Id |
Subject |
Object |
Predicate |
Lexical cue |
T703 |
11-14 |
DT |
denotes |
The |
T704 |
15-24 |
NN |
denotes |
evolution |
T705 |
55-65 |
VBN |
denotes |
associated |
T706 |
25-27 |
IN |
denotes |
of |
T707 |
28-35 |
JJ |
denotes |
complex |
T708 |
36-45 |
NNS |
denotes |
organisms |
T709 |
46-49 |
VBZ |
denotes |
has |
T710 |
50-54 |
VBN |
denotes |
been |
T711 |
66-70 |
IN |
denotes |
with |
T712 |
71-74 |
DT |
denotes |
the |
T713 |
75-85 |
NN |
denotes |
generation |
T714 |
86-88 |
IN |
denotes |
of |
T715 |
89-93 |
NN |
denotes |
gene |
T716 |
94-102 |
NNS |
denotes |
families |
T717 |
103-105 |
IN |
denotes |
by |
T718 |
106-109 |
DT |
denotes |
the |
T719 |
120-131 |
NN |
denotes |
duplication |
T720 |
110-119 |
JJ |
denotes |
continual |
T721 |
132-134 |
IN |
denotes |
of |
T722 |
135-137 |
DT |
denotes |
an |
T723 |
163-166 |
NN |
denotes |
set |
T724 |
138-145 |
JJ |
denotes |
initial |
T725 |
146-156 |
RB |
denotes |
relatively |
T726 |
157-162 |
JJ |
denotes |
small |
T727 |
167-169 |
IN |
denotes |
of |
T728 |
170-179 |
JJ |
denotes |
ancestral |
T729 |
180-185 |
NNS |
denotes |
genes |
T730 |
185-186 |
. |
denotes |
. |
T731 |
186-400 |
sentence |
denotes |
Through this process, followed by subsequent mutation, reduplication and exon shuffling between gene families, genes have evolved both discrete, and partially redundant functions with their related family members. |
T732 |
187-194 |
IN |
denotes |
Through |
T733 |
309-316 |
VBN |
denotes |
evolved |
T734 |
195-199 |
DT |
denotes |
this |
T735 |
200-207 |
NN |
denotes |
process |
T736 |
207-209 |
, |
denotes |
, |
T737 |
209-217 |
VBN |
denotes |
followed |
T738 |
218-220 |
IN |
denotes |
by |
T739 |
221-231 |
JJ |
denotes |
subsequent |
T740 |
232-240 |
NN |
denotes |
mutation |
T741 |
240-242 |
, |
denotes |
, |
T742 |
242-255 |
NN |
denotes |
reduplication |
T743 |
256-259 |
CC |
denotes |
and |
T744 |
260-264 |
NN |
denotes |
exon |
T745 |
265-274 |
NN |
denotes |
shuffling |
T746 |
275-282 |
IN |
denotes |
between |
T747 |
283-287 |
NN |
denotes |
gene |
T748 |
288-296 |
NNS |
denotes |
families |
T749 |
296-298 |
, |
denotes |
, |
T750 |
298-303 |
NNS |
denotes |
genes |
T751 |
304-308 |
VBP |
denotes |
have |
T752 |
317-321 |
CC |
denotes |
both |
T753 |
322-330 |
JJ |
denotes |
discrete |
T754 |
356-365 |
NNS |
denotes |
functions |
T755 |
330-332 |
, |
denotes |
, |
T756 |
332-335 |
CC |
denotes |
and |
T757 |
336-345 |
RB |
denotes |
partially |
T758 |
346-355 |
JJ |
denotes |
redundant |
T759 |
366-370 |
IN |
denotes |
with |
T760 |
371-376 |
PRP$ |
denotes |
their |
T761 |
392-399 |
NNS |
denotes |
members |
T762 |
377-384 |
VBN |
denotes |
related |
T763 |
385-391 |
NN |
denotes |
family |
T764 |
399-400 |
. |
denotes |
. |
T765 |
400-625 |
sentence |
denotes |
With the completion of the genome sequencing projects of human, mouse, rat, fruit fly and nematodes, we are now in a position to ask fundamental questions in regard to how genes interact in the context of the whole organism. |
T766 |
401-405 |
IN |
denotes |
With |
T767 |
505-508 |
VBP |
denotes |
are |
T768 |
406-409 |
DT |
denotes |
the |
T769 |
410-420 |
NN |
denotes |
completion |
T770 |
421-423 |
IN |
denotes |
of |
T771 |
424-427 |
DT |
denotes |
the |
T772 |
446-454 |
NNS |
denotes |
projects |
T773 |
428-434 |
NN |
denotes |
genome |
T774 |
435-445 |
NN |
denotes |
sequencing |
T775 |
455-457 |
IN |
denotes |
of |
T776 |
458-463 |
JJ |
denotes |
human |
T777 |
463-465 |
, |
denotes |
, |
T778 |
465-470 |
NN |
denotes |
mouse |
T779 |
470-472 |
, |
denotes |
, |
T780 |
472-475 |
NN |
denotes |
rat |
T781 |
475-477 |
, |
denotes |
, |
T782 |
477-482 |
NN |
denotes |
fruit |
T783 |
483-486 |
NN |
denotes |
fly |
T784 |
487-490 |
CC |
denotes |
and |
T785 |
491-500 |
NNS |
denotes |
nematodes |
T786 |
500-502 |
, |
denotes |
, |
T787 |
502-504 |
PRP |
denotes |
we |
T788 |
509-512 |
RB |
denotes |
now |
T789 |
513-515 |
IN |
denotes |
in |
T790 |
516-517 |
DT |
denotes |
a |
T791 |
518-526 |
NN |
denotes |
position |
T792 |
527-529 |
TO |
denotes |
to |
T793 |
530-533 |
VB |
denotes |
ask |
T794 |
534-545 |
JJ |
denotes |
fundamental |
T795 |
546-555 |
NNS |
denotes |
questions |
T796 |
556-558 |
IN |
denotes |
in |
T797 |
559-565 |
NN |
denotes |
regard |
T798 |
566-568 |
IN |
denotes |
to |
T799 |
569-572 |
WRB |
denotes |
how |
T800 |
579-587 |
VBP |
denotes |
interact |
T801 |
573-578 |
NNS |
denotes |
genes |
T802 |
588-590 |
IN |
denotes |
in |
T803 |
591-594 |
DT |
denotes |
the |
T804 |
595-602 |
NN |
denotes |
context |
T805 |
603-605 |
IN |
denotes |
of |
T806 |
606-609 |
DT |
denotes |
the |
T807 |
616-624 |
NN |
denotes |
organism |
T808 |
610-615 |
JJ |
denotes |
whole |
T809 |
624-625 |
. |
denotes |
. |
T810 |
625-809 |
sentence |
denotes |
Thus, with the appropriate application of bioinformatics, it is now possible to trace the lineage of particular genes and gene families, with related gene families in other organisms. |
T811 |
626-630 |
RB |
denotes |
Thus |
T812 |
687-689 |
VBZ |
denotes |
is |
T813 |
630-632 |
, |
denotes |
, |
T814 |
632-636 |
IN |
denotes |
with |
T815 |
637-640 |
DT |
denotes |
the |
T816 |
653-664 |
NN |
denotes |
application |
T817 |
641-652 |
JJ |
denotes |
appropriate |
T818 |
665-667 |
IN |
denotes |
of |
T819 |
668-682 |
NN |
denotes |
bioinformatics |
T820 |
682-684 |
, |
denotes |
, |
T821 |
684-686 |
PRP |
denotes |
it |
T822 |
690-693 |
RB |
denotes |
now |
T823 |
694-702 |
JJ |
denotes |
possible |
T824 |
703-705 |
TO |
denotes |
to |
T825 |
706-711 |
VB |
denotes |
trace |
T826 |
712-715 |
DT |
denotes |
the |
T827 |
716-723 |
NN |
denotes |
lineage |
T828 |
724-726 |
IN |
denotes |
of |
T829 |
727-737 |
JJ |
denotes |
particular |
T830 |
738-743 |
NNS |
denotes |
genes |
T831 |
