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PMC:441373 / 26419-27456 JSONTXT

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craft-sa-dev

Id Subject Object Predicate Lexical cue
T6552 0-11 JJ denotes Alternative
T6553 12-20 NN denotes splicing
T6554 81-86 VBN denotes noted
T6555 20-22 , denotes ,
T6556 22-30 RB denotes together
T6557 31-35 IN denotes with
T6558 36-48 JJ denotes differential
T6559 58-63 NN denotes usage
T6560 49-57 NN denotes promoter
T6561 64-67 VBZ denotes has
T6562 68-75 RB denotes already
T6563 76-80 VBN denotes been
T6564 87-90 IN denotes for
T6565 91-94 DT denotes the
T6566 107-111 NN denotes gene
T6567 95-100 JJ denotes human
T6568 101-106 NN denotes TACC1
T6569 112-113 -LRB- denotes [
T6570 116-118 CD denotes 19
T6571 113-115 CD denotes 18
T6572 115-116 , denotes ,
T6573 118-119 -RRB- denotes ]
T6574 119-120 . denotes .
T6575 120-252 sentence denotes In addition, as shown in Fig. 5, we have identified additional TACC1 isoforms that result from alternative splicing of exons 1b-4a.
T6576 121-123 IN denotes In
T6577 162-172 VBN denotes identified
T6578 124-132 NN denotes addition
T6579 132-134 , denotes ,
T6580 134-136 IN denotes as
T6581 137-142 VBN denotes shown
T6582 143-145 IN denotes in
T6583 146-150 NN denotes Fig.
T6584 151-152 CD denotes 5
T6585 152-154 , denotes ,
T6586 154-156 PRP denotes we
T6587 157-161 VBP denotes have
T6588 173-183 JJ denotes additional
T6589 190-198 NNS denotes isoforms
T6590 184-189 NN denotes TACC1
T6591 199-203 WDT denotes that
T6592 204-210 VBP denotes result
T6593 211-215 IN denotes from
T6594 216-227 JJ denotes alternative
T6595 228-236 NN denotes splicing
T6596 237-239 IN denotes of
T6597 240-245 NNS denotes exons
T6598 249-251 CD denotes 4a
T6599 246-248 CD denotes 1b
T6600 248-249 HYPH denotes -
T6601 251-252 . denotes .
T6602 252-536 sentence denotes The functions of these different isoforms are unknown, however the region deleted from the shorter variants can include the binding site for LSm7 [20] (variants C, D, F-I), and/or the nuclear localization signals and binding site for GAS41 [15] and PCTAIRE2BP [20] (isoforms B-D, S).
T6603 253-256 DT denotes The
T6604 257-266 NNS denotes functions
T6605 295-298 VBP denotes are
T6606 267-269 IN denotes of
T6607 270-275 DT denotes these
T6608 286-294 NNS denotes isoforms
T6609 276-285 JJ denotes different
T6610 365-372 VB denotes include
T6611 299-306 JJ denotes unknown
T6612 306-308 , denotes ,
T6613 308-315 RB denotes however
T6614 316-319 DT denotes the
T6615 320-326 NN denotes region
T6616 327-334 VBN denotes deleted
T6617 335-339 IN denotes from
T6618 340-343 DT denotes the
T6619 352-360 NNS denotes variants
T6620 344-351 JJR denotes shorter
T6621 361-364 MD denotes can
T6622 373-376 DT denotes the
T6623 385-389 NN denotes site
T6624 377-384 NN denotes binding
T6625 390-393 IN denotes for
T6626 394-398 NN denotes LSm7
T6627 399-400 -LRB- denotes [
T6628 400-402 CD denotes 20
T6629 402-403 -RRB- denotes ]
T6630 404-405 -LRB- denotes (
T6631 414-415 NN denotes C
T6632 405-413 NNS denotes variants
T6633 415-417 , denotes ,
T6634 417-418 NN denotes D
T6635 418-420 , denotes ,
T6636 420-421 NN denotes F
T6637 421-422 SYM denotes -
T6638 422-423 NN denotes I
T6639 423-424 -RRB- denotes )
T6640 424-426 , denotes ,
T6641 426-429 CC denotes and
T6642 429-430 HYPH denotes /
T6643 430-432 CC denotes or
T6644 433-436 DT denotes the
T6645 458-465 NNS denotes signals
T6646 437-444 JJ denotes nuclear
T6647 445-457 NN denotes localization
T6648 466-469 CC denotes and
T6649 470-477 NN denotes binding
T6650 478-482 NN denotes site
T6651 483-486 IN denotes for
T6652 487-492 NN denotes GAS41
T6653 493-494 -LRB- denotes [
T6654 494-496 CD denotes 15
T6655 496-497 -RRB- denotes ]
T6656 498-501 CC denotes and
T6657 502-512 NN denotes PCTAIRE2BP
T6658 513-514 -LRB- denotes [
T6659 514-516 CD denotes 20
T6660 516-517 -RRB- denotes ]
T6661 518-519 -LRB- denotes (
T6662 528-529 NN denotes B
T6663 519-527 NNS denotes isoforms
T6664 529-530 SYM denotes -
T6665 530-531 NN denotes D
T6666 531-533 , denotes ,
T6667 533-534 NN denotes S
T6668 534-535 -RRB- denotes )
T6669 535-536 . denotes .
