PMC:509410 / 16897-17181 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/509410","sourcedb":"PMC","sourceid":"509410","source_url":"https://www.ncbi.nlm.nih.gov/pmc/509410","text":" We show that targeted expression of an activated form of PPARδ produces profound and coordinated increases in oxidation enzymes, mitochondrial biogenesis, and production of specialized type I fiber contractile proteins—the three hallmarks for muscle fiber type switching (Figure 6C).","tracks":[{"project":"craft-sa-dev","denotations":[{"id":"T3216","span":{"begin":0,"end":284},"obj":"sentence"},{"id":"T3217","span":{"begin":1,"end":3},"obj":"PRP"},{"id":"T3218","span":{"begin":4,"end":8},"obj":"VBP"},{"id":"T3219","span":{"begin":9,"end":13},"obj":"IN"},{"id":"T3220","span":{"begin":64,"end":72},"obj":"VBZ"},{"id":"T3221","span":{"begin":14,"end":22},"obj":"VBN"},{"id":"T3222","span":{"begin":23,"end":33},"obj":"NN"},{"id":"T3223","span":{"begin":34,"end":36},"obj":"IN"},{"id":"T3224","span":{"begin":37,"end":39},"obj":"DT"},{"id":"T3225","span":{"begin":50,"end":54},"obj":"NN"},{"id":"T3226","span":{"begin":40,"end":49},"obj":"JJ"},{"id":"T3227","span":{"begin":55,"end":57},"obj":"IN"},{"id":"T3228","span":{"begin":58,"end":63},"obj":"NN"},{"id":"T3229","span":{"begin":73,"end":81},"obj":"JJ"},{"id":"T3230","span":{"begin":98,"end":107},"obj":"NNS"},{"id":"T3231","span":{"begin":82,"end":85},"obj":"CC"},{"id":"T3232","span":{"begin":86,"end":97},"obj":"VBN"},{"id":"T3233","span":{"begin":108,"end":110},"obj":"IN"},{"id":"T3234","span":{"begin":111,"end":120},"obj":"NN"},{"id":"T3235","span":{"begin":121,"end":128},"obj":"NNS"},{"id":"T3236","span":{"begin":128,"end":130},"obj":","},{"id":"T3237","span":{"begin":130,"end":143},"obj":"JJ"},{"id":"T3238","span":{"begin":144,"end":154},"obj":"NN"},{"id":"T3239","span":{"begin":154,"end":156},"obj":","},{"id":"T3240","span":{"begin":156,"end":159},"obj":"CC"},{"id":"T3241","span":{"begin":160,"end":170},"obj":"NN"},{"id":"T3242","span":{"begin":171,"end":173},"obj":"IN"},{"id":"T3243","span":{"begin":174,"end":185},"obj":"VBN"},{"id":"T3244","span":{"begin":211,"end":219},"obj":"NN"},{"id":"T3245","span":{"begin":186,"end":190},"obj":"NN"},{"id":"T3246","span":{"begin":193,"end":198},"obj":"NN"},{"id":"T3247","span":{"begin":191,"end":192},"obj":"CD"},{"id":"T3248","span":{"begin":199,"end":210},"obj":"JJ"},{"id":"T3249","span":{"begin":219,"end":220},"obj":":"},{"id":"T3250","span":{"begin":220,"end":223},"obj":"DT"},{"id":"T3251","span":{"begin":230,"end":239},"obj":"NNS"},{"id":"T3252","span":{"begin":224,"end":229},"obj":"CD"},{"id":"T3253","span":{"begin":240,"end":243},"obj":"IN"},{"id":"T3254","span":{"begin":244,"end":250},"obj":"NN"},{"id":"T3255","span":{"begin":251,"end":256},"obj":"NN"},{"id":"T3256","span":{"begin":262,"end":271},"obj":"NN"},{"id":"T3257","span":{"begin":257,"end":261},"obj":"NN"},{"id":"T3258","span":{"begin":272,"end":273},"obj":"-LRB-"},{"id":"T3259","span":{"begin":273,"end":279},"obj":"NN"},{"id":"T3260","span":{"begin":280,"end":282},"obj":"CD"},{"id":"T3261","span":{"begin":282,"end":283},"obj":"-RRB-"},{"id":"T3262","span":{"begin":283,"end":284},"obj":"."}],"relations":[{"id":"R2202","pred":"nsubj","subj":"T3217","obj":"T3218"},{"id":"R2203","pred":"mark","subj":"T3219","obj":"T3220"},{"id":"R2204","pred":"ccomp","subj":"T3220","obj":"T3218"},{"id":"R2205","pred":"amod","subj":"T3221","obj":"T3222"},{"id":"R2206","pred":"nsubj","subj":"T3222","obj":"T3220"},{"id":"R2207","pred":"prep","subj":"T3223","obj":"T3222"},{"id":"R2208","pred":"det","subj":"T3224","obj":"T3225"},{"id":"R2209","pred":"pobj","subj":"T3225","obj":"T3223"},{"id":"R2210","pred":"amod","subj":"T3226","obj":"T3225"},{"id":"R2211","pred":"prep","subj":"T3227","obj":"T3225"},{"id":"R2212","pred":"pobj","subj":"T3228","obj":"T3227"},{"id":"R2213","pred":"amod","subj":"T3229","obj":"T3230"},{"id":"R2