744-747 |
CC |
denotes |
and |
T832 |
748-752 |
NN |
denotes |
gene |
T833 |
753-761 |
NNS |
denotes |
families |
T834 |
761-763 |
, |
denotes |
, |
T835 |
763-767 |
IN |
denotes |
with |
T836 |
768-775 |
JJ |
denotes |
related |
T837 |
781-789 |
NNS |
denotes |
families |
T838 |
776-780 |
NN |
denotes |
gene |
T839 |
790-792 |
IN |
denotes |
in |
T840 |
793-798 |
JJ |
denotes |
other |
T841 |
799-808 |
NNS |
denotes |
organisms |
T842 |
808-809 |
. |
denotes |
. |
T843 |
809-1041 |
sentence |
denotes |
Furthermore, with the growing amount of large-scale proteomic and genomic data becoming publicly available, this analysis can now be extended to reveal the complex interplay between evolution of gene structure and protein function. |
T844 |
810-821 |
RB |
denotes |
Furthermore |
T845 |
943-951 |
VBN |
denotes |
extended |
T846 |
821-823 |
, |
denotes |
, |
T847 |
823-827 |
IN |
denotes |
with |
T848 |
828-831 |
DT |
denotes |
the |
T849 |
840-846 |
NN |
denotes |
amount |
T850 |
832-839 |
VBG |
denotes |
growing |
T851 |
889-897 |
VBG |
denotes |
becoming |
T852 |
847-849 |
IN |
denotes |
of |
T853 |
850-855 |
JJ |
denotes |
large |
T854 |
856-861 |
NN |
denotes |
scale |
T855 |
855-856 |
HYPH |
denotes |
- |
T856 |
884-888 |
NNS |
denotes |
data |
T857 |
862-871 |
JJ |
denotes |
proteomic |
T858 |
872-875 |
CC |
denotes |
and |
T859 |
876-883 |
JJ |
denotes |
genomic |
T860 |
898-906 |
RB |
denotes |
publicly |
T861 |
907-916 |
JJ |
denotes |
available |
T862 |
916-918 |
, |
denotes |
, |
T863 |
918-922 |
DT |
denotes |
this |
T864 |
923-931 |
NN |
denotes |
analysis |
T865 |
932-935 |
MD |
denotes |
can |
T866 |
936-939 |
RB |
denotes |
now |
T867 |
940-942 |
VB |
denotes |
be |
T868 |
952-954 |
TO |
denotes |
to |
T869 |
955-961 |
VB |
denotes |
reveal |
T870 |
962-965 |
DT |
denotes |
the |
T871 |
974-983 |
NN |
denotes |
interplay |
T872 |
966-973 |
JJ |
denotes |
complex |
T873 |
984-991 |
IN |
denotes |
between |
T874 |
992-1001 |
NN |
denotes |
evolution |
T875 |
1002-1004 |
IN |
denotes |
of |
T876 |
1005-1009 |
NN |
denotes |
gene |
T877 |
1010-1019 |
NN |
denotes |
structure |
T878 |
1020-1023 |
CC |
denotes |
and |
T879 |
1024-1031 |
NN |
denotes |
protein |
T880 |
1032-1040 |
NN |
denotes |
function |
T881 |
1040-1041 |
. |
denotes |
. |
T882 |
1041-1208 |
sentence |
denotes |
The first Transforming acidic coiled coil gene, TACC1, was identified during the development of an expression map of the proximal short arm of human chromosome 8 [1]. |
T883 |
1042-1045 |
DT |
denotes |
The |
T884 |
1084-1088 |
NN |
denotes |
gene |
T885 |
1046-1051 |
JJ |
denotes |
first |
T886 |
1052-1064 |
NN |
denotes |
Transforming |
T887 |
1065-1071 |
JJ |
denotes |
acidic |
T888 |
1072-1078 |
VBN |
denotes |
coiled |
T889 |
1079-1083 |
NN |
denotes |
coil |
T890 |
1101-1111 |
VBN |
denotes |
identified |
T891 |
1088-1090 |
, |
denotes |
, |
T892 |
1090-1095 |
NN |
denotes |
TACC1 |
T893 |
1095-1097 |
, |
denotes |
, |
T894 |
1097-1100 |
VBD |
denotes |
was |
T895 |
1112-1118 |
IN |
denotes |
during |
T896 |
1119-1122 |
DT |
denotes |
the |
T897 |
1123-1134 |
NN |
denotes |
development |
T898 |
1135-1137 |
IN |
denotes |
of |
T899 |
1138-1140 |
DT |
denotes |
an |
T900 |
1152-1155 |
NN |
denotes |
map |
T901 |
1141-1151 |
NN |
denotes |
expression |
T902 |
1156-1158 |
IN |
denotes |
of |
T903 |
1159-1162 |
DT |
denotes |
the |
T904 |
1178-1181 |
NN |
denotes |
arm |
T905 |
1163-1171 |
JJ |
denotes |
proximal |
T906 |
1172-1177 |
JJ |
denotes |
short |
T907 |
1182-1184 |
IN |
denotes |
of |
T908 |
1185-1190 |
JJ |
denotes |
human |
T909 |
1191-1201 |
NN |
denotes |
chromosome |
T910 |
1202-1203 |
CD |
denotes |
8 |
T911 |
1204-1205 |
-LRB- |
denotes |
[ |
T912 |
1205-1206 |
CD |
denotes |
1 |
T913 |
1206-1207 |
-RRB- |
denotes |
] |
T914 |
1207-1208 |
. |
denotes |
. |
T915 |
1208-1413 |
sentence |
denotes |
Two additional TACC family members were subsequently identified and mapped to paralogous chromosomal regions on human chromosomes 4p16 and 10q26, physically close to members of the FGFR gene family [1-3]. |
T916 |
1209-1212 |
CD |
denotes |
Two |
T917 |
1236-1243 |
NNS |
denotes |
members |
T918 |
1213-1223 |
JJ |
denotes |
additional |
T919 |
1224-1228 |
NN |
denotes |
TACC |
T920 |
1229-1235 |
NN |
denotes |
family |
T921 |
1262-1272 |
VBN |
denotes |
identified |
T922 |
1244-1248 |
VBD |
denotes |
were |
T923 |
1249-1261 |
RB |
denotes |
subsequently |
T924 |
1273-1276 |
CC |
denotes |
and |
T925 |
1277-1283 |
VBN |
denotes |
mapped |
T926 |
1284-1286 |
IN |
denotes |
to |
T927 |
1287-1297 |
JJ |
denotes |
paralogous |
T928 |
1310-1317 |
NNS |
denotes |
regions |
T929 |
1298-1309 |
JJ |
denotes |
chromosomal |
T930 |
1318-1320 |
IN |
denotes |
on |
T931 |
1321-1326 |
JJ |
denotes |
human |
T932 |
1339-1343 |
NN |
denotes |
4p16 |
T933 |
1327-1338 |
NNS |
denotes |
chromosomes |
T934 |
1344-1347 |
CC |
denotes |
and |
T935 |
1348-1353 |
NN |
denotes |
10q26 |
T936 |
1353-1355 |
, |
denotes |
, |
T937 |
1355-1365 |
RB |
denotes |
physically |
T938 |
1366-1371 |
JJ |
denotes |
close |
T939 |
1372-1374 |
IN |
denotes |
to |
T940 |
1375-1382 |
NNS |
denotes |
members |
T941 |
1383-1385 |
IN |
denotes |
of |
T942 |
1386-1389 |
DT |
denotes |
the |
T943 |
1400-1406 |
NN |
denotes |
family |
T944 |
1390-1394 |
NN |
denotes |
FGFR |
T945 |
1395-1399 |
NN |
denotes |
gene |
T946 |
1407-1408 |
-LRB- |
denotes |
[ |
T947 |
1408-1409 |
CD |
denotes |
1 |
T948 |
1409-1410 |
SYM |
denotes |
- |
T949 |
1410-1411 |
CD |
denotes |
3 |
T950 |
1411-1412 |
-RRB- |
denotes |
] |
T951 |
1412-1413 |
. |
denotes |
. |
T952 |
1413-1667 |
sentence |
denotes |
This mapping data, together with identification of a single TACC gene in the protostomes Caenorhabitis elegans, and Drosophila melanogaster [4-6], led to the speculation that the ancestral FGFR and TACC genes were located physically close to each other. |
