PMC:4701709 / 10665-11361 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4701709","sourcedb":"PMC","sourceid":"4701709","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4701709","text":"Intraperitoneal injection of acetic acid triggers writhing, most likely due to the release of TNF-α, interleukin 1β and interleukin 8 by macrophages and mast cells (Ribeiro et al. 2000). The mice were divided into groups of 6 for evaluation of the analgesic effect of Z. nummularia roots extract. One group was injected with normal saline (10 ml/kg) and used as negative control. Another group was injected with diclofenac (5 and 10 mg/kg). The last group was treated with Z. nummularia root extract at 50 and 100 mg/kg. The mice were injected with acetic acid (1 % intraperitoneal) and the subsequent abdominal constriction (writhing) was counted for 10 min after 5 min of acetic acid injection.","tracks":[{"project":"2_test","denotations":[{"id":"28330081-10633169-325","span":{"begin":180,"end":184},"obj":"10633169"}],"attributes":[{"subj":"28330081-10633169-325","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#9398ec","default":true}]}]}}