PMC:523229 / 20595-22491 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T4683","span":{"begin":0,"end":12},"obj":"JJ"},{"id":"T4684","span":{"begin":13,"end":23},"obj":"NN"},{"id":"T4685","span":{"begin":36,"end":46},"obj":"VBN"},{"id":"T4686","span":{"begin":24,"end":26},"obj":"VBZ"},{"id":"T4687","span":{"begin":27,"end":35},"obj":"RB"},{"id":"T4688","span":{"begin":47,"end":49},"obj":"IN"},{"id":"T4689","span":{"begin":50,"end":59},"obj":"NN"},{"id":"T4690","span":{"begin":60,"end":66},"obj":"IN"},{"id":"T4691","span":{"begin":67,"end":76},"obj":"JJ"},{"id":"T4692","span":{"begin":77,"end":88},"obj":"NN"},{"id":"T4693","span":{"begin":88,"end":90},"obj":","},{"id":"T4694","span":{"begin":90,"end":91},"obj":"DT"},{"id":"T4695","span":{"begin":92,"end":99},"obj":"NN"},{"id":"T4696","span":{"begin":100,"end":104},"obj":"WDT"},{"id":"T4697","span":{"begin":112,"end":122},"obj":"VBN"},{"id":"T4698","span":{"begin":105,"end":108},"obj":"MD"},{"id":"T4699","span":{"begin":109,"end":111},"obj":"VB"},{"id":"T4700","span":{"begin":123,"end":125},"obj":"IN"},{"id":"T4701","span":{"begin":126,"end":129},"obj":"NN"},{"id":"T4702","span":{"begin":130,"end":135},"obj":"NNS"},{"id":"T4703","span":{"begin":135,"end":137},"obj":","},{"id":"T4704","span":{"begin":137,"end":146},"obj":"VBN"},{"id":"T4705","span":{"begin":147,"end":149},"obj":"IN"},{"id":"T4706","span":{"begin":150,"end":156},"obj":"NN"},{"id":"T4707","span":{"begin":156,"end":158},"obj":","},{"id":"T4708","span":{"begin":158,"end":160},"obj":"CC"},{"id":"T4709","span":{"begin":161,"end":168},"obj":"VBN"},{"id":"T4710","span":{"begin":169,"end":171},"obj":"IN"},{"id":"T4711","span":{"begin":172,"end":186},"obj":"NN"},{"id":"T4712","span":{"begin":187,"end":189},"obj":"IN"},{"id":"T4713","span":{"begin":190,"end":198},"obj":"JJ"},{"id":"T4714","span":{"begin":199,"end":207},"obj":"JJ"},{"id":"T4715","span":{"begin":198,"end":199},"obj":"HYPH"},{"id":"T4716","span":{"begin":212,"end":221},"obj":"NNS"},{"id":"T4717","span":{"begin":208,"end":211},"obj":"NN"},{"id":"T4718","span":{"begin":222,"end":223},"obj":"-LRB-"},{"id":"T4719","span":{"begin":223,"end":229},"obj":"NNP"},{"id":"T4720","span":{"begin":229,"end":230},"obj":"HYPH"},{"id":"T4721","span":{"begin":230,"end":238},"obj":"NNP"},{"id":"T4722","span":{"begin":239,"end":241},"obj":"FW"},{"id":"T4723","span":{"begin":242,"end":245},"obj":"FW"},{"id":"T4724","span":{"begin":246,"end":250},"obj":"CD"},{"id":"T4725","span":{"begin":250,"end":251},"obj":":"},{"id":"T4726","span":{"begin":252,"end":260},"obj":"NNP"},{"id":"T4727","span":{"begin":261,"end":263},"obj":"FW"},{"id":"T4728","span":{"begin":264,"end":267},"obj":"FW"},{"id":"T4729","span":{"begin":268,"end":272},"obj":"CD"},{"id":"T4730","span":{"begin":272,"end":273},"obj":":"},{"id":"T4731","span":{"begin":274,"end":277},"obj":"NNP"},{"id":"T4732","span":{"begin":278,"end":281},"obj":"CC"},{"id":"T4733","span":{"begin":282,"end":291},"obj":"NNP"},{"id":"T4734","span":{"begin":292,"end":296},"obj":"CD"},{"id":"T4735","span":{"begin":296,"end":297},"obj":":"},{"id":"T4736","span":{"begin":298,"end":302},"obj":"NNP"},{"id":"T4737","span":{"begin":303,"end":305},"obj":"FW"},{"id":"T4738","span":{"begin":306,"end":309},"obj":"FW"},{"id":"T4739","span":{"begin":310,"end":314},"obj":"CD"},{"id":"T4740","span":{"begin":314,"end":315},"obj":"-RRB-"},{"id":"T4741","span":{"begin":315,"end":316},"obj":"."},{"id":"T4742","span":{"begin":316,"end":590},"obj":"sentence"},{"id":"T4743","span":{"begin":317,"end":322},"obj":"NNS"},{"id":"T4744","span":{"begin":362,"end":368},"obj":"VBD"},{"id":"T4745","span":{"begin":323,"end":325},"obj":"IN"},{"id":"T4746","span":{"begin":326,"end":330},"obj":"NN"},{"id":"T4747","span":{"begin":331,"end":334},"obj":"NN"},{"id":"T4748","span":{"begin":330,"end":331},"obj":"HYPH"},{"id":"T4749","span":{"begin":335,"end":346},"obj":"NN"},{"id":"T4750","span":{"begin":334,"end":335},"obj":"HYPH"},{"id":"T4751","span":{"begin":347,"end":353},"obj":"JJ"},{"id":"T4752","span":{"begin":354,"end":361},"obj":"NNS"},{"id":"T4753","span":{"begin":369,"end":376},"obj":"JJ"},{"id":"T4754","span":{"begin":377,"end":386},"obj":"NN"},{"id":"T4755","span":{"begin":387,"end":389},"obj":"IN"},{"id":"T4756","span":{"begin":390,"end":402},"obj":"JJ"},{"id":"T4757","span":{"begin":403,"end":410},"obj":"NN"},{"id":"T4758","span":{"begin":411,"end":418},"obj":"IN"},{"id":"T4759","span":{"begin":419,"end":422},"obj":"DT"},{"id":"T4760","span":{"begin":456,"end":462},"obj":"NNS"},{"id":"T4761","span":{"begin":423,"end":428},"obj":"JJ"},{"id":"T4762","span":{"begin":429,"end":432},"obj":"CC"},{"id":"T4763","span":{"begin":433,"end":439},"obj":"JJ"},{"id":"T4764","span":{"begin":439,"end":441},"obj":","},{"id":"T4765","span":{"begin":441,"end":444},"obj":"CC"},{"id":"T4766","span":{"begin":445,"end":448},"obj":"RB"},{"id":"T4767","span":{"begin":449,"end":454},"obj":"JJ"},{"id":"T4768","span":{"begin":454,"end":456},"obj":","},{"id":"T4769","span":{"begin":463,"end":465},"obj":"IN"},{"id":"T4770","span":{"begin":466,"end":471},"obj":"NN"},{"id":"T4771","span":{"begin":472,"end":481},"obj":"NNS"},{"id":"T4772","span":{"begin":482,"end":483},"obj":"-LRB-"},{"id":"T4773","span":{"begin":483,"end":489},"obj":"NN"},{"id":"T4774","span":{"begin":490,"end":492},"obj":"CD"},{"id":"T4775","span":{"begin":493,"end":496},"obj":"CC"},{"id":"T4776","span":{"begin":497,"end":499},"obj":"CD"},{"id":"T4777","span":{"begin":499,"end":500},"obj":"-RRB-"},{"id":"T4778","span":{"begin":500,"end":502},"obj":","},{"id":"T4779","span":{"begin":502,"end":503},"obj":"DT"},{"id":"T4780","span":{"begin":504,"end":511},"obj":"NN"},{"id":"T4781","span":{"begin":512,"end":516},"obj":"WDT"},{"id":"T4782","span":{"begin":517,"end":528},"obj":"VBZ"},{"id":"T4783","span":{"begin":529,"end":531},"obj":"IN"},{"id":"T4784","span":{"begin":532,"end":535},"obj":"DT"},{"id":"T4785","span":{"begin":536,"end":544},"obj":"NN"},{"id":"T4786","span":{"begin":545,"end":547},"obj":"CC"},{"id":"T4787","span":{"begin":548,"end":555},"obj":"NN"},{"id":"T4788","span":{"begin":556,"end":558},"obj":"IN"},{"id":"T4789","span":{"begin":559,"end":566},"obj":"NN"},{"id":"T4790","span":{"begin":567,"end":571},"obj":"VBN"},{"id":"T4791","span":{"begin":572,"end":574},"obj":"IN"},{"id":"T4792","span":{"begin":575,"end":578},"obj":"DT"},{"id":"T4793","span":{"begin":585,"end":589},"obj":"NN"},{"id":"T4794","span":{"begin":579,"end":584},"obj":"NN"},{"id":"T4795","span":{"begin":589,"end":590},"obj":"."},{"id":"T4796","span":{"begin":590,"end":684},"obj":"sentence"},{"id":"T4797","span":{"begin":591,"end":595},"obj":"PRP"},{"id":"T4798","span":{"begin":601,"end":607},"obj":"VBD"},{"id":"T4799","span":{"begin":596,"end":600},"obj":"RB"},{"id":"T4800","span":{"begin":608,"end":614},"obj":"JJ"},{"id":"T4801","span":{"begin":615,"end":621},"obj":"NN"},{"id":"T4802","span":{"begin":622,"end":624},"obj":"IN"},{"id":"T4803","span":{"begin":625,"end":628},"obj":"DT"},{"id":"T4804","span":{"begin":639,"end":645},"obj":"NN"},{"id":"T4805","span":{"begin":629,"end":638},"obj":"JJ"},{"id":"T4806","span":{"begin":646,"end":648},"obj":"IN"},{"id":"T4807","span":{"begin":649,"end":652},"obj":"DT"},{"id":"T4808","span":{"begin":659,"end":664},"obj":"NN"},{"id":"T4809","span":{"begin":653,"end":658},"obj":"JJ"},{"id":"T4810","span":{"begin":665,"end":666},"obj":"-LRB-"},{"id":"T4811","span":{"begin":677,"end":682},"obj":"NN"},{"id":"T4812","span":{"begin":666,"end":672},"obj":"NN"},{"id":"T4813","span":{"begin":673,"end":675},"obj":"CD"},{"id":"T4814","span":{"begin":675,"end":677},"obj":","},{"id":"T4815","span":{"begin":682,"end":683},"obj":"-RRB-"},{"id":"T4816","span":{"begin":683,"end":684},"obj":"."