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6 Functional evolution of the TACC proteins modeled in C. elegans and D. melanogaster. (A). C. elegans interaction map shows empirically defined interactions of ceTAC, and extrapolated interactions defined by [28]. (B): Using the BIND database [29], DTACC directly binds to TBPH and CG14540, and thus indirectly to chromatin remodeling complexes (SWI/SNF and histone acetyltransferases), DNA damage repair machinery (via RAD23), and RNA splicing, transport and translational machinery. (C): Predicted interaction map for vertebrate TACCs, based upon ceTAC, suggests an indirect interaction with the nuclear hormone receptor RXRβ. It is also of interest that this predicts a functional interaction with the LDB family, members of which are also found in TACC containing paralogous segments noted in Figs 2, 3 and Additional file 1. (D): Predicted TACC interaction map based upon DTACC. (E): Vertebrate TACC interactions identified to date. ? denotes uncertainty over the identity of a functional vertebrate homologue. In C, D and E, '*' denotes one or more members of the TACC or Aurora kinase family."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T13586","span":{"begin":43,"end":51},"obj":"CHEBI_PR_EXT:protein"},{"id":"T13587","span":{"begin":63,"end":73},"obj":"NCBITaxon:6239"},{"id":"T13588","span":{"begin":78,"end":93},"obj":"NCBITaxon:7227"},{"id":"T13589","span":{"begin":100,"end":110},"obj":"NCBITaxon:6239"},{"id":"T13590","span":{"begin":273,"end":278},"obj":"CHEMINF_GO_EXT:chemical_binding_or_bond_formation"},{"id":"T13591","span":{"begin":323,"end":332},"obj":"GO:0000785"},{"id":"T13592","span":{"begin":323,"end":343},"obj":"GO:0006338"},{"id":"T13593","span":{"begin":344,"end":353},"obj":"GO:0032991"},{"id":"T13594","span":{"begin":355,"end":362},"obj":"GO:0016514"},{"id":"T13595","span":{"begin":367,"end":374},"obj":"PR_EXT:000043452"},{"id":"T13596","span":{"begin":367,"end":374},"obj":"CHEBI:15358"},{"id":"T13597","span":{"begin":367,"end":393},"obj":"GO_EXT:0004402"},{"id":"T13598","span":{"begin":396,"end":399},"obj":"CHEBI_SO_EXT:DNA"},{"id":"T13599","span":{"begin":396,"end":413},"obj":"GO:0006281"},{"id":"T13600","span":{"begin":429,"end":434},"obj":"PR_EXT:RAD23"},{"id":"T13601","span":{"begin":441,"end":444},"obj":"CHEBI_SO_EXT:RNA"},{"id":"T13602","span":{"begin":441,"end":453},"obj":"GO:0008380"},{"id":"T13603","span":{"begin":441,"end":444},"obj":"_FRAGMENT"},{"id":"T13604","span":{"begin":455,"end":464},"obj":"GO:0050658"},{"id":"T13605","span":{"begin":469,"end":482},"obj":"GO:0006412"},{"id":"T13606","span":{"begin":529,"end":539},"obj":"NCBITaxon:7742"},{"id":"T13607","span":{"begin":607,"end":614},"obj":"GO:0005634"},{"id":"T13608","span":{"begin":615,"end":622},"obj":"CHEBI_GO_EXT:hormone"},{"id":"T13609","span":{"begin":623,"end":631},"obj":"GO_EXT:0004872"},{"id":"T13610","span":{"begin":632,"end":636},"obj":"PR_EXT:000014373"},{"id":"T13611","span":{"begin":777,"end":796},"obj":"SO_EXT:0000854"},{"id":"T13612","span":{"begin":898,"end":908},"obj":"NCBITaxon:7742"},{"id":"T13613","span":{"begin":1003,"end":1013},"obj":"NCBITaxon:7742"},{"id":"T13614","span":{"begin":1014,"end":1023},"obj":"SO_EXT:0000853"},{"id":"T13615","span":{"begin":1087,"end":1100},"obj":"PR_EXT:000035365"},{"id":"T13616","span":{"begin":1094,"end":1100},"obj":"GO_EXT:0016301"}],"relations":[{"id":"R8790","pred":"_lexicallyChainedTo","subj":"T13604","obj":"T13603"}],"text":"Figure 6 Functional evolution of the TACC proteins modeled in C. elegans and D. melanogaster. (A). C. elegans interaction map shows empirically defined interactions of ceTAC, and