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PMC:523229 / 17094-18056 JSONTXT

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craft-sa-dev

Id Subject Object Predicate Lexical cue
T3966 0-2 PRP denotes We
T3967 8-12 VBD denotes used
T3968 3-7 RB denotes next
T3969 13-16 DT denotes the
T3970 26-32 NN denotes system
T3971 17-21 NN denotes Gdf5
T3972 22-25 NN denotes Cre
T3973 21-22 HYPH denotes -
T3974 33-35 TO denotes to
T3975 36-40 VB denotes test
T3976 41-44 DT denotes the
T3977 45-49 NN denotes role
T3978 50-52 IN denotes of
T3979 53-56 NN denotes BMP
T3980 57-66 NN denotes signaling
T3981 67-73 IN denotes during
T3982 74-80 JJ denotes normal
T3983 87-98 NN denotes development
T3984 81-86 NN denotes joint
T3985 98-99 . denotes .
T3986 99-390 sentence denotes Gdf5-Cre transgenic mice were bred to animals carrying a conditional floxed allele of the Bmpr1a locus (Mishina et al. 2002), usually in the presence of the R26R reporter allele to facilitate simultaneous visualization of Cre-mediated recombination patterns (see typical cross in Figure 3).
T3987 100-104 NN denotes Gdf5
T3988 105-108 NN denotes Cre
T3989 104-105 HYPH denotes -
T3990 120-124 NNS denotes mice
T3991 109-119 JJ denotes transgenic
T3992 130-134 VBN denotes bred
T3993 125-129 VBD denotes were
T3994 135-137 IN denotes to
T3995 138-145 NNS denotes animals
T3996 146-154 VBG denotes carrying
T3997 155-156 DT denotes a
T3998 176-182 NN denotes allele
T3999 157-168 JJ denotes conditional
T4000 169-175 VBN denotes floxed
T4001 183-185 IN denotes of
T4002 186-189 DT denotes the
T4003 197-202 NN denotes locus
T4004 190-196 NN denotes Bmpr1a
T4005 203-204 -LRB- denotes (
T4006 204-211 NNP denotes Mishina
T4007 212-214 FW denotes et
T4008 215-218 FW denotes al.
T4009 219-223 CD denotes 2002
T4010 223-224 -RRB- denotes )
T4011 224-226 , denotes ,
T4012 226-233 RB denotes usually
T4013 234-236 IN denotes in
T4014 237-240 DT denotes the
T4015 241-249 NN denotes presence
T4016 250-252 IN denotes of
T4017 253-256 DT denotes the
T4018 271-277 NN denotes allele
T4019 257-261 NN denotes R26R
T4020 262-270 NN denotes reporter
T4021 278-280 TO denotes to
T4022 281-291 VB denotes facilitate
T4023 292-304 JJ denotes simultaneous
T4024 305-318 NN denotes visualization
T4025 319-321 IN denotes of
T4026 322-325 NN denotes Cre
T4027 326-334 VBN denotes mediated
T4028 325-326 HYPH denotes -
T4029 349-357 NNS denotes patterns
T4030 335-348 NN denotes recombination
T4031 358-359 -LRB- denotes (
T4032 359-362 VB denotes see
T4033 363-370 JJ denotes typical
T4034 371-376 NN denotes cross
T4035 377-379 IN denotes in
T4036 380-386 NN denotes Figure
T4037 387-388 CD denotes 3
T4038 388-389 -RRB- denotes )
T4039 389-390 . denotes .
T4040 390-534 sentence denotes PCR amplification confirmed that a key exon of the Bmpr1a gene was deleted in mice that also carried the Gdf5-Cre transgene (unpublished data).
T4041 391-394 NN denotes PCR
T4042 395-408 NN denotes amplification
T4043 409-418 VBD denotes confirmed
T4044 419-423 IN denotes that
T4045 458-465 VBN denotes deleted
T4046 424-425 DT denotes a
T4047 430-434 NN denotes exon
T4048 426-429 JJ denotes key
T4049 435-437 IN denotes of
T4050 438-441 DT denotes the
T4051 449-453 NN denotes gene
T4052 442-448 NN denotes Bmpr1a
T4053 454-457 VBD denotes was
T4054 466-468 IN denotes in
T4055 469-473 NNS denotes mice
T4056 474-478 WDT denotes that
T4057 484-491 VBD denotes carried
T4058 479-483 RB denotes also
T4059 492-495 DT denotes the
T4060 505-514 NN denotes transgene
T4061 496-500 NN denotes Gdf5
T4062 501-504 NN denotes Cre
T4063 500-501 HYPH denotes -
T4064 515-516 -LRB- denotes (
T4065 528-532 NNS denotes data
T4066 516-527 JJ denotes unpublished
T4067 532-533 -RRB- denotes )
T4068 533-534 . denotes .