},{"id":"T4817","span":{"begin":684,"end":928},"obj":"sentence"},{"id":"T4818","span":{"begin":685,"end":693},"obj":"NN"},{"id":"T4819","span":{"begin":747,"end":753},"obj":"VBD"},{"id":"T4820","span":{"begin":694,"end":696},"obj":"IN"},{"id":"T4821","span":{"begin":697,"end":701},"obj":"NN"},{"id":"T4822","span":{"begin":702,"end":712},"obj":"NN"},{"id":"T4823","span":{"begin":713,"end":715},"obj":"IN"},{"id":"T4824","span":{"begin":716,"end":720},"obj":"NN"},{"id":"T4825","span":{"begin":721,"end":724},"obj":"NN"},{"id":"T4826","span":{"begin":720,"end":721},"obj":"HYPH"},{"id":"T4827","span":{"begin":725,"end":729},"obj":"NN"},{"id":"T4828","span":{"begin":724,"end":725},"obj":"HYPH"},{"id":"T4829","span":{"begin":739,"end":746},"obj":"NNS"},{"id":"T4830","span":{"begin":730,"end":738},"obj":"NN"},{"id":"T4831","span":{"begin":754,"end":758},"obj":"IN"},{"id":"T4832","span":{"begin":790,"end":798},"obj":"VBN"},{"id":"T4833","span":{"begin":759,"end":762},"obj":"NN"},{"id":"T4834","span":{"begin":763,"end":771},"obj":"VBN"},{"id":"T4835","span":{"begin":762,"end":763},"obj":"HYPH"},{"id":"T4836","span":{"begin":772,"end":785},"obj":"NN"},{"id":"T4837","span":{"begin":786,"end":789},"obj":"VBZ"},{"id":"T4838","span":{"begin":799,"end":801},"obj":"IN"},{"id":"T4839","span":{"begin":802,"end":807},"obj":"NN"},{"id":"T4840","span":{"begin":808,"end":810},"obj":"IN"},{"id":"T4841","span":{"begin":811,"end":814},"obj":"DT"},{"id":"T4842","span":{"begin":837,"end":843},"obj":"NNS"},{"id":"T4843","span":{"begin":815,"end":825},"obj":"JJ"},{"id":"T4844","span":{"begin":826,"end":836},"obj":"JJ"},{"id":"T4845","span":{"begin":825,"end":826},"obj":"HYPH"},{"id":"T4846","span":{"begin":843,"end":845},"obj":","},{"id":"T4847","span":{"begin":845,"end":848},"obj":"CC"},{"id":"T4848","span":{"begin":849,"end":851},"obj":"IN"},{"id":"T4849","span":{"begin":852,"end":855},"obj":"DT"},{"id":"T4850","span":{"begin":869,"end":875},"obj":"NN"},{"id":"T4851","span":{"begin":856,"end":868},"obj":"JJ"},{"id":"T4852","span":{"begin":876,"end":883},"obj":"IN"},{"id":"T4853","span":{"begin":884,"end":887},"obj":"DT"},{"id":"T4854","span":{"begin":921,"end":927},"obj":"NNS"},{"id":"T4855","span":{"begin":888,"end":893},"obj":"JJ"},{"id":"T4856","span":{"begin":894,"end":897},"obj":"CC"},{"id":"T4857","span":{"begin":898,"end":904},"obj":"JJ"},{"id":"T4858","span":{"begin":904,"end":906},"obj":","},{"id":"T4859","span":{"begin":906,"end":909},"obj":"CC"},{"id":"T4860","span":{"begin":910,"end":913},"obj":"RB"},{"id":"T4861","span":{"begin":914,"end":919},"obj":"JJ"},{"id":"T4862","span":{"begin":919,"end":921},"obj":","},{"id":"T4863","span":{"begin":927,"end":928},"obj":"."},{"id":"T4864","span":{"begin":928,"end":1070},"obj":"sentence"},{"id":"T4865","span":{"begin":929,"end":931},"obj":"IN"},{"id":"T4866","span":{"begin":1012,"end":1016},"obj":"VBN"},{"id":"T4867","span":{"begin":932,"end":940},"obj":"NN"},{"id":"T4868","span":{"begin":940,"end":942},"obj":","},{"id":"T4869","span":{"begin":942,"end":943},"obj":"DT"},{"id":"T4870","span":{"begin":944,"end":950},"obj":"NN"},{"id":"T4871","span":{"begin":951,"end":953},"obj":"IN"},{"id":"T4872","span":{"begin":954,"end":967},"obj":"NN"},{"id":"T4873","span":{"begin":968,"end":971},"obj":"CC"},{"id":"T4874","span":{"begin":972,"end":982},"obj":"NN"},{"id":"T4875","span":{"begin":983,"end":985},"obj":"IN"},{"id":"T4876","span":{"begin":986,"end":990},"obj":"NN"},{"id":"T4877","span":{"begin":991,"end":993},"obj":"VBZ"},{"id":"T4878","span":{"begin":994,"end":998},"obj":"RB"},{"id":"T4879","span":{"begin":999,"end":1011},"obj":"RB"},{"id":"T4880","span":{"begin":1017,"end":1019},"obj":"IN"},{"id":"T4881","span":{"begin":1020,"end":1023},"obj":"DT"},{"id":"T4882","span":{"begin":1034,"end":1038},"obj":"NN"},{"id":"T4883","span":{"begin":1024,"end":1033},"obj":"JJ"},{"id":"T4884","span":{"begin":1039,"end":1041},"obj":"IN"},{"id":"T4885","span":{"begin":1042,"end":1045},"obj":"DT"},{"id":"T4886","span":{"begin":1052,"end":1057},"obj":"NN"},{"id":"T4887","span":{"begin":1046,"end":1051},"obj":"JJ"},{"id":"T4888","span":{"begin":1058,"end":1059},"obj":"-LRB-"},{"id":"T4889","span":{"begin":1059,"end":1065},"obj":"NN"},{"id":"T4890","span":{"begin":1066,"end":1068},"obj":"CD"},{"id":"T4891","span":{"begin":1068,"end":1069},"obj":"-RRB-"},{"id":"T4892","span":{"begin":1069,"end":1070},"obj":"."},{"id":"T4893","span":{"begin":1070,"end":1409},"obj":"sentence"},{"id":"T4894","span":{"begin":1071,"end":1079},"obj":"JJ"},{"id":"T4895","span":{"begin":1153,"end":1161},"obj":"NN"},{"id":"T4896","span":{"begin":1080,"end":1096},"obj":"NN"},{"id":"T4897","span":{"begin":1097,"end":1108},"obj":"NN"},{"id":"T4898","span":{"begin":1109,"end":1117},"obj":"VBN"},{"id":"T4899","span":{"begin":1108,"end":1109},"obj":"HYPH"},{"id":"T4900","span":{"begin":1118,"end":1130},"obj":"NN"},{"id":"T4901","span":{"begin":1131,"end":1143},"obj":"NN"},{"id":"T4902","span":{"begin":1144,"end":1148},"obj":"NN"},{"id":"T4903","span":{"begin":1149,"end":1152},"obj":"NN"},{"id":"T4904","span":{"begin":1170,"end":1178},"obj":"NN"},{"id":"T4905","span":{"begin":1162,"end":1163},"obj":"-LRB-"},{"id":"T4906","span":{"begin":1163,"end":1168},"obj":"NN"},{"id":"T4907","span":{"begin":1168,"end":1169},"obj":"-RRB-"},{"id":"T4908","span":{"begin":1301,"end":1307},"obj":"VBD"},{"id":"T4909","span":{"begin":1179,"end":1181},"obj":"IN"},{"id":"T4910","span":{"begin":1182,"end":1194},"obj":"JJ"},{"id":"T4911","span":{"begin":1195,"end":1205},"obj":"NN"},{"id":"T4912","span":{"begin":1206,"end":1213},"obj":"IN"},{"id":"T4913","span":{"begin":1214,"end":1217},"obj":"DT"},{"id":"T4914","span":{"begin":1235,"end":1241},"obj":"NNS"},{"id":"T4915","span":{"begin":1218,"end":1223},"obj":"JJ"},{"id":"T4916","span":{"begin":1224,"end":1227},"obj":"CC"},{"id":"T4917","span":{"begin":1228,"end":1234},"obj":"JJ"},{"id":"T4918","span":{"begin":1242,"end":1243},"obj":"-LRB-"},{"id":"T4919","span":{"begin":1243,"end":1249},"obj":"NN"},{"id":"T4920","span":{"begin":1250,"end":1252},"obj":"CD"},{"id":"T4921","span":{"begin":1253,"end":1256},"obj":"CC"},{"id":"T4922","span":{"begin":1257,"end":1259},"obj":"CD"},{"id":"T4923","span":{"begin":1259,"end":1260},"obj":"-RRB-"},{"id":"T4924","span":{"begin":1261,"end":1264},"obj":"CC"},{"id":"T4925","span":{"begin":1265,"end":1268},"obj":"DT"},{"id":"T4926","span":{"begin":1275,"end":1280},"obj":"NN"},{"id":"T4927","span":{"begin":1269,"end":1274},"obj":"JJ"},{"id":"T4928","span":{"begin":1281,"end":1289},"obj":"VBG"},{"id":"T4929","span":{"begin":1290,"end":1300},"obj":"NN"},{"id":"T4930","span":{"begin":1308,"end":1309},"obj":"DT"},{"id":"T4931","span":{"begin":1320,"end":1326},"obj":"NN"},{"id":"T4932","span":{"begin":1310,"end":1319},"obj":"VBN"},{"id":"T4933","span":{"begin":1327,"end":1329},"obj":"IN"},{"id":"T4934","span":{"begin":1330,"end":1335},"obj":"VBG"},{"id":"T4935","span":{"begin":1336,"end":1341},"obj":"NNS"},{"id":"T4936","span":{"begin":1342,"end":1344},"obj":"IN"},{"id":"T4937","span":{"begin":1345,"end":1348},"obj":"DT"},{"id":"T4938","span":{"begin":1349,"end":1356},"obj":"NNS"},{"id":"T4939","span":{"begin":1357,"end":1362},"obj":"WRB"},{"id":"T4940","span":{"begin":1380,"end":1388},"obj":"VBN"},{"id":"T4941","span":{"begin":1363,"end":1369},"obj":"JJ"},{"id":"T4942","span":{"begin":1370,"end":1376},"obj":"NN"},{"id":"T4943","span":{"begin":1377,"end":1379},"obj":"VBZ"},{"id":"T4944","span":{"begin":1389,"end":1391},"obj":"IN"},{"id":"T4945","span":{"begin":1392,"end":1395},"obj":"DT"},{"id":"T4946","span":{"begin":1403,"end":1408},"obj":"NNS"},{"id":"T4947","span":{"begin":1396,"end":1402},"obj":"NN"},{"id":"T4948","span":{"begin":1408,"end":1409},"obj":"."