PMC:5003446 / 56281-58079 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/5003446","sourcedb":"PMC","sourceid":"5003446","source_url":"https://www.ncbi.nlm.nih.gov/pmc/5003446","text":"11. Conclusions\nIn summary, SNP array studies have contributed significantly in our understanding of the genomics of various hematopoietic malignancies. A summary of the common genomic abnormalities identified by SNP arrays is presented in Table 1. Several oncogenes have been mapped through application of SNP array and were shown to be important in clinical applications. As the cost of next generation sequencing (NGS) continues to drop, NGS will be increasingly applied in clinical labs. As a result, SNP array will gradually phase out. However, as a mature technology with fully developed data analysis and relatively low cost, SNP array will continue to play a role in the clinical lab, especially in situations where diagnostic and prognostic significance of SNP lesions were well established.\nmicroarrays-05-00001-t001_Table 1 Table 1 Common genetic abnormalities detected by SNP array in hematopoietic malignancies. CNV, copy number variations; CAN, copy number aberrations; LOH, loss of heterozygosity; UPD, uniparental disomy; Ref, reference; B-ALL, B lymphoblastic leukemia; T-ALL, T lymphoblastic leukemia; AML, acute myeloid leukemia; MDS, myelodysplastic syndrome; CML, chronic myelogenous leukemia; MPN, myeloproliferative neoplasm; PV, polycythemia (Rubra) vera; ET, essential thrombocythemia; PMF, primary myelofibrosis; CMML, chronic myelomonocytic leukemia; cHL, classical Hodgkin lymphoma; DLBCL, diffuse large B-cell lymphoma; FL, follicular lymphoma; CLL, chronic lymphocytic leukemia; MCL, mantle cell lymphoma; MZL, marginal zone lymphoma; BL, Burkitt lymphoma; MM, multiple myeloma; PTCL, NOS, peripheral T-cell lymphoma, NOS; AILT, angioimmunoblastic T-cell lymphoma; ATLL, adult T-cell leukemia/lymphoma; T-PLL, T-cell prolymphocytic leukemia; SS, Sezary syndrome. ","divisions":[{"label":"Title","span":{"begin":0,"end":15}},{"label":"Table caption","span":{"begin":801,"end":1797}}],"tracks":[]}