T953 |
1414-1418 |
DT |
denotes |
This |
T954 |
1427-1431 |
NNS |
denotes |
data |
T955 |
1419-1426 |
NN |
denotes |
mapping |
T956 |
1561-1564 |
VBD |
denotes |
led |
T957 |
1431-1433 |
, |
denotes |
, |
T958 |
1433-1441 |
RB |
denotes |
together |
T959 |
1442-1446 |
IN |
denotes |
with |
T960 |
1447-1461 |
NN |
denotes |
identification |
T961 |
1462-1464 |
IN |
denotes |
of |
T962 |
1465-1466 |
DT |
denotes |
a |
T963 |
1479-1483 |
NN |
denotes |
gene |
T964 |
1467-1473 |
JJ |
denotes |
single |
T965 |
1474-1478 |
NN |
denotes |
TACC |
T966 |
1484-1486 |
IN |
denotes |
in |
T967 |
1487-1490 |
DT |
denotes |
the |
T968 |
1517-1524 |
NNP |
denotes |
elegans |
T969 |
1491-1502 |
NNS |
denotes |
protostomes |
T970 |
1503-1516 |
NNP |
denotes |
Caenorhabitis |
T971 |
1524-1526 |
, |
denotes |
, |
T972 |
1526-1529 |
CC |
denotes |
and |
T973 |
1530-1540 |
NNP |
denotes |
Drosophila |
T974 |
1541-1553 |
NNP |
denotes |
melanogaster |
T975 |
1554-1555 |
-LRB- |
denotes |
[ |
T976 |
1555-1556 |
CD |
denotes |
4 |
T977 |
1556-1557 |
SYM |
denotes |
- |
T978 |
1557-1558 |
CD |
denotes |
6 |
T979 |
1558-1559 |
-RRB- |
denotes |
] |
T980 |
1559-1561 |
, |
denotes |
, |
T981 |
1565-1567 |
IN |
denotes |
to |
T982 |
1568-1571 |
DT |
denotes |
the |
T983 |
1572-1583 |
NN |
denotes |
speculation |
T984 |
1584-1588 |
IN |
denotes |
that |
T985 |
1628-1635 |
VBN |
denotes |
located |
T986 |
1589-1592 |
DT |
denotes |
the |
T987 |
1617-1622 |
NNS |
denotes |
genes |
T988 |
1593-1602 |
JJ |
denotes |
ancestral |
T989 |
1603-1607 |
NN |
denotes |
FGFR |
T990 |
1608-1611 |
CC |
denotes |
and |
T991 |
1612-1616 |
NN |
denotes |
TACC |
T992 |
1623-1627 |
VBD |
denotes |
were |
T993 |
1636-1646 |
RB |
denotes |
physically |
T994 |
1647-1652 |
RB |
denotes |
close |
T995 |
1653-1655 |
IN |
denotes |
to |
T996 |
1656-1660 |
DT |
denotes |
each |
T997 |
1661-1666 |
JJ |
denotes |
other |
T998 |
1666-1667 |
. |
denotes |
. |
T999 |
1667-1859 |
sentence |
denotes |
Thus, during the evolution of vertebrates, subsequent successive duplications of the ancestral gene cluster have given rise to three TACC family members located close to FGFR genes in humans. |
T1000 |
1668-1672 |
RB |
denotes |
Thus |
T1001 |
1781-1786 |
VBN |
denotes |
given |
T1002 |
1672-1674 |
, |
denotes |
, |
T1003 |
1674-1680 |
IN |
denotes |
during |
T1004 |
1681-1684 |
DT |
denotes |
the |
T1005 |
1685-1694 |
NN |
denotes |
evolution |
T1006 |
1695-1697 |
IN |
denotes |
of |
T1007 |
1698-1709 |
NNS |
denotes |
vertebrates |
T1008 |
1709-1711 |
, |
denotes |
, |
T1009 |
1711-1721 |
JJ |
denotes |
subsequent |
T1010 |
1733-1745 |
NNS |
denotes |
duplications |
T1011 |
1722-1732 |
JJ |
denotes |
successive |
T1012 |
1746-1748 |
IN |
denotes |
of |
T1013 |
1749-1752 |
DT |
denotes |
the |
T1014 |
1768-1775 |
NN |
denotes |
cluster |
T1015 |
1753-1762 |
JJ |
denotes |
ancestral |
T1016 |
1763-1767 |
NN |
denotes |
gene |
T1017 |
1776-1780 |
VBP |
denotes |
have |
T1018 |
1787-1791 |
NN |
denotes |
rise |
T1019 |
1792-1794 |
IN |
denotes |
to |
T1020 |
1795-1800 |
CD |
denotes |
three |
T1021 |
1813-1820 |
NNS |
denotes |
members |
T1022 |
1801-1805 |
NN |
denotes |
TACC |
T1023 |
1806-1812 |
NN |
denotes |
family |
T1024 |
1821-1828 |
VBN |
denotes |
located |
T1025 |
1829-1834 |
RB |
denotes |
close |
T1026 |
1835-1837 |
IN |
denotes |
to |
T1027 |
1838-1842 |
NN |
denotes |
FGFR |
T1028 |
1843-1848 |
NNS |
denotes |
genes |
T1029 |
1849-1851 |
IN |
denotes |
in |
T1030 |
1852-1858 |
NNS |
denotes |
humans |
T1031 |
1858-1859 |
. |
denotes |
. |
T1032 |
1859-2102 |
sentence |
denotes |
In accordance with the proposed quadruplication of the vertebrate genome during evolution, there is a fourth FGFR family member in vertebrates, raising the question of whether a fourth TACC gene is associated with FGFR4 in vertebrate genomes. |
T1033 |
1860-1862 |
IN |
denotes |
In |
T1034 |
1957-1959 |
VBZ |
denotes |
is |
T1035 |
1863-1873 |
NN |
denotes |
accordance |
T1036 |
1874-1878 |
IN |
denotes |
with |
T1037 |
1879-1882 |
DT |
denotes |
the |
T1038 |
1892-1907 |
NN |
denotes |
quadruplication |
T1039 |
1883-1891 |
VBN |
denotes |
proposed |
T1040 |
1908-1910 |
IN |
denotes |
of |
T1041 |
1911-1914 |
DT |
denotes |
the |
T1042 |
1926-1932 |
NN |
denotes |
genome |
T1043 |
1915-1925 |
NN |
denotes |
vertebrate |
T1044 |
1933-1939 |
IN |
denotes |
during |
T1045 |
1940-1949 |
NN |
denotes |
evolution |
T1046 |
1949-1951 |
, |
denotes |
, |
T1047 |
1951-1956 |
EX |
denotes |
there |
T1048 |
1960-1961 |
DT |
denotes |
a |
T1049 |
1981-1987 |
NN |
denotes |
member |
T1050 |
1962-1968 |
JJ |
denotes |
fourth |
T1051 |
1969-1973 |
NN |
denotes |
FGFR |
T1052 |
1974-1980 |
NN |
denotes |
family |
T1053 |
1988-1990 |
IN |
denotes |
in |
T1054 |
1991-2002 |
NNS |
denotes |
vertebrates |
T1055 |
2002-2004 |
, |
denotes |
, |
T1056 |
2004-2011 |
VBG |
denotes |
raising |
T1057 |
2012-2015 |
DT |
denotes |
the |
T1058 |
2016-2024 |
NN |
denotes |
question |
T1059 |
2025-2027 |
IN |
denotes |
of |
T1060 |
2028-2035 |
IN |
denotes |
whether |
T1061 |
2058-2068 |
VBN |
denotes |
associated |
T1062 |
2036-2037 |
DT |
denotes |
a |
T1063 |
2050-2054 |
NN |
denotes |
gene |
T1064 |
2038-2044 |
JJ |
denotes |
fourth |
T1065 |
2045-2049 |
NN |
denotes |
TACC |
T1066 |
2055-2057 |
VBZ |
denotes |
is |
T1067 |
2069-2073 |
IN |
denotes |
with |
T1068 |
2074-2079 |
NN |
denotes |
FGFR4 |
T1069 |
2080-2082 |
IN |
denotes |
in |
T1070 |
2083-2093 |
NN |
denotes |
vertebrate |
T1071 |
2094-2101 |
NNS |
denotes |
genomes |
T1072 |
2101-2102 |
. |
denotes |
. |
T1073 |
2102-2263 |
sentence |
denotes |