T6670 536-770 sentence denotes One of these isoforms, TACC1S is localized exclusively to the cytoplasm [19], suggesting that the shorter isoforms would not be able to interact with elements of the chomatin remodeling and/or RNA processing machinery in the nucleus.
T6671 537-540 CD denotes One
T6672 570-579 VBN denotes localized
T6673 541-543 IN denotes of
T6674 544-549 DT denotes these
T6675 550-558 NNS denotes isoforms
T6676 558-560 , denotes ,
T6677 560-566 NN denotes TACC1S
T6678 567-569 VBZ denotes is
T6679 580-591 RB denotes exclusively
T6680 592-594 IN denotes to
T6681 595-598 DT denotes the
T6682 599-608 NN denotes cytoplasm
T6683 609-610 -LRB- denotes [
T6684 610-612 CD denotes 19
T6685 612-613 -RRB- denotes ]
T6686 613-615 , denotes ,
T6687 615-625 VBG denotes suggesting
T6688 626-630 IN denotes that
T6689 662-664 VB denotes be
T6690 631-634 DT denotes the
T6691 643-651 NNS denotes isoforms
T6692 635-642 JJR denotes shorter
T6693 652-657 MD denotes would
T6694 658-661 RB denotes not
T6695 665-669 JJ denotes able
T6696 670-672 TO denotes to
T6697 673-681 VB denotes interact
T6698 682-686 IN denotes with
T6699 687-695 NNS denotes elements
T6700 696-698 IN denotes of
T6701 699-702 DT denotes the
T6702 712-722 NN denotes remodeling
T6703 703-711 NN denotes chomatin
T6704 723-726 CC denotes and
T6705 726-727 HYPH denotes /
T6706 727-729 CC denotes or
T6707 730-733 NN denotes RNA
T6708 745-754 NN denotes machinery
T6709 734-744 NN denotes processing
T6710 755-757 IN denotes in
T6711 758-761 DT denotes the
T6712 762-769 NN denotes nucleus
T6713 769-770 . denotes .
T6714 770-1037 sentence denotes Thus, changes in the complement of TACC1 isoforms in the cell may result in alterations in cellular RNA metabolism at multiple levels, and may account for the observation that TACC1D and TACC1F isoforms are associated with tumorigenic changes in gastric mucosa [18].