},{"id":"T4949","span":{"begin":1409,"end":1523},"obj":"sentence"},{"id":"T4950","span":{"begin":1410,"end":1417},"obj":"NNS"},{"id":"T4951","span":{"begin":1485,"end":1493},"obj":"VBN"},{"id":"T4952","span":{"begin":1418,"end":1420},"obj":"IN"},{"id":"T4953","span":{"begin":1421,"end":1435},"obj":"VBN"},{"id":"T4954","span":{"begin":1444,"end":1446},"obj":"NN"},{"id":"T4955","span":{"begin":1436,"end":1443},"obj":"NN"},{"id":"T4956","span":{"begin":1447,"end":1454},"obj":"VBN"},{"id":"T4957","span":{"begin":1446,"end":1447},"obj":"HYPH"},{"id":"T4958","span":{"begin":1469,"end":1474},"obj":"NNS"},{"id":"T4959","span":{"begin":1455,"end":1468},"obj":"VBG"},{"id":"T4960","span":{"begin":1475,"end":1479},"obj":"VBD"},{"id":"T4961","span":{"begin":1480,"end":1484},"obj":"RB"},{"id":"T4962","span":{"begin":1494,"end":1496},"obj":"IN"},{"id":"T4963","span":{"begin":1497,"end":1502},"obj":"DT"},{"id":"T4964","span":{"begin":1503,"end":1510},"obj":"NNS"},{"id":"T4965","span":{"begin":1511,"end":1512},"obj":"-LRB-"},{"id":"T4966","span":{"begin":1512,"end":1518},"obj":"NN"},{"id":"T4967","span":{"begin":1519,"end":1521},"obj":"CD"},{"id":"T4968","span":{"begin":1521,"end":1522},"obj":"-RRB-"},{"id":"T4969","span":{"begin":1522,"end":1523},"obj":"."},{"id":"T4970","span":{"begin":1523,"end":1682},"obj":"sentence"},{"id":"T4971","span":{"begin":1524,"end":1528},"obj":"JJS"},{"id":"T4972","span":{"begin":1529,"end":1534},"obj":"NNS"},{"id":"T4973","span":{"begin":1616,"end":1625},"obj":"VBD"},{"id":"T4974","span":{"begin":1535,"end":1540},"obj":"VBN"},{"id":"T4975","span":{"begin":1541,"end":1543},"obj":"IN"},{"id":"T4976","span":{"begin":1544,"end":1547},"obj":"DT"},{"id":"T4977","span":{"begin":1555,"end":1561},"obj":"NN"},{"id":"T4978","span":{"begin":1548,"end":1554},"obj":"VBN"},{"id":"T4979","span":{"begin":1562,"end":1569},"obj":"IN"},{"id":"T4980","span":{"begin":1570,"end":1573},"obj":"DT"},{"id":"T4981","span":{"begin":1591,"end":1597},"obj":"NNS"},{"id":"T4982","span":{"begin":1574,"end":1579},"obj":"JJ"},{"id":"T4983","span":{"begin":1580,"end":1583},"obj":"CC"},{"id":"T4984","span":{"begin":1584,"end":1590},"obj":"JJ"},{"id":"T4985","span":{"begin":1598,"end":1600},"obj":"IN"},{"id":"T4986","span":{"begin":1601,"end":1606},"obj":"NN"},{"id":"T4987","span":{"begin":1607,"end":1615},"obj":"RB"},{"id":"T4988","span":{"begin":1626,"end":1630},"obj":"NN"},{"id":"T4989","span":{"begin":1631,"end":1633},"obj":"IN"},{"id":"T4990","span":{"begin":1634,"end":1638},"obj":"NN"},{"id":"T4991","span":{"begin":1639,"end":1642},"obj":"NN"},{"id":"T4992","span":{"begin":1638,"end":1639},"obj":"HYPH"},{"id":"T4993","span":{"begin":1643,"end":1654},"obj":"NN"},{"id":"T4994","span":{"begin":1642,"end":1643},"obj":"HYPH"},{"id":"T4995","span":{"begin":1662,"end":1669},"obj":"NNS"},{"id":"T4996","span":{"begin":1655,"end":1661},"obj":"NN"},{"id":"T4997","span":{"begin":1670,"end":1671},"obj":"-LRB-"},{"id":"T4998","span":{"begin":1671,"end":1677},"obj":"NN"},{"id":"T4999","span":{"begin":1678,"end":1680},"obj":"CD"},{"id":"T5000","span":{"begin":1680,"end":1681},"obj":"-RRB-"},{"id":"T5001","span":{"begin":1681,"end":1682},"obj":"."},{"id":"T5002","span":{"begin":1682,"end":1896},"obj":"sentence"},{"id":"T5003","span":{"begin":1683,"end":1688},"obj":"DT"},{"id":"T5004","span":{"begin":1689,"end":1693},"obj":"NNS"},{"id":"T5005","span":{"begin":1694,"end":1701},"obj":"VBP"},{"id":"T5006","span":{"begin":1702,"end":1706},"obj":"IN"},{"id":"T5007","span":{"begin":1750,"end":1756},"obj":"VBZ"},{"id":"T5008","span":{"begin":1707,"end":1715},"obj":"JJ"},{"id":"T5009","span":{"begin":1716,"end":1720},"obj":"NN"},{"id":"T5010","span":{"begin":1721,"end":1723},"obj":"IN"},{"id":"T5011","span":{"begin":1724,"end":1730},"obj":"NN"},{"id":"T5012","span":{"begin":1740,"end":1749},"obj":"NN"},{"id":"T5013","span":{"begin":1731,"end":1739},"obj":"NN"},{"id":"T5014","span":{"begin":1757,"end":1767},"obj":"VBN"},{"id":"T5015","span":{"begin":1773,"end":1778},"obj":"NN"},{"id":"T5016","span":{"begin":1768,"end":1772},"obj":"NN"},{"id":"T5017","span":{"begin":1779,"end":1781},"obj":"IN"},{"id":"T5018","span":{"begin":1782,"end":1794},"obj":"JJ"},{"id":"T5019","span":{"begin":1795,"end":1805},"obj":"NN"},{"id":"T5020","span":{"begin":1805,"end":1807},"obj":","},{"id":"T5021","span":{"begin":1807,"end":1810},"obj":"CC"},{"id":"T5022","span":{"begin":1811,"end":1815},"obj":"IN"},{"id":"T5023","span":{"begin":1837,"end":1844},"obj":"VBP"},{"id":"T5024","span":{"begin":1816,"end":1819},"obj":"DT"},{"id":"T5025","span":{"begin":1831,"end":1836},"obj":"NNS"},{"id":"T5026","span":{"begin":1820,"end":1830},"obj":"VBN"},{"id":"T5027","span":{"begin":1845,"end":1848},"obj":"CC"},{"id":"T5028","span":{"begin":1849,"end":1860},"obj":"VBP"},{"id":"T5029","span":{"begin":1861,"end":1863},"obj":"IN"},{"id":"T5030","span":{"begin":1864,"end":1867},"obj":"DT"},{"id":"T5031","span":{"begin":1868,"end":1875},"obj":"NN"},{"id":"T5032","span":{"begin":1876,"end":1878},"obj":"IN"},{"id":"T5033","span":{"begin":1879,"end":1885},"obj":"NN"},{"id":"T5034","span":{"begin":1886,"end":1895},"obj":"NN"},{"id":"T5035","span":{"begin":1895,"end":1896},"obj":"."}],"relations":[{"id":"R2950","pred":"amod","subj":"T4683","obj":"T4684"},{"id":"R2951","pred":"nsubjpass","subj":"T4684","obj":"T4685"},{"id":"R2952","pred":"auxpass","subj":"T4686","obj":"T4685"},{"id":"R2953","pred":"advmod","subj":"T4687","obj":"T4685"},{"id":"R2954","pred":"agent","subj":"T4688","obj":"T4685"},{"id":"R2955","pred":"pobj","subj":"T4689","obj":"T4688"},{"id":"R2956","pred":"prep","subj":"T4690","obj":"T4685"},{"id":"R2957","pred":"amod","subj":"T4691","obj":"T4692"},{"id":"R2958","pred":"pobj","subj":"T4692","obj":"T4690"},{"id":"R2959","pred":"punct","subj":"T4693","obj":"T4685"},{"id":"R2960","pred":"det","subj":"T4694","obj":"T4695"},{"id":"R2961","pred":"npadvmod","subj":"T4695","obj":"T4685"},{"id":"R2962","pred":"dep","subj":"T4696","obj":"T4697"},{"id":"R2963","pred":"relcl","subj":"T4697","obj":"T4695"},{"id":"R2964","pred":"aux","subj":"T4698","obj":"T4697"},{"id":"R2965","pred":"auxpass","subj":"T4699","obj":"T4697"},{"id":"R2966","pred":"agent","subj":"T4700","obj":"T4697"},{"id":"R2967","pred":"compound","subj":"T4701","obj":"T4702"},{"id":"R2968","pred":"pobj","subj":"T4702","obj":"T4700"},{"id":"R2969","pred":"punct","subj":"T4703","obj":"T4697"},{"id":"R2970","pred":"conj","subj":"T4704","obj":"T4697"},{"id":"R2971","pred":"agent","subj":"T4705","obj":"T4704"},{"id":"R2972","pred":"pobj","subj":"T4706","obj":"T4705"},{"id":"R2973","pred":"punct","subj":"T4707","obj":"T4704"},{"id":"R2974","pred":"cc","subj":"T4708","obj":"T4704"},{"id":"R2975","pred":"conj","subj":"T4709","obj":"T4704"},{"id":"R2976","pred":"agent","subj":"T4710","obj":"T4709"},{"id":"R2977","pred":"pobj","subj":"T4711","obj":"T4710"},{"id":"R2978","pred":"prep","subj":"T4712","obj":"T4711"},{"id":"R2979","pred":"amod","subj":"T4713","obj":"T4714"},{"id":"R2980","pred":"nmod","subj":"T4714","obj":"T4716"},{"id":"R2981","pred":"punct","subj":"T4715","obj":"T4714"},{"id