214","pred":"dobj","subj":"T3230","obj":"T3220"},{"id":"R2215","pred":"cc","subj":"T3231","obj":"T3229"},{"id":"R2216","pred":"conj","subj":"T3232","obj":"T3229"},{"id":"R2217","pred":"prep","subj":"T3233","obj":"T3230"},{"id":"R2218","pred":"compound","subj":"T3234","obj":"T3235"},{"id":"R2219","pred":"pobj","subj":"T3235","obj":"T3233"},{"id":"R2220","pred":"punct","subj":"T3236","obj":"T3235"},{"id":"R2221","pred":"amod","subj":"T3237","obj":"T3238"},{"id":"R2222","pred":"conj","subj":"T3238","obj":"T3235"},{"id":"R2223","pred":"punct","subj":"T3239","obj":"T3238"},{"id":"R2224","pred":"cc","subj":"T3240","obj":"T3238"},{"id":"R2225","pred":"conj","subj":"T3241","obj":"T3238"},{"id":"R2226","pred":"prep","subj":"T3242","obj":"T3241"},{"id":"R2227","pred":"amod","subj":"T3243","obj":"T3244"},{"id":"R2228","pred":"pobj","subj":"T3244","obj":"T3242"},{"id":"R2229","pred":"nmod","subj":"T3245","obj":"T3246"},{"id":"R2230","pred":"nmod","subj":"T3246","obj":"T3244"},{"id":"R2231","pred":"nummod","subj":"T3247","obj":"T3245"},{"id":"R2232","pred":"amod","subj":"T3248","obj":"T3244"},{"id":"R2233","pred":"punct","subj":"T3249","obj":"T3235"},{"id":"R2234","pred":"det","subj":"T3250","obj":"T3251"},{"id":"R2235","pred":"appos","subj":"T3251","obj":"T3235"},{"id":"R2236","pred":"nummod","subj":"T3252","obj":"T3251"},{"id":"R2237","pred":"prep","subj":"T3253","obj":"T3251"},{"id":"R2238","pred":"compound","subj":"T3254","obj":"T3255"},{"id":"R2239","pred":"compound","subj":"T3255","obj":"T3256"},{"id":"R2240","pred":"pobj","subj":"T3256","obj":"T3253"},{"id":"R2241","pred":"compound","subj":"T3257","obj":"T3256"},{"id":"R2242","pred":"punct","subj":"T3258","obj":"T3259"},{"id":"R2243","pred":"parataxis","subj":"T3259","obj":"T3220"},{"id":"R2244","pred":"nummod","subj":"T3260","obj":"T3259"},{"id":"R2245","pred":"punct","subj":"T3261","obj":"T3259"},{"id":"R2246","pred":"punct","subj":"T3262","obj":"T3218"}],"attributes":[{"subj":"T3216","pred":"source","obj":"craft-sa-dev"},{"subj":"T3217","pred":"source","obj":"craft-sa-dev"},{"subj":"T3218","pred":"source","obj":"craft-sa-dev"},{"subj":"T3219","pred":"source","obj":"craft-sa-dev"},{"subj":"T3220","pred":"source","obj":"craft-sa-dev"},{"subj":"T3221","pred":"source","obj":"craft-sa-dev"},{"subj":"T3222","pred":"source","obj":"craft-sa-dev"},{"subj":"T3223","pred":"source","obj":"craft-sa-dev"},{"subj":"T3224","pred":"source","obj":"craft-sa-dev"},{"subj":"T3225","pred":"source","obj":"craft-sa-dev"},{"subj":"T3226","pred":"source","obj":"craft-sa-dev"},{"subj":"T3227","pred":"source","obj":"craft-sa-dev"},{"subj":"T3228","pred":"source","obj":"craft-sa-dev"},{"subj":"T3229","pred":"source","obj":"craft-sa-dev"},{"subj":"T3230","pred":"source","obj":"craft-sa-dev"},{"subj":"T3231","pred":"source","obj":"craft-sa-dev"},{"subj":"T3232","pred":"source","obj":"craft-sa-dev"},{"subj":"T3233","pred":"source","obj":"craft-sa-dev"},{"subj":"T3234","pred":"source","obj":"craft-sa-dev"},{"subj":"T3235","pred":"source","obj":"craft-sa-dev"},{"subj":"T3236","pred":"source","obj":"craft-sa-dev"},{"subj":"T3237","pred":"source","obj":"craft-sa-dev"},{"subj":"T3238","pred":"source","obj":"craft-sa-dev"},{"subj":"T3239","pred":"source","obj":"craft-sa-dev"},{"subj":"T3240","pred":"source","obj":"craft-sa-dev"},{"subj":"T3241","pred":"source","obj":"craft-sa-dev"},{"subj":"T3242","pred":"source","obj":"craft-sa-dev"},{"subj":"T3243","pred":"source","obj":"craft-sa-dev"},{"subj":"T3244","pred":"source","obj":"craft-sa-dev"},{"subj":"T3245","pred":"source","obj":"craft-sa-dev"},{"subj":"T3246","pred":"source","obj":"craft-sa-dev"},{"subj":"T3247","pred":"source","obj":"craft-sa-dev"},{"subj":"T3248","pred":"source","obj":"craft-sa-dev"},{"subj":"T3249","pred":"source","obj":"craft-sa-dev"},{"subj":"T3250","pred":"source","obj":"craft-sa-dev"},{"subj":"T3251","pred":"source","obj":"craft-sa-dev"},{"subj":"T3