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evolution of complex organisms has been associated with the generation of gene families by the continual duplication of an initial relatively small set of ancestral genes. Through this process, followed by subsequent mutation, reduplication and exon shuffling between gene families, genes have evolved both discrete, and partially redundant functions with their related family members. With the completion of the genome sequencing projects of human, mouse, rat, fruit fly and nematodes, we are now in a position to ask fundamental questions in regard to how genes interact in the context of the whole organism. Thus, with the appropriate application of bioinformatics, it is now possible to trace the lineage of particular genes and gene families, with related gene families in other organisms. Furthermore, with the growing amount of large-scale proteomic and genomic data becoming publicly available, this analysis can now be extended to reveal the complex interplay between evolution of gene structure and protein function.\nThe first Transforming acidic coiled coil gene, TACC1, was identified during the development of an expression map of the proximal short arm of human chromosome 8 [1]. Two additional TACC family members were subsequently identified and mapped to paralogous chromosomal regions on human chromosomes 4p16 and 10q26, physically close to members of the FGFR gene family [1-3]. This mapping data, together with identification of a single TACC gene in the protostomes Caenorhabitis elegans, and Drosophila melanogaster [4-6], led to the speculation that the ancestral FGFR and TACC genes were located physically close to each other. Thus, during the evolution of vertebrates, subsequent successive duplications of the ancestral gene cluster have given rise to three TACC family members located close to FGFR genes in humans. In accordance with the proposed quadruplication of the vertebrate genome during evolution, there is a fourth FGFR family member in vertebrates, raising the question of whether a fourth TACC gene is associated with FGFR4 in vertebrate genomes. To date, only three active TACC genes have been cloned in humans [1-3], one in each of mouse [7], Xenopus laevis [8], D. melanogaster [4], and C. elegans [5,6]. Although two additional new candidate TACC family members, Oryctolagus cuniculus TACC4 [9] and human RHAMM [10] have been proposed, their true identity and placement in the evolution of the TACC family is under debate. Thus, the identification and functional characterization of new members of the TACC family in other organisms, alternatively spliced isoforms of each TACC and comparison of the phylogenetic relationship of these genes relative to other members of the coiled coil superfamily will resolve this issue and provide clues to the evolution of TACC function."}

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evolution of complex organisms has been associated with the generation of gene families by the continual duplication of an initial relatively small set of ancestral genes. Through this process, followed by subsequent mutation, reduplication and exon shuffling between gene families, genes have evolved both discrete, and partially redundant functions with their related family members. With the completion of the genome sequencing projects of human, mouse, rat, fruit fly and nematodes, we are now in a position to ask fundamental questions in regard to how genes interact in the context of the whole organism. Thus, with the appropriate application of bioinformatics, it is now possible to trace the lineage of particular genes and gene families, with related gene families in other organisms. Furthermore, with the growing amount of large-scale proteomic and genomic data becoming publicly available, this analysis can now be extended to reveal the complex interplay between evolution of gene structure and protein function.\nThe first Transforming acidic coiled coil gene, TACC1, was identified during the development of an expression map of the proximal short arm of human chromosome 8 [1]. Two additional TACC family members were subsequently identified and mapped to paralogous chromosomal regions on human chromosomes 4p16 and 10q26, physically close to members of the FGFR gene family [1-3]. This mapping data, together with identification of a single TACC gene in the protostomes Caenorhabitis elegans, and Drosophila melanogaster [4-6], led to the speculation that the ancestral FGFR and TACC genes were located physically close to each other. Thus, during the evolution of vertebrates, subsequent successive duplications of the ancestral gene cluster have given rise to three TACC family members located close to FGFR genes in humans. In accordance with the proposed quadruplication of the vertebrate genome during evolution, there is a fourth FGFR family member in vertebrates, raising the question of whether a fourth TACC gene is associated with FGFR4 in vertebrate genomes. To date, only three active TACC genes have been cloned in humans [1-3], one in each of mouse [7], Xenopus laevis [8], D. melanogaster [4], and C. elegans [5,6]. Although two additional new candidate TACC family members, Oryctolagus cuniculus TACC4 [9] and human RHAMM [10] have been proposed, their true identity and placement in the evolution of the TACC family is under debate. Thus, the identification and functional characterization of new members of the TACC family in other organisms, alternatively spliced isoforms of each TACC and comparison of the phylogenetic relationship of these genes relative to other members of the coiled coil superfamily will resolve this issue and provide clues to the evolution of TACC function."}