":"R2982","pred":"pobj","subj":"T4716","obj":"T4712"},{"id":"R2983","pred":"compound","subj":"T4717","obj":"T4716"},{"id":"R2984","pred":"punct","subj":"T4718","obj":"T4719"},{"id":"R2985","pred":"meta","subj":"T4719","obj":"T4685"},{"id":"R2986","pred":"punct","subj":"T4720","obj":"T4719"},{"id":"R2987","pred":"nmod","subj":"T4721","obj":"T4719"},{"id":"R2988","pred":"nmod","subj":"T4722","obj":"T4719"},{"id":"R2989","pred":"nmod","subj":"T4723","obj":"T4719"},{"id":"R2990","pred":"nummod","subj":"T4724","obj":"T4719"},{"id":"R2991","pred":"punct","subj":"T4725","obj":"T4719"},{"id":"R2992","pred":"conj","subj":"T4726","obj":"T4719"},{"id":"R2993","pred":"nmod","subj":"T4727","obj":"T4726"},{"id":"R2994","pred":"nmod","subj":"T4728","obj":"T4726"},{"id":"R2995","pred":"nummod","subj":"T4729","obj":"T4726"},{"id":"R2996","pred":"punct","subj":"T4730","obj":"T4726"},{"id":"R2997","pred":"conj","subj":"T4731","obj":"T4726"},{"id":"R2998","pred":"cc","subj":"T4732","obj":"T4731"},{"id":"R2999","pred":"conj","subj":"T4733","obj":"T4731"},{"id":"R3000","pred":"nummod","subj":"T4734","obj":"T4733"},{"id":"R3001","pred":"punct","subj":"T4735","obj":"T4733"},{"id":"R3002","pred":"conj","subj":"T4736","obj":"T4733"},{"id":"R3003","pred":"nmod","subj":"T4737","obj":"T4736"},{"id":"R3004","pred":"nmod","subj":"T4738","obj":"T4736"},{"id":"R3005","pred":"nummod","subj":"T4739","obj":"T4736"},{"id":"R3006","pred":"punct","subj":"T4740","obj":"T4736"},{"id":"R3007","pred":"punct","subj":"T4741","obj":"T4685"},{"id":"R3008","pred":"nsubj","subj":"T4743","obj":"T4744"},{"id":"R3009","pred":"prep","subj":"T4745","obj":"T4743"},{"id":"R3010","pred":"compound","subj":"T4746","obj":"T4747"},{"id":"R3011","pred":"compound","subj":"T4747","obj":"T4749"},{"id":"R3012","pred":"punct","subj":"T4748","obj":"T4747"},{"id":"R3013","pred":"npadvmod","subj":"T4749","obj":"T4751"},{"id":"R3014","pred":"punct","subj":"T4750","obj":"T4749"},{"id":"R3015","pred":"amod","subj":"T4751","obj":"T4752"},{"id":"R3016","pred":"pobj","subj":"T4752","obj":"T4745"},{"id":"R3017","pred":"amod","subj":"T4753","obj":"T4754"},{"id":"R3018","pred":"dobj","subj":"T4754","obj":"T4744"},{"id":"R3019","pred":"prep","subj":"T4755","obj":"T4754"},{"id":"R3020","pred":"amod","subj":"T4756","obj":"T4757"},{"id":"R3021","pred":"pobj","subj":"T4757","obj":"T4755"},{"id":"R3022","pred":"prep","subj":"T4758","obj":"T4757"},{"id":"R3023","pred":"det","subj":"T4759","obj":"T4760"},{"id":"R3024","pred":"pobj","subj":"T4760","obj":"T4758"},{"id":"R3025","pred":"amod","subj":"T4761","obj":"T4760"},{"id":"R3026","pred":"cc","subj":"T4762","obj":"T4761"},{"id":"R3027","pred":"conj","subj":"T4763","obj":"T4761"},{"id":"R3028","pred":"punct","subj":"T4764","obj":"T4761"},{"id":"R3029","pred":"cc","subj":"T4765","obj":"T4761"},{"id":"R3030","pred":"neg","subj":"T4766","obj":"T4765"},{"id":"R3031","pred":"conj","subj":"T4767","obj":"T4761"},{"id":"R3032","pred":"punct","subj":"T4768","obj":"T4760"},{"id":"R3033","pred":"prep","subj":"T4769","obj":"T4760"},{"id":"R3034","pred":"compound","subj":"T4770","obj":"T4771"},{"id":"R3035","pred":"pobj","subj":"T4771","obj":"T4769"},{"id":"R3036","pred":"punct","subj":"T4772","obj":"T4773"},{"id":"R3037","pred":"parataxis","subj":"T4773","obj":"T4760"},{"id":"R3038","pred":"nummod","subj":"T4774","obj":"T4773"},{"id":"R3039","pred":"cc","subj":"T4775","obj":"T4773"},{"id":"R3040","pred":"conj","subj":"T4776","obj":"T4773"},{"id":"R3041","pred":"punct","subj":"T4777","obj":"T4773"},{"id":"R3042","pred":"punct","subj":"T4778","obj":"T4744"},{"id":"R3043","pred":"det","subj":"T4779","obj":"T4780"},{"id":"R3044","pred":"npadvmod","subj":"T4780","obj":"T4744"},{"id":"R3045","pred":"dep","subj":"T4781","obj":"T4782"},{"id":"R3046","pred":"relcl","subj":"T4782","obj":"T4780"},{"id":"R3047","pred":"prep","subj":"T4783","obj":"T4782"},{"id":"R3048","pred":"det","subj":"T4784","obj":"T4785"},{"id":"R3049","pred":"pobj","subj":"T4785","obj":"T4783"},{"id":"R3050","pred":"cc","subj":"T4786","obj":"T4785"},{"id":"R3051","pred":"conj","subj":"T4787","obj":"T4785"},{"id":"R3052","pred":"prep","subj":"T4788","obj":"T4785"},{"id":"R3053","pred":"pobj","subj":"T4789","obj":"T4788"},{"id":"R3054","pred":"acl","subj":"T4790","obj":"T4789"},{"id":"R3055","pred":"prep","subj":"T4791","obj":"T4790"},{"id":"R3056","pred":"det","subj":"T4792","obj":"T4793"},{"id":"R3057","pred":"pobj","subj":"T4793","obj":"T4791"},{"id":"R3058","pred":"compound","subj":"T4794","obj":"T4793"},{"id":"R3059","pred":"punct","subj":"T4795","obj":"T4744"},{"id":"R3060","pred":"nsubj","subj":"T4797","obj":"T4798"},{"id":"R3061","pred":"advmod","subj":"T4799","obj":"T4798"},{"id":"R3062","pred":"amod","subj":"T4800","obj":"T4801"},{"id":"R3063","pred":"dobj","subj":"T4801","obj":"T4798"},{"id":"R3064","pred":"prep","subj":"T4802","obj":"T4798"},{"id":"R3065","pred":"det","subj":"T4803","obj":"T4804"},{"id":"R3066","pred":"pobj","subj":"T4804","obj":"T4802"},{"id":"R3067","pred":"amod","subj":"T4805","obj":"T4804"},{"id":"R3068","pred":"prep","subj":"T4806","obj":"T4804"},{"id":"R3069","pred":"det","subj":"T4807","obj":"T4808"},{"id":"R3070","pred":"pobj","subj":"T4808","obj":"T4806"},{"id":"R3071","pred":"amod","subj":"T4809","obj":"T4808"},{"id":"R3072","pred":"punct","subj":"T4810","obj":"T4811"},{"id":"R3073","pred":"parataxis","subj":"T4811","obj":"T4798"},{"id":"R3074","pred":"dep","subj":"T4812","obj":"T4811"},{"id":"R3075","pred":"nummod","subj":"T4813","obj":"T4812"},{"id":"R3076","pred":"punct","subj":"T4814","obj":"T4811"},{"id":"R3077","pred":"punct","subj":"T4815","obj":"T4811"},{"id":"R3078","pred":"punct","subj":"T4816","obj":"T4798"},{"id":"R3079","pred":"nsubj","subj":"T4818","obj":"T4819"},{"id":"R3080","pred":"prep","subj":"T4820","obj":"T4818"},{"id":"R3081","pred":"compound","subj":"T4821","obj":"T4822"},{"id":"R3082","pred":"pobj","subj":"T4822","obj":"T4820"},{"id":"R3083","pred":"prep","subj":"T4823","obj":"T4818"},{"id":"R3084","pred":"compound","subj":"T4824","obj":"T4825"},{"id":"R3085","pred":"compound","subj":"T4825","obj":"T4827"},{"id":"R3086","pred":"punct","subj":"T4826","obj":"T4825"},{"id":"R3087","pred":"compound","subj":"T4827","obj":"T4829"},{"id":"R3088","pred":"punct","subj":"T4828","obj":"T4827"},{"id":"R3089","pred":"pobj","subj":"T4829","obj":"T4823"},{"id":"R3090","pred":"compound","subj":"T4830","obj":"T4829"},{"id":"R3091","pred":"mark","subj":"T4831","obj":"T4832"},{"id":"R3092","pred":"ccomp","subj":"T4832","obj":"T4819"},{"id":"R3093","pred":"npadvmod","subj":"T4833","obj":"T4834"},{"id":"R3094","pred":"amod","subj":"T4834","obj":"T4836"},{"id":"R3095","pred":"punct","subj":"T4835","obj":"T4834"},{"id":"R3096","pred":"nsubj","subj":"T4836","obj":"T4832"},{"id":"R3097","pred":"aux","subj":"T4837","obj":"T4832"},{"id":"R3098","pred":"prep","subj":"T4838","obj":"T4832"},{"id":"R3099","pred":"pobj","subj":"T4839","obj":"T4838"},{"id":"R3100","pred":"prep","subj":"T4840","obj":"T4832"},{"id":"R3101","pred":"det","subj":"T4841","obj":"T4842"},{"id":"R3102","pred":"pobj","subj":"T4842","obj":"T4840"},{"id":"R3103","pred":"amod","subj":"T4843","obj":"T4844"},{"id":"R3104","pred":"amod","subj":"T4844","obj":"T4842"},{"id":"R3105","pred":"punct","subj":"T4845","obj":"T4844"},{"id":"R3106","pred":"punct","subj":"T4846","obj":"T4840"},{"id":"R3107","pred":"cc","subj":"T4847","obj":"T4840"},{"id":"R3108","pred":"conj","subj":"T4848","obj":"T4840"},{"id":"R3109","pred":"det","subj":"T4849","obj":"T4850"},{"id":"R3110","