PMC:4766795 / 10785-11663 JSONTXT

{"project":"AxD_symptoms","denotations":[{"id":"T67","span":{"begin":374,"end":390},"obj":"Phenotype"},{"id":"T68","span":{"begin":689,"end":702},"obj":"Phenotype"},{"id":"T69","span":{"begin":803,"end":816},"obj":"Phenotype"}],"attributes":[{"id":"A67","pred":"hp_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/HP_0100320"},{"id":"A68","pred":"hp_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/HP_0011096"},{"id":"A69","pred":"hp_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/HP_0011096"}],"text":"Figure 1. A: T2-weighted sagittal image of the lower brainstem, cervical and thoracic spinal cord. Diffuse atrophy of the cord is present from medulla to thoracic spinal cord. B: T1-weighted sagittal image of the brain and upper spinal cord taken without contrast. Severe atrophy of the medulla oblongata and cervical cord is noted by arrows. C: Scattered and perivascular Rosenthal fibers within the neuropil of cerebellum, hippocampus (D), (H\u0026E, 600×) and the periventricular zone of basal ganglia (E) (H\u0026E, 400×). F: Atrophic cerebellar folia with white matter demonstrating a lack of myelin (arrows). Intact myelination is shown in blue (Luxol Fast Blue stain, 200×). G: White matter demyelination in the pons/midbrain area of the brain stem (arrows) (Luxol Fast Blue stain, 400×). H: White matter demyelination of the corpus collosum (arrow) (Luxol Fast Blue stain, 100×)."}