Clinical characteristics of subjects having migraine with and without RLS
We investigated demographics, headache characteristics, associated symptoms, headache frequency per month, the visual analogue scale (VAS) score for pain intensity, and the Headache Impact Test (HIT-6) score of migraineurs according to the presence of RLS (Table 4). The only variable that showed a significant association with RLS was the HIT-6 score. The HIT-6 scores of migraineurs with RLS were significantly higher relative to migraineurs without RLS (59.1 ± 9.4 vs. 53.7 ± 9.2, p = 0.047).
Table 4 Clinical characteristics of migraine according to the presence of restless legs syndrome
Migraine with RLS, N =13 Migraine without RLS, N =130 P-value
Women, N (%) 10 (76.9) 97 (74.8) 0.867
Age, mean ± SD 39.8 ± 12.6 41.5 ± 12.5 0.640
Frequency per month, mean ± SD 5.8 ± 8.6 3.7 ± 6.0 0.251
Headache characteristics Unilateral, N (%) 9 (69.2) 72 (55.0) 0.323
Pulsating, N (%) 11 (84.6) 97 (74.8) 0.432
Moderate-to-severe intensity, N (%) 12 (92.3) 103 (78.6) 0.241
Aggravation by movement, N (%) 8 (61.5) 92 (70.2) 0.516
Associated symptoms Nausea, N (%) 11 (84.6) 114 (87.8) 0.742
Vomiting, N (%) 6 (46.2) 49 (38.2) 0.573
Photophobia, N (%) 8 (61.5) 76 (58.0) 0.806
Phonophobia, N (%) 10 (76.9) 91 (69.5) 0.575
Osmophobia, N (%) 7 (53.8) 61 (46.6) 0.616
Headache Impact test-6, mean ± SD 59.1 ± 9.4 53.7 ± 9.2 0.047
Visual analogue scale for pain intensity, mean ± SD 6.8 ± 2.2 6.1 ± 1.9 0.212
RLS restless legs syndrome, SD standard deviation