PMC:4277126 / 88499-89281 JSONTXT

{"project":"NEUROSES","denotations":[{"id":"T2008","span":{"begin":748,"end":761},"obj":"PATO_0001648"},{"id":"T2011","span":{"begin":74,"end":81},"obj":"CHEBI_4167"},{"id":"T2012","span":{"begin":277,"end":284},"obj":"CHEBI_4167"},{"id":"T2013","span":{"begin":464,"end":471},"obj":"CHEBI_4167"},{"id":"T2014","span":{"begin":74,"end":81},"obj":"CHEBI_42758"},{"id":"T2015","span":{"begin":277,"end":284},"obj":"CHEBI_42758"},{"id":"T2016","span":{"begin":464,"end":471},"obj":"CHEBI_42758"},{"id":"T2017","span":{"begin":74,"end":81},"obj":"CHEBI_17234"},{"id":"T2018","span":{"begin":277,"end":284},"obj":"CHEBI_17234"},{"id":"T2019","span":{"begin":464,"end":471},"obj":"CHEBI_17234"},{"id":"T2020","span":{"begin":180,"end":187},"obj":"PATO_0000025"},{"id":"T2021","span":{"begin":338,"end":353},"obj":"PATO_0002262"},{"id":"T2022","span":{"begin":416,"end":423},"obj":"CHEBI_5931"},{"id":"T2023","span":{"begin":446,"end":453},"obj":"CHEBI_5931"},{"id":"T2024","span":{"begin":586,"end":593},"obj":"CHEBI_5931"},{"id":"T2025","span":{"begin":594,"end":605},"obj":"PATO_0000085"}],"text":"Summary of the hypoglycemic activities of LBPs\nLBPs significantly promote glucose uptake involving several signaling pathways in the liver and muscle (Figure 8). LBPs increase the content of GLUT4 and promote the translocation of GLUT4 from cytosol to cell membrane, enhancing glucose uptake in Wistar rats muscle. LBPs also increase the phosphorylation of PI3K/Akt/Nrf2 and repress the activation of JNK, promoting insulin-signaling pathway and insulin-dependent glucose uptake in C57BL/6J mice liver. Furthermore, LBPs activate PI3K- and p38MAPK-mediated signaling pathway, improving insulin sensitivity in rats. Moreover, consumption of GoChi, a standardized Goji juice containing 13.6 mg/mL LBPs, promotes caloric expenditure and reduces waist circumference in healthy subjects."}