PMC:539061 / 42460-42983
Annnotations
craft-ca-core-dev
{"project":"craft-ca-core-dev","denotations":[{"id":"T6953","span":{"begin":49,"end":54},"obj":"PR:000015308"},{"id":"T6954","span":{"begin":59,"end":65},"obj":"PR:000000183"},{"id":"T6955","span":{"begin":93,"end":98},"obj":"PR:000015308"},{"id":"T6956","span":{"begin":99,"end":109},"obj":"GO:0010467"},{"id":"T6957","span":{"begin":113,"end":119},"obj":"PR:000000183"},{"id":"T6958","span":{"begin":125,"end":129},"obj":"UBERON:0001037"},{"id":"T6959","span":{"begin":171,"end":176},"obj":"PR:000015308"},{"id":"T6960","span":{"begin":215,"end":221},"obj":"PR:000000183"},{"id":"T6961","span":{"begin":227,"end":234},"obj":"UBERON:0000922"},{"id":"T6962","span":{"begin":360,"end":365},"obj":"PR:000015308"},{"id":"T6963","span":{"begin":395,"end":401},"obj":"PR:000000183"},{"id":"T6964","span":{"begin":407,"end":411},"obj":"UBERON:0001037"},{"id":"T6965","span":{"begin":482,"end":486},"obj":"UBERON:0001037"}],"text":"To further explore the possible relation between Snail and TGF-β2, we examined the status of Snail expression in TGF-β2-null hair buds. As judged by immunohistochemistry, Snail protein was absent from E17.5 skin of TGF-β2-null embryos but not from that of control littermates (Figure 6C). This effect appeared to be exerted at the transcriptional level, since Snail mRNAs were also not found in TGF-β2 null hair buds under conditions in which the signal was readily detected in the hair buds of littermate skin (Figure 6D)."}
craft-ca-core-ex-dev
{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T7241","span":{"begin":49,"end":54},"obj":"PR_EXT:000015308"},{"id":"T7242","span":{"begin":59,"end":65},"obj":"PR_EXT:000000183"},{"id":"T7243","span":{"begin":93,"end":98},"obj":"PR_EXT:000015308"},{"id":"T7244","span":{"begin":99,"end":109},"obj":"GO:0010467"},{"id":"T7245","span":{"begin":113,"end":119},"obj":"PR_EXT:000000183"},{"id":"T7246","span":{"begin":120,"end":124},"obj":"SO_EXT:sequence_nullness"},{"id":"T7247","span":{"begin":125,"end":129},"obj":"UBERON:0001037"},{"id":"T7248","span":{"begin":171,"end":176},"obj":"PR_EXT:000015308"},{"id":"T7249","span":{"begin":177,"end":184},"obj":"CHEBI_PR_EXT:protein"},{"id":"T7250","span":{"begin":207,"end":211},"obj":"UBERON_EXT:zone_of_skin_or_skin_of_body"},{"id":"T7251","span":{"begin":215,"end":221},"obj":"PR_EXT:000000183"},{"id":"T7252","span":{"begin":222,"end":226},"obj":"SO_EXT:sequence_nullness"},{"id":"T7253","span":{"begin":227,"end":234},"obj":"UBERON:0000922"},{"id":"T7254","span":{"begin":331,"end":346},"obj":"GO_EXT:transcription"},{"id":"T7255","span":{"begin":360,"end":365},"obj":"PR_EXT:000015308"},{"id":"T7256","span":{"begin":366,"end":371},"obj":"CHEBI_SO_EXT:mRNA"},{"id":"T7257","span":{"begin":395,"end":401},"obj":"PR_EXT:000000183"},{"id":"T7258","span":{"begin":402,"end":406},"obj":"SO_EXT:sequence_nullness"},{"id":"T7259","span":{"begin":407,"end":411},"obj":"UBERON:0001037"},{"id":"T7260","span":{"begin":482,"end":486},"obj":"UBERON:0001037"},{"id":"T7261","span":{"begin":506,"end":510},"obj":"UBERON_EXT:zone_of_skin_or_skin_of_body"}],"text":"To further explore the possible relation between Snail and TGF-β2, we examined the status of Snail expression in TGF-β2-null hair buds. As judged by immunohistochemistry, Snail protein was absent from E17.5 skin of TGF-β2-null embryos but not from that of control littermates (Figure 6C). This effect appeared to be exerted at the transcriptional level, since Snail mRNAs were also not found in TGF-β2 null hair buds under conditions in which the signal was readily detected in the hair buds of littermate skin (Figure 6D)."}
