PMC:441373 / 14660-16171 JSONTXT

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This suggests that the ancestral FGFR-TACC gene pair most probably arose prior to the initial duplication and subsequent divergence of these paralogous chromosomal segments, estimated to have occurred 687 ± 155.7 MYA. This has raised the suggestion that a fourth TACC gene in vertebrates would reside in the same chromosomal region as FGFR4. Indeed this hypothesis has been used in support for the RHAMM gene as a member of the TACC family [10]. Human RHAMM maps to chromosome 5q32 in a region bounded by GPX3 and NKX2E. These loci separate two clusters of genes on human chromosome 5 that are paralogous with 4p16. 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