T6715 771-775 RB denotes Thus
T6716 837-843 VB denotes result
T6717 775-777 , denotes ,
T6718 777-784 NNS denotes changes
T6719 785-787 IN denotes in
T6720 788-791 DT denotes the
T6721 792-802 NN denotes complement
T6722 803-805 IN denotes of
T6723 806-811 NN denotes TACC1
T6724 812-820 NNS denotes isoforms
T6725 821-823 IN denotes in
T6726 824-827 DT denotes the
T6727 828-832 NN denotes cell
T6728 833-836 MD denotes may
T6729 844-846 IN denotes in
T6730 847-858 NNS denotes alterations
T6731 859-861 IN denotes in
T6732 862-870 JJ denotes cellular
T6733 875-885 NN denotes metabolism
T6734 871-874 NN denotes RNA
T6735 886-888 IN denotes at
T6736 889-897 JJ denotes multiple
T6737 898-904 NNS denotes levels
T6738 904-906 , denotes ,
T6739 906-909 CC denotes and
T6740 910-913 MD denotes may
T6741 914-921 VB denotes account
T6742 922-925 IN denotes for
T6743 926-929 DT denotes the
T6744 930-941 NN denotes observation
T6745 942-946 IN denotes that
T6746 978-988 VBN denotes associated
T6747 947-953 NN denotes TACC1D
T6748 965-973 NNS denotes isoforms
T6749 954-957 CC denotes and
T6750 958-964 NN denotes TACC1F
T6751 974-977 VBP denotes are
T6752 989-993 IN denotes with
T6753 994-1005 JJ denotes tumorigenic
T6754 1006-1013 NNS denotes changes
T6755 1014-1016 IN denotes in
T6756 1017-1024 JJ denotes gastric
T6757 1025-1031 NN denotes mucosa
T6758 1032-1033 -LRB- denotes [
T6759 1033-1035 CD denotes 18
T6760 1035-1036 -RRB- denotes ]
T6761 1036-1037 . denotes .
R4223 T6552 T6553 amod Alternative,splicing
R4224 T6553 T6554 nsubjpass splicing,noted
R4225 T6555 T6553 punct ", ",splicing
R4226 T6556 T6553 advmod together,splicing
R4227 T6557 T6556 prep with,together
R4228 T6558 T6559 amod differential,usage
R4229 T6559 T6557 pobj usage,with
R4230 T6560 T6559 compound promoter,usage
R4231 T6561 T6554 aux has,noted
R4232 T6562 T6554 advmod already,noted
R4233 T6563 T6554 auxpass been,noted
R4234 T6564 T6554 prep for,noted
R4235 T6565 T6566 det the,gene
R4236 T6566 T6564 pobj gene,for
R4237 T6567 T6566 amod human,gene
R4238 T6568 T6566 compound TACC1,gene
R4239 T6569 T6570 punct [,19
R4240 T6570 T6554 parataxis 19,noted
R4241 T6571 T6570 nummod 18,19
R4242 T6572 T6570 punct ",",19
R4243 T6573 T6570 punct ],19
R4244 T6574 T6554 punct .,noted
R4245 T6576 T6577 prep In,identified
R4246 T6578 T6576 pobj addition,In
R4247 T6579 T6577 punct ", ",identified
R4248 T6580 T6581 mark as,shown
R4249 T6581 T6577 advcl shown,identified
R4250 T6582 T6581 prep in,shown
R4251 T6583 T6582 pobj Fig.,in
R4252 T6584 T6583 nummod 5,Fig.
R4253 T6585 T6577 punct ", ",identified
R4254 T6586 T6577 nsubj we,identified
R4255 T6587 T6577 aux have,identified
R4256 T6588 T6589 amod additional,isoforms
R4257 T6589 T6577 dobj isoforms,identified
R4258 T6590 T6589 compound TACC1,isoforms
R4259 T6591 T6592 dep that,result
R4260 T6592 T6589 relcl result,isoforms
R4261 T6593 T6592 prep from,result
R4262 T6594 T6595 amod alternative,splicing
R4263 T6595 T6593 pobj splicing,from
R4264 T6596 T6595 prep of,splicing
R4265 T6597 T6598 nmod exons,4a
R4266 T6598 T6596 pobj 4a,of
R4267 T6599 T6598 nummod 1b,4a
R4268 T6600 T6598 punct -,4a
R4269 T6601 T6577 punct .,identified
R4270 T6603 T6604 det The,functions
R4271 T6604 T6605 nsubj functions,are
