Id |
Subject |
Object |
Predicate |
Lexical cue |
T9197 |
615-617 |
, |
denotes |
, |
T9102 |
0-6 |
IN |
denotes |
During |
T9103 |
97-103 |
VBP |
denotes |
govern |
T9104 |
7-14 |
NN |
denotes |
budding |
T9105 |
15-28 |
NN |
denotes |
morphogenesis |
T9106 |
28-30 |
, |
denotes |
, |
T9107 |
30-42 |
VBG |
denotes |
intersecting |
T9108 |
53-61 |
NNS |
denotes |
networks |
T9109 |
43-52 |
NN |
denotes |
signaling |
T9110 |
62-66 |
IN |
denotes |
from |
T9111 |
67-70 |
DT |
denotes |
the |
T9112 |
71-81 |
NN |
denotes |
epithelium |
T9113 |
82-85 |
CC |
denotes |
and |
T9114 |
86-96 |
NN |
denotes |
mesenchyme |
T9115 |
104-119 |
JJ |
denotes |
transcriptional |
T9116 |
154-162 |
NNS |
denotes |
programs |
T9117 |
119-121 |
, |
denotes |
, |
T9118 |
121-129 |
JJ |
denotes |
adhesive |
T9119 |
129-131 |
, |
denotes |
, |
T9120 |
131-139 |
NN |
denotes |
polarity |
T9121 |
139-141 |
, |
denotes |
, |
T9122 |
141-144 |
CC |
denotes |
and |
T9123 |
145-153 |
NN |
denotes |
motility |
T9124 |
163-165 |
IN |
denotes |
in |
T9125 |
166-171 |
DT |
denotes |
these |
T9126 |
179-185 |
NNS |
denotes |
groups |
T9127 |
172-178 |
JJ |
denotes |
select |
T9128 |
186-188 |
IN |
denotes |
of |
T9129 |
189-194 |
NNS |
denotes |
cells |
T9130 |
194-195 |
. |
denotes |
. |
T9131 |
195-316 |
sentence |
denotes |
The dynamic nuclear and cytosolic changes that take place during this time form the cornerstone for organ morphogenesis. |
T9132 |
196-199 |
DT |
denotes |
The |
T9133 |
230-237 |
NNS |
denotes |
changes |
T9134 |
200-207 |
JJ |
denotes |
dynamic |
T9135 |
208-215 |
JJ |
denotes |
nuclear |
T9136 |
216-219 |
CC |
denotes |
and |
T9137 |
220-229 |
JJ |
denotes |
cytosolic |
T9138 |
271-275 |
VBP |
denotes |
form |
T9139 |
238-242 |
WDT |
denotes |
that |
T9140 |
243-247 |
VBP |
denotes |
take |
T9141 |
248-253 |
NN |
denotes |
place |
T9142 |
254-260 |
IN |
denotes |
during |
T9143 |
261-265 |
DT |
denotes |
this |
T9144 |
266-270 |
NN |
denotes |
time |
T9145 |
276-279 |
DT |
denotes |
the |
T9146 |
280-291 |
NN |
denotes |
cornerstone |
T9147 |
292-295 |
IN |
denotes |
for |
T9148 |
296-301 |
NN |
denotes |
organ |
T9149 |
302-315 |
NN |
denotes |
morphogenesis |
T9150 |
315-316 |
. |
denotes |
. |
T9151 |
316-637 |
sentence |
denotes |
Two major challenges in understanding the mechanisms underlying a particular budding process are to order the temporal sequence of external cues involved and then to dissect how the cells of the developing bud translate these signals into the downstream events of cellular remodeling, proliferation, and differentiation. |
T9152 |
317-320 |
CD |
denotes |
Two |
T9153 |
327-337 |
NNS |
denotes |
challenges |
T9154 |
321-326 |
JJ |
denotes |
major |
T9155 |
410-413 |
VBP |
denotes |
are |
T9156 |