To date, only three active TACC genes have been cloned in humans [1-3], one in each of mouse [7], Xenopus laevis [8], D. melanogaster [4], and C. elegans [5,6]. |
T1074 |
2103-2105 |
IN |
denotes |
To |
T1075 |
2175-2178 |
CD |
denotes |
one |
T1076 |
2106-2110 |
NN |
denotes |
date |
T1077 |
2110-2112 |
, |
denotes |
, |
T1078 |
2112-2116 |
RB |
denotes |
only |
T1079 |
2135-2140 |
NNS |
denotes |
genes |
T1080 |
2117-2122 |
CD |
denotes |
three |
T1081 |
2123-2129 |
JJ |
denotes |
active |
T1082 |
2130-2134 |
NN |
denotes |
TACC |
T1083 |
2151-2157 |
VBN |
denotes |
cloned |
T1084 |
2141-2145 |
VBP |
denotes |
have |
T1085 |
2146-2150 |
VBN |
denotes |
been |
T1086 |
2158-2160 |
IN |
denotes |
in |
T1087 |
2161-2167 |
NNS |
denotes |
humans |
T1088 |
2168-2169 |
-LRB- |
denotes |
[ |
T1089 |
2169-2170 |
CD |
denotes |
1 |
T1090 |
2170-2171 |
SYM |
denotes |
- |
T1091 |
2171-2172 |
CD |
denotes |
3 |
T1092 |
2172-2173 |
-RRB- |
denotes |
] |
T1093 |
2173-2175 |
, |
denotes |
, |
T1094 |
2179-2181 |
IN |
denotes |
in |
T1095 |
2182-2186 |
DT |
denotes |
each |
T1096 |
2187-2189 |
IN |
denotes |
of |
T1097 |
2190-2195 |
NN |
denotes |
mouse |
T1098 |
2196-2197 |
-LRB- |
denotes |
[ |
T1099 |
2197-2198 |
CD |
denotes |
7 |
T1100 |
2198-2199 |
-RRB- |
denotes |
] |
T1101 |
2199-2201 |
, |
denotes |
, |
T1102 |
2201-2208 |
NNP |
denotes |
Xenopus |
T1103 |
2209-2215 |
NNP |
denotes |
laevis |
T1104 |
2216-2217 |
-LRB- |
denotes |
[ |
T1105 |
2217-2218 |
CD |
denotes |
8 |
T1106 |
2218-2219 |
-RRB- |
denotes |
] |
T1107 |
2219-2221 |
, |
denotes |
, |
T1108 |
2221-2223 |
NNP |
denotes |
D. |
T1109 |
2224-2236 |
NNP |
denotes |
melanogaster |
T1110 |
2237-2238 |
-LRB- |
denotes |
[ |
T1111 |
2238-2239 |
CD |
denotes |
4 |
T1112 |
2239-2240 |
-RRB- |
denotes |
] |
T1113 |
2240-2242 |
, |
denotes |
, |
T1114 |
2242-2245 |
CC |
denotes |
and |
T1115 |
2246-2248 |
NNP |
denotes |
C. |
T1116 |
2249-2256 |
NNP |
denotes |
elegans |
T1117 |
2257-2258 |
-LRB- |
denotes |
[ |
T1118 |
2260-2261 |
CD |
denotes |
6 |
T1119 |
2258-2259 |
CD |
denotes |
5 |
T1120 |
2259-2260 |
, |
denotes |
, |
T1121 |
2261-2262 |
-RRB- |
denotes |
] |
T1122 |
2262-2263 |
. |
denotes |
. |
T1123 |
2263-2482 |
sentence |
denotes |
Although two additional new candidate TACC family members, Oryctolagus cuniculus TACC4 [9] and human RHAMM [10] have been proposed, their true identity and placement in the evolution of the TACC family is under debate. |
T1124 |
2264-2272 |
IN |
denotes |
Although |
T1125 |
2386-2394 |
VBN |
denotes |
proposed |
T1126 |
2273-2276 |
CD |
denotes |
two |
T1127 |
2314-2321 |
NNS |
denotes |
members |
T1128 |
2277-2287 |
JJ |
denotes |
additional |
T1129 |
2288-2291 |
JJ |
denotes |
new |
T1130 |
2292-2301 |
NN |
denotes |
candidate |
T1131 |
2302-2306 |
NN |
denotes |
TACC |
T1132 |
2307-2313 |
NN |
denotes |
family |
T1133 |
2321-2323 |
, |
denotes |
, |
T1134 |
2323-2334 |
NNP |
denotes |
Oryctolagus |
T1135 |
2345-2350 |
NN |
denotes |
TACC4 |
T1136 |
2335-2344 |
NNP |
denotes |
cuniculus |
T1137 |
2351-2352 |
-LRB- |
denotes |
[ |
T1138 |
2352-2353 |
CD |
denotes |
9 |
T1139 |
2353-2354 |
-RRB- |
denotes |
] |
T1140 |
2355-2358 |
CC |
denotes |
and |
T1141 |
2359-2364 |
JJ |
denotes |
human |
T1142 |
2365-2370 |
NN |
denotes |
RHAMM |
T1143 |
2371-2372 |
-LRB- |
denotes |
[ |
T1144 |
2372-2374 |
CD |
denotes |
10 |
T1145 |
2374-2375 |
-RRB- |
denotes |
] |
T1146 |
2376-2380 |
VBP |
denotes |
have |
T1147 |
2381-2385 |
VBN |
denotes |
been |
T1148 |
2466-2468 |
VBZ |
denotes |
is |
T1149 |
2394-2396 |
, |
denotes |
, |
T1150 |
2396-2401 |
PRP$ |
denotes |
their |
T1151 |
2407-2415 |
NN |
denotes |
identity |
T1152 |
2402-2406 |
JJ |
denotes |
true |
T1153 |
2416-2419 |
CC |
denotes |
and |
T1154 |
2420-2429 |
NN |
denotes |
placement |
T1155 |
2430-2432 |
IN |
denotes |
in |
T1156 |
2433-2436 |
DT |
denotes |
the |
T1157 |
2437-2446 |
NN |
denotes |
evolution |
T1158 |
2447-2449 |
IN |
denotes |
of |
T1159 |
2450-2453 |
DT |
denotes |
the |
T1160 |
2459-2465 |
NN |
denotes |
family |
T1161 |
2454-2458 |
NN |
denotes |
TACC |
T1162 |
2469-2474 |
IN |
denotes |
under |
T1163 |
2475-2481 |
NN |
denotes |
debate |
T1164 |
2481-2482 |
. |
denotes |
. |
T1165 |
2482-2834 |
sentence |
denotes |
Thus, the identification and functional characterization of new members of the TACC family in other organisms, alternatively spliced isoforms of each TACC and comparison of the phylogenetic relationship of these genes relative to other members of the coiled coil superfamily will resolve this issue and provide clues to the evolution of TACC function. |
T1166 |
2483-2487 |
RB |
denotes |
Thus |
T1167 |
2763-2770 |
VB |
denotes |
resolve |
T1168 |
2487-2489 |
, |
denotes |
, |
T1169 |
2489-2492 |
DT |
denotes |
the |
T1170 |
2493-2507 |
NN |
denotes |
identification |
T1171 |
2508-2511 |
CC |
denotes |
and |
T1172 |
2512-2522 |
JJ |
denotes |
functional |
T1173 |
2523-2539 |
NN |
denotes |
characterization |
T1174 |
2540-2542 |
IN |
denotes |
of |
T1175 |
2543-2546 |
JJ |
denotes |
new |
T1176 |
2547-2554 |
NNS |
denotes |
members |
T1177 |
2555-2557 |
IN |
denotes |
of |
T1178 |
2558-2561 |
DT |
denotes |
the |
T1179 |
2567-2573 |
NN |
denotes |
family |
T1180 |
2562-2566 |
NN |
denotes |
TACC |
T1181 |
2574-2576 |
IN |
denotes |
in |
T1182 |
2577-2582 |
JJ |
denotes |
other |
T1183 |
2583-2592 |
NNS |
denotes |
organisms |
T1184 |
2592-2594 |
, |
denotes |
, |
T1185 |
2594-2607 |
RB |
denotes |
alternatively |
T1186 |
2608-2615 |
VBN |
denotes |
spliced |
T1187 |
2616-2624 |
NNS |
denotes |
isoforms |
T1188 |
2625-2627 |
IN |
denotes |
of |
T1189 |
2628-2632 |
DT |
denotes |
each |
T1190 |
2633-2637 |
NN |
denotes |
TACC |
T1191 |
2638-2641 |
CC |
denotes |
and |
T1192 |
2642-2652 |
NN |
denotes |
comparison |
T1193 |
2653-2655 |
IN |
denotes |
of |
T1194 |
2656-2659 |
