Table 2  Distribution of MBL (codon 54, H-550L, and Y-221X) polymorphisms in P. falciparum malaria.
MBL 2 polymorphism    Clinical categories, %V of subject   CM vs. UM   MOD vs. UM   NCSM vs. UM   SM vs. UM
CM (n = 94)   MOD (n = 120)   NCSM (n = 122)   SM (n = 336)   UM (n = 131)   OR (95%CI)   P-value   OR (95%CI)   P-value   OR (95%CI)   P-value   OR (95%CI)   P-value
MBL 54 (A/B)
Co-dominant inheritance
AA  64 (68)  76 (63)  91 (75)  231 (69)  104(80)  1  Ref  1  Ref  1  Ref  1  Ref
AB  25 (27)  36 (30)  24 (20)  85 (25)  21 (16)  1.93 (1.00to3.73)  0.06   2.34 (1.26 to 4.33)   0.006  1.30 (0.68to2.50)  0.50  1.82 (1.07to3.09)  0.02
BB  5 (5)  8 (7)  7 (5)  20 (6)  6 (4)  1.35 (0.39to4.62)  0.75  1.77 (0.59to5.33)  0.40  1.33 (0.43to4.11)  0.77  1.50 (0.58to3.84  0.50
Dominant Inheritance
AA  64 (68)  76 (63)  91 (75)  231 (69)  104(80)  1  Ref  1  Ref  1  Ref  1  Ref
AB+BB  30 (32)  44 (37)  31 (25)  105 (31)  27 (20)  1.80 (0.98to3.31)  0.06   2.23 (1.27 to 3.91)   0.005  1.31 (0.72to2.36)  0.37  1.75 (1.08to2.83)  0.02
Recessive inheritance
AA+AB  89 (95)  112 (93)  115 (95)  316 (94)  125 (96)  1  Ref  1  Ref  1  Ref  1  Ref
BB  5 (5)  8 (7)  7 (5)  20 (6)  6 (4)  1.17 (0.34to3.95)  1.00  1.48 (0.50to4.42)  0.58  1.26 (0.41to3.88)  0.77  1.31 (0.51to3.36)  0.65
Allele
A  153 (81)  188 (78)  206 (84)  547 (81)  229 (87)  1  Ref  1  Ref  1  Ref  1  Ref
B  35 (19)  52 (22)  38 (16)  125 (19)  33 (13)  1.58 (0.94to2.66)   0.08   1.91 (1.19 to 3.09)   0.008  1.28 (0.77to2.11)  0.37  1.58(1.04to2.39)  0.03
H-550L
Co-dominant inheritance
HH  5 (5)  7 (6)  9 (7)  21 (6)  7 (5)  1  Ref  1  Ref  1  Ref  1  Ref
HL  24 (26)  30 (25)  33 (27)  87 (26)  33 (25)  1.01 (0.28to3.59)  1.00  0.90 (0.28to2.89)  1.00  0.77 (0.25to2.33)  0.78  0.87 (0.34to2.26)  1.00
LL  65 (69)  83 (69)  80 (66)  228 (68)  91 (70)  1.00 (0.30to3.29)  1.00  0.91 (0.30to2.71)  1.00
Dominant inheritance
HH  5 (5)  7 (6)  9 (7)  21 (6)  7 (5)  1  Ref  1  Ref  1  Ref  1  Ref
HL+LL  89 (95)  113 (94)  113 (93)  315 (94)  124 (95)  1.00 (0.30to3.26)  1.00  0.91 (0.30to2.67)  1.00  0.70 (0.25to1.96)  0.60  0.84 (0.35to2.04)  0.83
Recessive inheritance
HH+HL  29 (31)  37 (31)  42 (34)  108 (32)  40 (30)  1  Ref  1  Ref  1  Ref  1  Ref
LL  65 (69)  83 (69)  80 (66)  228 (68)  91 (70)  0.98 (0.55to1.75)  1.00  0.98 (0.57to1.68)  1.00  0.83 (0.49to1.41)  0.59  0.92 (0.59to1.43)  0.82
Allele
H  34 (18)  44 (18)  51 (21)  129 (19)  47 (18)  1  Ref  1  Ref  1  Ref  1  Ref
L  154 (82)  196 (82)  193 (79)  543 (81)  215 (82)  0.99 (0.60to1.61)  1.00  0.97 (0.61to1.53)  0.90  0.82 (0.53to1.28)  0.42  0.92 (0.63to1.33)  0.70
Y-221X
Co-dominant inheritance
YY  43 (46)  50 (42)  63 (52)  156 (46)  72 (55)  1  Ref  1  Ref  1  Ref  1  Ref
YX  38 (40)  56 (47)  44 (36)  138 (41)  39 (30)  1.63 (0.90to2.92)  0.10   2.06 (1.19 to 3.56)   0.009  1.28 (0.74to2.23)  0.40  1.63 (1.03to2.56)  0.03
XX  13 (14)  14 (11)  15 (12)  42 (13)  20 (15)  1.08 (0.49to2.40)  0.84  1.00 (0.46to2.18)  1.00  0.85 (0.40to1.81)  0.70  0.96 (0.53to1.76)  1.00
Dominant inheritance
YY  43 (46)  50 (42)  63 (52)  156 (46)  72 (55)  1  Ref  1  Ref  1  Ref  1  Ref
YX+XX  51 (54)  70 (58)  59 (48)  180 (54)  59 (45)  1.44 (0.85to2.46)  0.17  1.70 (1.03to2.81)  0.04  1.14 (0.69to1.87)  0.61  1.40 (0.93to2.11)  0.10
Recessive inheritance
YY+YX  81  106  107  294  111 (85)  1  Ref  1  Ref  1  Ref  1  Ref
XX  13 (14)  14 (11)  15 (12)  42 (13)  20 (15)  0.89 (0.41to1.89)  0.84  0.73 (0.35to1.52)  0.46  0.77 (0.37to1.59)  0.58  0.79 (0.44to1.41)  0.44
Allele
Y  124 (66)  156 (65)  170 (70)  450 (67)  183 (70)  1  Ref  1  Ref  1  Ref  1  Ref
X  64 (34)  84 (35)  74 (30)  222 (33)  79 (30)  1.19 (0.80to1.78)  0.41  1.24 (0.85to1.81)  0.25  1.00 (0.68to1.47)  1.00  1.14 (0.83to1.55)  0.43
Data are no. (%) of participants unless otherwise specified. SM, severe malaria; CM, cerebral malaria; MOD, multi-organ dysfunction; NCSM, non-cerebral severe malaria; UM, uncomplicated malaria. Bold values are values which showed statistical significance.