T4069 534-703 sentence denotes Previous studies have shown that the recombined Bmpr1afloxP allele mimics a null allele of the Bmpr1a locus when transmitted through the germline (Mishina et al. 2002).
T4070 535-543 JJ denotes Previous
T4071 544-551 NNS denotes studies
T4072 557-562 VBN denotes shown
T4073 552-556 VBP denotes have
T4074 563-567 IN denotes that
T4075 602-608 VBZ denotes mimics
T4076 568-571 DT denotes the
T4077 595-601 NN denotes allele
T4078 572-582 JJ denotes recombined
T4079 583-594 NN denotes Bmpr1afloxP
T4080 609-610 DT denotes a
T4081 616-622 NN denotes allele
T4082 611-615 JJ denotes null
T4083 623-625 IN denotes of
T4084 626-629 DT denotes the
T4085 637-642 NN denotes locus
T4086 630-636 NN denotes Bmpr1a
T4087 643-647 WRB denotes when
T4088 648-659 VBN denotes transmitted
T4089 660-667 IN denotes through
T4090 668-671 DT denotes the
T4091 672-680 NN denotes germline
T4092 681-682 -LRB- denotes (
T4093 682-689 NNP denotes Mishina
T4094 690-692 FW denotes et
T4095 693-696 FW denotes al.
T4096 697-701 CD denotes 2002
T4097 701-702 -RRB- denotes )
T4098 702-703 . denotes .
T4099 703-962 sentence denotes The Gdf5-Cre/Bmpr1afloxP conditional knockout mice were viable and survived to adulthood, showing that the Gdf5-Cre driver can bypass the early embryonic lethality previously reported in animals with a null mutation in the Bmpr1a locus (Mishina et al. 1995).
T4100 704-707 DT denotes The
T4101 750-754 NNS denotes mice
T4102 708-712 NN denotes Gdf5
T4103 713-716 NN denotes Cre
T4104 712-713 HYPH denotes -
T4105 717-728 NN denotes Bmpr1afloxP
T4106 716-717 HYPH denotes /
T4107 741-749 NN denotes knockout
T4108 729-740 JJ denotes conditional
T4109 755-759 VBD denotes were
T4110 760-766 JJ denotes viable
T4111 767-770 CC denotes and
T4112 771-779 VBD denotes survived
T4113 780-782 IN denotes to
T4114 783-792 NN denotes adulthood
T4115 792-794 , denotes ,
T4116 794-801 VBG denotes showing
T4117 802-806 IN denotes that
T4118 831-837 VB denotes bypass
T4119 807-810 DT denotes the
T4120 820-826 NN denotes driver
T4121 811-815 NN denotes Gdf5
T4122 816-819 NN denotes Cre
T4123 815-816 HYPH denotes -
T4124 827-830 MD denotes can
T4125 838-841 DT denotes the
T4126 858-867 NN denotes lethality
T4127 842-847 JJ denotes early
T4128 848-857 JJ denotes embryonic
T4129 868-878 RB denotes previously
T4130 879-887 VBN denotes reported
T4131 888-890 IN denotes in
T4132 891-898 NNS denotes animals
T4133 899-903 IN denotes with
T4134 904-905 DT denotes a
T4135 911-919 NN denotes mutation
T4136 906-910 JJ denotes null
T4137 920-922 IN denotes in
T4138 923-926 DT denotes the
T4139 934-939 NN denotes locus
T4140 927-933 NN denotes Bmpr1a
T4141 940-941 -LRB- denotes (
T4142 941-948 NNP denotes Mishina
T4143 949-951 FW denotes et
T4144 952-955 FW denotes al.
T4145 956-960 CD denotes 1995
T4146 960-961 -RRB- denotes )
T4147 961-962 . denotes .