craft-sa-dev
{"project":"craft-sa-dev","denotations":[{"id":"T8447","span":{"begin":0,"end":2},"obj":"TO"},{"id":"T8448","span":{"begin":11,"end":18},"obj":"VB"},{"id":"T8449","span":{"begin":3,"end":10},"obj":"RB"},{"id":"T8450","span":{"begin":70,"end":78},"obj":"VBD"},{"id":"T8451","span":{"begin":19,"end":22},"obj":"DT"},{"id":"T8452","span":{"begin":32,"end":40},"obj":"NN"},{"id":"T8453","span":{"begin":23,"end":31},"obj":"JJ"},{"id":"T8454","span":{"begin":41,"end":48},"obj":"IN"},{"id":"T8455","span":{"begin":49,"end":54},"obj":"NN"},{"id":"T8456","span":{"begin":55,"end":58},"obj":"CC"},{"id":"T8457","span":{"begin":59,"end":62},"obj":"NN"},{"id":"T8458","span":{"begin":63,"end":65},"obj":"NN"},{"id":"T8459","span":{"begin":62,"end":63},"obj":"HYPH"},{"id":"T8460","span":{"begin":65,"end":67},"obj":","},{"id":"T8461","span":{"begin":67,"end":69},"obj":"PRP"},{"id":"T8462","span":{"begin":79,"end":82},"obj":"DT"},{"id":"T8463","span":{"begin":83,"end":89},"obj":"NN"},{"id":"T8464","span":{"begin":90,"end":92},"obj":"IN"},{"id":"T8465","span":{"begin":93,"end":98},"obj":"NN"},{"id":"T8466","span":{"begin":99,"end":109},"obj":"NN"},{"id":"T8467","span":{"begin":110,"end":112},"obj":"IN"},{"id":"T8468","span":{"begin":113,"end":116},"obj":"NN"},{"id":"T8469","span":{"begin":117,"end":119},"obj":"NN"},{"id":"T8470","span":{"begin":116,"end":117},"obj":"HYPH"},{"id":"T8471","span":{"begin":120,"end":124},"obj":"JJ"},{"id":"T8472","span":{"begin":119,"end":120},"obj":"HYPH"},{"id":"T8473","span":{"begin":130,"end":134},"obj":"NNS"},{"id":"T8474","span":{"begin":125,"end":129},"obj":"NN"},{"id":"T8475","span":{"begin":134,"end":135},"obj":"."},{"id":"T8476","span":{"begin":135,"end":288},"obj":"sentence"},{"id":"T8477","span":{"begin":136,"end":138},"obj":"IN"},{"id":"T8478","span":{"begin":139,"end":145},"obj":"VBN"},{"id":"T8479","span":{"begin":185,"end":188},"obj":"VBD"},{"id":"T8480","span":{"begin":146,"end":148},"obj":"IN"},{"id":"T8481","span":{"begin":149,"end":169},"obj":"NN"},{"id":"T8482","span":{"begin":169,"end":171},"obj":","},{"id":"T8483","span":{"begin":171,"end":176},"obj":"NN"},{"id":"T8484","span":{"begin":177,"end":184},"obj":"NN"},{"id":"T8485","span":{"begin":189,"end":195},"obj":"JJ"},{"id":"T8486","span":{"begin":196,"end":200},"obj":"IN"},{"id":"T8487","span":{"begin":201,"end":206},"obj":"NN"},{"id":"T8488","span":{"begin":207,"end":211},"obj":"NN"},{"id":"T8489","span":{"begin":212,"end":214},"obj":"IN"},{"id":"T8490","span":{"begin":215,"end":218},"obj":"NN"},{"id":"T8491","span":{"begin":219,"end":221},"obj":"NN"},{"id":"T8492","span":{"begin":218,"end":219},"obj":"HYPH"},{"id":"T8493","span":{"begin":222,"end":226},"obj":"JJ"},{"id":"T8494","span":{"begin":221,"end":222},"obj":"HYPH"},{"id":"T8495","span":{"begin":227,"end":234},"obj":"NNS"},{"id":"T8496","span":{"begin":235,"end":238},"obj":"CC"},{"id":"T8497","span":{"begin":239,"end":242},"obj":"RB"},{"id":"T8