pred":"pobj","subj":"T4850","obj":"T4848"},{"id":"R3111","pred":"amod","subj":"T4851","obj":"T4850"},{"id":"R3112","pred":"prep","subj":"T4852","obj":"T4850"},{"id":"R3113","pred":"det","subj":"T4853","obj":"T4854"},{"id":"R3114","pred":"pobj","subj":"T4854","obj":"T4852"},{"id":"R3115","pred":"amod","subj":"T4855","obj":"T4854"},{"id":"R3116","pred":"cc","subj":"T4856","obj":"T4855"},{"id":"R3117","pred":"conj","subj":"T4857","obj":"T4855"},{"id":"R3118","pred":"punct","subj":"T4858","obj":"T4855"},{"id":"R3119","pred":"cc","subj":"T4859","obj":"T4855"},{"id":"R3120","pred":"neg","subj":"T4860","obj":"T4859"},{"id":"R3121","pred":"conj","subj":"T4861","obj":"T4855"},{"id":"R3122","pred":"punct","subj":"T4862","obj":"T4854"},{"id":"R3123","pred":"punct","subj":"T4863","obj":"T4819"},{"id":"R3124","pred":"prep","subj":"T4865","obj":"T4866"},{"id":"R3125","pred":"pobj","subj":"T4867","obj":"T4865"},{"id":"R3126","pred":"punct","subj":"T4868","obj":"T4866"},{"id":"R3127","pred":"det","subj":"T4869","obj":"T4870"},{"id":"R3128","pred":"nsubjpass","subj":"T4870","obj":"T4866"},{"id":"R3129","pred":"prep","subj":"T4871","obj":"T4870"},{"id":"R3130","pred":"pobj","subj":"T4872","obj":"T4871"},{"id":"R3131","pred":"cc","subj":"T4873","obj":"T4872"},{"id":"R3132","pred":"conj","subj":"T4874","obj":"T4872"},{"id":"R3133","pred":"prep","subj":"T4875","obj":"T4872"},{"id":"R3134","pred":"pobj","subj":"T4876","obj":"T4875"},{"id":"R3135","pred":"auxpass","subj":"T4877","obj":"T4866"},{"id":"R3136","pred":"advmod","subj":"T4878","obj":"T4866"},{"id":"R3137","pred":"advmod","subj":"T4879","obj":"T4866"},{"id":"R3138","pred":"prep","subj":"T4880","obj":"T4866"},{"id":"R3139","pred":"det","subj":"T4881","obj":"T4882"},{"id":"R3140","pred":"pobj","subj":"T4882","obj":"T4880"},{"id":"R3141","pred":"amod","subj":"T4883","obj":"T4882"},{"id":"R3142","pred":"prep","subj":"T4884","obj":"T4882"},{"id":"R3143","pred":"det","subj":"T4885","obj":"T4886"},{"id":"R3144","pred":"pobj","subj":"T4886","obj":"T4884"},{"id":"R3145","pred":"amod","subj":"T4887","obj":"T4886"},{"id":"R3146","pred":"punct","subj":"T4888","obj":"T4889"},{"id":"R3147","pred":"parataxis","subj":"T4889","obj":"T4866"},{"id":"R3148","pred":"nummod","subj":"T4890","obj":"T4889"},{"id":"R3149","pred":"punct","subj":"T4891","obj":"T4889"},{"id":"R3150","pred":"punct","subj":"T4892","obj":"T4866"},{"id":"R3151","pred":"amod","subj":"T4894","obj":"T4895"},{"id":"R3152","pred":"nmod","subj":"T4895","obj":"T4904"},{"id":"R3153","pred":"compound","subj":"T4896","obj":"T4897"},{"id":"R3154","pred":"npadvmod","subj":"T4897","obj":"T4898"},{"id":"R3155","pred":"amod","subj":"T4898","obj":"T4895"},{"id":"R3156","pred":"punct","subj":"T4899","obj":"T4898"},{"id":"R3157","pred":"nmod","subj":"T4900","obj":"T4901"},{"id":"R3158","pred":"nmod","subj":"T4901","obj":"T4895"},{"id":"R3159","pred":"nmod","subj":"T4902","obj":"T4903"},{"id":"R3160","pred":"nmod","subj":"T4903","obj":"T4895"},{"id":"R3161","pred":"nsubj","subj":"T4904","obj":"T4908"},{"id":"R3162","pred":"punct","subj":"T4905","obj":"T4906"},{"id":"R3163","pred":"appos","subj":"T4906","obj":"T4895"},{"id":"R3164","pred":"punct","subj":"T4907","obj":"T4906"},{"id":"R3165","pred":"prep","subj":"T4909","obj":"T4904"},{"id":"R3166","pred":"amod","subj":"T4910","obj":"T4911"},{"id":"R3167","pred":"pobj","subj":"T4911","obj":"T4909"},{"id":"R3168","pred":"prep","subj":"T4912","obj":"T4911"},{"id":"R3169","pred":"det","subj":"T4913","obj":"T4914"},{"id":"R3170","pred":"pobj","subj":"T4914","obj":"T4912"},{"id":"R3171","pred":"amod","subj":"T4915","obj":"T4914"},{"id":"R3172","pred":"cc","subj":"T4916","obj":"T4915"},{"id":"R3173","pred":"conj","subj":"T4917","obj":"T4915"},{"id":"R3174","pred":"punct","subj":"T4918","obj":"T4919"},{"id":"R3175","pred":"parataxis","subj":"T4919","obj":"T4914"},{"id":"R3176","pred":"nummod","subj":"T4920","obj":"T4919"},{"id":"R3177","pred":"cc","subj":"T4921","obj":"T4919"},{"id":"R3178","pred":"conj","subj":"T4922","obj":"T4919"},{"id":"R3179","pred":"punct","subj":"T4923","obj":"T4919"},{"id":"R3180","pred":"cc","subj":"T4924","obj":"T4914"},{"id":"R3181","pred":"det","subj":"T4925","obj":"T4926"},{"id":"R3182","pred":"conj","subj":"T4926","obj":"T4914"},{"id":"R3183","pred":"amod","subj":"T4927","obj":"T4926"},{"id":"R3184","pred":"acl","subj":"T4928","obj":"T4914"},{"id":"R3185","pred":"dobj","subj":"T4929","obj":"T4928"},{"id":"R3186","pred":"det","subj":"T4930","obj":"T4931"},{"id":"R3187","pred":"dobj","subj":"T4931","obj":"T4908"},{"id":"R3188","pred":"amod","subj":"T4932","obj":"T4931"},{"id":"R3189","pred":"prep","subj":"T4933","obj":"T4931"},{"id":"R3190","pred":"amod","subj":"T4934","obj":"T4935"},{"id":"R3191","pred":"pobj","subj":"T4935","obj":"T4933"},{"id":"R3192","pred":"prep","subj":"T4936","obj":"T4908"},{"id":"R3193","pred":"det","subj":"T4937","obj":"T4938"},{"id":"R3194","pred":"pobj","subj":"T4938","obj":"T4936"},{"id":"R3195","pred":"advmod","subj":"T4939","obj":"T4940"},{"id":"R3196","pred":"relcl","subj":"T4940","obj":"T4938"},{"id":"R3197","pred":"amod","subj":"T4941","obj":"T4942"},{"id":"R3198","pred":"nsubjpass","subj":"T4942","obj":"T4940"},{"id":"R3199","pred":"auxpass","subj":"T4943","obj":"T4940"},{"id":"R3200","pred":"prep","subj":"T4944","obj":"T4940"},{"id":"R3201","pred":"det","subj":"T4945","obj":"T4946"},{"id":"R3202","pred":"pobj","subj":"T4946","obj":"T4944"},{"id":"R3203","pred":"compound","subj":"T4947","obj":"T4946"},{"id":"R3204","pred":"punct","subj":"T4948","obj":"T4908"},{"id":"R3205","pred":"nsubjpass","subj":"T4950","obj":"T4951"},{"id":"R3206","pred":"prep","subj":"T4952","obj":"T4950"},{"id":"R3207","pred":"amod","subj":"T4953","obj":"T4954"},{"id":"R3208","pred":"npadvmod","subj":"T4954","obj":"T4956"},{"id":"R3209","pred":"compound","subj":"T4955","obj":"T4954"},{"id":"R3210","pred":"amod","subj":"T4956","obj":"T4958"},{"id":"R3211","pred":"punct","subj":"T4957","obj":"T4956"},{"id":"R3212","pred":"pobj","subj":"T4958","obj":"T4952"},{"id":"R3213","pred":"amod","subj":"T4959","obj":"T4958"},{"id":"R3214","pred":"auxpass","subj":"T4960","obj":"T4951"},{"id":"R3215","pred":"advmod","subj":"T4961","obj":"T4951"},{"id":"R3216","pred":"prep","subj":"T4962","obj":"T4951"},{"id":"R3217","pred":"det","subj":"T4963","obj":"T4964"},{"id":"R3218","pred":"pobj","subj":"T4964","obj":"T4962"},{"id":"R3219","pred":"punct","subj":"T4965","obj":"T4966"},{"id":"R3220","pred":"parataxis","subj":"T4966","obj":"T4951"},{"id":"R3221","pred":"nummod","subj":"T4967","obj":"T4966"},{"id":"R3222","pred":"punct","subj":"T4968","obj":"T4966"},{"id":"R3223","pred":"punct","subj":"T4969","obj":"T4951"},{"id":"R3224","pred":"amod","subj":"T4971","obj":"T4972"},{"id":"R3225","pred":"nsubj","subj":"T4972","obj":"T4973"},{"id":"R3226","pred":"acl","subj":"T4974","obj":"T4972"},{"id":"R3227","pred":"prep","subj":"T4975","obj":"T4974"},{"id":"R3228","pred":"det","subj":"T4976","obj":"T4977"},{"id":"R3229","pred":"pobj","subj":"T4977","obj":"T4975"},{"id":"R3230","pred":"amod","subj":"T4978","obj":"T4977"},{"id":"R3231","pred":"prep","subj":"T4979","obj":"T4977"},{"id":"R3232","pred":"det","subj":"T4980","obj":"T4981"},{"id":"R3233","pred":"pobj","subj":"T4981","obj":"T4979"},{"id":"R3234","pred":"amod","subj":"T4982","obj":"T4981"},{"id":"R3235","pred":"cc","subj":"T4983","obj":"T4982"},{"id":"R3236","pred":"conj","subj":"T4984","obj":"T4982"},{"id":"R3237","pred":"prep","subj":"T4985","obj":"T4974"},{"id":"R3238","pred":"pobj","subj":"T4