R4272 T6605 T6610 ccomp are,include
R4273 T6606 T6604 prep of,functions
R4274 T6607 T6608 det these,isoforms
R4275 T6608 T6606 pobj isoforms,of
R4276 T6609 T6608 amod different,isoforms
R4277 T6611 T6605 acomp unknown,are
R4278 T6612 T6610 punct ", ",include
R4279 T6613 T6610 advmod however,include
R4280 T6614 T6615 det the,region
R4281 T6615 T6610 nsubj region,include
R4282 T6616 T6615 acl deleted,region
R4283 T6617 T6616 prep from,deleted
R4284 T6618 T6619 det the,variants
R4285 T6619 T6617 pobj variants,from
R4286 T6620 T6619 amod shorter,variants
R4287 T6621 T6610 aux can,include
R4288 T6622 T6623 det the,site
R4289 T6623 T6610 dobj site,include
R4290 T6624 T6623 compound binding,site
R4291 T6625 T6623 prep for,site
R4292 T6626 T6625 pobj LSm7,for
R4293 T6627 T6628 punct [,20
R4294 T6628 T6623 parataxis 20,site
R4295 T6629 T6628 punct ],20
R4296 T6630 T6631 punct (,C
R4297 T6631 T6623 parataxis C,site
R4298 T6632 T6631 compound variants,C
R4299 T6633 T6631 punct ", ",C
R4300 T6634 T6631 appos D,C
R4301 T6635 T6631 punct ", ",C
R4302 T6636 T6631 appos F,C
R4303 T6637 T6638 punct -,I
R4304 T6638 T6636 prep I,F
R4305 T6639 T6631 punct ),C
R4306 T6640 T6623 punct ", ",site
R4307 T6641 T6623 cc and,site
R4308 T6642 T6641 punct /,and
R4309 T6643 T6641 cc or,and
R4310 T6644 T6645 det the,signals
R4311 T6645 T6623 conj signals,site
R4312 T6646 T6645 amod nuclear,signals
R4313 T6647 T6645 compound localization,signals
R4314 T6648 T6645 cc and,signals
R4315 T6649 T6650 compound binding,site
R4316 T6650 T6645 conj site,signals
R4317 T6651 T6650 prep for,site
R4318 T6652 T6651 pobj GAS41,for
R4319 T6653 T6654 punct [,15
R4320 T6654 T6650 parataxis 15,site
R4321 T6655 T6654 punct ],15
R4322 T6656 T6645 cc and,signals
R4323 T6657 T6645 conj PCTAIRE2BP,signals
R4324 T6658 T6659 punct [,20
R4325 T6659 T6657 parataxis 20,PCTAIRE2BP
R4326 T6660 T6659 punct ],20
R4327 T6661 T6662 punct (,B
R4328 T6662 T6657 parataxis B,PCTAIRE2BP
R4329 T6663 T6662 compound isoforms,B
R4330 T6664 T6665 punct -,D
R4331 T6665 T6662 prep D,B
R4332 T6666 T6662 punct ", ",B
R4333 T6667 T6662 appos S,B
R4334 T6668 T6662 punct ),B
R4335 T6669 T6610 punct .,include
R4336 T6671 T6672 nsubjpass One,localized
R4337 T6673 T6671 prep of,One
R4338 T6674 T6675 det these,isoforms
R4339 T6675 T6673 pobj isoforms,of
R4340 T6676 T6671 punct ", ",One
R4341 T6677 T6671 appos TACC1S,One
R4342 T6678 T6672 auxpass is,localized
R4343 T6679 T6680 advmod exclusively,to
R4344 T6680 T6672 prep to,localized
R4345 T6681 T6682 det the,cytoplasm
R4346 T6682 T6680 pobj cytoplasm,to
R4347 T6683 T6684 punct [,19
R4348 T6684 T6672 parataxis 19,localized
R4349 T6685 T6684 punct ],19
R4350 T6686 T6672 punct ", ",localized
R4351 T6687 T6672 advcl suggesting,localized
R4352 T6688 T6689 mark that,be
R4353 T6689 T6687 ccomp be,suggesting
R4354 T6690 T6691 det the,isoforms
R4355 T6691 T6689 nsubj isoforms,be
R4356 T6692 T6691 amod shorter,isoforms
R4357 T6693 T6689 aux would,be
R4358 T6694 T6689 neg not,be
R4359 T6695 T6689 acomp able,be
R4360 T6696 T6697 aux to,interact
R4361 T6697 T6695 xcomp interact,able
R4362 T6698 T6697 prep with,interact
R4363 T6699 T6698 pobj elements,with
R4364 T6700 T6699 prep of,elements
R4365 T6701 T6702 det the,remodeling
