj":"T878"},{"id":"R439","pred":"cc","subj":"T880","obj":"T879"},{"id":"R440","pred":"compound","subj":"T881","obj":"T882"},{"id":"R441","pred":"conj","subj":"T882","obj":"T879"},{"id":"R442","pred":"punct","subj":"T883","obj":"T873"},{"id":"R443","pred":"det","subj":"T884","obj":"T885"},{"id":"R444","pred":"attr","subj":"T885","obj":"T873"},{"id":"R445","pred":"advmod","subj":"T886","obj":"T887"},{"id":"R446","pred":"amod","subj":"T887","obj":"T885"},{"id":"R447","pred":"punct","subj":"T888","obj":"T885"},{"id":"R448","pred":"advmod","subj":"T889","obj":"T890"},{"id":"R449","pred":"amod","subj":"T890","obj":"T885"},{"id":"R450","pred":"punct","subj":"T891","obj":"T885"},{"id":"R451","pred":"compound","subj":"T892","obj":"T885"},{"id":"R452","pred":"compound","subj":"T893","obj":"T885"},{"id":"R453","pred":"punct","subj":"T894","obj":"T895"},{"id":"R454","pred":"parataxis","subj":"T895","obj":"T885"},{"id":"R455","pred":"punct","subj":"T896","obj":"T895"},{"id":"R456","pred":"dep","subj":"T897","obj":"T898"},{"id":"R457","pred":"relcl","subj":"T898","obj":"T885"},{"id":"R458","pred":"prep","subj":"T899","obj":"T898"},{"id":"R459","pred":"det","subj":"T900","obj":"T901"},{"id":"R460","pred":"pobj","subj":"T901","obj":"T899"},{"id":"R461","pred":"cc","subj":"T902","obj":"T901"},{"id":"R462","pred":"amod","subj":"T903","obj":"T904"},{"id":"R463","pred":"conj","subj":"T904","obj":"T901"},{"id":"R464","pred":"amod","subj":"T905","obj":"T904"},{"id":"R465","pred":"punct","subj":"T906","obj":"T907"},{"id":"R466","pred":"parataxis","subj":"T907","obj":"T898"},{"id":"R467","pred":"punct","subj":"T908","obj":"T909"},{"id":"R468","pred":"prep","subj":"T909","obj":"T907"},{"id":"R469","pred":"punct","subj":"T910","obj":"T907"},{"id":"R470","pred":"punct","subj":"T911","obj":"T873"},{"id":"R471","pred":"compound","subj":"T913","obj":"T914"},{"id":"R472","pred":"nsubj","subj":"T914","obj":"T915"},{"id":"R473","pred":"aux","subj":"T916","obj":"T917"},{"id":"R474","pred":"xcomp","subj":"T917","obj":"T915"},{"id":"R475","pred":"auxpass","subj":"T918","obj":"T917"},{"id":"R476","pred":"punct","subj":"T919","obj":"T917"},{"id":"R477","pred":"mark","subj":"T920","obj":"T921"},{"id":"R478","pred":"advcl","subj":"T921","obj":"T917"},{"id":"R479","pred":"nsubj","subj":"T922","obj":"T921"},{"id":"R480","pred":"prep","subj":"T923","obj":"T922"},{"id":"R481","pred":"pobj","subj":"T924","obj":"T923"},{"id":"R482","pred":"punct","subj":"T925","obj":"T924"},{"id":"R483","pred":"det","subj":"T926","obj":"T927"},{"id":"R484","pred":"appos","subj":"T927","obj":"T924"},{"id":"R485","pred":"compound","subj":"T928","obj":"T927"},{"id":"R486","pred":"compound","subj":"T929","obj":"T927"},{"id":"R487","pred":"punct","subj":"T930","obj":"T921"},{"id":"R488","pred":"aux","subj":"T931","obj":"T921"},{"id":"R489","pred":"dobj","subj":"T932","obj":"T921"},{"id":"R490","pred":"prep","subj":"T933","obj":"T921"},{"id":"R491","pred":"amod","subj":"T934","obj":"T935"},{"id":"R492","pred":"pobj","subj":"T935","obj":"T933"},{"id":"R493","pred":"compound","subj":"T936","obj":"T935"},{"id":"R494","pred":"cc","subj":"T937","obj":"T935"},{"id":"R495","pred":"compound","subj":"T938","obj":"T939"},{"id":"R496","pred":"compound","subj":"T939","obj":"T940"},{"id":"R497","pred":"conj","subj":"T940","obj":"T935"},{"id":"R498","pred":"punct","subj":"T941","obj":"T942"},{"id":"R499","pred":"parataxis","subj":"T942","obj":"T921"},{"id":"R500","pred":"nummod","subj":"T943","obj":"T942"},{"id":"R501","pred":"punct","subj":"T944","obj":"T942"},{"id":"R502","pred":"punct","subj":"T945","obj":"T942"},{"id":"R503","pred":"punct","subj":"T946","obj":"T915"},{"id":"R504","pred":"aux","subj":"T948","obj":"T949"},{"id":"R505","pred":"advcl","subj":"T949","obj":"T950"},{"id":"R506","pred