986","obj":"T4985"},{"id":"R3239","pred":"advmod","subj":"T4987","obj":"T4973"},{"id":"R3240","pred":"dobj","subj":"T4988","obj":"T4973"},{"id":"R3241","pred":"prep","subj":"T4989","obj":"T4973"},{"id":"R3242","pred":"compound","subj":"T4990","obj":"T4991"},{"id":"R3243","pred":"compound","subj":"T4991","obj":"T4993"},{"id":"R3244","pred":"punct","subj":"T4992","obj":"T4991"},{"id":"R3245","pred":"compound","subj":"T4993","obj":"T4995"},{"id":"R3246","pred":"punct","subj":"T4994","obj":"T4993"},{"id":"R3247","pred":"pobj","subj":"T4995","obj":"T4989"},{"id":"R3248","pred":"compound","subj":"T4996","obj":"T4995"},{"id":"R3249","pred":"punct","subj":"T4997","obj":"T4998"},{"id":"R3250","pred":"parataxis","subj":"T4998","obj":"T4973"},{"id":"R3251","pred":"nummod","subj":"T4999","obj":"T4998"},{"id":"R3252","pred":"punct","subj":"T5000","obj":"T4998"},{"id":"R3253","pred":"punct","subj":"T5001","obj":"T4973"},{"id":"R3254","pred":"det","subj":"T5003","obj":"T5004"},{"id":"R3255","pred":"nsubj","subj":"T5004","obj":"T5005"},{"id":"R3256","pred":"mark","subj":"T5006","obj":"T5007"},{"id":"R3257","pred":"advcl","subj":"T5007","obj":"T5005"},{"id":"R3258","pred":"amod","subj":"T5008","obj":"T5009"},{"id":"R3259","pred":"nsubj","subj":"T5009","obj":"T5007"},{"id":"R3260","pred":"prep","subj":"T5010","obj":"T5009"},{"id":"R3261","pred":"compound","subj":"T5011","obj":"T5012"},{"id":"R3262","pred":"pobj","subj":"T5012","obj":"T5010"},{"id":"R3263","pred":"compound","subj":"T5013","obj":"T5012"},{"id":"R3264","pred":"amod","subj":"T5014","obj":"T5015"},{"id":"R3265","pred":"dobj","subj":"T5015","obj":"T5007"},{"id":"R3266","pred":"compound","subj":"T5016","obj":"T5015"},{"id":"R3267","pred":"prep","subj":"T5017","obj":"T5007"},{"id":"R3268","pred":"amod","subj":"T5018","obj":"T5019"},{"id":"R3269","pred":"pobj","subj":"T5019","obj":"T5017"},{"id":"R3270","pred":"punct","subj":"T5020","obj":"T5007"},{"id":"R3271","pred":"cc","subj":"T5021","obj":"T5007"},{"id":"R3272","pred":"mark","subj":"T5022","obj":"T5023"},{"id":"R3273","pred":"conj","subj":"T5023","obj":"T5007"},{"id":"R3274","pred":"det","subj":"T5024","obj":"T5025"},{"id":"R3275","pred":"nsubj","subj":"T5025","obj":"T5023"},{"id":"R3276","pred":"amod","subj":"T5026","obj":"T5025"},{"id":"R3277","pred":"cc","subj":"T5027","obj":"T5023"},{"id":"R3278","pred":"conj","subj":"T5028","obj":"T5023"},{"id":"R3279","pred":"prep","subj":"T5029","obj":"T5028"},{"id":"R3280","pred":"det","subj":"T5030","obj":"T5031"},{"id":"R3281","pred":"pobj","subj":"T5031","obj":"T5029"},{"id":"R3282","pred":"prep","subj":"T5032","obj":"T5031"},{"id":"R3283","pred":"compound","subj":"T5033","obj":"T5034"},{"id":"R3284","pred":"pobj","subj":"T5034","obj":"T5032"},{"id":"R3285","pred":"punct","subj":"T5035","obj":"T5005"}],"text":"Interdigital mesenchyme is normally eliminated by apoptosis during embryonic development, a process that can be stimulated by BMP beads, inhibited by Noggin, or blocked by overexpression of dominant-negative BMP receptors (Garcia-Martinez et al. 1993; Yokouchi et al. 1996; Zou and Niswander 1996; Guha et al. 2002). Limbs of Gdf5-Cre/Bmpr1afloxP mutant embryos showed obvious retention of interdigital webbing between the first and second, but not other, digits of E14.5 forelimbs (Figure 2A and 2B), a pattern that corresponds to the presence or absence of webbing seen in the adult limb. They also showed excess tissue on the posterior margin of the fifth digit (Figure 2B, arrow). Analysis of LACZ expression in Gdf5-Cre/R26R reporter embryos showed that Cre-mediated recombination has occurred by E13.5 in the metacarpal-phalangeal joints, and in the interdigital region between the first and second, but not other, digits. In addition, a domain of recombination and expression of LACZ is also reproducibly seen in the posterior half of the fifth digit (Figure 2C). Terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick end labeling (TUNEL) staining of interdigital mesenchyme between the first and second digits (Figure 2D and 2E) and the fifth digit flanking mesenchyme showed a decreased number of dying cells in the regions where excess tissue is retained in the mutant limbs. Numbers of phosphorylated histone H3-labeled proliferating cells were also elevated in these regions (Figure 2F). Most cells found in the webbed region between the first and second digits at E15.5 strongly expressed LACZ in Gdf5-Cre/Bmpr1afloxP mutant embryos (Figure 2H). These data suggest that regional loss of BMPR1A receptor signaling blocks programmed cell death in interdigital mesenchyme, and that the recombined cells survive and proliferate in the absence of BMPR1A signaling."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T4595","span":{"begin":0,"end":23},"obj":"UBERON:0009585"},{"id":"T4596","span":{"begin":36,"end":46},"obj":"GO_EXT:killing"},{"id":"T4597","span":{"begin":50,"end":59},"obj":"GO:0006915"},{"id":"T4598","span":{"begin":67,"end":76},"obj":"UBERON:0000922"},{"id":"T4599","span":{"begin":67,"end":88},"obj":"GO:0009790"},{"id":"T4600","span":{"begin":126,"end":129},"obj":"PR_EXT:000000034"},{"id":"T4601","span":{"begin":150,"end":156},"obj":"PR_EXT:000000021"},{"id":"T4602","span":{"begin":176,"end":186},"obj":"GO:0010467"},{"id":"T4603","span":{"begin":208,"end":211},"obj":"PR_EXT:000000034"},{"id":"T4604","span":{"begin":208,"end":221},"obj":"GO_EXT:0098821"},{"id":"T4605","span":{"begin":317,"end":322},"obj":"UBERON:0002101"},{"id":"T4606","span":{"begin":326,"end":330},"obj":"PR_EXT:000000281"},{"id":"T4607","span":{"begin":335,"end":341},"obj":"PR_EXT:000000035"},{"id":"T4608","span":{"begin":341,"end":346},"obj":"SO:0000359"},{"id":"T4609","span":{"begin":347,"end":353},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T4611","span":{"begin":390,"end":410},"obj":"UBERON:0006015"},{"id":"T4612","span":{"begin":423,"end":428},"obj":"_FRAGMENT"},{"id":"T4613","span":{"begin":456,"end":465},"obj":"_FRAGMENT"},{"id":"T4614","span":{"begin":472,"end":481},"obj":"UBERON:0001463"},{"id":"T4615","span":{"begin":433,"end":439},"obj":"_FRAGMENT"},{"id":"T4616","span":{"begin":472,"end":481},"obj":"UBERON:0003622"},{"id":"T4617","span":{"begin":579,"end":584},"obj":"UBERON:0007023"},{"id":"T4618","span":{"begin":585,"end":589},"obj":"UBERON:0002101"},{"id":"T4619","span":{"begin":615,"end":621},"obj":"UBERON:0000479"},{"id":"T4620","span":{"begin":653,"end":664},"obj":"UBERON:0006052"},{"id":"T4621","span":{"begin":697,"end":701},"obj":"PR_EXT:000033987"},{"id":"T4622","span":{"begin":702,"end":712},"obj":"GO:0010467"},{"id":"T4623","span":{"begin":716,"end":720},"obj":"PR_EXT:000000281"},{"id":"T4624","span":{"begin":739,"end":746},"obj":"UBERON:0000922"},{"id":"T4625","span":{"begin":772,"end":785},"obj":"GO_SO_EXT:sequence_rearrangement_process"},{"id":"T4626","span":{"begin":815,"end":843},"obj":"UBERON:0003695"},{"id":"T4627","span":{"begin":856,"end":883},"obj":"_FRAGMENT"},{"id":"T4628","span":{"begin":888,"end":904},"obj":"_FRAGMENT"},{"id":"T4629","span":{"begin":921,"end":927},"obj":"UBERON:0006016"},{"id":"T4630","span":{"begin":954,"end":967},"obj":"GO_SO_EXT:sequence_rearrangement_process"},{"id":"T4631","span":{"begin":972,"end":982},"obj":"GO:0010467"},{"id":"T4632","span":{"begin":986,"end":990},"obj":"PR_EXT:000033987"},{"id":"T4633","span":{"begin":1046,"end":1057},"obj":"UBERON:0006052"},{"id":"T4634","span":{"begin":1071,"end":1108},"obj":"GO_PR_EXT:DNA_nucleotidylexotransferase"},{"id":"T4635","span":{"begin":1080,"end":