PMC:4996398 / 16404-17434 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4996398","sourcedb":"PMC","sourceid":"4996398","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4996398","text":"2.2.2. Covalent Gelation\nCovalently cross-linked hydrogels can be prepared from chemically modified alginates [39,40]. To better control the physical properties of alginate gels, covalent cross-linking has been broadly investigated [41]. A covalently cross-linked hydrogel is chemically stable and can provide different modes of stress relaxation. By covalently conjugating methacrylate groups onto the alginate backbone, covalently cross-linked hydrogels can be prepared in the presence of a photoinitiator and UV light. Cells will be evenly distributed throughout the hydrogel if the cells are suspended in the alginate solution prior to photocrosslinking [17,42]. Photocrosslinking has a number of different advantages. By comparison with ionic gelation, photocrosslinking allows formation of more stable alginate hydrogels independent of the level of gel forming ions and non-gelling ions [42]. Mechanical properties and biodegradation rates of a hydrogel can be adjusted by varying the degree of alginate methacrylation [43].","divisions":[{"label":"Title","span":{"begin":0,"end":24}}],"tracks":[{"project":"2_test","denotations":[{"id":"27600217-14751730-69475902","span":{"begin":114,"end":116},"obj":"14751730"},{"id":"27600217-22125349-69475903","span":{"begin":233,"end":235},"obj":"22125349"}],"attributes":[{"subj":"27600217-14751730-69475902","pred":"source","obj":"2_test"},{"subj":"27600217-22125349-69475903","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ec93d2","default":true}]}]}}