":"compound","subj":"T951","obj":"T952"},{"id":"R507","pred":"dobj","subj":"T952","obj":"T949"},{"id":"R508","pred":"cc","subj":"T953","obj":"T952"},{"id":"R509","pred":"compound","subj":"T954","obj":"T955"},{"id":"R510","pred":"conj","subj":"T955","obj":"T952"},{"id":"R511","pred":"punct","subj":"T956","obj":"T950"},{"id":"R512","pred":"nsubj","subj":"T957","obj":"T950"},{"id":"R513","pred":"advmod","subj":"T958","obj":"T950"},{"id":"R514","pred":"det","subj":"T959","obj":"T960"},{"id":"R516","pred":"advmod","subj":"T961","obj":"T962"},{"id":"R517","pred":"amod","subj":"T962","obj":"T960"},{"id":"R518","pred":"compound","subj":"T963","obj":"T960"},{"id":"R519","pred":"compound","subj":"T964","obj":"T960"},{"id":"R520","pred":"punct","subj":"T965","obj":"T950"},{"id":"R521","pred":"nmod","subj":"T967","obj":"T968"},{"id":"R522","pred":"nsubj","subj":"T968","obj":"T974"},{"id":"R523","pred":"punct","subj":"T969","obj":"T967"},{"id":"R524","pred":"nummod","subj":"T970","obj":"T967"},{"id":"R525","pred":"amod","subj":"T971","obj":"T968"},{"id":"R526","pred":"punct","subj":"T972","obj":"T971"},{"id":"R527","pred":"prt","subj":"T973","obj":"T971"},{"id":"R528","pred":"det","subj":"T975","obj":"T976"},{"id":"R529","pred":"dobj","subj":"T976","obj":"T974"},{"id":"R530","pred":"punct","subj":"T977","obj":"T978"},{"id":"R531","pred":"nummod","subj":"T978","obj":"T979"},{"id":"R532","pred":"nmod","subj":"T979","obj":"T976"},{"id":"R533","pred":"amod","subj":"T980","obj":"T976"},{"id":"R534","pred":"compound","subj":"T981","obj":"T976"},{"id":"R535","pred":"cc","subj":"T982","obj":"T974"},{"id":"R536","pred":"conj","subj":"T983","obj":"T974"},{"id":"R537","pred":"det","subj":"T984","obj":"T985"},{"id":"R538","pred":"dobj","subj":"T985","obj":"T983"},{"id":"R539","pred":"amod","subj":"T986","obj":"T985"},{"id":"R540","pred":"compound","subj":"T987","obj":"T988"},{"id":"R541","pred":"compound","subj":"T988","obj":"T985"},{"id":"R542","pred":"dep","subj":"T989","obj":"T990"},{"id":"R543","pred":"relcl","subj":"T990","obj":"T985"},{"id":"R544","pred":"acomp","subj":"T991","obj":"T990"},{"id":"R545","pred":"prep","subj":"T992","obj":"T990"},{"id":"R546","pred":"pobj","subj":"T993","obj":"T992"},{"id":"R547","pred":"acl","subj":"T994","obj":"T993"},{"id":"R548","pred":"npadvmod","subj":"T995","obj":"T996"},{"id":"R549","pred":"amod","subj":"T996","obj":"T998"},{"id":"R550","pred":"punct","subj":"T997","obj":"T996"},{"id":"R551","pred":"dobj","subj":"T998","obj":"T994"},{"id":"R552","pred":"punct","subj":"T999","obj":"T974"},{"id":"R553","pred":"amod","subj":"T1001","obj":"T1002"},{"id":"R554","pred":"nsubj","subj":"T1002","obj":"T1009"},{"id":"R555","pred":"nmod","subj":"T1003","obj":"T1002"},{"id":"R556","pred":"punct","subj":"T1004","obj":"T1003"},{"id":"R557","pred":"nummod","subj":"T1005","obj":"T1003"},{"id":"R558","pred":"amod","subj":"T1006","obj":"T1002"},{"id":"R559","pred":"punct","subj":"T1007","obj":"T1006"},{"id":"R560","pred":"prt","subj":"T1008","obj":"T1006"},{"id":"R561","pred":"det","subj":"T1010","obj":"T1011"},{"id":"R563","pred":"amod","subj":"T1012","obj":"T1011"},{"id":"R564","pred":"npadvmod","subj":"T1013","obj":"T1014"},{"id":"R565","pred":"amod","subj":"T1014","obj":"T1011"},{"id":"R566","pred":"punct","subj":"T1015","obj":"T1014"},{"id":"R567","pred":"punct","subj":"T1016","obj":"T1011"},{"id":"R568","pred":"prep","subj":"T1017","obj":"T1011"},{"id":"R569","pred":"amod","subj":"T1018","obj":"T1019"},{"id":"R570","pred":"pobj","subj":"T1019","obj":"T1017"},{"id":"R571","pred":"prep","subj":"T1020","obj":"T1019"},{"id":"R572","pred":"compound","subj":"T1021","obj":"T1022"},{"id":"R573","pred":"compound","subj":"T1022","obj":"T1023"},{"id":"R574","pred":"pobj","subj":"T1023","obj":"T1020"},{"id":"R575","pred":"prep","subj":"T1024","obj":"T1023"},{"id":"R576","pred":"amod","subj":"T1025","obj":"T1026"},{"id":"R577","pred":"pobj","subj":"T1026","obj":"T1024"},{"id":"R578","pred":"compound","subj":"T1027","obj":"T1026"},{"id":"R579","pred":"cc","subj":"T1028","obj":"T1019"},{"id":"R580","pred":"amod","subj":"T1029","obj":"T1030"},{"id":"R581","pred":"conj","subj":"T1030","obj":"T1019"},{"id":"R582","pred":"prep","subj":"T1031","obj":"T1030"},{"id":"R583","pred":"amod","subj":"T1032","obj":"T1033"},{"id":"R584","pred":"pobj","subj":"T1033","obj":"T1031"},{"id":"R585","pred":"cc","subj":"T1034","obj":"T1033"},{"id":"R586","pred":"amod","subj":"T1035","obj":"T1036"},{"id":"R587","pred":"conj","subj":"T1036","obj":"T1033"},{"id":"R588","pred":"punct","subj":"T1037","obj":"T1038"},{"id":"R589","pred":"parataxis","subj":"T1038","obj":"T1009"},{"id":"R590","pred":"punct","subj":"T1039","obj":"T1038"},{"id":"R591","pred":"punct","subj":"T1040","obj":"T1009"},{"id":"R592","pred":"det","subj":"T1042","obj":"T1043"},{"id":"R593","pred":"nsubj","subj":"T1043","obj":"T1044"},{"id":"R594","pred":"mark","subj":"T1045","obj":"T1046"},{"id":"R596","pred":"det","subj":"T1047","obj":"T1048"},{"id":"R597","pred":"nsubj","subj":"T1048","obj":"T1046"},{"id":"R598","pred":"amod","subj":"T1049","obj":"T1048"},{"id":"R599","pred":"compound","subj":"T1050","obj":"T1048"},{"id":"R600","pred":"prep","subj":"T1051","obj":"T1046"},{"id":"R601","pred":"amod","subj":"T1052","obj":"T1053"},{"id":"R602","pred":"pobj","subj":"T1053","obj":"T1051"},{"id":"R603","pred":"prep","subj":"T1054","obj":"T1053"},{"id":"R604","pred":"amod","subj":"T1055","obj":"T1056"},{"id":"R605","pred":"pobj","subj":"T1056","obj":"T1054"},{"id":"R606","pred":"compound","subj":"T1057","obj":"T1056"},{"id":"R607","pred":"punct","subj":"T1058","obj":"T1046"},{"id":"R608","pred":"prep","subj":"T1059","obj":"T1046"},{"id":"R609","pred":"det","subj":"T1060","obj":"T1061"},{"id":"R610","pred":"pobj","subj":"T1061","obj":"T1059"},{"id":"R611","pred":"dep","subj":"T1062","obj":"T1063"},{"id":"R612","pred":"relcl","subj":"T1063","obj":"T1061"},{"id":"R613","pred":"advmod","subj":"T1064","obj":"T1063"},{"id":"R614","pred":"compound","subj":"T1065","obj":"T1066"},{"id":"R615","pred":"dobj","subj":"T1066","obj":"T1063"},{"id":"R616","pred":"punct","subj":"T1067","obj":"T1044"},{"id":"R617","pred":"advmod","subj":"T1069","obj":"T1070"},{"id":"R618","pred":"punct","subj":"T1071","obj":"T1070"},{"id":"R619","pred":"expl","subj":"T1072","obj":"T1070"},{"id":"R620","pred":"det","subj":"T1073","obj":"T1074"},{"id":"R621","pred":"attr","subj":"T1074","obj":"T1070"},{"id":"R622","pred":"amod","subj":"T1075","obj":"T1074"},{"id":"R623","pred":"amod","subj":"T1076","obj":"T1077"},{"id":"R624","pred":"compound","subj":"T1077","obj":"T1074"},{"id":"R625","pred":"aux","subj":"T1078","obj":"T1079"},{"id":"R626","pred":"advcl","subj":"T1079","obj":"T1074"},{"id":"R627","pred":"det","subj":"T1080","obj":"T1081"},{"id":"R628","pred":"dobj","subj":"T1081","obj":"T1079"},{"id":"R629","pred":"prep","subj":"T1082","obj":"T1081"},{"id":"R630","pred":"det","subj":"T1083","obj":"T1084"},{"id":"R631","pred":"pobj","subj":"T1084","obj":"T1082"},{"id":"R632","pred":"amod","subj":"T1085","obj":"T1084"},{"id":"R633","pred":"compound","subj":"T1086","obj":"T1084"},{"id":"R634","pred":"prep","subj":"T1087","obj":"T1081"},{"id":"R635","pred":"amod","subj":"T1088","obj":"T1089"},{"id":"R636","pred":"pobj","subj":"T1089","obj":"T1087"},{"id":"R637","pred":"punct","subj":"T1090","obj":"T1070"},{"id":"R638","pred":"advmod","subj":"T1092","obj":"T1093"},{"id":"R639","pred":"punct","subj":"T1094","obj":"T1093"},{"id":"R640","pred":"nsubj","subj":"T1095","obj":"T1093"},{"id":"R641","pred":"aux","subj":"T1096","obj":"T1093"},