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next used the Gdf5-Cre system to test the role of BMP signaling during normal joint development. Gdf5-Cre transgenic mice were bred to animals carrying a conditional floxed allele of the Bmpr1a locus (Mishina et al. 2002), usually in the presence of the R26R reporter allele to facilitate simultaneous visualization of Cre-mediated recombination patterns (see typical cross in Figure 3). PCR amplification confirmed that a key exon of the Bmpr1a gene was deleted in mice that also carried the Gdf5-Cre transgene (unpublished data). Previous studies have shown that the recombined Bmpr1afloxP allele mimics a null allele of the Bmpr1a locus when transmitted through the germline (Mishina et al. 2002). The Gdf5-Cre/Bmpr1afloxP conditional knockout mice were viable and survived to adulthood, showing that the Gdf5-Cre driver can bypass the early embryonic lethality previously reported in animals with a null mutation in the Bmpr1a locus (Mishina et al. 1995)."}

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