498","span":{"begin":243,"end":247},"obj":"IN"},{"id":"T8499","span":{"begin":248,"end":252},"obj":"DT"},{"id":"T8500","span":{"begin":253,"end":255},"obj":"IN"},{"id":"T8501","span":{"begin":256,"end":263},"obj":"NN"},{"id":"T8502","span":{"begin":264,"end":275},"obj":"NNS"},{"id":"T8503","span":{"begin":276,"end":277},"obj":"-LRB-"},{"id":"T8504","span":{"begin":284,"end":286},"obj":"NN"},{"id":"T8505","span":{"begin":277,"end":283},"obj":"NN"},{"id":"T8506","span":{"begin":286,"end":287},"obj":"-RRB-"},{"id":"T8507","span":{"begin":287,"end":288},"obj":"."},{"id":"T8508","span":{"begin":288,"end":523},"obj":"sentence"},{"id":"T8509","span":{"begin":289,"end":293},"obj":"DT"},{"id":"T8510","span":{"begin":294,"end":300},"obj":"NN"},{"id":"T8511","span":{"begin":301,"end":309},"obj":"VBD"},{"id":"T8512","span":{"begin":310,"end":312},"obj":"TO"},{"id":"T8513","span":{"begin":316,"end":323},"obj":"VBN"},{"id":"T8514","span":{"begin":313,"end":315},"obj":"VB"},{"id":"T8515","span":{"begin":324,"end":326},"obj":"IN"},{"id":"T8516","span":{"begin":327,"end":330},"obj":"DT"},{"id":"T8517","span":{"begin":347,"end":352},"obj":"NN"},{"id":"T8518","span":{"begin":331,"end":346},"obj":"JJ"},{"id":"T8519","span":{"begin":352,"end":354},"obj":","},{"id":"T8520","span":{"begin":354,"end":359},"obj":"IN"},{"id":"T8521","span":{"begin":386,"end":391},"obj":"VBN"},{"id":"T8522","span":{"begin":360,"end":365},"obj":"NN"},{"id":"T8523","span":{"begin":366,"end":371},"obj":"NNS"},{"id":"T8524","span":{"begin":372,"end":376},"obj":"VBD"},{"id":"T8525","span":{"begin":377,"end":381},"obj":"RB"},{"id":"T8526","span":{"begin":382,"end":385},"obj":"RB"},{"id":"T8527","span":{"begin":392,"end":394},"obj":"IN"},{"id":"T8528","span":{"begin":395,"end":398},"obj":"NN"},{"id":"T8529","span":{"begin":399,"end":401},"obj":"NN"},{"id":"T8530","span":{"begin":398,"end":399},"obj":"HYPH"},{"id":"T8531","span":{"begin":402,"end":406},"obj":"JJ"},{"id":"T8532","span":{"begin":412,"end":416},"obj":"NNS"},{"id":"T8533","span":{"begin":407,"end":411},"obj":"NN"},{"id":"T8534","span":{"begin":417,"end":422},"obj":"IN"},{"id":"T8535","span":{"begin":423,"end":433},"obj":"NNS"},{"id":"T8536","span":{"begin":434,"end":436},"obj":"IN"},{"id":"T8537","span":{"begin":466,"end":474},"obj":"VBN"},{"id":"T8538","span":{"begin":437,"end":442},"obj":"WDT"},{"id":"T8539","span":{"begin":443,"end":446},"obj":"DT"},{"id":"T8540","span":{"begin":447,"end":453},"obj":"NN"},{"id":"T8541","span":{"begin":454,"end":457},"obj":"VBD"},{"id":"T8542","span":{"begin":458,"end":465},"obj":"RB"},{"id":"T8543","span":{"begin":475,"end":477},"obj":"IN"},{"id":"T8544","span":{"begin":478,"end":481},"obj":"DT"},{"id":"T8545","span":{"begin":487,"end":491},"obj":"NNS"},{"id":"T8546","span":{"begin":482,"end":486},"obj":"NN"},{"id":"T8547","span":{"begin":492,"end":494},"obj":"IN"},{"id":"T8548","span":{"begin":495,"end":505},"obj":"NN"},{"id":"T8549","span":{"begin":506,"end":510},"obj":"NN"},{"id":"T8550","span":{"begin":511,"end":512},"obj":"-LRB-"},{"id":"T8551","span":{"begin":519,"end":521},"obj":"NN"},{"id":"T8552","span":{"begin":512,"end":518},"obj":"NN"},{"id":"T8553","span":{"begin":521,"end":522},"obj":"-RRB-"},{"id":"T8554","span":{"begin":522,"end":523},"obj":"."