PMC:4996406 / 5271-5829 JSONTXT

{"project":"2_test","denotations":[{"id":"27600233-22510468-69473802","span":{"begin":278,"end":280},"obj":"22510468"},{"id":"27600233-25838314-69473803","span":{"begin":281,"end":283},"obj":"25838314"},{"id":"27600233-12169536-69473804","span":{"begin":369,"end":371},"obj":"12169536"}],"text":"To the best of our knowledge, there are no variance stabilization methods designed for dealing with heterogeneity of variance in kinome microarray data. Therefore, available methods for dealing with this phenomenon in DNA microarrays have been used in the kinome array context [13,14]. Among these are the Log2 method [15] and variance-stabilizing normalization (VSN) [16]. These techniques are among the most widely used and studied methods for this purpose in DNA microarray community. They are described in more detail than that given here in Section 2.2."}