338-340 |
IN |
denotes |
in |
T9157 |
341-354 |
VBG |
denotes |
understanding |
T9158 |
355-358 |
DT |
denotes |
the |
T9159 |
359-369 |
NNS |
denotes |
mechanisms |
T9160 |
370-380 |
VBG |
denotes |
underlying |
T9161 |
381-382 |
DT |
denotes |
a |
T9162 |
402-409 |
NN |
denotes |
process |
T9163 |
383-393 |
JJ |
denotes |
particular |
T9164 |
394-401 |
NN |
denotes |
budding |
T9165 |
414-416 |
TO |
denotes |
to |
T9166 |
417-422 |
VB |
denotes |
order |
T9167 |
423-426 |
DT |
denotes |
the |
T9168 |
436-444 |
NN |
denotes |
sequence |
T9169 |
427-435 |
JJ |
denotes |
temporal |
T9170 |
445-447 |
IN |
denotes |
of |
T9171 |
448-456 |
JJ |
denotes |
external |
T9172 |
457-461 |
NNS |
denotes |
cues |
T9173 |
462-470 |
VBN |
denotes |
involved |
T9174 |
471-474 |
CC |
denotes |
and |
T9175 |
475-479 |
RB |
denotes |
then |
T9176 |
483-490 |
VB |
denotes |
dissect |
T9177 |
480-482 |
TO |
denotes |
to |
T9178 |
491-494 |
WRB |
denotes |
how |
T9179 |
527-536 |
VB |
denotes |
translate |
T9180 |
495-498 |
DT |
denotes |
the |
T9181 |
499-504 |
NNS |
denotes |
cells |
T9182 |
505-507 |
IN |
denotes |
of |
T9183 |
508-511 |
DT |
denotes |
the |
T9184 |
523-526 |
NN |
denotes |
bud |
T9185 |
512-522 |
VBG |
denotes |
developing |
T9186 |
537-542 |
DT |
denotes |
these |
T9187 |
543-550 |
NNS |
denotes |
signals |
T9188 |
551-555 |
IN |
denotes |
into |
T9189 |
556-559 |
DT |
denotes |
the |
T9190 |
571-577 |
NNS |
denotes |
events |
T9191 |
560-570 |
JJ |
denotes |
downstream |
T9192 |
578-580 |
IN |
denotes |
of |
T9193 |
581-589 |
JJ |
denotes |
cellular |
T9194 |
590-600 |
NN |
denotes |
remodeling |
T9195 |
600-602 |
, |
denotes |
, |
T9196 |
602-615 |
NN |
denotes |
proliferation |
T9198 |
617-620 |
CC |
denotes |
and |
T9199 |
621-636 |
NN |
denotes |
differentiation |
T9200 |
636-637 |
. |
denotes |
. |
T9201 |
637-761 |
sentence |
denotes |
Our studies here provide some insights into how these events are orchestrated during hair bud formation in developing skin. |
T9202 |
638-641 |
PRP$ |
denotes |
Our |
T9203 |
642-649 |
NNS |
denotes |
studies |
T9204 |
655-662 |
VBP |
denotes |
provide |
T9205 |
650-654 |
RB |
denotes |
here |
T9206 |
663-667 |
DT |
denotes |
some |
T9207 |
668-676 |
NNS |
denotes |
insights |
T9208 |
677-681 |
IN |
denotes |
into |
T9209 |
682-685 |
WRB |
denotes |
how |
T9210 |
703-715 |
VBN |
denotes |
orchestrated |
T9211 |
686-691 |
DT |
denotes |
these |
T9212 |
692-698 |
NNS |
denotes |
events |
T9213 |
699-702 |
VBP |
denotes |
are |
T9214 |
716-722 |
IN |
denotes |
during |
T9215 |
723-727 |
NN |
denotes |
hair |
T9216 |
728-731 |
NN |
denotes |
bud |
T9217 |
732-741 |
NN |
denotes |
formation |
T9218 |
742-744 |
IN |
denotes |
in |
T9219 |
745-755 |
VBG |
denotes |
developing |