252","pred":"source","obj":"craft-sa-dev"},{"subj":"T3253","pred":"source","obj":"craft-sa-dev"},{"subj":"T3254","pred":"source","obj":"craft-sa-dev"},{"subj":"T3255","pred":"source","obj":"craft-sa-dev"},{"subj":"T3256","pred":"source","obj":"craft-sa-dev"},{"subj":"T3257","pred":"source","obj":"craft-sa-dev"},{"subj":"T3258","pred":"source","obj":"craft-sa-dev"},{"subj":"T3259","pred":"source","obj":"craft-sa-dev"},{"subj":"T3260","pred":"source","obj":"craft-sa-dev"},{"subj":"T3261","pred":"source","obj":"craft-sa-dev"},{"subj":"T3262","pred":"source","obj":"craft-sa-dev"}]},{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T3055","span":{"begin":23,"end":33},"obj":"GO:0010467"},{"id":"T3056","span":{"begin":58,"end":63},"obj":"PR_EXT:000013057"},{"id":"T3057","span":{"begin":111,"end":120},"obj":"MOP:0000568"},{"id":"T3058","span":{"begin":121,"end":128},"obj":"CHEBI_GO_SO_EXT:enzyme"},{"id":"T3059","span":{"begin":130,"end":143},"obj":"GO:0005739"},{"id":"T3060","span":{"begin":144,"end":154},"obj":"GO_EXT:biogenesis_or_biosynthesis"},{"id":"T3061","span":{"begin":160,"end":173},"obj":"_FRAGMENT"},{"id":"T3062","span":{"begin":211,"end":219},"obj":"GO:0006412"},{"id":"T3063","span":{"begin":186,"end":198},"obj":"CL:0002211"},{"id":"T3064","span":{"begin":199,"end":210},"obj":"GO:0006936"},{"id":"T3065","span":{"begin":211,"end":219},"obj":"CHEBI_PR_EXT:protein"},{"id":"T3066","span":{"begin":244,"end":250},"obj":"UBERON_EXT:muscle_structure_or_tissue"},{"id":"T3067","span":{"begin":244,"end":256},"obj":"CL:0000187"}],"relations":[{"id":"R2167","pred":"_lexicallyChainedTo","subj":"T3062","obj":"T3061"}],"attributes":[{"subj":"T3055","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3056","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3057","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3058","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3059","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3060","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3061","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3062","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3063","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3064","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3065","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3066","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T3067","pred":"source","obj":"craft-ca-core-ex-dev"}]},{"project":"craft-ca-core-dev","denotations":[{"id":"T2972","span":{"begin":23,"end":33},"obj":"GO:0010467"},{"id":"T2973","span":{"begin":58,"end":63},"obj":"PR:000013057"},{"id":"T2974","span":{"begin":111,"end":120},"obj":"MOP:0000568"},{"id":"T2975","span":{"begin":130,"end":143},"obj":"GO:0005739"},{"id":"T2976","span":{"begin":160,"end":173},"obj":"_FRAGMENT"},{"id":"T2977","span":{"begin":211,"end":219},"obj":"GO:0006412"},{"id":"T2978","span":{"begin":186,"end":198},"obj":"CL:0002211"},{"id":"T2979","span":{"begin":199,"end":210},"obj":"GO:0006936"},{"id":"T2980","span":{"begin":244,"end":256},"obj":"CL:0000187"}],"relations":[{"id":"R2165","pred":"_lexicallyChainedTo","subj":"T2977","obj":"T2976"}],"attributes":[{"subj":"T2972","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T2973","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T2974","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T2975","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T2976","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T2977","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T2978","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T2979","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T2980","pred":"source","obj":"craft-ca-core-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-sa-dev","color":"#bb93ec","default":true},{"id":"craft-ca-core-ex-dev","color":"#93eca1"},{"id":"craft-ca-core-dev","color":"#ec939e"}]}]}}