R4366 T6702 T6700 pobj remodeling,of
R4367 T6703 T6702 compound chomatin,remodeling
R4368 T6704 T6699 cc and,elements
R4369 T6705 T6704 punct /,and
R4370 T6706 T6704 cc or,and
R4371 T6707 T6708 compound RNA,machinery
R4372 T6708 T6699 conj machinery,elements
R4373 T6709 T6708 compound processing,machinery
R4374 T6710 T6697 prep in,interact
R4375 T6711 T6712 det the,nucleus
R4376 T6712 T6710 pobj nucleus,in
R4377 T6713 T6672 punct .,localized
R4378 T6715 T6716 advmod Thus,result
R4379 T6717 T6716 punct ", ",result
R4380 T6718 T6716 nsubj changes,result
R4381 T6719 T6718 prep in,changes
R4382 T6720 T6721 det the,complement
R4383 T6721 T6719 pobj complement,in
R4384 T6722 T6721 prep of,complement
R4385 T6723 T6724 compound TACC1,isoforms
R4386 T6724 T6722 pobj isoforms,of
R4387 T6725 T6718 prep in,changes
R4388 T6726 T6727 det the,cell
R4389 T6727 T6725 pobj cell,in
R4390 T6728 T6716 aux may,result
R4391 T6729 T6716 prep in,result
R4392 T6730 T6729 pobj alterations,in
R4393 T6731 T6730 prep in,alterations
R4394 T6732 T6733 amod cellular,metabolism
R4395 T6733 T6731 pobj metabolism,in
R4396 T6734 T6733 compound RNA,metabolism
R4397 T6735 T6730 prep at,alterations
R4398 T6736 T6737 amod multiple,levels
R4399 T6737 T6735 pobj levels,at
R4400 T6738 T6716 punct ", ",result
R4401 T6739 T6716 cc and,result
R4402 T6740 T6741 aux may,account
R4403 T6741 T6716 conj account,result
R4404 T6742 T6741 prep for,account
R4405 T6743 T6744 det the,observation
R4406 T6744 T6742 pobj observation,for
R4407 T6745 T6746 mark that,associated
R4408 T6746 T6744 acl associated,observation
R4409 T6747 T6748 nmod TACC1D,isoforms
R4410 T6748 T6746 nsubjpass isoforms,associated
R4411 T6749 T6747 cc and,TACC1D
R4412 T6750 T6747 conj TACC1F,TACC1D
R4413 T6751 T6746 auxpass are,associated
R4414 T6752 T6746 prep with,associated
R4415 T6753 T6754 amod tumorigenic,changes
R4416 T6754 T6752 pobj changes,with
R4417 T6755 T6746 prep in,associated
R4418 T6756 T6757 amod gastric,mucosa
R4419 T6757 T6755 pobj mucosa,in
R4420 T6758 T6759 punct [,18
R4421 T6759 T6744 parataxis 18,observation
R4422 T6760 T6759 punct ],18
R4423 T6761 T6716 punct .,result

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T6337 0-20 GO:0000380 denotes Alternative splicing
T6338 49-57 SO_EXT:0000167 denotes promoter
T6339 95-100 NCBITaxon:9606 denotes human
T6340 101-106 PR_EXT:000016006 denotes TACC1
T6341 107-111 SO_EXT:0000704 denotes gene
T6342 184-189 PR_EXT:000016006 denotes TACC1
T6343 190-198 SO_EXT:0001060 denotes isoforms
T6344 216-236 GO:0000380 denotes alternative splicing
T6345 240-245 SO_EXT:0000147 denotes exons
T6346 286-294 SO_EXT:0001060 denotes isoforms
T6347 327-334 SO_EXT:sequence_deletion_process denotes deleted
T6348 352-360 SO_EXT:sequence_variant_entity denotes variants
T6349 377-384 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T6350 377-389 SO_EXT:0000409 denotes binding site
T6351 394-398 PR_EXT:000009965 denotes LSm7
T6352 405-413 SO_EXT:sequence_variant_entity denotes variants
T6353 437-444 GO:0005634 denotes nuclear
T6354 437-465 SO_EXT:0001528 denotes nuclear localization signals
T6355 445-457 GO_PATO_EXT:biological_localization_process_or_quality denotes localization