R2430 T3966 T3967 nsubj We,used
R2431 T3968 T3967 advmod next,used
R2432 T3969 T3970 det the,system
R2433 T3970 T3967 dobj system,used
R2434 T3971 T3972 compound Gdf5,Cre
R2435 T3972 T3970 compound Cre,system
R2436 T3973 T3972 punct -,Cre
R2437 T3974 T3975 aux to,test
R2438 T3975 T3967 advcl test,used
R2439 T3976 T3977 det the,role
R2440 T3977 T3975 dobj role,test
R2441 T3978 T3977 prep of,role
R2442 T3979 T3980 compound BMP,signaling
R2443 T3980 T3978 pobj signaling,of
R2444 T3981 T3975 prep during,test
R2445 T3982 T3983 amod normal,development
R2446 T3983 T3981 pobj development,during
R2447 T3984 T3983 compound joint,development
R2448 T3985 T3967 punct .,used
R2449 T3987 T3988 nmod Gdf5,Cre
R2450 T3988 T3990 nmod Cre,mice
R2451 T3989 T3988 punct -,Cre
R2452 T3990 T3992 nsubjpass mice,bred
R2453 T3991 T3990 amod transgenic,mice
R2454 T3993 T3992 auxpass were,bred
R2455 T3994 T3992 prep to,bred
R2456 T3995 T3994 pobj animals,to
R2457 T3996 T3995 acl carrying,animals
R2458 T3997 T3998 det a,allele
R2459 T3998 T3996 dobj allele,carrying
R2460 T3999 T3998 amod conditional,allele
R2461 T4000 T3998 amod floxed,allele
R2462 T4001 T3998 prep of,allele
R2463 T4002 T4003 det the,locus
R2464 T4003 T4001 pobj locus,of
R2465 T4004 T4003 compound Bmpr1a,locus
R2466 T4005 T4006 punct (,Mishina
R2467 T4006 T3992 meta Mishina,bred
R2468 T4007 T4006 nmod et,Mishina
R2469 T4008 T4006 nmod al.,Mishina
R2470 T4009 T4006 nummod 2002,Mishina
R2471 T4010 T4006 punct ),Mishina
R2472 T4011 T3992 punct ", ",bred
R2473 T4012 T4013 advmod usually,in
R2474 T4013 T3992 prep in,bred
R2475 T4014 T4015 det the,presence
R2476 T4015 T4013 pobj presence,in
R2477 T4016 T4015 prep of,presence
R2478 T4017 T4018 det the,allele
R2479 T4018 T4016 pobj allele,of
R2480 T4019 T4020 compound R26R,reporter
R2481 T4020 T4018 compound reporter,allele
R2482 T4021 T4022 aux to,facilitate
R2483 T4022 T3992 advcl facilitate,bred
R2484 T4023 T4024 amod simultaneous,visualization
R2485 T4024 T4022 dobj visualization,facilitate
R2486 T4025 T4024 prep of,visualization
R2487 T4026 T4027 npadvmod Cre,mediated
R2488 T4027 T4029 amod mediated,patterns
R2489 T4028 T4027 punct -,mediated
R2490 T4029 T4025 pobj patterns,of
R2491 T4030 T4029 compound recombination,patterns
R2492 T4031 T4032 punct (,see
R2493 T4032 T3992 parataxis see,bred
R2494 T4033 T4034 amod typical,cross
R2495 T4034 T4032 dobj cross,see
R2496 T4035 T4032 prep in,see
R2497 T4036 T4035 pobj Figure,in
R2498 T4037 T4036 nummod 3,Figure
R2499 T4038 T4032 punct ),see
R2500 T4039 T3992 punct .,bred
R2501 T4041 T4042 compound PCR,amplification
R2502 T4042 T4043 nsubj amplification,confirmed
R2503 T4044 T4045 mark that,deleted
R2504 T4045 T4043 ccomp deleted,confirmed
R2505 T4046 T4047 det a,exon
R2506 T4047 T4045 nsubjpass exon,deleted
R2507 T4048 T4047 amod key,exon
R2508 T4049 T4047 prep of,exon
R2509 T4050 T4051 det the,gene
R2510 T4051 T4049 pobj gene,of
R2511 T4052 T4051 compound Bmpr1a,gene
R2512 T4053 T4045 auxpass was,deleted
R2513 T4054 T4045 prep in,deleted
R2514 T4055 T4054 pobj mice,in
R2515 T4056 T4057 dep that,carried
R2516 T4057 T4055 relcl carried,mice
R2517 T4058 T4057 advmod also,carried
R2518 T4059 T4060 det the,transgene
R2519 T4060 T4057 dobj transgene,carried
R2520 T4061 T4062 compound Gdf5,Cre
