PMC:4428493 / 20978-21843 JSONTXT

{"project":"0_colil","denotations":[{"id":"25988110-22332246-908648","span":{"begin":313,"end":315},"obj":"22332246"},{"id":"25988110-22731395-908649","span":{"begin":331,"end":333},"obj":"22731395"},{"id":"25988110-23867558-908650","span":{"begin":359,"end":361},"obj":"23867558"},{"id":"25988110-22731395-908651","span":{"begin":372,"end":374},"obj":"22731395"},{"id":"25988110-22332246-908652","span":{"begin":448,"end":450},"obj":"22332246"},{"id":"25988110-21633398-908653","span":{"begin":708,"end":710},"obj":"21633398"},{"id":"25988110-19675107-908654","span":{"begin":860,"end":862},"obj":"19675107"}],"text":"In three studies using a nutrition and lifestyle intervention, brain activation at the commencement of the intervention was associated with degree of weight-loss success and maintenance. This included areas associated with reward processing and anticipation [insula, anterior cingulate cortex, nucleus accumbens (55), and the OFC (56)], decision making [PFC (54) and OFC (56)], and impulsivity [nucleus accumbens and the anterior cingulate cortex (55)]. Participants who had successfully lost and maintained weight-loss displayed differential neural responses to food cues to those of healthy weight participants in areas involved in emotion, memory, and visual processing [cingulate gyrus, parietal cortex (51)], and to that of obese participants in regions associated with emotion, impulse control, and reward-based learning [PFC and the anterior cingulate (50)]."}

{"project":"2_test","denotations":[{"id":"25988110-22332246-38724575","span":{"begin":313,"end":315},"obj":"22332246"},{"id":"25988110-22731395-38724576","span":{"begin":331,"end":333},"obj":"22731395"},{"id":"25988110-23867558-38724577","span":{"begin":359,"end":361},"obj":"23867558"},{"id":"25988110-22731395-38724578","span":{"begin":372,"end":374},"obj":"22731395"},{"id":"25988110-22332246-38724579","span":{"begin":448,"end":450},"obj":"22332246"},{"id":"25988110-21633398-38724580","span":{"begin":708,"end":710},"obj":"21633398"},{"id":"25988110-19675107-38724581","span":{"begin":860,"end":862},"obj":"19675107"}],"text":"In three studies using a nutrition and lifestyle intervention, brain activation at the commencement of the intervention was associated with degree of weight-loss success and maintenance. This included areas associated with reward processing and anticipation [insula, anterior cingulate cortex, nucleus accumbens (55), and the OFC (56)], decision making [PFC (54) and OFC (56)], and impulsivity [nucleus accumbens and the anterior cingulate cortex (55)]. Participants who had successfully lost and maintained weight-loss displayed differential neural responses to food cues to those of healthy weight participants in areas involved in emotion, memory, and visual processing [cingulate gyrus, parietal cortex (51)], and to that of obese participants in regions associated with emotion, impulse control, and reward-based learning [PFC and the anterior cingulate (50)]."}