DT |
denotes |
the |
T1195 |
2673-2685 |
NN |
denotes |
relationship |
T1196 |
2660-2672 |
JJ |
denotes |
phylogenetic |
T1197 |
2686-2688 |
IN |
denotes |
of |
T1198 |
2689-2694 |
DT |
denotes |
these |
T1199 |
2695-2700 |
NNS |
denotes |
genes |
T1200 |
2701-2709 |
JJ |
denotes |
relative |
T1201 |
2710-2712 |
IN |
denotes |
to |
T1202 |
2713-2718 |
JJ |
denotes |
other |
T1203 |
2719-2726 |
NNS |
denotes |
members |
T1204 |
2727-2729 |
IN |
denotes |
of |
T1205 |
2730-2733 |
DT |
denotes |
the |
T1206 |
2746-2757 |
NN |
denotes |
superfamily |
T1207 |
2734-2740 |
VBN |
denotes |
coiled |
T1208 |
2741-2745 |
NN |
denotes |
coil |
T1209 |
2758-2762 |
MD |
denotes |
will |
T1210 |
2771-2775 |
DT |
denotes |
this |
T1211 |
2776-2781 |
NN |
denotes |
issue |
T1212 |
2782-2785 |
CC |
denotes |
and |
T1213 |
2786-2793 |
VB |
denotes |
provide |
T1214 |
2794-2799 |
NNS |
denotes |
clues |
T1215 |
2800-2802 |
IN |
denotes |
to |
T1216 |
2803-2806 |
DT |
denotes |
the |
T1217 |
2807-2816 |
NN |
denotes |
evolution |
T1218 |
2817-2819 |
IN |
denotes |
of |
T1219 |
2820-2824 |
NN |
denotes |
TACC |
T1220 |
2825-2833 |
NN |
denotes |
function |
T1221 |
2833-2834 |
. |
denotes |
. |
R316 |
T703 |
T704 |
det |
The,evolution |
R317 |
T704 |
T705 |
nsubjpass |
evolution,associated |
R318 |
T706 |
T704 |
prep |
of,evolution |
R319 |
T707 |
T708 |
amod |
complex,organisms |
R320 |
T708 |
T706 |
pobj |
organisms,of |
R321 |
T709 |
T705 |
aux |
has,associated |
R322 |
T710 |
T705 |
auxpass |
been,associated |
R323 |
T711 |
T705 |
prep |
with,associated |
R324 |
T712 |
T713 |
det |
the,generation |
R325 |
T713 |
T711 |
pobj |
generation,with |
R326 |
T714 |
T713 |
prep |
of,generation |
R327 |
T715 |
T716 |
compound |
gene,families |
R328 |
T716 |
T714 |
pobj |
families,of |
R329 |
T717 |
T705 |
prep |
by,associated |
R330 |
T718 |
T719 |
det |
the,duplication |
R331 |
T719 |
T717 |
pobj |
duplication,by |
R332 |
T720 |
T719 |
amod |
continual,duplication |
R333 |
T721 |
T719 |
prep |
of,duplication |
R334 |
T722 |
T723 |
det |
an,set |
R335 |
T723 |
T721 |
pobj |
set,of |
R336 |
T724 |
T723 |
amod |
initial,set |
R337 |
T725 |
T726 |
advmod |
relatively,small |
R338 |
T726 |
T723 |
amod |
small,set |
R339 |
T727 |
T723 |
prep |
of,set |
R340 |
T728 |
T729 |
amod |
ancestral,genes |
R341 |
T729 |
T727 |
pobj |
genes,of |
R342 |
T730 |
T705 |
punct |
.,associated |
R343 |
T732 |
T733 |
prep |
Through,evolved |
R344 |
T734 |
T735 |
det |
this,process |
R345 |
T735 |
T732 |
pobj |
process,Through |
R346 |
T736 |
T735 |
punct |
", ",process |
R347 |
T737 |
T735 |
acl |
followed,process |
R348 |
T738 |
T737 |
agent |
by,followed |
R349 |
T739 |
T740 |
amod |
subsequent,mutation |
R350 |
T740 |
T738 |
pobj |
mutation,by |
R351 |
T741 |
T740 |
punct |
", ",mutation |
R352 |
T742 |
T740 |
conj |
reduplication,mutation |
R353 |
T743 |
T742 |
cc |
and,reduplication |
R354 |
T744 |
T745 |
compound |
exon,shuffling |
R355 |
T745 |
T742 |
conj |
shuffling,reduplication |
R356 |
T746 |
T740 |
prep |
between,mutation |
R357 |
T747 |
T748 |
compound |
gene,families |
R358 |
T748 |
T746 |
pobj |
families,between |
R359 |
T749 |
T733 |
punct |
", ",evolved |
R360 |
T750 |
T733 |
nsubj |
genes,evolved |
R361 |
T751 |
T733 |
aux |
have,evolved |
R362 |
T752 |
T753 |
preconj |
both,discrete |
R363 |
T753 |
T754 |
amod |
discrete,functions |
R364 |
T754 |
T733 |
dobj |
functions,evolved |
R365 |
T755 |
T753 |
punct |
", ",discrete |
R366 |
T756 |
T753 |
cc |
and,discrete |
R367 |
T757 |
T758 |
advmod |
partially,redundant |
R368 |
T758 |
T753 |
conj |
redundant,discrete |
R369 |
T759 |
T754 |
prep |
with,functions |
R370 |
T760 |
T761 |
poss |
their,members |
R371 |
T761 |
T759 |
pobj |
members,with |
R372 |
T762 |
T761 |
amod |
related,members |
R373 |
T763 |
T761 |
compound |
family,members |
R374 |
T764 |
T733 |
punct |
.,evolved |
R375 |
T766 |
T767 |
prep |
With,are |
R376 |
T768 |
T769 |
det |
the,completion |
R377 |
T769 |
T766 |
pobj |
completion,With |
R378 |
T770 |
T769 |
prep |
of,completion |
R379 |
T771 |
T772 |
det |
the,projects |
R380 |
T772 |
T770 |
pobj |
projects,of |
R381 |
T773 |
T774 |
compound |
genome,sequencing |
R382 |
T774 |
T772 |
compound |
sequencing,projects |
R383 |
T775 |
T772 |
prep |
of,projects |
R384 |
T776 |
T775 |
pobj |
human,of |
R385 |
T777 |
T776 |
punct |
", ",human |
R386 |
T778 |
T776 |
conj |
mouse,human |
R387 |
T779 |
T778 |
punct |
", ",mouse |
R388 |
T780 |
T778 |
conj |
rat,mouse |
R389 |
T781 |
T780 |
punct |
", ",rat |
R390 |
T782 |
T783 |
compound |
fruit,fly |
R391 |
T783 |
T780 |
conj |
fly,rat |
R392 |
T784 |
T783 |
cc |
and,fly |
R393 |
T785 |
T783 |
conj |
nematodes,fly |
R394 |
T786 |
T767 |
punct |
", ",are |
R395 |
T787 |
T767 |
nsubj |
we,are |
R396 |
T788 |
T767 |
advmod |
now,are |
R397 |
T789 |
T767 |
prep |
in,are |
R398 |
T790 |
T791 |
det |
a,position |
R399 |
T791 |
T789 |
pobj |
position,in |
R400 |
T792 |
T793 |
aux |
to,ask |
R401 |
T793 |
T791 |
acl |
ask,position |
R402 |
T794 |
T795 |
amod |
fundamental,questions |
R403 |
T795 |
T793 |
dobj |
questions,ask |
R404 |
T796 |
T793 |
prep |
in,ask |
R405 |
T797 |
T796 |
pobj |
regard,in |
R406 |
T798 |
T797 |
prep |
to,regard |
R407 |
T799 |
T800 |
advmod |
how,interact |
R408 |
T800 |
T798 |
pcomp |
interact,to |
R409 |
T801 |
T800 |
nsubj |
genes,interact |
R410 |
T802 |
T800 |
prep |
in,interact |
R411 |
T803 |
T804 |
det |
the,context |
R412 |
T804 |
T802 |
pobj |
context,in |
R413 |
T805 |
T804 |
prep |
of,context |
R414 |
T806 |
T807 |
det |
the,organism |
R415 |
T807 |
T805 |
pobj |
organism,of |
R416 |
T808 |
T807 |
amod |
whole,organism |
R417 |
T809 |
T767 |
punct |
.,are |
R418 |
T811 |
T812 |
advmod |
Thus,is |
R419 |
T813 |
T812 |
punct |
", ",is |
R420 |
T814 |
T812 |
prep |
