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In C, D and E, '*' denotes one or more members of the TACC or Aurora kinase family."}

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{"project":"craft-ca-core-dev","denotations":[{"id":"T13564","span":{"begin":53,"end":63},"obj":"NCBITaxon:6239"},{"id":"T13565","span":{"begin":68,"end":83},"obj":"NCBITaxon:7227"},{"id":"T13566","span":{"begin":90,"end":100},"obj":"NCBITaxon:6239"},{"id":"T13567","span":{"begin":313,"end":322},"obj":"GO:0000785"},{"id":"T13568","span":{"begin":313,"end":333},"obj":"GO:0006338"},{"id":"T13569","span":{"begin":334,"end":343},"obj":"GO:0032991"},{"id":"T13570","span":{"begin":345,"end":352},"obj":"GO:0016514"},{"id":"T13571","span":{"begin":357,"end":364},"obj":"PR:000043452"},{"id":"T13572","span":{"begin":357,"end":364},"obj":"CHEBI:15358"},{"id":"T13573","span":{"begin":386,"end":403},"obj":"GO:0006281"},{"id":"T13574","span":{"begin":431,"end":443},"obj":"GO:0008380"},{"id":"T13575","span":{"begin":431,"end":434},"obj":"_FRAGMENT"},{"id":"T13576","span":{"begin":445,"end":454},"obj":"GO:0050658"},{"id":"T13577","span":{"begin":459,"end":472},"obj":"GO:0006412"},{"id":"T13578","span":{"begin":519,"end":529},"obj":"NCBITaxon:7742"},{"id":"T13579","span":{"begin":597,"end":604},"obj":"GO:0005634"},{"id":"T13580","span":{"begin":622,"end":626},"obj":"PR:000014373"},{"id":"T13581","span":{"begin":767,"end":786},"obj":"SO:0000854"},{"id":"T13582","span":{"begin":888,"end":898},"obj":"NCBITaxon:7742"},{"id":"T13583","span":{"begin":993,"end":1003},"obj":"NCBITaxon:7742"},{"id":"T13584","span":{"begin":1004,"end":1013},"obj":"SO:0000853"},{"id":"T13585","span":{"begin":1077,"end":1090},"obj":"PR:000035365"}],"relations":[{"id":"R8789","pred":"_lexicallyChainedTo","subj":"T13576","obj":"T13575"}],"text":"Functional evolution of the TACC proteins modeled in C. elegans and D. melanogaster. (A). C. elegans interaction map shows empirically defined interactions of ceTAC, and extrapolated interactions defined by [28]. (B): Using the BIND database [29], DTACC directly binds to TBPH and CG14540, and thus indirectly to chromatin remodeling complexes (SWI/SNF and histone acetyltransferases), DNA damage repair machinery (via RAD23), and RNA splicing, transport and translational machinery. (C): Predicted interaction map for vertebrate TACCs, based upon ceTAC, suggests an indirect interaction with the nuclear hormone receptor RXRβ. It is also of interest that this predicts a functional interaction with the LDB family, members of which are also found in TACC containing paralogous segments noted in Figs 2, 3 and Additional file 1. (D): Predicted TACC interaction map based upon DTACC. (E): Vertebrate TACC interactions identified to date. ? denotes uncertainty over the identity of a functional vertebrate homologue. In C, D and E, '*' denotes one or more members of the TACC or Aurora kinase family."}