extrapolated interactions defined by [28]. (B): Using the BIND database [29], DTACC directly binds to TBPH and CG14540, and thus indirectly to chromatin remodeling complexes (SWI/SNF and histone acetyltransferases), DNA damage repair machinery (via RAD23), and RNA splicing, transport and translational machinery. (C): Predicted interaction map for vertebrate TACCs, based upon ceTAC, suggests an indirect interaction with the nuclear hormone receptor RXRβ. It is also of interest that this predicts a functional interaction with the LDB family, members of which are also found in TACC containing paralogous segments noted in Figs 2, 3 and Additional file 1. (D): Predicted TACC interaction map based upon DTACC. (E): Vertebrate TACC interactions identified to date. ? denotes uncertainty over the identity of a functional vertebrate homologue. In C, D and E, '*' denotes one or more members of the TACC or Aurora kinase family."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T13564","span":{"begin":63,"end":73},"obj":"NCBITaxon:6239"},{"id":"T13565","span":{"begin":78,"end":93},"obj":"NCBITaxon:7227"},{"id":"T13566","span":{"begin":100,"end":110},"obj":"NCBITaxon:6239"},{"id":"T13567","span":{"begin":323,"end":332},"obj":"GO:0000785"},{"id":"T13568","span":{"begin":323,"end":343},"obj":"GO:0006338"},{"id":"T13569","span":{"begin":344,"end":353},"obj":"GO:0032991"},{"id":"T13570","span":{"begin":355,"end":362},"obj":"GO:0016514"},{"id":"T13571","span":{"begin":367,"end":374},"obj":"PR:000043452"},{"id":"T13572","span":{"begin":367,"end":374},"obj":"CHEBI:15358"},{"id":"T13573","span":{"begin":396,"end":413},"obj":"GO:0006281"},{"id":"T13574","span":{"begin":441,"end":453},"obj":"GO:0008380"},{"id":"T13575","span":{"begin":441,"end":444},"obj":"_FRAGMENT"},{"id":"T13576","span":{"begin":455,"end":464},"obj":"GO:0050658"},{"id":"T13577","span":{"begin":469,"end":482},"obj":"GO:0006412"},{"id":"T13578","span":{"begin":529,"end":539},"obj":"NCBITaxon:7742"},{"id":"T13579","span":{"begin":607,"end":614},"obj":"GO:0005634"},{"id":"T13580","span":{"begin":632,"end":636},"obj":"PR:000014373"},{"id":"T13581","span":{"begin":777,"end":796},"obj":"SO:0000854"},{"id":"T13582","span":{"begin":898,"end":908},"obj":"NCBITaxon:7742"},{"id":"T13583","span":{"begin":1003,"end":1013},"obj":"NCBITaxon:7742"},{"id":"T13584","span":{"begin":1014,"end":1023},"obj":"SO:0000853"},{"id":"T13585","span":{"begin":1087,"end":1100},"obj":"PR:000035365"}],"relations":[{"id":"R8789","pred":"_lexicallyChainedTo","subj":"T13576","obj":"T13575"}],"text":"Figure 6 Functional evolution of the TACC proteins modeled in C. elegans and D. melanogaster. (A). C. elegans interaction map shows empirically defined interactions of ceTAC, and extrapolated interactions defined by [28]. (B): Using the BIND database [29], DTACC directly binds to TBPH and CG14540, and thus indirectly to chromatin remodeling complexes (SWI/SNF and histone acetyltransferases), DNA damage repair machinery (via RAD23), and RNA splicing, transport and translational machinery. (C): Predicted interaction map for vertebrate TACCs, based upon ceTAC, suggests an indirect interaction with the nuclear hormone receptor RXRβ. It is also of interest that this predicts a functional interaction with the LDB family, members of which are also found in TACC containing paralogous segments noted in Figs 2, 3 and Additional file 1. (D): Predicted TACC interaction map based upon DTACC. (E): Vertebrate TACC interactions identified to date. ? denotes uncertainty over the identity of a functional vertebrate homologue. In C, D and E, '*' denotes one or more members of the TACC or Aurora kinase family."}