PMC:509282 / 2066-4252 JSONTXT

{"project":"2_test","denotations":[{"id":"15287987-9315389-66505205","span":{"begin":153,"end":154},"obj":"9315389"},{"id":"15287987-15052336-66505206","span":{"begin":804,"end":805},"obj":"15052336"},{"id":"15287987-1519234-66505207","span":{"begin":1138,"end":1139},"obj":"1519234"},{"id":"15287987-10936499-66505207","span":{"begin":1138,"end":1139},"obj":"10936499"},{"id":"15287987-11937101-66505207","span":{"begin":1138,"end":1139},"obj":"11937101"},{"id":"15287987-11150923-66505208","span":{"begin":1556,"end":1557},"obj":"11150923"},{"id":"15287987-8482502-66505209","span":{"begin":1558,"end":1559},"obj":"8482502"},{"id":"15287987-8869002-66505210","span":{"begin":1594,"end":1595},"obj":"8869002"}],"text":"Background\nSyndrome X comprises a plethora of conditions such as obesity, dyslipidemia, impaired glucose tolerance, insulin resistance and hypertension [1]. It places stress on multiple organ systems and plays a significant role in the development of other related cardiovascular disorders. Western style diet, which contains high levels of fat, is also considered to be one of the main factors in the development of obesity and insulin resistance. The most common reason for the development of hyperinsulinemia (decreased hepatic insulin clearance and/or increased insulin secretion) from insulin resistance is obesity. Excess fat deposits in the white adipose tissue affects insulin mediated glucose metabolism in non adipose tissues, causes disordered insulin response and increases lipid deposition [2]. However, pathophysiologies of vascular complications in syndrome X have not been fully understood. 5-hydroxytryptamine (5-HT) is shown to be related to pathogenesis of vasculopathy in diabetes. Various studies in humans and rabbits have reported increased plasma 5-HT levels and enhanced contraction to 5-HT in diabetes mellitus [3-5]. Another vasopressor peptide, Angiotensin II (Ang II) is involved in cardiovascular complications of diabetes mellitus. Many have reported that the vascular Renin angiotensin system is one of the key systems in the etiology of vascular alterations in early stages of diabetes. It is already established that 5-HT and Ang II responses are altered in the aortic rings of streptozotocin (STZ) induced diabetic rats [6,7] and high fructose diet fed rats [8]. However, very little information is available in the literature regarding the vascular contractile responses to vasopressor agents such as 5-HT and Ang II in HFD fed rats.\nThe aim of this study was to elucidate the contractile responses to 5-HT and Ang II in HFD fed rat thoracic aorta which will provide an avenue for further exploratory studies. We have selected HFD fed rat model for our study because it is a useful model of the putative effects of excess fat intake in humans and it represents the major sub type of diabetes mellitus, non insulin dependent diabetes mellitus (NIDDM)."}