{"id":"R642","pred":"amod","subj":"T1097","obj":"T1098"},{"id":"R643","pred":"dobj","subj":"T1098","obj":"T1093"},{"id":"R644","pred":"amod","subj":"T1099","obj":"T1098"},{"id":"R645","pred":"compound","subj":"T1100","obj":"T1098"},{"id":"R646","pred":"compound","subj":"T1101","obj":"T1098"},{"id":"R647","pred":"prep","subj":"T1102","obj":"T1093"},{"id":"R648","pred":"nmod","subj":"T1103","obj":"T1104"},{"id":"R649","pred":"pobj","subj":"T1104","obj":"T1102"},{"id":"R650","pred":"punct","subj":"T1105","obj":"T1103"},{"id":"R651","pred":"nummod","subj":"T1106","obj":"T1103"},{"id":"R652","pred":"amod","subj":"T1107","obj":"T1104"},{"id":"R653","pred":"punct","subj":"T1108","obj":"T1107"},{"id":"R654","pred":"prt","subj":"T1109","obj":"T1107"},{"id":"R655","pred":"punct","subj":"T1110","obj":"T1093"},{"id":"R656","pred":"amod","subj":"T1112","obj":"T1113"},{"id":"R657","pred":"nsubj","subj":"T1113","obj":"T1117"},{"id":"R658","pred":"nmod","subj":"T1114","obj":"T1113"},{"id":"R659","pred":"punct","subj":"T1115","obj":"T1114"},{"id":"R660","pred":"nummod","subj":"T1116","obj":"T1114"},{"id":"R661","pred":"amod","subj":"T1118","obj":"T1119"},{"id":"R662","pred":"dobj","subj":"T1119","obj":"T1117"},{"id":"R663","pred":"prep","subj":"T1120","obj":"T1119"},{"id":"R664","pred":"det","subj":"T1121","obj":"T1122"},{"id":"R665","pred":"pobj","subj":"T1122","obj":"T1120"},{"id":"R666","pred":"punct","subj":"T1123","obj":"T1117"},{"id":"R667","pred":"cc","subj":"T1124","obj":"T1117"},{"id":"R668","pred":"det","subj":"T1125","obj":"T1126"},{"id":"R669","pred":"nsubj","subj":"T1126","obj":"T1127"},{"id":"R670","pred":"conj","subj":"T1127","obj":"T1117"},{"id":"R671","pred":"prep","subj":"T1128","obj":"T1126"},{"id":"R672","pred":"compound","subj":"T1129","obj":"T1130"},{"id":"R673","pred":"pobj","subj":"T1130","obj":"T1128"},{"id":"R674","pred":"npadvmod","subj":"T1131","obj":"T1132"},{"id":"R675","pred":"amod","subj":"T1132","obj":"T1133"},{"id":"R676","pred":"dobj","subj":"T1133","obj":"T1127"},{"id":"R677","pred":"cc","subj":"T1134","obj":"T1133"},{"id":"R678","pred":"amod","subj":"T1135","obj":"T1136"},{"id":"R679","pred":"conj","subj":"T1136","obj":"T1133"},{"id":"R680","pred":"prep","subj":"T1137","obj":"T1127"},{"id":"R681","pred":"amod","subj":"T1138","obj":"T1139"},{"id":"R682","pred":"nmod","subj":"T1139","obj":"T1140"},{"id":"R683","pred":"pobj","subj":"T1140","obj":"T1137"},{"id":"R684","pred":"nmod","subj":"T1141","obj":"T1140"},{"id":"R685","pred":"punct","subj":"T1142","obj":"T1141"},{"id":"R686","pred":"nummod","subj":"T1143","obj":"T1141"},{"id":"R687","pred":"punct","subj":"T1144","obj":"T1127"},{"id":"R310","pred":"parataxis","subj":"T743","obj":"T738"},{"id":"R320","pred":"attr","subj":"T753","obj":"T741"},{"id":"R515","pred":"dobj","subj":"T960","obj":"T950"},{"id":"R562","pred":"dobj","subj":"T1011","obj":"T1009"},{"id":"R595","pred":"ccomp","subj":"T1046","obj":"T1044"}],"text":"Background\nJuvenile neuronal ceroid lipofuscinosis (JNCL), or Batten disease, is a recessively inherited childhood-onset neurodegenerative disorder characterized by progressive blindness, seizures, motor and cognitive decline, and early death [1]. The primary genetic defect (\u003e80% disease chromosomes) leading to JNCL is a 1.02 kb genomic DNA deletion in the CLN3 gene, which eliminates exons 7 and 8 and surrounding intronic DNA, predicting a non-functional protein product [2].\nThe pathological hallmark of JNCL is autofluorescent ceroid lipofuscin deposits within autolysosomes that are enriched in subunit c of the mitochondrial ATP synthase complex [3-5]. Remarkably, these deposits are not only found in CNS neurons but are also abundant in non-neuronal cells outside of the nervous system. The relationship of subunit c deposits to the JNCL disease process, and the underlying reason for the neuronal specificity of the disease remain poorly understood.