1096},"obj":"CHEBI_SO_EXT:deoxyribonucleotide"},{"id":"T4636","span":{"begin":1118,"end":1143},"obj":"CHEBI_EXT:dUTP"},{"id":"T4637","span":{"begin":1153,"end":1161},"obj":"CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process"},{"id":"T4638","span":{"begin":1182,"end":1213},"obj":"_FRAGMENT"},{"id":"T4639","span":{"begin":1218,"end":1241},"obj":"UBERON:0009596"},{"id":"T4640","span":{"begin":1269,"end":1280},"obj":"UBERON:0006052"},{"id":"T4641","span":{"begin":1290,"end":1300},"obj":"UBERON:0003104"},{"id":"T4642","span":{"begin":1330,"end":1335},"obj":"GO:0016265"},{"id":"T4643","span":{"begin":1336,"end":1341},"obj":"CL_GO_EXT:cell"},{"id":"T4644","span":{"begin":1370,"end":1376},"obj":"UBERON:0000479"},{"id":"T4645","span":{"begin":1396,"end":1402},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T4646","span":{"begin":1403,"end":1408},"obj":"UBERON:0002101"},{"id":"T4647","span":{"begin":1421,"end":1435},"obj":"GO_PATO_EXT:phosphorylation_process_or_quality"},{"id":"T4648","span":{"begin":1436,"end":1443},"obj":"CHEBI:15358"},{"id":"T4649","span":{"begin":1436,"end":1446},"obj":"PR_EXT:000027594"},{"id":"T4650","span":{"begin":1447,"end":1454},"obj":"CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process"},{"id":"T4651","span":{"begin":1455,"end":1468},"obj":"GO:0008283"},{"id":"T4652","span":{"begin":1469,"end":1474},"obj":"CL_GO_EXT:cell"},{"id":"T4653","span":{"begin":1529,"end":1534},"obj":"CL_GO_EXT:cell"},{"id":"T4654","span":{"begin":1548,"end":1569},"obj":"_FRAGMENT"},{"id":"T4655","span":{"begin":1591,"end":1597},"obj":"UBERON:0006015"},{"id":"T4656","span":{"begin":1574,"end":1579},"obj":"_FRAGMENT"},{"id":"T4657","span":{"begin":1591,"end":1597},"obj":"UBERON:0006048"},{"id":"T4658","span":{"begin":1584,"end":1597},"obj":"UBERON:0006049"},{"id":"T4659","span":{"begin":1616,"end":1625},"obj":"GO:0010467"},{"id":"T4660","span":{"begin":1626,"end":1630},"obj":"PR_EXT:000033987"},{"id":"T4661","span":{"begin":1634,"end":1638},"obj":"PR_EXT:000000281"},{"id":"T4662","span":{"begin":1643,"end":1649},"obj":"PR_EXT:000000035"},{"id":"T4663","span":{"begin":1649,"end":1654},"obj":"SO:0000359"},{"id":"T4664","span":{"begin":1655,"end":1661},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T4665","span":{"begin":1662,"end":1669},"obj":"UBERON:0000922"},{"id":"T4666","span":{"begin":1724,"end":1730},"obj":"PR_EXT:000000035"},{"id":"T4667","span":{"begin":1731,"end":1739},"obj":"GO_EXT:0004872"},{"id":"T4668","span":{"begin":1740,"end":1749},"obj":"GO_EXT:cell_communication_or_signaling_or_signal_transduction"},{"id":"T4669","span":{"begin":1757,"end":1778},"obj":"GO:0012501"},{"id":"T4670","span":{"begin":1768,"end":1772},"obj":"CL_GO_EXT:cell"},{"id":"T4671","span":{"begin":1782,"end":1805},"obj":"UBERON:0009585"},{"id":"T4672","span":{"begin":1820,"end":1830},"obj":"GO_SO_EXT:sequence_rearrangement_process"},{"id":"T4673","span":{"begin":1831,"end":1836},"obj":"CL_GO_EXT:cell"},{"id":"T4674","span":{"begin":1849,"end":1860},"obj":"GO:0008283"},{"id":"T4675","span":{"begin":1879,"end":1885},"obj":"PR_EXT:000000035"},{"id":"T4676","span":{"begin":1886,"end":1895},"obj":"GO_EXT:cell_communication_or_signaling_or_signal_transduction"},{"id":"T4610","span":{"begin":354,"end":361},"obj":"UBERON:0000922"}],"relations":[{"id":"R2937","pred":"_lexicallyChainedTo","subj":"T4613","obj":"T4612"},{"id":"R2938","pred":"_lexicallyChainedTo","subj":"T4613","obj":"T4615"},{"id":"R2939","pred":"_lexicallyChainedTo","subj":"T4614","obj":"T4613"},{"id":"R2940","pred":"_lexicallyChainedTo","subj":"T4616","obj":"T4613"},{"id":"R2941","pred":"_lexicallyChainedTo","subj":"T4628","obj":"T4627"},{"id":"R2942","pred":"_lexicallyChainedTo","subj":"T4629","obj":"T4628"},{"id":"R2943","pred":"_lexicallyChainedTo","subj":"T4639","obj":"T4638"},{"id":"R2944","pred":"_lexicallyChainedTo","subj":"T4655","obj":"T4654"},{"id":"R2945","pred":"_lexicallyChainedTo","subj":"T4657","obj":"T4656"}],"text":"Interdigital mesenchyme is normally eliminated by apoptosis during embryonic development, a process that can be stimulated by BMP beads, inhibited by Noggin, or blocked by overexpression of dominant-negative BMP receptors (Garcia-Martinez et al. 1993; Yokouchi et al. 1996; Zou and Niswander 1996; Guha et al. 2002). Limbs of Gdf5-Cre/Bmpr1afloxP mutant embryos showed obvious retention of interdigital webbing between the first and second, but not other, digits of E14.5 forelimbs (Figure 2A and 2B), a pattern that corresponds to the presence or absence of webbing seen in the adult limb. They also showed excess tissue on the posterior margin of the fifth digit (Figure 2B, arrow). Analysis of LACZ expression in Gdf5-Cre/R26R reporter embryos showed that Cre-mediated recombination has occurred by E13.5 in the metacarpal-phalangeal joints, and in the interdigital region between the first and second, but not other, digits. In addition, a domain of recombination and expression of LACZ is also reproducibly seen in the posterior half of the fifth digit (Figure 2C). Terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick end labeling (TUNEL) staining of interdigital mesenchyme between the first and second digits (Figure 2D and 2E) and the fifth digit flanking mesenchyme showed a decreased number of dying cells in the regions where excess tissue is retained in the mutant limbs. Numbers of phosphorylated histone H3-labeled proliferating cells were also elevated in these regions (Figure 2F). Most cells found in the webbed region between the first and second digits at E15.5 strongly expressed LACZ in Gdf5-Cre/Bmpr1afloxP mutant embryos (Figure 2H). These data suggest that regional loss of BMPR1A receptor signaling blocks programmed cell death in interdigital mesenchyme, and that the recombined cells survive and proliferate in the absence of BMPR1A signaling."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T4535","span":{"begin":0,"end":23},"obj":"UBERON:0009585"},{"id":"T4536","span":{"begin":50,"end":59},"obj":"GO:0006915"},{"id":"T4537","span":{"begin":67,"end":76},"obj":"UBERON:0000922"},{"id":"T4538","span":{"begin":67,"end":88},"obj":"GO:0009790"},{"id":"T4539","span":{"begin":126,"end":129},"obj":"PR:000000034"},{"id":"T4540","span":{"begin":150,"end":156},"obj":"PR:000000021"},{"id":"T4541","span":{"begin":176,"end":186},"obj":"GO:0010467"},{"id":"T4542","span":{"begin":208,"end":211},"obj":"PR:000000034"},{"id":"T4543","span":{"begin":317,"end":322},"obj":"UBERON:0002101"},{"id":"T4544","span":{"begin":326,"end":330},"obj":"PR:000000281"},{"id":"T4545","span":{"begin":335,"end":341},"obj":"PR:000000035"},{"id":"T4546","span":{"begin":341,"end":346},"obj":"SO:0000359"},{"id":"T4547","span":{"begin":354,"end":361},"obj":"UBERON:0000922"},{"id":"T4548","span":{"begin":390,"end":410},"obj":"UBERON:0006015"},{"id":"T4549","span":{"begin":423,"end":428},"obj":"_FRAGMENT"},{"id":"T4550","span":{"begin":456,"end":465},"obj":"_FRAGMENT"},{"id":"T4551","span":{"begin":472,"end":481},"obj":"UBERON:0001463"},{"id":"T4552","span":{"begin":433,"end":439},"obj":"_FRAGMENT"},{"id":"T4553","span":{"begin":472,"end":481},"obj":"UBERON:0003622"},{"id":"T4554","span":{"begin":579,"end":584},"obj":"UBERON:0007023"},{"id":"T4555","span":{"begin":585,"end":589},"obj":"UBERON:0002101"},{"id":"T4556","span":{"begin":615,"end":621},"obj":"UBERON:0000479"},{"id":"T4557","span":{"begin":653,"end":664},"obj":"UBERON:0006052"},{"id":"T4558","span":{"begin":697,"end":701},"obj":"PR:000033987"},{"id":"T4559","span