with,is |
R421 |
T815 |
T816 |
det |
the,application |
R422 |
T816 |
T814 |
pobj |
application,with |
R423 |
T817 |
T816 |
amod |
appropriate,application |
R424 |
T818 |
T816 |
prep |
of,application |
R425 |
T819 |
T818 |
pobj |
bioinformatics,of |
R426 |
T820 |
T812 |
punct |
", ",is |
R427 |
T821 |
T812 |
nsubj |
it,is |
R428 |
T822 |
T812 |
advmod |
now,is |
R429 |
T823 |
T812 |
acomp |
possible,is |
R430 |
T824 |
T825 |
aux |
to,trace |
R431 |
T825 |
T812 |
xcomp |
trace,is |
R432 |
T826 |
T827 |
det |
the,lineage |
R433 |
T827 |
T825 |
dobj |
lineage,trace |
R434 |
T828 |
T827 |
prep |
of,lineage |
R435 |
T829 |
T830 |
amod |
particular,genes |
R436 |
T830 |
T828 |
pobj |
genes,of |
R437 |
T831 |
T830 |
cc |
and,genes |
R438 |
T832 |
T833 |
compound |
gene,families |
R439 |
T833 |
T830 |
conj |
families,genes |
R440 |
T834 |
T825 |
punct |
", ",trace |
R441 |
T835 |
T825 |
prep |
with,trace |
R442 |
T836 |
T837 |
amod |
related,families |
R443 |
T837 |
T835 |
pobj |
families,with |
R444 |
T838 |
T837 |
compound |
gene,families |
R445 |
T839 |
T837 |
prep |
in,families |
R446 |
T840 |
T841 |
amod |
other,organisms |
R447 |
T841 |
T839 |
pobj |
organisms,in |
R448 |
T842 |
T812 |
punct |
.,is |
R449 |
T844 |
T845 |
advmod |
Furthermore,extended |
R450 |
T846 |
T845 |
punct |
", ",extended |
R451 |
T847 |
T845 |
prep |
with,extended |
R452 |
T848 |
T849 |
det |
the,amount |
R453 |
T849 |
T851 |
nsubj |
amount,becoming |
R454 |
T850 |
T849 |
amod |
growing,amount |
R455 |
T851 |
T847 |
pcomp |
becoming,with |
R456 |
T852 |
T849 |
prep |
of,amount |
R457 |
T853 |
T854 |
amod |
large,scale |
R458 |
T854 |
T856 |
nmod |
scale,data |
R459 |
T855 |
T854 |
punct |
-,scale |
R460 |
T856 |
T852 |
pobj |
data,of |
R461 |
T857 |
T856 |
amod |
proteomic,data |
R462 |
T858 |
T857 |
cc |
and,proteomic |
R463 |
T859 |
T857 |
conj |
genomic,proteomic |
R464 |
T860 |
T861 |
advmod |
publicly,available |
R465 |
T861 |
T851 |
acomp |
available,becoming |
R466 |
T862 |
T845 |
punct |
", ",extended |
R467 |
T863 |
T864 |
det |
this,analysis |
R468 |
T864 |
T845 |
nsubjpass |
analysis,extended |
R469 |
T865 |
T845 |
aux |
can,extended |
R470 |
T866 |
T845 |
advmod |
now,extended |
R471 |
T867 |
T845 |
auxpass |
be,extended |
R472 |
T868 |
T869 |
aux |
to,reveal |
R473 |
T869 |
T845 |
advcl |
reveal,extended |
R474 |
T870 |
T871 |
det |
the,interplay |
R475 |
T871 |
T869 |
dobj |
interplay,reveal |
R476 |
T872 |
T871 |
amod |
complex,interplay |
R477 |
T873 |
T871 |
prep |
between,interplay |
R478 |
T874 |
T873 |
pobj |
evolution,between |
R479 |
T875 |
T874 |
prep |
of,evolution |
R480 |
T876 |
T877 |
compound |
gene,structure |
R481 |
T877 |
T875 |
pobj |
structure,of |
R482 |
T878 |
T874 |
cc |
and,evolution |
R483 |
T879 |
T880 |
compound |
protein,function |
R484 |
T880 |
T874 |
conj |
function,evolution |
R485 |
T881 |
T845 |
punct |
.,extended |
R486 |
T883 |
T884 |
det |
The,gene |
R488 |
T885 |
T884 |
amod |
first,gene |
R489 |
T886 |
T884 |
nmod |
Transforming,gene |
R490 |
T887 |
T884 |
amod |
acidic,gene |
R491 |
T888 |
T889 |
amod |
coiled,coil |
R492 |
T889 |
T884 |
compound |
coil,gene |
R493 |
T891 |
T884 |
punct |
", ",gene |
R494 |
T892 |
T884 |
appos |
TACC1,gene |
R495 |
T893 |
T890 |
punct |
", ",identified |
R496 |
T894 |
T890 |
auxpass |
was,identified |
R497 |
T895 |
T890 |
prep |
during,identified |
R498 |
T896 |
T897 |
det |
the,development |
R499 |
T897 |
T895 |
pobj |
development,during |
R500 |
T898 |
T897 |
prep |
of,development |
R501 |
T899 |
T900 |
det |
an,map |
R502 |
T900 |
T898 |
pobj |
map,of |
R503 |
T901 |
T900 |
compound |
expression,map |
R504 |
T902 |
T900 |
prep |
of,map |
R505 |
T903 |
T904 |
det |
the,arm |
R506 |
T904 |
T902 |
pobj |
arm,of |
R507 |
T905 |
T904 |
amod |
proximal,arm |
R508 |
T906 |
T904 |
amod |
short,arm |
R509 |
T907 |
T904 |
prep |
of,arm |
R510 |
T908 |
T909 |
amod |
human,chromosome |
R511 |
T909 |
T907 |
pobj |
chromosome,of |
R512 |
T910 |
T909 |
nummod |
8,chromosome |
R513 |
T911 |
T912 |
punct |
[,1 |
R514 |
T912 |
T890 |
parataxis |
1,identified |
R515 |
T913 |
T912 |
punct |
],1 |
R516 |
T914 |
T890 |
punct |
.,identified |
R517 |
T916 |
T917 |
nummod |
Two,members |
R518 |
T917 |
T921 |
nsubjpass |
members,identified |
R519 |
T918 |
T917 |
amod |
additional,members |
R520 |
T919 |
T917 |
compound |
TACC,members |
R521 |
T920 |
T917 |
compound |
family,members |
R522 |
T922 |
T921 |
auxpass |
were,identified |
R523 |
T923 |
T921 |
advmod |
subsequently,identified |
R524 |
T924 |
T921 |
cc |
and,identified |
R525 |
T925 |
T921 |
conj |
mapped,identified |
R526 |
T926 |
T925 |
prep |
to,mapped |
R527 |
T927 |
T928 |
amod |
paralogous,regions |
R528 |
T928 |
T926 |
pobj |
regions,to |
R529 |
T929 |
T928 |
amod |
chromosomal,regions |
R530 |
T930 |
T928 |
prep |
on,regions |
R531 |
T931 |
T932 |
amod |
human,4p16 |
R532 |
T932 |
T930 |
pobj |
4p16,on |
R533 |
T933 |
T932 |
compound |
chromosomes,4p16 |
R534 |
T934 |
T932 |
cc |
and,4p16 |
R535 |
T935 |
T932 |
conj |
10q26,4p16 |
R536 |
T936 |
T932 |
punct |
", ",4p16 |
R537 |
T937 |
T938 |
advmod |
physically,close |
R538 |
T938 |
T932 |
amod |
close,4p16 |
R539 |
T939 |
T938 |
prep |
to,close |
R540 |
T940 |
T939 |
pobj |
members,to |
R541 |
T941 |
T940 |
prep |
of,members |
R542 |
T942 |
T943 |
det |
the,family |
R543 |
T943 |
T941 |
pobj |
family,of |
R544 |
T944 |
T943 |
compound |
FGFR,family |
R545 |
T945 |
T943 |
compound |
gene,family |
R546 |
T946 |
T947 |
punct |
[,1 |
R547 |
T947 |
T925 |
parataxis |
1,mapped |
R548 |
T948 |
T949 |
punct |
-,3 |
R549 |
T949 |
T947 |
prep |
3,1 |
R550 |
T950 |
T947 |
punct |
],1 |
R551 |
T951 |
T921 |
punct |
.,identified |
R552 |
T953 |
T954 |
det |
This,data |
R553 |
T954 |
T956 |
nsubj |
data,led |
R554 |
T955 |
T954 |
compound |