\nThe CLN3-encoded protein (battenin, also called CLN3 or cln3 p) is a highly conserved, ubiquitously expressed, multi-pass membrane protein [6] that localizes to the lysosome and other vesicular compartments [7-9]. Battenin function remains to be elucidated, although studies of btn1, the yeast CLN3 ortholog, have implicated battenin in lysosomal pH homeostasis and amino acid transport [10,11].\nTo explore JNCL pathogenesis and battenin function, we previously generated a genetically precise JNCL mouse model. Cln3Δex7/8 knock-in mice harbor the ~1 kb common JNCL mutation and express a non-truncated mutant battenin isoform that is detectable with antibodies recognizing C-terminal epitopes. Homozygous Cln3Δex7/8 knock-in mice exhibit a progressive JNCL-like disease, with perinatal onset of subunit c deposition in many cell types and later onset of neuronal dysfunction and behavioral deficits [12]. These findings suggest that the major JNCL defect leads to abnormal turnover of mitochondrial subunit c, in a manner that selectively compromises CNS neurons.\nCurrently, there is no suitable neuronal cell system to investigate the impact of the common JNCL mutation on biological processes. Therefore, we have established cerebellar neuronal precursor cell lines from Cln3Δex7/8 knock-in mice. Homozygous CbCln3Δex7/8 cells exhibit pathological hallmarks of the disease, and a survey of membrane organelles revealed membrane trafficking defects and mitochondrial dysfunction in homozygous mutant CbCln3Δex7/8 cells."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T619","span":{"begin":710,"end":713},"obj":"UBERON:0001017"},{"id":"T620","span":{"begin":710,"end":721},"obj":"CL:0000117"},{"id":"T621","span":{"begin":751,"end":759},"obj":"CL:0000540"},{"id":"T622","span":{"begin":760,"end":765},"obj":"CL_GO_EXT:cell"},{"id":"T623","span":{"begin":781,"end":795},"obj":"UBERON:0001016"},{"id":"T624","span":{"begin":817,"end":826},"obj":"PR_EXT:000022190"},{"id":"T625","span":{"begin":899,"end":907},"obj":"CL:0000540"},{"id":"T626","span":{"begin":965,"end":969},"obj":"PR_EXT:000005591"},{"id":"T627","span":{"begin":970,"end":977},"obj":"SO_EXT:sequence_coding_function"},{"id":"T628","span":{"begin":978,"end":985},"obj":"CHEBI_PR_EXT:protein"},{"id":"T629","span":{"begin":987,"end":995},"obj":"PR_EXT:000005591"},{"id":"T630","span":{"begin":1009,"end":1013},"obj":"PR_EXT:000005591"},{"id":"T631","span":{"begin":1017,"end":1023},"obj":"PR_EXT:000005591"},{"id":"T632","span":{"begin":1037,"end":1046},"obj":"SO_EXT:biological_conservation_process_or_quality"},{"id":"T633","span":{"begin":1061,"end":1070},"obj":"GO:0010467"},{"id":"T634","span":{"begin":1083,"end":1091},"obj":"GO:0016020"},{"id":"T635","span":{"begin":1092,"end":1099},"obj":"CHEBI_PR_EXT:protein"},{"id":"T636","span":{"begin":1109,"end":1118},"obj":"GO_PATO_EXT:biological_localization_process_or_quality"},{"id":"T637","span":{"begin":1126,"end":1134},"obj":"GO:0005764"},{"id":"T638","span":{"begin":1145,"end":1154},"obj":"GO:0031982"},{"id":"T639","span":{"begin":1175,"end":1183},"obj":"PR_EXT:000005591"},{"id":"T640","span":{"begin":1239,"end":1243},"obj":"PR_EXT:Q9US09"},{"id":"T641","span":{"begin":1249,"end":1254},"obj":"NCBITaxon_EXT:yeast"},{"id":"T642","span":{"begin":1255,"end":1259},"obj":"PR_EXT:000005591"},{"id":"T643","span":{"begin":1260,"end":1268},"obj":"SO_EXT:0000855"},{"id":"T644","span":{"begin":1286,"end":1294},"obj":"PR_EXT:000005591"},{"id":"T645","span":{"begin":1298,"end":1307},"obj":"GO:0005764"},{"id":"T646","span":{"begin":1308,"end":1322},"obj":"GO:0006885"},{"id":"T647","span":{"begin":1327,"end":1337},"obj":"CHEBI_SO