T6356 470-477 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T6357 470-482 SO_EXT:0000409 denotes binding site
T6358 487-492 PR_EXT:000017527 denotes GAS41
T6359 502-512 PR_EXT:000029784 denotes PCTAIRE2BP
T6360 519-527 SO_EXT:0001060 denotes isoforms
T6361 550-558 SO_EXT:0001060 denotes isoforms
T6362 570-579 GO_PATO_EXT:biological_localization_process_or_quality denotes localized
T6363 599-608 GO:0005737 denotes cytoplasm
T6364 643-651 SO_EXT:0001060 denotes isoforms
T6365 703-711 GO:0000785 denotes chomatin
T6366 703-722 GO:0006338 denotes chomatin remodeling
T6367 730-733 CHEBI_SO_EXT:RNA denotes RNA
T6368 730-744 GO:0006396 denotes RNA processing
T6369 734-744 SO_EXT:sequence_alteration_process denotes processing
T6370 762-769 GO:0005634 denotes nucleus
T6371 806-811 PR_EXT:000016006 denotes TACC1
T6372 812-820 SO_EXT:0001060 denotes isoforms
T6373 828-832 CL_GO_EXT:cell denotes cell
T6374 862-870 CL_GO_EXT:cell denotes cellular
T6375 862-870 _FRAGMENT denotes cellular
T6376 875-885 GO:0044237 denotes metabolism
T6377 871-874 CHEBI_SO_EXT:RNA denotes RNA
T6378 871-885 GO:0016070 denotes RNA metabolism
T6379 965-973 SO_EXT:0001060 denotes isoforms
T6380 1017-1031 UBERON:0001199 denotes gastric mucosa
R4063 T6376 T6375 _lexicallyChainedTo metabolism,cellular

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T6271 0-20 GO:0000380 denotes Alternative splicing
T6272 49-57 SO:0000167 denotes promoter
T6273 95-100 NCBITaxon:9606 denotes human
T6274 101-106 PR:000016006 denotes TACC1
T6275 107-111 SO:0000704 denotes gene
T6276 184-189 PR:000016006 denotes TACC1
T6277 190-198 SO:0001060 denotes isoforms
T6278 216-236 GO:0000380 denotes alternative splicing
T6279 240-245 SO:0000147 denotes exons
T6280 286-294 SO:0001060 denotes isoforms
T6281 377-389 SO:0000409 denotes binding site
T6282 394-398 PR:000009965 denotes LSm7
T6283 437-444 GO:0005634 denotes nuclear
T6284 437-465 SO:0001528 denotes nuclear localization signals
T6285 470-482 SO:0000409 denotes binding site
T6286 487-492 PR:000017527 denotes GAS41
T6287 502-512 PR:000029784 denotes PCTAIRE2BP
T6288 519-527 SO:0001060 denotes isoforms
T6289 550-558 SO:0001060 denotes isoforms
T6290 599-608 GO:0005737 denotes cytoplasm
T6291 643-651 SO:0001060 denotes isoforms
T6292 703-711 GO:0000785 denotes chomatin
T6293 703-722 GO:0006338 denotes chomatin remodeling
T6294 730-744 GO:0006396 denotes RNA processing
T6295 762-769 GO:0005634 denotes nucleus
T6296 806-811 PR:000016006 denotes TACC1
T6297 812-820 SO:0001060 denotes isoforms
T6298 862-870 _FRAGMENT denotes cellular
T6299 875-885 GO:0044237 denotes metabolism
T6300 871-885 GO:0016070 denotes RNA metabolism
T6301 965-973 SO:0001060 denotes isoforms
T6302 1017-1031 UBERON:0001199 denotes gastric mucosa
R4061 T6299 T6298 _lexicallyChainedTo metabolism,cellular

2_test

Id Subject Object Predicate Lexical cue
15207008-12547166-9666015 113-115 12547166 denotes 18
15207008-12165861-9666016 116-118 12165861 denotes 19
15207008-14603251-9666017 400-402 14603251 denotes 20
15207008-11903063-9666018 494-496 11903063 denotes 15
15207008-14603251-9666019 514-516 14603251 denotes 20
15207008-12165861-9666020 610-612 12165861 denotes 19
15207008-12547166-9666021 1033-1035 12547166 denotes 18