R2521 T4062 T4060 compound Cre,transgene
R2522 T4063 T4062 punct -,Cre
R2523 T4064 T4065 punct (,data
R2524 T4065 T4045 meta data,deleted
R2525 T4066 T4065 amod unpublished,data
R2526 T4067 T4065 punct ),data
R2527 T4068 T4043 punct .,confirmed
R2528 T4070 T4071 amod Previous,studies
R2529 T4071 T4072 nsubj studies,shown
R2530 T4073 T4072 aux have,shown
R2531 T4074 T4075 mark that,mimics
R2532 T4075 T4072 ccomp mimics,shown
R2533 T4076 T4077 det the,allele
R2534 T4077 T4075 nsubj allele,mimics
R2535 T4078 T4077 amod recombined,allele
R2536 T4079 T4077 compound Bmpr1afloxP,allele
R2537 T4080 T4081 det a,allele
R2538 T4081 T4075 dobj allele,mimics
R2539 T4082 T4081 amod null,allele
R2540 T4083 T4081 prep of,allele
R2541 T4084 T4085 det the,locus
R2542 T4085 T4083 pobj locus,of
R2543 T4086 T4085 compound Bmpr1a,locus
R2544 T4087 T4088 advmod when,transmitted
R2545 T4088 T4075 advcl transmitted,mimics
R2546 T4089 T4088 prep through,transmitted
R2547 T4090 T4091 det the,germline
R2548 T4091 T4089 pobj germline,through
R2549 T4092 T4093 punct (,Mishina
R2550 T4093 T4072 meta Mishina,shown
R2551 T4094 T4093 nmod et,Mishina
R2552 T4095 T4093 nmod al.,Mishina
R2553 T4096 T4093 nummod 2002,Mishina
R2554 T4097 T4093 punct ),Mishina
R2555 T4098 T4072 punct .,shown
R2556 T4100 T4101 det The,mice
R2557 T4101 T4109 nsubj mice,were
R2558 T4102 T4103 nmod Gdf5,Cre
R2559 T4103 T4105 nmod Cre,Bmpr1afloxP
R2560 T4104 T4103 punct -,Cre
R2561 T4105 T4107 nmod Bmpr1afloxP,knockout
R2562 T4106 T4105 punct /,Bmpr1afloxP
R2563 T4107 T4101 compound knockout,mice
R2564 T4108 T4107 amod conditional,knockout
R2565 T4110 T4109 acomp viable,were
R2566 T4111 T4109 cc and,were
R2567 T4112 T4109 conj survived,were
R2568 T4113 T4112 prep to,survived
R2569 T4114 T4113 pobj adulthood,to
R2570 T4115 T4109 punct ", ",were
R2571 T4116 T4109 advcl showing,were
R2572 T4117 T4118 mark that,bypass
R2573 T4118 T4116 ccomp bypass,showing
R2574 T4119 T4120 det the,driver
R2575 T4120 T4118 nsubj driver,bypass
R2576 T4121 T4122 compound Gdf5,Cre
R2577 T4122 T4120 compound Cre,driver
R2578 T4123 T4122 punct -,Cre
R2579 T4124 T4118 aux can,bypass
R2580 T4125 T4126 det the,lethality
R2581 T4126 T4118 dobj lethality,bypass
R2582 T4127 T4126 amod early,lethality
R2583 T4128 T4126 amod embryonic,lethality
R2584 T4129 T4130 advmod previously,reported
R2585 T4130 T4126 acl reported,lethality
R2586 T4131 T4130 prep in,reported
R2587 T4132 T4131 pobj animals,in
R2588 T4133 T4132 prep with,animals
R2589 T4134 T4135 det a,mutation
R2590 T4135 T4133 pobj mutation,with
R2591 T4136 T4135 amod null,mutation
R2592 T4137 T4135 prep in,mutation
R2593 T4138 T4139 det the,locus
R2594 T4139 T4137 pobj locus,in
R2595 T4140 T4139 compound Bmpr1a,locus
R2596 T4141 T4142 punct (,Mishina
R2597 T4142 T4109 meta Mishina,were
R2598 T4143 T4142 nmod et,Mishina
R2599 T4144 T4142 nmod al.,Mishina
R2600 T4145 T4142 nummod 1995,Mishina
R2601 T4146 T4142 punct ),Mishina
R2602 T4147 T4109 punct .,were

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3850 17-21 PR_EXT:000000281 denotes Gdf5
T3851 53-56 PR_EXT:000000034 denotes BMP
T3852 53-66 GO:0030509 denotes BMP signaling
T3853 81-86 UBERON:0004905 denotes joint
T3854 100-104 PR_EXT:000000281 denotes Gdf5
T3855 109-119 SO_EXT:transgenic_entity denotes transgenic