_EXT:amino_acid"},{"id":"T648","span":{"begin":1327,"end":1347},"obj":"GO:0006865"},{"id":"T649","span":{"begin":1390,"end":1398},"obj":"PR_EXT:000005591"},{"id":"T650","span":{"begin":1435,"end":1446},"obj":"SO_EXT:0000704"},{"id":"T651","span":{"begin":1460,"end":1465},"obj":"NCBITaxon:10088"},{"id":"T652","span":{"begin":1473,"end":1477},"obj":"PR_EXT:000005591"},{"id":"T653","span":{"begin":1493,"end":1497},"obj":"NCBITaxon:10088"},{"id":"T654","span":{"begin":1513,"end":1514},"obj":"CHEBI_SO_EXT:base"},{"id":"T655","span":{"begin":1527,"end":1535},"obj":"SO_EXT:sequence_alteration_entity_or_process"},{"id":"T656","span":{"begin":1540,"end":1547},"obj":"GO:0010467"},{"id":"T657","span":{"begin":1554,"end":1563},"obj":"SO_EXT:sequence_truncation_process"},{"id":"T658","span":{"begin":1564,"end":1570},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T659","span":{"begin":1571,"end":1579},"obj":"PR_EXT:000005591"},{"id":"T660","span":{"begin":1580,"end":1587},"obj":"SO_EXT:0001060"},{"id":"T661","span":{"begin":1612,"end":1622},"obj":"GO:0042571"},{"id":"T662","span":{"begin":1635,"end":1645},"obj":"CHEBI_SO_EXT:C_terminus_or_C_terminal_region"},{"id":"T663","span":{"begin":1646,"end":1654},"obj":"CHEBI_SO_EXT:epitope"},{"id":"T664","span":{"begin":1667,"end":1671},"obj":"PR_EXT:000005591"},{"id":"T665","span":{"begin":1687,"end":1691},"obj":"NCBITaxon:10088"},{"id":"T666","span":{"begin":1738,"end":1747},"obj":"UBERON:0012101"},{"id":"T667","span":{"begin":1742,"end":1747},"obj":"GO:0007567"},{"id":"T668","span":{"begin":1757,"end":1766},"obj":"PR_EXT:000022190"},{"id":"T669","span":{"begin":1786,"end":1790},"obj":"CL_GO_EXT:cell"},{"id":"T670","span":{"begin":1816,"end":1824},"obj":"CL:0000540"},{"id":"T671","span":{"begin":1841,"end":1851},"obj":"GO_PATO_EXT:biological_behavior"},{"id":"T672","span":{"begin":1947,"end":1960},"obj":"GO:0005739"},{"id":"T673","span":{"begin":1947,"end":1970},"obj":"PR_EXT:000022190"},{"id":"T674","span":{"begin":2013,"end":2016},"obj":"UBERON:0001017"},{"id":"T675","span":{"begin":2013,"end":2024},"obj":"CL:0000117"},{"id":"T676","span":{"begin":2058,"end":2071},"obj":"CL:0000540"},{"id":"T677","span":{"begin":2067,"end":2071},"obj":"CL_GO_EXT:cell"},{"id":"T678","span":{"begin":2124,"end":2132},"obj":"SO_EXT:sequence_alteration_entity_or_process"},{"id":"T679","span":{"begin":2136,"end":2146},"obj":"CHEBI_GO_EXT:biological_process_or_quality_or_role"},{"id":"T680","span":{"begin":2136,"end":2156},"obj":"GO:0008150"},{"id":"T681","span":{"begin":2189,"end":2199},"obj":"UBERON:0002037"},{"id":"T682","span":{"begin":2189,"end":2208},"obj":"CL:1001611"},{"id":"T683","span":{"begin":2219,"end":2223},"obj":"CL_GO_EXT:cell"},{"id":"T684","span":{"begin":2235,"end":2239},"obj":"PR_EXT:000005591"},{"id":"T685","span":{"begin":2255,"end":2259},"obj":"NCBITaxon:10088"},{"id":"T686","span":{"begin":2272,"end":2274},"obj":"UBERON:0002037"},{"id":"T687","span":{"begin":2274,"end":2278},"obj":"PR_EXT:000005591"},{"id":"T688","span":{"begin":2285,"end":2290},"obj":"CL_GO_EXT:cell"},{"id":"T689","span":{"begin":2354,"end":2373},"obj":"GO:0043227"},{"id":"T690","span":{"begin":2383,"end":2391},"obj":"GO:0016020"},{"id":"T691","span":{"begin":2383,"end":2403},"obj":"GO:0055085"},{"id":"T692","span":{"begin":2416,"end":2429},"obj":"GO:0005739"},{"id":"T693","span":{"begin":2456,"end":2462},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T694","span":{"begin":2463,"end":2465},"obj":"UBERON:0002037"},{"id":"T695","span":{"begin":2476,"end":2481},"obj":"CL_GO_EXT:cell"},{"id":"T596","span":{"begin":11,"end":19},"obj":"PATO_UBERON_EXT:juvenile_organism"},{"id":"T597","span":{"begin":20,"end":28},"obj":"CL:0000540"},{"id":"T598","span":{"begin":105,"end":114},"obj":"UBERON_EXT:childhood"},{"id