":{"begin":702,"end":712},"obj":"GO:0010467"},{"id":"T4560","span":{"begin":716,"end":720},"obj":"PR:000000281"},{"id":"T4561","span":{"begin":739,"end":746},"obj":"UBERON:0000922"},{"id":"T4562","span":{"begin":815,"end":843},"obj":"UBERON:0003695"},{"id":"T4563","span":{"begin":856,"end":883},"obj":"_FRAGMENT"},{"id":"T4564","span":{"begin":888,"end":904},"obj":"_FRAGMENT"},{"id":"T4565","span":{"begin":921,"end":927},"obj":"UBERON:0006016"},{"id":"T4566","span":{"begin":972,"end":982},"obj":"GO:0010467"},{"id":"T4567","span":{"begin":986,"end":990},"obj":"PR:000033987"},{"id":"T4568","span":{"begin":1046,"end":1057},"obj":"UBERON:0006052"},{"id":"T4569","span":{"begin":1182,"end":1213},"obj":"_FRAGMENT"},{"id":"T4570","span":{"begin":1218,"end":1241},"obj":"UBERON:0009596"},{"id":"T4571","span":{"begin":1269,"end":1280},"obj":"UBERON:0006052"},{"id":"T4572","span":{"begin":1290,"end":1300},"obj":"UBERON:0003104"},{"id":"T4573","span":{"begin":1330,"end":1335},"obj":"GO:0016265"},{"id":"T4574","span":{"begin":1370,"end":1376},"obj":"UBERON:0000479"},{"id":"T4575","span":{"begin":1403,"end":1408},"obj":"UBERON:0002101"},{"id":"T4576","span":{"begin":1436,"end":1443},"obj":"CHEBI:15358"},{"id":"T4577","span":{"begin":1436,"end":1446},"obj":"PR:000027594"},{"id":"T4578","span":{"begin":1455,"end":1468},"obj":"GO:0008283"},{"id":"T4579","span":{"begin":1548,"end":1569},"obj":"_FRAGMENT"},{"id":"T4580","span":{"begin":1591,"end":1597},"obj":"UBERON:0006015"},{"id":"T4581","span":{"begin":1574,"end":1579},"obj":"_FRAGMENT"},{"id":"T4582","span":{"begin":1591,"end":1597},"obj":"UBERON:0006048"},{"id":"T4583","span":{"begin":1584,"end":1597},"obj":"UBERON:0006049"},{"id":"T4584","span":{"begin":1616,"end":1625},"obj":"GO:0010467"},{"id":"T4585","span":{"begin":1626,"end":1630},"obj":"PR:000033987"},{"id":"T4586","span":{"begin":1634,"end":1638},"obj":"PR:000000281"},{"id":"T4587","span":{"begin":1643,"end":1649},"obj":"PR:000000035"},{"id":"T4588","span":{"begin":1649,"end":1654},"obj":"SO:0000359"},{"id":"T4589","span":{"begin":1662,"end":1669},"obj":"UBERON:0000922"},{"id":"T4590","span":{"begin":1724,"end":1730},"obj":"PR:000000035"},{"id":"T4591","span":{"begin":1757,"end":1778},"obj":"GO:0012501"},{"id":"T4592","span":{"begin":1782,"end":1805},"obj":"UBERON:0009585"},{"id":"T4593","span":{"begin":1849,"end":1860},"obj":"GO:0008283"},{"id":"T4594","span":{"begin":1879,"end":1885},"obj":"PR:000000035"}],"relations":[{"id":"R2928","pred":"_lexicallyChainedTo","subj":"T4550","obj":"T4549"},{"id":"R2929","pred":"_lexicallyChainedTo","subj":"T4550","obj":"T4552"},{"id":"R2930","pred":"_lexicallyChainedTo","subj":"T4551","obj":"T4550"},{"id":"R2931","pred":"_lexicallyChainedTo","subj":"T4553","obj":"T4550"},{"id":"R2932","pred":"_lexicallyChainedTo","subj":"T4564","obj":"T4563"},{"id":"R2933","pred":"_lexicallyChainedTo","subj":"T4565","obj":"T4564"},{"id":"R2934","pred":"_lexicallyChainedTo","subj":"T4570","obj":"T4569"},{"id":"R2935","pred":"_lexicallyChainedTo","subj":"T4580","obj":"T4579"},{"id":"R2936","pred":"_lexicallyChainedTo","subj":"T4582","obj":"T4581"}],"text":"Interdigital mesenchyme is normally eliminated by apoptosis during embryonic development, a process that can be stimulated by BMP beads, inhibited by Noggin, or blocked by overexpression of dominant-negative BMP receptors (Garcia-Martinez et al. 1993; Yokouchi et al. 1996; Zou and Niswander 1996; Guha et al. 2002). Limbs of Gdf5-Cre/Bmpr1afloxP mutant embryos showed obvious retention of interdigital webbing between the first and second, but not other, digits of E14.5 forelimbs (Figure 2A and 2B), a pattern that corresponds to the presence or absence of webbing seen in the adult limb. They also showed excess tissue on the posterior margin of the fifth digit (Figure 2B, arrow). Analysis of LACZ expression in Gdf5-Cre/R26R reporter embryos showed that Cre-mediated recombination has occurred by E13.5 in the metacarpal-phalangeal joints, and in the interdigital region between the first and second, but not other, digits. In addition, a domain of recombination and expression of LACZ is also reproducibly seen in the posterior half of the fifth digit (Figure 2C). Terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick end labeling (TUNEL) staining of interdigital mesenchyme between the first and second digits (Figure 2D and 2E) and the fifth digit flanking mesenchyme showed a decreased number of dying cells in the regions where excess tissue is retained in the mutant limbs. Numbers of phosphorylated histone H3-labeled proliferating cells were also elevated in these regions (Figure 2F). Most cells found in the webbed region between the first and second digits at E15.5 strongly expressed LACZ in Gdf5-Cre/Bmpr1afloxP mutant embryos (Figure 2H). These data suggest that regional loss of BMPR1A receptor signaling blocks programmed cell death in interdigital mesenchyme, and that the recombined cells survive and proliferate in the absence of BMPR1A signaling."}

{"project":"2_test","denotations":[{"id":"15492776-8270624-84887311","span":{"begin":246,"end":250},"obj":"8270624"},{"id":"15492776-9012494-84887312","span":{"begin":268,"end":272},"obj":"9012494"},{"id":"15492776-8614838-84887313","span":{"begin":292,"end":296},"obj":"8614838"},{"id":"15492776-12217322-84887314","span":{"begin":310,"end":314},"obj":"12217322"},{"id":"T80418","span":{"begin":246,"end":250},"obj":"8270624"},{"id":"T21180","span":{"begin":268,"end":272},"obj":"9012494"},{"id":"T13954","span":{"begin":292,"end":296},"obj":"8614838"},{"id":"T30694","span":{"begin":310,"end":314},"obj":"12217322"}],"text":"Interdigital mesenchyme is normally eliminated by apoptosis during embryonic development, a process that can be stimulated by BMP beads, inhibited by Noggin, or blocked by overexpression of dominant-negative BMP receptors (Garcia-Martinez et al. 1993; Yokouchi et al. 1996; Zou and Niswander 1996; Guha et al. 2002). Limbs of Gdf5-Cre/Bmpr1afloxP mutant embryos showed obvious retention of interdigital webbing between the first and second, but not other, digits of E14.5 forelimbs (Figure 2A and 2B), a pattern that corresponds to the presence or absence of webbing seen in the adult limb. They also showed excess tissue on the posterior margin of the fifth digit (Figure 2B, arrow). Analysis of LACZ expression in Gdf5-Cre/R26R reporter embryos showed that Cre-mediated recombination has occurred by E13.5 in the metacarpal-phalangeal joints, and in the interdigital region between the first and second, but not other, digits. In addition, a domain of recombination and expression of LACZ is also reproducibly seen in the posterior half of the fifth digit (Figure 2C). Terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick end labeling (TUNEL) staining of interdigital mesenchyme between the first and second digits (Figure 2D and 2E) and the fifth digit flanking mesenchyme showed a decreased number of dying cells in the regions where excess tissue is retained in the mutant limbs. Numbers of phosphorylated histone H3-labeled proliferating cells were also elevated in these regions (Figure 2F). Most cells found in the webbed region between the first and second digits at E15.5 strongly expressed LACZ in Gdf5-Cre/Bmpr1afloxP mutant embryos (Figure 2H). These data suggest that regional loss of BMPR1A receptor signaling blocks programmed cell death in interdigital mesenchyme, and that the recombined cells survive and proliferate in the absence of BMPR1A signaling."}