During budding morphogenesis, intersecting signaling networks from the epithelium and mesenchyme govern transcriptional, adhesive, polarity, and motility programs in these select groups of cells. The dynamic nuclear and cytosolic changes that take place during this time form the cornerstone for organ morphogenesis. Two major challenges in understanding the mechanisms underlying a particular budding process are to order the temporal sequence of external cues involved and then to dissect how the cells of the developing bud translate these signals into the downstream events of cellular remodeling, proliferation, and differentiation. Our studies here provide some insights into how these events are orchestrated during hair bud formation in developing skin.