":"T599","span":{"begin":198,"end":203},"obj":"GO_EXT:biological_movement_or_translocation_process"},{"id":"T600","span":{"begin":208,"end":217},"obj":"GO:0050890"},{"id":"T601","span":{"begin":237,"end":242},"obj":"GO:0016265"},{"id":"T602","span":{"begin":260,"end":267},"obj":"SO_EXT:0000704"},{"id":"T603","span":{"begin":289,"end":300},"obj":"GO_SO_EXT:chromosome"},{"id":"T604","span":{"begin":329,"end":330},"obj":"CHEBI_SO_EXT:base"},{"id":"T605","span":{"begin":331,"end":342},"obj":"SO_EXT:genomic_DNA"},{"id":"T606","span":{"begin":339,"end":342},"obj":"CHEBI_SO_EXT:DNA"},{"id":"T607","span":{"begin":343,"end":351},"obj":"SO_EXT:sequence_deletion_entity_or_process"},{"id":"T608","span":{"begin":359,"end":363},"obj":"PR_EXT:000005591"},{"id":"T609","span":{"begin":364,"end":368},"obj":"SO_EXT:0000704"},{"id":"T610","span":{"begin":387,"end":392},"obj":"SO_EXT:0000147"},{"id":"T611","span":{"begin":417,"end":425},"obj":"SO_EXT:0000188"},{"id":"T612","span":{"begin":426,"end":429},"obj":"CHEBI_SO_EXT:DNA"},{"id":"T613","span":{"begin":459,"end":466},"obj":"CHEBI_PR_EXT:protein"},{"id":"T614","span":{"begin":567,"end":580},"obj":"GO:0044754"},{"id":"T615","span":{"begin":602,"end":614},"obj":"_FRAGMENT"},{"id":"T616","span":{"begin":619,"end":653},"obj":"PR_EXT:000022190"},{"id":"T617","span":{"begin":619,"end":653},"obj":"GO:0005753"},{"id":"T618","span":{"begin":633,"end":636},"obj":"CHEBI_EXT:ATP"}],"relations":[{"id":"R265","pred":"_lexicallyChainedTo","subj":"T616","obj":"T615"}],"text":"Background\nJuvenile neuronal ceroid lipofuscinosis (JNCL), or Batten disease, is a recessively inherited childhood-onset neurodegenerative disorder characterized by progressive blindness, seizures, motor and cognitive decline, and early death [1]. The primary genetic defect (\u003e80% disease chromosomes) leading to JNCL is a 1.02 kb genomic DNA deletion in the CLN3 gene, which eliminates exons 7 and 8 and surrounding intronic DNA, predicting a non-functional protein product [2].\nThe pathological hallmark of JNCL is autofluorescent ceroid lipofuscin deposits within autolysosomes that are enriched in subunit c of the mitochondrial ATP synthase complex [3-5]. Remarkably, these deposits are not only found in CNS neurons but are also abundant in non-neuronal cells outside of the nervous system. The relationship of subunit c deposits to the JNCL disease process, and the underlying reason for the neuronal specificity of the disease remain poorly understood.\nThe CLN3-encoded protein (battenin, also called CLN3 or cln3 p) is a highly conserved, ubiquitously expressed, multi-pass membrane protein [6] that localizes to the lysosome and other vesicular compartments [7-9]. Battenin function remains to be elucidated, although studies of btn1, the yeast CLN3 ortholog, have implicated battenin in lysosomal pH homeostasis and amino acid transport [10,11].\nTo explore JNCL pathogenesis and battenin function, we previously generated a genetically precise JNCL mouse model. Cln3Δex7/8 knock-in mice harbor the ~1 kb common JNCL mutation and express a non-truncated mutant battenin isoform that is detectable with antibodies recognizing C-terminal epitopes. Homozygous Cln3Δex7/8 knock-in mice exhibit a progressive JNCL-like disease, with perinatal onset of subunit c deposition in many cell types and later onset of neuronal dysfunction and behavioral deficits [12]. These findings suggest that the major JNCL defect leads to abnormal turnover of mitochondrial subunit c, in a manner that selectively compromises CNS neurons.\nCurrently, there is no suitable neuronal cell system to investigate the impact of the common JNCL mutation on biological processes. Therefore, we have established cerebellar neuronal precursor cell lines from Cln3Δex7/8 knock-in mice. Homozygous CbCln3Δex7/8 cells exhibit pathological hallmarks of the disease, and a survey of membrane organelles revealed membrane trafficking defects and mitochondrial dysfunction in homozygous mutant CbCln3Δex7/8 cells."}

