PMC:4521172 / 16632-20657 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4521172","sourcedb":"PMC","sourceid":"4521172","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4521172","text":"Table 2 Distribution of MBL (codon 54, H-550L, and Y-221X) polymorphisms in P. falciparum malaria.\nMBL 2 polymorphism Clinical categories, %V of subject CM vs. UM MOD vs. UM NCSM vs. UM SM vs. UM\nCM (n = 94) MOD (n = 120) NCSM (n = 122) SM (n = 336) UM (n = 131) OR (95%CI) P-value OR (95%CI) P-value OR (95%CI) P-value OR (95%CI) P-value\nMBL 54 (A/B)\nCo-dominant inheritance\nAA 64 (68) 76 (63) 91 (75) 231 (69) 104(80) 1 Ref 1 Ref 1 Ref 1 Ref\nAB 25 (27) 36 (30) 24 (20) 85 (25) 21 (16) 1.93 (1.00to3.73) 0.06 2.34 (1.26 to 4.33) 0.006 1.30 (0.68to2.50) 0.50 1.82 (1.07to3.09) 0.02\nBB 5 (5) 8 (7) 7 (5) 20 (6) 6 (4) 1.35 (0.39to4.62) 0.75 1.77 (0.59to5.33) 0.40 1.33 (0.43to4.11) 0.77 1.50 (0.58to3.84 0.50\nDominant Inheritance\nAA 64 (68) 76 (63) 91 (75) 231 (69) 104(80) 1 Ref 1 Ref 1 Ref 1 Ref\nAB+BB 30 (32) 44 (37) 31 (25) 105 (31) 27 (20) 1.80 (0.98to3.31) 0.06 2.23 (1.27 to 3.91) 0.005 1.31 (0.72to2.36) 0.37 1.75 (1.08to2.83) 0.02\nRecessive inheritance\nAA+AB 89 (95) 112 (93) 115 (95) 316 (94) 125 (96) 1 Ref 1 Ref 1 Ref 1 Ref\nBB 5 (5) 8 (7) 7 (5) 20 (6) 6 (4) 1.17 (0.34to3.95) 1.00 1.48 (0.50to4.42) 0.58 1.26 (0.41to3.88) 0.77 1.31 (0.51to3.36) 0.65\nAllele\nA 153 (81) 188 (78) 206 (84) 547 (81) 229 (87) 1 Ref 1 Ref 1 Ref 1 Ref\nB 35 (19) 52 (22) 38 (16) 125 (19) 33 (13) 1.58 (0.94to2.66) 0.08 1.91 (1.19 to 3.09) 0.008 1.28 (0.77to2.11) 0.37 1.58(1.04to2.39) 0.03\nH-550L\nCo-dominant inheritance\nHH 5 (5) 7 (6) 9 (7) 21 (6) 7 (5) 1 Ref 1 Ref 1 Ref 1 Ref\nHL 24 (26) 30 (25) 33 (27) 87 (26) 33 (25) 1.01 (0.28to3.59) 1.00 0.90 (0.28to2.89) 1.00 0.77 (0.25to2.33) 0.78 0.87 (0.34to2.26) 1.00\nLL 65 (69) 83 (69) 80 (66) 228 (68) 91 (70) 1.00 (0.30to3.29) 1.00 0.91 (0.30to2.71) 1.00\nDominant inheritance\nHH 5 (5) 7 (6) 9 (7) 21 (6) 7 (5) 1 Ref 1 Ref 1 Ref 1 Ref\nHL+LL 89 (95) 113 (94) 113 (93) 315 (94) 124 (95) 1.00 (0.30to3.26) 1.00 0.91 (0.30to2.67) 1.00 0.70 (0.25to1.96) 0.60 0.84 (0.35to2.04) 0.83\nRecessive inheritance\nHH+HL 29 (31) 37 (31) 42 (34) 108 (32) 40 (30) 1 Ref 1 Ref 1 Ref 1 Ref\nLL 65 (69) 83 (69) 80 (66) 228 (68) 91 (70) 0.98 (0.55to1.75) 1.00 0.98 (0.57to1.68) 1.00 0.83 (0.49to1.41) 0.59 0.92 (0.59to1.43) 0.82\nAllele\nH 34 (18) 44 (18) 51 (21) 129 (19) 47 (18) 1 Ref 1 Ref 1 Ref 1 Ref\nL 154 (82) 196 (82) 193 (79) 543 (81) 215 (82) 0.99 (0.60to1.61) 1.00 0.97 (0.61to1.53) 0.90 0.82 (0.53to1.28) 0.42 0.92 (0.63to1.33) 0.70\nY-221X\nCo-dominant inheritance\nYY 43 (46) 50 (42) 63 (52) 156 (46) 72 (55) 1 Ref 1 Ref 1 Ref 1 Ref\nYX 38 (40) 56 (47) 44 (36) 138 (41) 39 (30) 1.63 (0.90to2.92) 0.10 2.06 (1.19 to 3.56) 0.009 1.28 (0.74to2.23) 0.40 1.63 (1.03to2.56) 0.03\nXX 13 (14) 14 (11) 15 (12) 42 (13) 20 (15) 1.08 (0.49to2.40) 0.84 1.00 (0.46to2.18) 1.00 0.85 (0.40to1.81) 0.70 0.96 (0.53to1.76) 1.00\nDominant inheritance\nYY 43 (46) 50 (42) 63 (52) 156 (46) 72 (55) 1 Ref 1 Ref 1 Ref 1 Ref\nYX+XX 51 (54) 70 (58) 59 (48) 180 (54) 59 (45) 1.44 (0.85to2.46) 0.17 1.70 (1.03to2.81) 0.04 1.14 (0.69to1.87) 0.61 1.40 (0.93to2.11) 0.10\nRecessive inheritance\nYY+YX 81 106 107 294 111 (85) 1 Ref 1 Ref 1 Ref 1 Ref\nXX 13 (14) 14 (11) 15 (12) 42 (13) 20 (15) 0.89 (0.41to1.89) 0.84 0.73 (0.35to1.52) 0.46 0.77 (0.37to1.59) 0.58 0.79 (0.44to1.41) 0.44\nAllele\nY 124 (66) 156 (65) 170 (70) 450 (67) 183 (70) 1 Ref 1 Ref 1 Ref 1 Ref\nX 64 (34) 84 (35) 74 (30) 222 (33) 79 (30) 1.19 (0.80to1.78) 0.41 1.24 (0.85to1.81) 0.25 1.00 (0.68to1.47) 1.00 1.14 (0.83to1.55) 0.43\nData are no. (%) of participants unless otherwise specified. SM, severe malaria; CM, cerebral malaria; MOD, multi-organ dysfunction; NCSM, non-cerebral severe malaria; UM, uncomplicated malaria. 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