mapping,data |
R555 |
T957 |
T954 |
punct |
", ",data |
R556 |
T958 |
T959 |
advmod |
together,with |
R557 |
T959 |
T954 |
prep |
with,data |
R558 |
T960 |
T959 |
pobj |
identification,with |
R559 |
T961 |
T960 |
prep |
of,identification |
R560 |
T962 |
T963 |
det |
a,gene |
R561 |
T963 |
T961 |
pobj |
gene,of |
R562 |
T964 |
T963 |
amod |
single,gene |
R563 |
T965 |
T963 |
compound |
TACC,gene |
R564 |
T966 |
T960 |
prep |
in,identification |
R565 |
T967 |
T968 |
det |
the,elegans |
R566 |
T968 |
T966 |
pobj |
elegans,in |
R567 |
T969 |
T968 |
compound |
protostomes,elegans |
R568 |
T970 |
T968 |
compound |
Caenorhabitis,elegans |
R569 |
T971 |
T968 |
punct |
", ",elegans |
R570 |
T972 |
T968 |
cc |
and,elegans |
R571 |
T973 |
T974 |
compound |
Drosophila,melanogaster |
R572 |
T974 |
T968 |
conj |
melanogaster,elegans |
R573 |
T975 |
T976 |
punct |
[,4 |
R574 |
T976 |
T954 |
parataxis |
4,data |
R575 |
T977 |
T978 |
punct |
-,6 |
R576 |
T978 |
T976 |
prep |
6,4 |
R577 |
T979 |
T976 |
punct |
],4 |
R578 |
T980 |
T956 |
punct |
", ",led |
R579 |
T981 |
T956 |
prep |
to,led |
R580 |
T982 |
T983 |
det |
the,speculation |
R581 |
T983 |
T981 |
pobj |
speculation,to |
R582 |
T984 |
T985 |
mark |
that,located |
R583 |
T985 |
T983 |
acl |
located,speculation |
R584 |
T986 |
T987 |
det |
the,genes |
R585 |
T987 |
T985 |
nsubjpass |
genes,located |
R586 |
T988 |
T987 |
amod |
ancestral,genes |
R587 |
T989 |
T987 |
nmod |
FGFR,genes |
R588 |
T990 |
T989 |
cc |
and,FGFR |
R589 |
T991 |
T989 |
conj |
TACC,FGFR |
R590 |
T992 |
T985 |
auxpass |
were,located |
R591 |
T993 |
T994 |
advmod |
physically,close |
R592 |
T994 |
T985 |
advmod |
close,located |
R593 |
T995 |
T994 |
prep |
to,close |
R594 |
T996 |
T997 |
det |
each,other |
R595 |
T997 |
T995 |
pobj |
other,to |
R596 |
T998 |
T956 |
punct |
.,led |
R597 |
T1000 |
T1001 |
advmod |
Thus,given |
R598 |
T1002 |
T1001 |
punct |
", ",given |
R599 |
T1003 |
T1001 |
prep |
during,given |
R600 |
T1004 |
T1005 |
det |
the,evolution |
R601 |
T1005 |
T1003 |
pobj |
evolution,during |
R602 |
T1006 |
T1005 |
prep |
of,evolution |
R603 |
T1007 |
T1006 |
pobj |
vertebrates,of |
R604 |
T1008 |
T1001 |
punct |
", ",given |
R605 |
T1009 |
T1010 |
amod |
subsequent,duplications |
R606 |
T1010 |
T1001 |
nsubj |
duplications,given |
R607 |
T1011 |
T1010 |
amod |
successive,duplications |
R608 |
T1012 |
T1010 |
prep |
of,duplications |
R609 |
T1013 |
T1014 |
det |
the,cluster |
R610 |
T1014 |
T1012 |
pobj |
cluster,of |
R611 |
T1015 |
T1014 |
amod |
ancestral,cluster |
R612 |
T1016 |
T1014 |
compound |
gene,cluster |
R613 |
T1017 |
T1001 |
aux |
have,given |
R614 |
T1018 |
T1001 |
dobj |
rise,given |
R615 |
T1019 |
T1001 |
prep |
to,given |
R616 |
T1020 |
T1021 |
nummod |
three,members |
R617 |
T1021 |
T1019 |
pobj |
members,to |
R618 |
T1022 |
T1021 |
compound |
TACC,members |
R619 |
T1023 |
T1021 |
compound |
family,members |
R620 |
T1024 |
T1021 |
acl |
located,members |
R621 |
T1025 |
T1024 |
advmod |
close,located |
R622 |
T1026 |
T1025 |
prep |
to,close |
R623 |
T1027 |
T1028 |
compound |
FGFR,genes |
R624 |
T1028 |
T1026 |
pobj |
genes,to |
R625 |
T1029 |
T1024 |
prep |
in,located |
R626 |
T1030 |
T1029 |
pobj |
humans,in |
R627 |
T1031 |
T1001 |
punct |
.,given |
R628 |
T1033 |
T1034 |
prep |
In,is |
R629 |
T1035 |
T1033 |
pobj |
accordance,In |
R630 |
T1036 |
T1035 |
prep |
with,accordance |
R631 |
T1037 |
T1038 |
det |
the,quadruplication |
R632 |
T1038 |
T1036 |
pobj |
quadruplication,with |
R633 |
T1039 |
T1038 |
amod |
proposed,quadruplication |
R634 |
T1040 |
T1038 |
prep |
of,quadruplication |
R635 |
T1041 |
T1042 |
det |
the,genome |
R636 |
T1042 |
T1040 |
pobj |
genome,of |
R637 |
T1043 |
T1042 |
compound |
vertebrate,genome |
R638 |
T1044 |
T1038 |
prep |
during,quadruplication |
R639 |
T1045 |
T1044 |
pobj |
evolution,during |
R640 |
T1046 |
T1034 |
punct |
", ",is |
R641 |
T1047 |
T1034 |
expl |
there,is |
R642 |
T1048 |
T1049 |
det |
a,member |
R643 |
T1049 |
T1034 |
attr |
member,is |
R644 |
T1050 |
T1049 |
amod |
fourth,member |
R645 |
T1051 |
T1049 |
compound |
FGFR,member |
R646 |
T1052 |
T1049 |
compound |
family,member |
R647 |
T1053 |
T1034 |
prep |
in,is |
R648 |
T1054 |
T1053 |
pobj |
vertebrates,in |
R649 |
T1055 |
T1034 |
punct |
", ",is |
R650 |
T1056 |
T1034 |
advcl |
raising,is |
R651 |
T1057 |
T1058 |
det |
the,question |
R652 |
T1058 |
T1056 |
dobj |
question,raising |
R653 |
T1059 |
T1058 |
prep |
of,question |
R654 |
T1060 |
T1061 |
mark |
whether,associated |
R656 |
T1062 |
T1063 |
det |
a,gene |
R657 |
T1063 |
T1061 |
nsubjpass |
gene,associated |
R658 |
T1064 |
T1063 |
amod |
fourth,gene |
R659 |
T1065 |
T1063 |
compound |
TACC,gene |
R660 |
T1066 |
T1061 |
auxpass |
is,associated |
R661 |
T1067 |
T1061 |
prep |
with,associated |
R662 |
T1068 |
T1067 |
pobj |
FGFR4,with |
R663 |
T1069 |
T1061 |
prep |
in,associated |
R664 |
T1070 |
T1071 |
compound |
vertebrate,genomes |
R665 |
T1071 |
T1069 |
pobj |
genomes,in |
R666 |
T1072 |
T1034 |
punct |
.,is |
R667 |
T1074 |
T1075 |
prep |
To,one |
R668 |
T1076 |
T1074 |
pobj |
date,To |
R669 |
T1077 |
T1075 |
punct |
", ",one |
R670 |
T1078 |
T1079 |
advmod |
only,genes |
R671 |
T1079 |
T1083 |
nsubjpass |
genes,cloned |
R672 |
T1080 |
T1079 |
nummod |
three,genes |
R673 |
T1081 |
T1079 |
amod |
active,genes |
R674 |
T1082 |
T1079 |
compound |
TACC,genes |
R675 |
T1083 |
T1075 |
ccomp |
cloned,one |
R676 |
T1084 |
T1083 |
aux |
have,cloned |
R677 |
T1085 |
T1083 |
auxpass |
been,cloned |
R678 |
T1086 |
T1083 |
prep |
in,cloned |
R679 |
T1087 |
T1086 |
pobj |
humans,in |
R680 |
T1088 |
T1089 |
punct |
[,1 |
R681 |
T1089 |
T1083 |
parataxis |
1,cloned |
R682 |
T1090 |
T1091 |
punct |
-,3 |
R683 |
T1091 |
T1089 |
prep |
3,1 |
R684 |
T1092 |
T1089 |
punct |
],1 |
R685 |
T1093 |
