PMC:4996403 / 8192-9239
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4996403","sourcedb":"PMC","sourceid":"4996403","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4996403","text":"3.5. MicroRNA(miRNA) Array\nIn 1993, Lee et al. [47] discovered that lin-4, a gene known to control the timing of Caenorhabditis elegans larval development, does not code for a protein but instead produces a pair of small RNAs approximately 22 and 61 nt in length. The shorter lin-4RNA is now recognized as the founding member of an abundant class of short regulatory RNAs called microRNAs or miRNAs [48,49,50]. The importance and the role of miRNA-directed gene regulation are coming into focus as their regulatory targets and functions [51]. Liu et al. [52] described the using of the first miRNA microarray. After that, the miRNA microarrays revealed their functions in control of cell proliferation, cell death associated with carcinogenesis [53,54], fat metabolism in flies [55,56], and modulation of hematopoietic lineage differentiation in mammals [57]. For example, miR-21 was detected by miRNA array in various cancers [58], and high miR-21 expression is associated with the poor survival and poor therapeutic outcome in colon cancer [59].","divisions":[{"label":"Title","span":{"begin":0,"end":26}}],"tracks":[{"project":"2_test","denotations":[{"id":"27600234-16823376-69479920","span":{"begin":48,"end":50},"obj":"16823376"},{"id":"27600234-23284754-69479921","span":{"begin":400,"end":402},"obj":"23284754"},{"id":"27600234-18599741-69479922","span":{"begin":406,"end":408},"obj":"18599741"},{"id":"27600234-18978789-69479923","span":{"begin":538,"end":540},"obj":"18978789"},{"id":"27600234-1105573-69479924","span":{"begin":555,"end":557},"obj":"1105573"},{"id":"27600234-118435-69479925","span":{"begin":746,"end":748},"obj":"118435"},{"id":"27600234-6162155-69479926","span":{"begin":749,"end":751},"obj":"6162155"},{"id":"27600234-7569999-69479927","span":{"begin":779,"end":781},"obj":"7569999"},{"id":"27600234-8944026-69479928","span":{"begin":782,"end":784},"obj":"8944026"},{"id":"27600234-8829658-69479929","span":{"begin":855,"end":857},"obj":"8829658"},{"id":"27600234-12117754-69479930","span":{"begin":928,"end":930},"obj":"12117754"},{"id":"27600234-11283592-69479931","span":{"begin":1043,"end":1045},"obj":"11283592"}],"attributes":[{"subj":"27600234-16823376-69479920","pred":"source","obj":"2_test"},{"subj":"27600234-23284754-69479921","pred":"source","obj":"2_test"},{"subj":"27600234-18599741-69479922","pred":"source","obj":"2_test"},{"subj":"27600234-18978789-69479923","pred":"source","obj":"2_test"},{"subj":"27600234-1105573-69479924","pred":"source","obj":"2_test"},{"subj":"27600234-118435-69479925","pred":"source","obj":"2_test"},{"subj":"27600234-6162155-69479926","pred":"source","obj":"2_test"},{"subj":"27600234-7569999-69479927","pred":"source","obj":"2_test"},{"subj":"27600234-8944026-69479928","pred":"source","obj":"2_test"},{"subj":"27600234-8829658-69479929","pred":"source","obj":"2_test"},{"subj":"27600234-12117754-69479930","pred":"source","obj":"2_test"},{"subj":"27600234-11283592-69479931","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93cdec","default":true}]}]}}