T9220 |
756-760 |
NN |
denotes |
skin |
T9221 |
760-761 |
. |
denotes |
. |
R5772 |
T9102 |
T9103 |
prep |
During,govern |
R5773 |
T9104 |
T9105 |
compound |
budding,morphogenesis |
R5774 |
T9105 |
T9102 |
pobj |
morphogenesis,During |
R5775 |
T9106 |
T9103 |
punct |
", ",govern |
R5776 |
T9107 |
T9108 |
amod |
intersecting,networks |
R5777 |
T9108 |
T9103 |
nsubj |
networks,govern |
R5778 |
T9109 |
T9108 |
compound |
signaling,networks |
R5779 |
T9110 |
T9108 |
prep |
from,networks |
R5780 |
T9111 |
T9112 |
det |
the,epithelium |
R5781 |
T9112 |
T9110 |
pobj |
epithelium,from |
R5782 |
T9113 |
T9112 |
cc |
and,epithelium |
R5783 |
T9114 |
T9112 |
conj |
mesenchyme,epithelium |
R5784 |
T9115 |
T9116 |
amod |
transcriptional,programs |
R5785 |
T9116 |
T9103 |
dobj |
programs,govern |
R5786 |
T9117 |
T9115 |
punct |
", ",transcriptional |
R5787 |
T9118 |
T9115 |
conj |
adhesive,transcriptional |
R5788 |
T9119 |
T9118 |
punct |
", ",adhesive |
R5789 |
T9120 |
T9118 |
conj |
polarity,adhesive |
R5790 |
T9121 |
T9120 |
punct |
", ",polarity |
R5791 |
T9122 |
T9120 |
cc |
and,polarity |
R5792 |
T9123 |
T9120 |
conj |
motility,polarity |
R5793 |
T9124 |
T9103 |
prep |
in,govern |
R5794 |
T9125 |
T9126 |
det |
these,groups |
R5795 |
T9126 |
T9124 |
pobj |
groups,in |
R5796 |
T9127 |
T9126 |
amod |
select,groups |
R5797 |
T9128 |
T9126 |
prep |
of,groups |
R5798 |
T9129 |
T9128 |
pobj |
cells,of |
R5799 |
T9130 |
T9103 |
punct |
.,govern |
R5800 |
T9132 |
T9133 |
det |
The,changes |
R5801 |
T9133 |
T9138 |
nsubj |
changes,form |
R5802 |
T9134 |
T9133 |
amod |
dynamic,changes |
R5803 |
T9135 |
T9133 |
amod |
nuclear,changes |
R5804 |
T9136 |
T9135 |
cc |
and,nuclear |
R5805 |
T9137 |
T9135 |
conj |
cytosolic,nuclear |
R5806 |
T9139 |
T9140 |
dep |
that,take |
R5807 |
T9140 |
T9133 |
relcl |
take,changes |
R5808 |
T9141 |
T9140 |
dobj |
place,take |
R5809 |
T9142 |
T9140 |
prep |
during,take |
R5810 |
T9143 |
T9144 |
det |
this,time |
R5811 |
T9144 |
T9142 |
pobj |
time,during |
R5812 |
T9145 |
T9146 |
det |
the,cornerstone |
R5813 |
T9146 |
T9138 |
dobj |
cornerstone,form |
R5814 |
T9147 |
T9146 |
prep |
for,cornerstone |
R5815 |
T9148 |
T9149 |
compound |
organ,morphogenesis |
R5816 |
T9149 |
T9147 |
pobj |
morphogenesis,for |
R5817 |
T9150 |
T9138 |
punct |
.,form |
R5818 |
T9152 |
T9153 |
nummod |
Two,challenges |
R5819 |
T9153 |
T9155 |
nsubj |
challenges,are |
R5820 |
T9154 |
T9153 |
amod |
major,challenges |
R5821 |
T9156 |
T9153 |
prep |
in,challenges |
R5822 |
T9157 |
T9156 |
pcomp |
understanding,in |
R5823 |
T9158 |
T9159 |
det |
the,mechanisms |
R5824 |
T9159 |
T9157 |
dobj |
mechanisms,understanding |
R5825 |
T9160 |
T9159 |
acl |
underlying,mechanisms |
R5826 |
T9161 |
T9162 |
det |
a,process |
R5827 |
T9162 |