{"project":"2_test","denotations":[{"id":"15588329-3146319-12950135","span":{"begin":244,"end":245},"obj":"3146319"},{"id":"15588329-7553855-12950136","span":{"begin":476,"end":477},"obj":"7553855"},{"id":"15588329-1535180-12950137","span":{"begin":655,"end":656},"obj":"1535180"},{"id":"15588329-1535179-12950137","span":{"begin":655,"end":656},"obj":"1535179"},{"id":"15588329-3146325-12950137","span":{"begin":655,"end":656},"obj":"3146325"},{"id":"15588329-12706816-12950138","span":{"begin":1101,"end":1102},"obj":"12706816"},{"id":"15588329-14622109-12950139","span":{"begin":1169,"end":1170},"obj":"14622109"},{"id":"15588329-11590129-12950139","span":{"begin":1169,"end":1170},"obj":"11590129"},{"id":"15588329-14699076-12950139","span":{"begin":1169,"end":1170},"obj":"14699076"},{"id":"15588329-10319861-12950140","span":{"begin":1349,"end":1351},"obj":"10319861"},{"id":"15588329-14660799-12950141","span":{"begin":1352,"end":1354},"obj":"14660799"},{"id":"15588329-12374761-12950142","span":{"begin":1862,"end":1864},"obj":"12374761"}],"text":"Background\nJuvenile neuronal ceroid lipofuscinosis (JNCL), or Batten disease, is a recessively inherited childhood-onset neurodegenerative disorder characterized by progressive blindness, seizures, motor and cognitive decline, and early death [1]. The primary genetic defect (\u003e80% disease chromosomes) leading to JNCL is a 1.02 kb genomic DNA deletion in the CLN3 gene, which eliminates exons 7 and 8 and surrounding intronic DNA, predicting a non-functional protein product [2].\nThe pathological hallmark of JNCL is autofluorescent ceroid lipofuscin deposits within autolysosomes that are enriched in subunit c of the mitochondrial ATP synthase complex [3-5]. Remarkably, these deposits are not only found in CNS neurons but are also abundant in non-neuronal cells outside of the nervous system. The relationship of subunit c deposits to the JNCL disease process, and the underlying reason for the neuronal specificity of the disease remain poorly understood.\nThe CLN3-encoded protein (battenin, also called CLN3 or cln3 p) is a highly conserved, ubiquitously expressed, multi-pass membrane protein [6] that localizes to the lysosome and other vesicular compartments [7-9]. Battenin function remains to be elucidated, although studies of btn1, the yeast CLN3 ortholog, have implicated battenin in lysosomal pH homeostasis and amino acid transport [10,11].\nTo explore JNCL pathogenesis and battenin function, we previously generated a genetically precise JNCL mouse model. Cln3Δex7/8 knock-in mice harbor the ~1 kb common JNCL mutation and express a non-truncated mutant battenin isoform that is detectable with antibodies recognizing C-terminal epitopes. Homozygous Cln3Δex7/8 knock-in mice exhibit a progressive JNCL-like disease, with perinatal onset of subunit c deposition in many cell types and later onset of neuronal dysfunction and behavioral deficits [12]. These findings suggest that the major JNCL defect leads to abnormal turnover of mitochondrial subunit c, in a manner that selectively compromises CNS neurons.\nCurrently, there is no suitable neuronal cell system to investigate the impact of the common JNCL mutation on biological processes. Therefore, we have established cerebellar neuronal precursor cell lines from Cln3Δex7/8 knock-in mice. Homozygous CbCln3Δex7/8 cells exhibit pathological hallmarks of the disease, and a survey of membrane organelles revealed membrane trafficking defects and mitochondrial dysfunction in homozygous mutant CbCln3Δex7/8 cells."}