T3856 120-124 NCBITaxon:10088 denotes mice
T3857 130-134 GO_EXT:breeding denotes bred
T3858 138-145 NCBITaxon:33208 denotes animals
T3859 169-175 SO:0000359 denotes floxed
T3860 176-182 SO_EXT:0001023 denotes allele
T3861 190-196 PR_EXT:000000035 denotes Bmpr1a
T3862 271-277 SO_EXT:0001023 denotes allele
T3863 335-348 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T3864 430-434 SO_EXT:0000147 denotes exon
T3865 442-448 PR_EXT:000000035 denotes Bmpr1a
T3866 449-453 SO_EXT:0000704 denotes gene
T3867 458-465 SO_EXT:sequence_deletion_process denotes deleted
T3868 469-473 NCBITaxon:10088 denotes mice
T3869 496-500 PR_EXT:000000281 denotes Gdf5
T3870 505-514 SO_EXT:0000902 denotes transgene
T3871 572-582 GO_SO_EXT:sequence_rearrangement_process denotes recombined
T3872 583-589 PR_EXT:000000035 denotes Bmpr1a
T3873 589-594 SO:0000359 denotes floxP
T3874 595-601 SO_EXT:0001023 denotes allele
T3875 611-615 SO_EXT:sequence_nullness denotes null
T3876 616-622 SO_EXT:0001023 denotes allele
T3877 630-636 PR_EXT:000000035 denotes Bmpr1a
T3878 708-712 PR_EXT:000000281 denotes Gdf5
T3879 717-723 PR_EXT:000000035 denotes Bmpr1a
T3880 723-728 SO:0000359 denotes floxP
T3881 750-754 NCBITaxon:10088 denotes mice
T3882 783-792 UBERON:0000113 denotes adulthood
T3883 811-815 PR_EXT:000000281 denotes Gdf5
T3884 842-857 UBERON:0019248 denotes early embryonic
T3885 858-867 GO_EXT:fatality_or_lethality denotes lethality
T3886 891-898 NCBITaxon:33208 denotes animals
T3887 906-910 SO_EXT:sequence_nullness denotes null
T3888 911-919 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T3889 927-933 PR_EXT:000000035 denotes Bmpr1a

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3762 17-21 PR:000000281 denotes Gdf5
T3763 53-56 PR:000000034 denotes BMP
T3764 53-66 GO:0030509 denotes BMP signaling
T3765 81-86 UBERON:0004905 denotes joint
T3766 100-104 PR:000000281 denotes Gdf5
T3767 120-124 NCBITaxon:10088 denotes mice
T3768 138-145 NCBITaxon:33208 denotes animals
T3769 169-175 SO:0000359 denotes floxed
T3770 176-182 SO:0001023 denotes allele
T3771 190-196 PR:000000035 denotes Bmpr1a
T3772 271-277 SO:0001023 denotes allele
T3773 430-434 SO:0000147 denotes exon
T3774 442-448 PR:000000035 denotes Bmpr1a
T3775 449-453 SO:0000704 denotes gene
T3776 469-473 NCBITaxon:10088 denotes mice
T3777 496-500 PR:000000281 denotes Gdf5
T3778 505-514 SO:0000902 denotes transgene
T3779 583-589 PR:000000035 denotes Bmpr1a
T3780 589-594 SO:0000359 denotes floxP
T3781 595-601 SO:0001023 denotes allele
T3782 616-622 SO:0001023 denotes allele
T3783 630-636 PR:000000035 denotes Bmpr1a
T3784 708-712 PR:000000281 denotes Gdf5
T3785 717-723 PR:000000035 denotes Bmpr1a
T3786 723-728 SO:0000359 denotes floxP
T3787 750-754 NCBITaxon:10088 denotes mice
T3788 783-792 UBERON:0000113 denotes adulthood
T3789 811-815 PR:000000281 denotes Gdf5
T3790 842-857 UBERON:0019248 denotes early embryonic
T3791 891-898 NCBITaxon:33208 denotes animals
T3792 927-933 PR:000000035 denotes Bmpr1a

2_test

Id Subject Object Predicate Lexical cue
15492776-11857780-84887307 219-223 11857780 denotes 2002
15492776-11857780-84887308 697-701 11857780 denotes 2002
15492776-8543149-84887309 956-960 8543149 denotes 1995
T80010 219-223 11857780 denotes 2002
T88995 697-701 11857780 denotes 2002
T59203 956-960 8543149 denotes 1995