T1075 |
punct |
", ",one |
R686 |
T1094 |
T1075 |
prep |
in,one |
R687 |
T1095 |
T1094 |
pobj |
each,in |
R688 |
T1096 |
T1095 |
prep |
of,each |
R689 |
T1097 |
T1096 |
pobj |
mouse,of |
R690 |
T1098 |
T1099 |
punct |
[,7 |
R691 |
T1099 |
T1097 |
parataxis |
7,mouse |
R692 |
T1100 |
T1099 |
punct |
],7 |
R693 |
T1101 |
T1097 |
punct |
", ",mouse |
R694 |
T1102 |
T1103 |
compound |
Xenopus,laevis |
R695 |
T1103 |
T1097 |
conj |
laevis,mouse |
R696 |
T1104 |
T1105 |
punct |
[,8 |
R697 |
T1105 |
T1103 |
parataxis |
8,laevis |
R698 |
T1106 |
T1105 |
punct |
],8 |
R699 |
T1107 |
T1103 |
punct |
", ",laevis |
R700 |
T1108 |
T1109 |
compound |
D.,melanogaster |
R701 |
T1109 |
T1103 |
conj |
melanogaster,laevis |
R702 |
T1110 |
T1111 |
punct |
[,4 |
R703 |
T1111 |
T1109 |
parataxis |
4,melanogaster |
R704 |
T1112 |
T1111 |
punct |
],4 |
R705 |
T1113 |
T1109 |
punct |
", ",melanogaster |
R706 |
T1114 |
T1109 |
cc |
and,melanogaster |
R707 |
T1115 |
T1116 |
compound |
C.,elegans |
R708 |
T1116 |
T1109 |
conj |
elegans,melanogaster |
R709 |
T1117 |
T1118 |
punct |
[,6 |
R710 |
T1118 |
T1116 |
parataxis |
6,elegans |
R711 |
T1119 |
T1118 |
nummod |
5,6 |
R712 |
T1120 |
T1118 |
punct |
",",6 |
R713 |
T1121 |
T1118 |
punct |
],6 |
R714 |
T1122 |
T1075 |
punct |
.,one |
R715 |
T1124 |
T1125 |
mark |
Although,proposed |
R716 |
T1125 |
T1148 |
advcl |
proposed,is |
R717 |
T1126 |
T1127 |
nummod |
two,members |
R718 |
T1127 |
T1125 |
nsubjpass |
members,proposed |
R719 |
T1128 |
T1127 |
amod |
additional,members |
R720 |
T1129 |
T1127 |
amod |
new,members |
R721 |
T1130 |
T1127 |
compound |
candidate,members |
R722 |
T1131 |
T1127 |
compound |
TACC,members |
R723 |
T1132 |
T1127 |
compound |
family,members |
R724 |
T1133 |
T1127 |
punct |
", ",members |
R725 |
T1134 |
T1135 |
compound |
Oryctolagus,TACC4 |
R726 |
T1135 |
T1127 |
appos |
TACC4,members |
R727 |
T1136 |
T1135 |
compound |
cuniculus,TACC4 |
R728 |
T1137 |
T1138 |
punct |
[,9 |
R729 |
T1138 |
T1135 |
parataxis |
9,TACC4 |
R730 |
T1139 |
T1138 |
punct |
],9 |
R731 |
T1140 |
T1135 |
cc |
and,TACC4 |
R732 |
T1141 |
T1142 |
amod |
human,RHAMM |
R733 |
T1142 |
T1135 |
conj |
RHAMM,TACC4 |
R734 |
T1143 |
T1144 |
punct |
[,10 |
R735 |
T1144 |
T1142 |
parataxis |
10,RHAMM |
R736 |
T1145 |
T1144 |
punct |
],10 |
R737 |
T1146 |
T1125 |
aux |
have,proposed |
R738 |
T1147 |
T1125 |
auxpass |
been,proposed |
R739 |
T1149 |
T1148 |
punct |
", ",is |
R740 |
T1150 |
T1151 |
poss |
their,identity |
R741 |
T1151 |
T1148 |
nsubj |
identity,is |
R742 |
T1152 |
T1151 |
amod |
true,identity |
R743 |
T1153 |
T1151 |
cc |
and,identity |
R744 |
T1154 |
T1151 |
conj |
placement,identity |
R745 |
T1155 |
T1151 |
prep |
in,identity |
R746 |
T1156 |
T1157 |
det |
the,evolution |
R747 |
T1157 |
T1155 |
pobj |
evolution,in |
R748 |
T1158 |
T1157 |
prep |
of,evolution |
R749 |
T1159 |
T1160 |
det |
the,family |
R750 |
T1160 |
T1158 |
pobj |
family,of |
R751 |
T1161 |
T1160 |
compound |
TACC,family |
R752 |
T1162 |
T1148 |
prep |
under,is |
R753 |
T1163 |
T1162 |
pobj |
debate,under |
R754 |
T1164 |
T1148 |
punct |
.,is |
R755 |
T1166 |
T1167 |
advmod |
Thus,resolve |
R756 |
T1168 |
T1167 |
punct |
", ",resolve |
R757 |
T1169 |
T1170 |
det |
the,identification |
R758 |
T1170 |
T1167 |
nsubj |
identification,resolve |
R759 |
T1171 |
T1170 |
cc |
and,identification |
R760 |
T1172 |
T1173 |
amod |
functional,characterization |
R761 |
T1173 |
T1170 |
conj |
characterization,identification |
R762 |
T1174 |
T1170 |
prep |
of,identification |
R763 |
T1175 |
T1176 |
amod |
new,members |
R764 |
T1176 |
T1174 |
pobj |
members,of |
R765 |
T1177 |
T1176 |
prep |
of,members |
R766 |
T1178 |
T1179 |
det |
the,family |
R767 |
T1179 |
T1177 |
pobj |
family,of |
R768 |
T1180 |
T1179 |
compound |
TACC,family |
R769 |
T1181 |
T1170 |
prep |
in,identification |
R770 |
T1182 |
T1183 |
amod |
other,organisms |
R771 |
T1183 |
T1181 |
pobj |
organisms,in |
R772 |
T1184 |
T1170 |
punct |
", ",identification |
R773 |
T1185 |
T1186 |
advmod |
alternatively,spliced |
R774 |
T1186 |
T1187 |
amod |
spliced,isoforms |
R775 |
T1187 |
T1170 |
conj |
isoforms,identification |
R776 |
T1188 |
T1187 |
prep |
of,isoforms |
R777 |
T1189 |
T1190 |
det |
each,TACC |
R778 |
T1190 |
T1188 |
pobj |
TACC,of |
R779 |
T1191 |
T1187 |
cc |
and,isoforms |
R780 |
T1192 |
T1187 |
conj |
comparison,isoforms |
R781 |
T1193 |
T1192 |
prep |
of,comparison |
R782 |
T1194 |
T1195 |
det |
the,relationship |
R783 |
T1195 |
T1193 |
pobj |
relationship,of |
R784 |
T1196 |
T1195 |
amod |
phylogenetic,relationship |
R785 |
T1197 |
T1195 |
prep |
of,relationship |
R786 |
T1198 |
T1199 |
det |
these,genes |
R787 |
T1199 |
T1197 |
pobj |
genes,of |
R788 |
T1200 |
T1195 |
amod |
relative,relationship |
R789 |
T1201 |
T1200 |
prep |
to,relative |
R790 |
T1202 |
T1203 |
amod |
other,members |
R791 |
T1203 |
T1201 |
pobj |
members,to |
R792 |
T1204 |
T1203 |
prep |
of,members |
R793 |
T1205 |
T1206 |
det |
the,superfamily |
R794 |
T1206 |
T1204 |
pobj |
superfamily,of |
R795 |
T1207 |
T1208 |
amod |
coiled,coil |
R796 |
T1208 |
T1206 |
compound |
coil,superfamily |
R797 |
T1209 |
T1167 |
aux |
will,resolve |
R798 |
T1210 |
T1211 |
det |
this,issue |
R799 |
T1211 |
T1167 |
dobj |
issue,resolve |
R800 |
T1212 |
T1167 |
cc |
and,resolve |
R801 |
T1213 |
T1167 |
conj |
provide,resolve |
R802 |
T1214 |
T1213 |
dobj |
clues,provide |
R803 |
T1215 |
T1214 |
prep |
to,clues |
R804 |
T1216 |
T1217 |
det |
the,evolution |
R805 |
T1217 |
T1215 |
pobj |
evolution,to |
R806 |
T1218 |
T1217 |
prep |
of,evolution |
R807 |
T1219 |
T1220 |
compound |
TACC,function |
R808 |
T1220 |
T1218 |
pobj |
function,of |
R809 |
T1221 |
T1167 |
punct |
.,resolve |
R487 |
T884 |
T890 |
nsubjpass |
gene,identified |
R655 |
T1061 |
T1059 |
pcomp |
associated,of |