}],"relations":[{"id":"R5199","pred":"aux","subj":"T8447","obj":"T8448"},{"id":"R5200","pred":"advcl","subj":"T8448","obj":"T8450"},{"id":"R5201","pred":"advmod","subj":"T8449","obj":"T8448"},{"id":"R5202","pred":"det","subj":"T8451","obj":"T8452"},{"id":"R5203","pred":"dobj","subj":"T8452","obj":"T8448"},{"id":"R5204","pred":"amod","subj":"T8453","obj":"T8452"},{"id":"R5205","pred":"prep","subj":"T8454","obj":"T8452"},{"id":"R5206","pred":"pobj","subj":"T8455","obj":"T8454"},{"id":"R5207","pred":"cc","subj":"T8456","obj":"T8455"},{"id":"R5208","pred":"compound","subj":"T8457","obj":"T8458"},{"id":"R5209","pred":"conj","subj":"T8458","obj":"T8455"},{"id":"R5210","pred":"punct","subj":"T8459","obj":"T8458"},{"id":"R5211","pred":"punct","subj":"T8460","obj":"T8450"},{"id":"R5212","pred":"nsubj","subj":"T8461","obj":"T8450"},{"id":"R5213","pred":"det","subj":"T8462","obj":"T8463"},{"id":"R5214","pred":"dobj","subj":"T8463","obj":"T8450"},{"id":"R5215","pred":"prep","subj":"T8464","obj":"T8463"},{"id":"R5216","pred":"compound","subj":"T8465","obj":"T8466"},{"id":"R5217","pred":"pobj","subj":"T8466","obj":"T8464"},{"id":"R5218","pred":"prep","subj":"T8467","obj":"T8463"},{"id":"R5219","pred":"compound","subj":"T8468","obj":"T8469"},{"id":"R5220","pred":"npadvmod","subj":"T8469","obj":"T8471"},{"id":"R5221","pred":"punct","subj":"T8470","obj":"T8469"},{"id":"R5222","pred":"amod","subj":"T8471","obj":"T8473"},{"id":"R5223","pred":"punct","subj":"T8472","obj":"T8471"},{"id":"R5224","pred":"pobj","subj":"T8473","obj":"T8467"},{"id":"R5225","pred":"compound","subj":"T8474","obj":"T8473"},{"id":"R5226","pred":"punct","subj":"T8475","obj":"T8450"},{"id":"R5227","pred":"mark","subj":"T8477","obj":"T8478"},{"id":"R5228","pred":"advcl","subj":"T8478","obj":"T8479"},{"id":"R5229","pred":"prep","subj":"T8480","obj":"T8478"},{"id":"R5230","pred":"pobj","subj":"T8481","obj":"T8480"},{"id":"R5231","pred":"punct","subj":"T8482","obj":"T8479"},{"id":"R5232","pred":"compound","subj":"T8483","obj":"T8484"},{"id":"R5233","pred":"nsubj","subj":"T8484","obj":"T8479"},{"id":"R5234","pred":"acomp","subj":"T8485","obj":"T8479"},{"id":"R5235","pred":"prep","subj":"T8486","obj":"T8485"},{"id":"R5236","pred":"compound","subj":"T8487","obj":"T8488"},{"id":"R5237","pred":"pobj","subj":"T8488","obj":"T8486"},{"id":"R5238","pred":"prep","subj":"T8489","obj":"T8488"},{"id":"R5239","pred":"compound","subj":"T8490","obj":"T8491"},{"id":"R5240","pred":"npadvmod","subj":"T8491","obj":"T8493"},{"id":"R5241","pred":"punct","subj":"T8492","obj":"T8491"},{"id":"R5242","pred":"amod","subj":"T8493","obj":"T8495"},{"id":"R5243","pred":"punct","subj":"T8494","obj":"T8493"},{"id":"R5244","pred":"pobj","subj":"T8495","obj":"T8489"},{"id":"R5245","pred":"cc","subj":"T8496","obj":"T8486"},{"id":"R5246","pred":"neg","subj":"T8497","obj":"T8496"},{"id":"R5247","pred":"conj","subj":"T8498","obj":"T8486"},{"id":"R5248","pred":"pobj","subj":"T8499","obj":"T8498"},{"id":"R5249","pred":"prep","subj":"T8500","obj":"T8499"},{"id":"R5250","pred":"compound","subj":"T8501","obj":"T8502"},{"id":"R5251","pred":"pobj","subj":"T8502","obj":"T8500"},{"id":"R5252","pred":"punct","subj":"T8503","obj":"T8504"},{"id":"R5253","pred":"parataxis","subj":"T8504","obj":"T8479"},{"id":"R5254","pred":"compound","subj":"T8505","obj":"T8504"},{"id":"R5255","pred