Figure 1.  A: T2-weighted sagittal image of the lower brainstem, cervical and thoracic spinal cord. Diffuse atrophy of the cord is present from medulla to thoracic spinal cord. B: T1-weighted sagittal image of the brain and upper spinal cord taken without contrast. Severe atrophy of the medulla oblongata and cervical cord is noted by arrows. C: Scattered and perivascular Rosenthal fibers within the neuropil of cerebellum, hippocampus (D), (H&E, 600×) and the periventricular zone of basal ganglia (E) (H&E, 400×). F: Atrophic cerebellar folia with white matter demonstrating a lack of myelin (arrows). Intact myelination is shown in blue (Luxol Fast Blue stain, 200×). G: White matter demyelination in the pons/midbrain area of the brain stem (arrows) (Luxol Fast Blue stain, 400×). H: White matter demyelination of the corpus collosum (arrow) (Luxol Fast Blue stain, 100×).