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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4536239","sourcedb":"PMC","sourceid":"4536239","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4536239","text":"Clinical characteristics of subjects having migraine with and without RLS\nWe investigated demographics, headache characteristics, associated symptoms, headache frequency per month, the visual analogue scale (VAS) score for pain intensity, and the Headache Impact Test (HIT-6) score of migraineurs according to the presence of RLS (Table 4). The only variable that showed a significant association with RLS was the HIT-6 score. The HIT-6 scores of migraineurs with RLS were significantly higher relative to migraineurs without RLS (59.1 ± 9.4 vs. 53.7 ± 9.2, p = 0.047).\nTable 4 Clinical characteristics of migraine according to the presence of restless legs syndrome\nMigraine with RLS, N =13 Migraine without RLS, N =130 P-value\nWomen, N (%) 10 (76.9) 97 (74.8) 0.867\nAge, mean ± SD 39.8 ± 12.6 41.5 ± 12.5 0.640\nFrequency per month, mean ± SD 5.8 ± 8.6 3.7 ± 6.0 0.251\nHeadache characteristics Unilateral, N (%) 9 (69.2) 72 (55.0) 0.323\nPulsating, N (%) 11 (84.6) 97 (74.8) 0.432\nModerate-to-severe intensity, N (%) 12 (92.3) 103 (78.6) 0.241\nAggravation by movement, N (%) 8 (61.5) 92 (70.2) 0.516\nAssociated symptoms Nausea, N (%) 11 (84.6) 114 (87.8) 0.742\nVomiting, N (%) 6 (46.2) 49 (38.2) 0.573\nPhotophobia, N (%) 8 (61.5) 76 (58.0) 0.806\nPhonophobia, N (%) 10 (76.9) 91 (69.5) 0.575\nOsmophobia, N (%) 7 (53.8) 61 (46.6) 0.616\nHeadache Impact test-6, mean ± SD 59.1 ± 9.4 53.7 ± 9.2 0.047\nVisual analogue scale for pain intensity, mean ± SD 6.8 ± 2.2 6.1 ± 1.9 0.212\nRLS restless legs syndrome, SD standard deviation","divisions":[{"label":"title","span":{"begin":0,"end":73}},{"label":"label","span":{"begin":570,"end":577}},{"label":"caption","span":{"begin":578,"end":666}},{"label":"p","span":{"begin":578,"end":666}},{"label":"table","span":{"begin":667,"end":1473}},{"label":"tr","span":{"begin":667,"end":728}},{"label":"th","span":{"begin":667,"end":691}},{"label":"th","span":{"begin":692,"end":720}},{"label":"th","span":{"begin":721,"end":728}},{"label":"tr","span":{"begin":729,"end":767}},{"label":"td","span":{"begin":729,"end":741}},{"label":"td","span":{"begin":742,"end":751}},{"label":"td","span":{"begin":752,"end":761}},{"label":"td","span":{"begin":762,"end":767}},{"label":"tr","span":{"begin":768,"end":812}},{"label":"td","span":{"begin":768,"end":782}},{"label":"td","span":{"begin":783,"end":794}},{"label":"td","span":{"begin":795,"end":806}},{"label":"td","span":{"begin":807,"end":812}},{"label":"tr","span":{"begin":813,"end":869}},{"label":"td","span":{"begin":813,"end":843}},{"label":"td","span":{"begin":844,"end":853}},{"label":"td","span":{"begin":854,"end":863}},{"label":"td","span":{"begin":864,"end":869}},{"label":"tr","span":{"begin":870,"end":937}},{"label":"td","span":{"begin":870,"end":894}},{"label":"td","span":{"begin":895,"end":912}},{"label":"td","span":{"begin":913,"end":921}},{"label":"td","span":{"begin":922,"end":931}},{"label":"td","span":{"begin":932,"end":937}},{"label":"tr","span":{"begin":938,"end":980}},{"label":"td","span":{"begin":938,"end":954}},{"label":"td","span":{"begin":955,"end":964}},{"label":"td","span":{"begin":965,"end":974}},{"label":"td","span":{"begin":975,"end":980}},{"label":"tr","span":{"begin":981,"end":1043}},{"label":"td","span":{"begin":981,"end":1016}},{"label":"td","span":{"begin":1017,"end":1026}},{"label":"td","span":{"begin":1027,"end":1037}},{"label":"td","span":{"begin":1038,"end":1043}},{"label":"tr","span":{"begin":1044,"end":1099}},{"label":"td","span":{"begin":1044,"end":1074}},{"label":"td","span":{"begin":1075,"end":1083}},{"label":"td","span":{"begin":1084,"end":1093}},{"label":"td","span":{"begin":1094,"end":1099}},{"label":"tr","span":{"begin":1100,"end":1160}},{"label":"td","span":{"begin":1100,"end":1119}},{"label":"td","span":{"begin":1120,"end":1133}},{"label":"td","span":{"begin":1134,"end":1143}},{"label":"td","span":{"begin":1144,"end":1154}},{"label":"td","span":{"begin":1155,"end":1160}},{"label":"tr","span":{"begin":1161,"end":1201}},{"label":"td","span":{"begin":1161,"end":1176}},{"label":"td","span":{"begin":1177,"end":1185}},{"label":"td","span":{"begin":1186,"end":1195}},{"label":"td","span":{"begin":1196,"end":1201}},{"label":"tr","span":{"begin":1202,"end":1245}},{"label":"td","span":{"begin":1202,"end":1220}},{"label":"td","span":{"begin":1221,"end":1229}},{"label":"td","span":{"begin":1230,"end":1239}},{"label":"td","span":{"begin":1240,"end":1245}},{"label":"tr","span":{"begin":1246,"end":1290}},{"label":"td","span":{"begin":1246,"end":1264}},{"label":"td","span":{"begin":1265,"end":1274}},{"label":"td","span":{"begin":1275,"end":1284}},{"label":"td","span":{"begin":1285,"end":1290}},{"label":"tr","span":{"begin":1291,"end":1333}},{"label":"td","span":{"begin":1291,"end":1308}},{"label":"td","span":{"begin":1309,"end":1317}},{"label":"td","span":{"begin":1318,"end":1327}},{"label":"td","span":{"begin":1328,"end":1333}},{"label":"tr","span":{"begin":1334,"end":1395}},{"label":"td","span":{"begin":1334,"end":1367}},{"label":"td","span":{"begin":1368,"end":1378}},{"label":"td","span":{"begin":1379,"end":1389}},{"label":"td","span":{"begin":1390,"end":1395}},{"label":"tr","span":{"begin":1396,"end":1473}},{"label":"td","span":{"begin":1396,"end":1447}},{"label":"td","span":{"begin":1448,"end":1457}},{"label":"td","span":{"begin":1458,"end":1467}},{"label":"td","span":{"begin":1468,"end":1473}}],"tracks":[]}