T9160 |
dobj |
process,underlying |
R5828 |
T9163 |
T9162 |
amod |
particular,process |
R5829 |
T9164 |
T9162 |
compound |
budding,process |
R5830 |
T9165 |
T9166 |
aux |
to,order |
R5831 |
T9166 |
T9155 |
xcomp |
order,are |
R5832 |
T9167 |
T9168 |
det |
the,sequence |
R5833 |
T9168 |
T9166 |
dobj |
sequence,order |
R5834 |
T9169 |
T9168 |
amod |
temporal,sequence |
R5835 |
T9170 |
T9168 |
prep |
of,sequence |
R5836 |
T9171 |
T9172 |
amod |
external,cues |
R5837 |
T9172 |
T9170 |
pobj |
cues,of |
R5838 |
T9173 |
T9172 |
acl |
involved,cues |
R5839 |
T9174 |
T9166 |
cc |
and,order |
R5840 |
T9175 |
T9176 |
advmod |
then,dissect |
R5841 |
T9176 |
T9166 |
conj |
dissect,order |
R5842 |
T9177 |
T9176 |
aux |
to,dissect |
R5843 |
T9178 |
T9179 |
advmod |
how,translate |
R5844 |
T9179 |
T9176 |
ccomp |
translate,dissect |
R5845 |
T9180 |
T9181 |
det |
the,cells |
R5846 |
T9181 |
T9179 |
nsubj |
cells,translate |
R5847 |
T9182 |
T9181 |
prep |
of,cells |
R5848 |
T9183 |
T9184 |
det |
the,bud |
R5849 |
T9184 |
T9182 |
pobj |
bud,of |
R5850 |
T9185 |
T9184 |
amod |
developing,bud |
R5851 |
T9186 |
T9187 |
det |
these,signals |
R5852 |
T9187 |
T9179 |
dobj |
signals,translate |
R5853 |
T9188 |
T9179 |
prep |
into,translate |
R5854 |
T9189 |
T9190 |
det |
the,events |
R5855 |
T9190 |
T9188 |
pobj |
events,into |
R5856 |
T9191 |
T9190 |
amod |
downstream,events |
R5857 |
T9192 |
T9190 |
prep |
of,events |
R5858 |
T9193 |
T9194 |
amod |
cellular,remodeling |
R5859 |
T9194 |
T9192 |
pobj |
remodeling,of |
R5860 |
T9195 |
T9194 |
punct |
", ",remodeling |
R5861 |
T9196 |
T9194 |
conj |
proliferation,remodeling |
R5862 |
T9197 |
T9196 |
punct |
", ",proliferation |
R5863 |
T9198 |
T9196 |
cc |
and,proliferation |
R5864 |
T9199 |
T9196 |
conj |
differentiation,proliferation |
R5865 |
T9200 |
T9155 |
punct |
.,are |
R5866 |
T9202 |
T9203 |
poss |
Our,studies |
R5867 |
T9203 |
T9204 |
nsubj |
studies,provide |
R5868 |
T9205 |
T9203 |
advmod |
here,studies |
R5869 |
T9206 |
T9207 |
det |
some,insights |
R5870 |
T9207 |
T9204 |
dobj |
insights,provide |
R5871 |
T9208 |
T9207 |
prep |
into,insights |
R5872 |
T9209 |
T9210 |
advmod |
how,orchestrated |
R5873 |
T9210 |
T9208 |
pcomp |
orchestrated,into |
R5874 |
T9211 |
T9212 |
det |
these,events |
R5875 |
T9212 |
T9210 |
nsubjpass |
events,orchestrated |
R5876 |
T9213 |
T9210 |
auxpass |
are,orchestrated |
R5877 |
T9214 |
T9210 |
prep |
during,orchestrated |
R5878 |
T9215 |
T9216 |
compound |
hair,bud |
R5879 |
T9216 |
T9217 |
compound |
bud,formation |
R5880 |
T9217 |
T9214 |
pobj |
formation,during |
R5881 |
T9218 |
T9210 |
prep |
in,orchestrated |
R5882 |
T9219 |
T9220 |
amod |
developing,skin |
R5883 |
T9220 |
T9218 |
pobj |
skin,in |
R5884 |
T9221 |
T9204 |
punct |
.,provide |