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Through this process, followed by subsequent mutation, reduplication and exon shuffling between gene families, genes have evolved both discrete, and partially redundant functions with their related family members. With the completion of the genome sequencing projects of human, mouse, rat, fruit fly and nematodes, we are now in a position to ask fundamental questions in regard to how genes interact in the context of the whole organism. Thus, with the appropriate application of bioinformatics, it is now possible to trace the lineage of particular genes and gene families, with related gene families in other organisms. Furthermore, with the growing amount of large-scale proteomic and genomic data becoming publicly available, this analysis can now be extended to reveal the complex interplay between evolution of gene structure and protein function.\nThe first Transforming acidic coiled coil gene, TACC1, was identified during the development of an expression map of the proximal short arm of human chromosome 8 [1]. Two additional TACC family members were subsequently identified and mapped to paralogous chromosomal regions on human chromosomes 4p16 and 10q26, physically close to members of the FGFR gene family [1-3]. This mapping data, together with identification of a single TACC gene in the protostomes Caenorhabitis elegans, and Drosophila melanogaster [4-6], led to the speculation that the ancestral FGFR and TACC genes were located physically close to each other. Thus, during the evolution of vertebrates, subsequent successive duplications of the ancestral gene cluster have given rise to three TACC family members located close to FGFR genes in humans. In accordance with the proposed quadruplication of the vertebrate genome during evolution, there is a fourth FGFR family member in vertebrates, raising the question of whether a fourth TACC gene is associated with FGFR4 in vertebrate genomes. To date, only three active TACC genes have been cloned in humans [1-3], one in each of mouse [7], Xenopus laevis [8], D. melanogaster [4], and C. elegans [5,6]. Although two additional new candidate TACC family members, Oryctolagus cuniculus TACC4 [9] and human RHAMM [10] have been proposed, their true identity and placement in the evolution of the TACC family is under debate. Thus, the identification and functional characterization of new members of the TACC family in other organisms, alternatively spliced isoforms of each TACC and comparison of the phylogenetic relationship of these genes relative to other members of the coiled coil superfamily will resolve this issue and provide clues to the evolution of TACC function."}

{"project":"2_test","denotations":[{"id":"15207008-10435627-9665981","span":{"begin":1205,"end":1206},"obj":"10435627"},{"id":"15207008-10435627-9665982","span":{"begin":1408,"end":1409},"obj":"10435627"},{"id":"15207008-10366448-9665982","span":{"begin":1408,"end":1409},"obj":"10366448"},{"id":"15207008-12620397-9665982","span":{"begin":1408,"end":1409},"obj":"12620397"},{"id":"15207008-10637228-9665983","span":{"begin":1555,"end":1556},"obj":"10637228"},{"id":"15207008-12956952-9665983","span":{"begin":1555,"end":1556},"obj":"12956952"},{"id":"15207008-12956951-9665983","span":{"begin":1555,"end":1556},"obj":"12956951"},{"id":"15207008-10435627-9665984","span":{"begin":2169,"end":2170},"obj":"10435627"},{"id":"15207008-10366448-9665984","span":{"begin":2169,"end":2170},"obj":"10366448"},{"id":"15207008-12620397-9665984","span":{"begin":2169,"end":2170},"obj":"12620397"},{"id":"15207008-11025203-9665985","span":{"begin":2197,"end":2198},"obj":"11025203"},{"id":"15207008-10635326-9665986","span":{"begin":2217,"end":2218},"obj":"10635326"},{"id":"15207008-10637228-9665987","span":{"begin":2238,"end":2239},"obj":"10637228"},{"id":"15207008-12956952-9665988","span":{"begin":2258,"end":2259},"obj":"12956952"},{"id":"15207008-12956951-9665989","span":{"begin":2260,"end":2261},"obj":"12956951"},{"id":"15207008-12015314-9665990","span":{"begin":2352,"end":2353},"obj":"12015314"},{"id":"15207008-12808028-9665991","span":{"begin":2372,"end":2374},"obj":"12808028"}],"text":"Background\nThe evolution of complex organisms has been associated with the generation of gene families by the continual duplication of an initial relatively small set of ancestral genes. Through this process, followed by subsequent mutation, reduplication and exon shuffling between gene families, genes have evolved both discrete, and partially redundant functions with their related family members. With the completion of the genome sequencing projects of human, mouse, rat, fruit fly and nematodes, we are now in a position to ask fundamental questions in regard to how genes interact in the context of the whole organism. Thus, with the appropriate application of bioinformatics, it is now possible to trace the lineage of particular genes and gene families, with related gene families in other organisms. Furthermore, with the growing amount of large-scale proteomic and genomic data becoming publicly available, this analysis can now be extended to reveal the complex interplay between evolution of gene structure and protein function.\nThe first Transforming acidic coiled coil gene, TACC1, was identified during the development of an expression map of the proximal short arm of human chromosome 8 [1]. Two additional TACC family members were subsequently identified and mapped to paralogous chromosomal regions on human chromosomes 4p16 and 10q26, physically close to members of the FGFR gene family [1-3]. This mapping data, together with identification of a single TACC gene in the protostomes Caenorhabitis elegans, and Drosophila melanogaster [4-6], led to the speculation that the ancestral FGFR and TACC genes were located physically close to each other. Thus, during the evolution of vertebrates, subsequent successive duplications of the ancestral gene cluster have given rise to three TACC family members located close to FGFR genes in humans. In accordance with the proposed quadruplication of the vertebrate genome during evolution, there is a fourth FGFR family member in vertebrates, raising the question of whether a fourth TACC gene is associated with FGFR4 in vertebrate genomes. To date, only three active TACC genes have been cloned in humans [1-3], one in each of mouse [7], Xenopus laevis [8], D. melanogaster [4], and C. elegans [5,6]. Although two additional new candidate TACC family members, Oryctolagus cuniculus TACC4 [9] and human RHAMM [10] have been proposed, their true identity and placement in the evolution of the TACC family is under debate. Thus, the identification and functional characterization of new members of the TACC family in other organisms, alternatively spliced isoforms of each TACC and comparison of the phylogenetic relationship of these genes relative to other members of the coiled coil superfamily will resolve this issue and provide clues to the evolution of TACC function."}