":"punct","subj":"T8506","obj":"T8504"},{"id":"R5256","pred":"punct","subj":"T8507","obj":"T8479"},{"id":"R5257","pred":"det","subj":"T8509","obj":"T8510"},{"id":"R5258","pred":"nsubj","subj":"T8510","obj":"T8511"},{"id":"R5259","pred":"aux","subj":"T8512","obj":"T8513"},{"id":"R5260","pred":"xcomp","subj":"T8513","obj":"T8511"},{"id":"R5261","pred":"auxpass","subj":"T8514","obj":"T8513"},{"id":"R5262","pred":"prep","subj":"T8515","obj":"T8513"},{"id":"R5263","pred":"det","subj":"T8516","obj":"T8517"},{"id":"R5264","pred":"pobj","subj":"T8517","obj":"T8515"},{"id":"R5265","pred":"amod","subj":"T8518","obj":"T8517"},{"id":"R5266","pred":"punct","subj":"T8519","obj":"T8511"},{"id":"R5267","pred":"mark","subj":"T8520","obj":"T8521"},{"id":"R5268","pred":"advcl","subj":"T8521","obj":"T8511"},{"id":"R5269","pred":"compound","subj":"T8522","obj":"T8523"},{"id":"R5270","pred":"nsubjpass","subj":"T8523","obj":"T8521"},{"id":"R5271","pred":"auxpass","subj":"T8524","obj":"T8521"},{"id":"R5272","pred":"advmod","subj":"T8525","obj":"T8521"},{"id":"R5273","pred":"neg","subj":"T8526","obj":"T8521"},{"id":"R5274","pred":"prep","subj":"T8527","obj":"T8521"},{"id":"R5275","pred":"compound","subj":"T8528","obj":"T8529"},{"id":"R5276","pred":"npadvmod","subj":"T8529","obj":"T8531"},{"id":"R5277","pred":"punct","subj":"T8530","obj":"T8529"},{"id":"R5278","pred":"amod","subj":"T8531","obj":"T8532"},{"id":"R5279","pred":"pobj","subj":"T8532","obj":"T8527"},{"id":"R5280","pred":"compound","subj":"T8533","obj":"T8532"},{"id":"R5281","pred":"prep","subj":"T8534","obj":"T8521"},{"id":"R5282","pred":"pobj","subj":"T8535","obj":"T8534"},{"id":"R5283","pred":"prep","subj":"T8536","obj":"T8537"},{"id":"R5284","pred":"relcl","subj":"T8537","obj":"T8535"},{"id":"R5285","pred":"pobj","subj":"T8538","obj":"T8536"},{"id":"R5286","pred":"det","subj":"T8539","obj":"T8540"},{"id":"R5288","pred":"nsubjpass","subj":"T8540","obj":"T8537"},{"id":"R5289","pred":"auxpass","subj":"T8541","obj":"T8537"},{"id":"R5292","pred":"advmod","subj":"T8542","obj":"T8537"},{"id":"R5296","pred":"prep","subj":"T8543","obj":"T8537"},{"id":"R5302","pred":"det","subj":"T8544","obj":"T8545"},{"id":"R5306","pred":"pobj","subj":"T8545","obj":"T8543"},{"id":"R5308","pred":"compound","subj":"T8546","obj":"T8545"},{"id":"R5311","pred":"prep","subj":"T8547","obj":"T8545"},{"id":"R5315","pred":"compound","subj":"T8548","obj":"T8549"},{"id":"R5316","pred":"pobj","subj":"T8549","obj":"T8547"},{"id":"R5319","pred":"punct","subj":"T8550","obj":"T8551"},{"id":"R5323","pred":"parataxis","subj":"T8551","obj":"T8521"},{"id":"R5326","pred":"compound","subj":"T8552","obj":"T8551"},{"id":"R5329","pred":"punct","subj":"T8553","obj":"T8551"},{"id":"R5331","pred":"punct","subj":"T8554","obj":"T8511"}],"text":"To further explore the possible relation between Snail and TGF-β2, we examined the status of Snail expression in TGF-β2-null hair buds. As judged by immunohistochemistry, Snail protein was absent from E17.5 skin of TGF-β2-null embryos but not from that of control littermates (Figure 6C). This effect appeared to be exerted at the transcriptional level, since Snail mRNAs were also not found in TGF-β2 null hair buds under conditions in which the signal was readily detected in the hair buds of littermate skin (Figure 6D)."}