PMC:4277126 / 37625-39387 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4277126","sourcedb":"PMC","sourceid":"4277126","source_url":"http://www.ncbi.nlm.nih.gov/pmc/4277126","text":"Sarcoma\nSarcoma is a type of cancer that develops from certain tissues such as bone or muscle.48 There are two main types of sarcoma: bone sarcomas and soft tissue sarcomas. Soft tissue sarcomas can develop from soft tissues like fat, muscle, nerves, fibrous tissues, blood vessels, or deep skin tissues. The most common types of sarcoma in adults are malignant fibrous histiocytoma, liposarcoma, and leiomyosarcoma. About 12,020 people (6,550 males and 5,470 females) will be diagnosed with soft-tissue sarcoma in the US and an estimated 4,740 people will die of the disease in 2014.40 Around 3,300 people were diagnosed with soft tissue sarcoma in 2010 in the UK. For sarcomas that have spread to distant parts of the body, the five-year survival is 16%. The effect of a polysaccharide–protein complex from L. barbarum (LBP3p) on the immune system in S180-bearing mice was investigated by Gan et al.49 The mice inoculated with S180 cell suspension were treated orally with 5 mg/kg, 10 mg/kg, and 20 mg/kg LBP3p for 10 days. The effects of LBP3p on transplantable tumors and macrophage phagocytosis, quantitative hemolysis of mouse red blood cells, lymphocyte proliferation, cytotoxic T lymphocyte (CTL) activity, IL-2 gene expression, and lipid peroxidation were determined. LBP3p significantly inhibited the growth of transplantable sarcoma S180 and increased macrophage phagocytosis, the form of antibody secreted by spleen cells, spleen lymphocyte proliferation, CTL activity, IL-2 messenger (m) RNA expression level and reduced the lipid peroxidation in S180-bearing mice.49 The dose of 10 mg/kg LBP3p was more effective than that of 5 mg/kg and 20 mg/kg LBP3p. These data suggest that LBP3p inhibited sarcoma growth in vivo via enhanced immune activities.","divisions":[{"label":"Title","span":{"begin":0,"end":7}}],"tracks":[{"project":"2_test","denotations":[{"id":"25552899-23719330-26094234","span":{"begin":94,"end":96},"obj":"23719330"},{"id":"25552899-24399786-26094235","span":{"begin":584,"end":586},"obj":"24399786"},{"id":"25552899-15099534-26094236","span":{"begin":901,"end":903},"obj":"15099534"},{"id":"25552899-15099534-26094237","span":{"begin":1578,"end":1580},"obj":"15099534"}],"attributes":[{"subj":"25552899-23719330-26094234","pred":"source","obj":"2_test"},{"subj":"25552899-24399786-26094235","pred":"source","obj":"2_test"},{"subj":"25552899-15099534-26094236","pred":"source","obj":"2_test"},{"subj":"25552899-15099534-26094237","pred":"source","obj":"2_test"}]},{"project":"NEUROSES","denotations":[{"id":"T757","span":{"begin":627,"end":646},"obj":"PM8880"},{"id":"T759","span":{"begin":152,"end":172},"obj":"PM8881"},{"id":"T709","span":{"begin":152,"end":156},"obj":"PATO_0000387"},{"id":"T710","span":{"begin":174,"end":178},"obj":"PATO_0000387"},{"id":"T711","span":{"begin":212,"end":216},"obj":"PATO_0000387"},{"id":"T712","span":{"begin":492,"end":496},"obj":"PATO_0000387"},{"id":"T713","span":{"begin":627,"end":631},"obj":"PATO_0000387"},{"id":"T714","span":{"begin":286,"end":290},"obj":"PATO_0001596"},{"id":"T715","span":{"begin":796,"end":803},"obj":"PATO_0001504"},{"id":"T716","span":{"begin":836,"end":842},"obj":"PATO_0001179"},{"id":"T717","span":{"begin":1101,"end":1113},"obj":"PATO_0000070"},{"id":"T718","span":{"begin":1133,"end":1136},"obj":"PATO_0000322"},{"id":"T719","span":{"begin":1241,"end":1246},"obj":"CHEBI_18059"},{"id":"T720","span":{"begin":1353,"end":1362},"obj":"PATO_0000470"},{"id":"T721","span":{"begin":1501,"end":1504},"obj":"CHEBI_18273"},{"id":"T722","span":{"begin":1501,"end":1504},"obj":"CHEBI_33697"},{"id":"T723","span":{"begin":1526,"end":1533},"obj":"PATO_0001997"},{"id":"T726","span":{"begin":1538,"end":1543},"obj":"CHEBI_18059"},{"id":"T727","span":{"begin":1735,"end":1743},"obj":"PATO_0001589"},{"id":"T728","span":{"begin":1744,"end":1750},"obj":"PATO_0001179"}],"attributes":[{"subj":"T757","pred":"source","obj":"NEUROSES"},{"subj":"T759","pred":"source","obj":"NEUROSES"},{"subj":"T709","pred":"source","obj":"NEUROSES"},{"subj":"T710","pred":"source","obj":"NEUROSES"},{"subj":"T711","pred":"source","obj":"NEUROSES"},{"subj":"T712","pred":"source","obj":"NEUROSES"},{"subj":"T713","pred":"source","obj":"NEUROSES"},{"subj":"T714","pred":"source","obj":"NEUROSES"},{"subj":"T715","pred":"source","obj":"NEUROSES"},{"subj":"T716","pred":"source","obj":"NEUROSES"},{"subj":"T717","pred":"source","obj":"NEUROSES"},{"subj":"T718","pred":"source","obj":"NEUROSES"},{"subj":"T719","pred":"source","obj":"NEUROSES"},{"subj":"T720","pred":"source","obj":"NEUROSES"},{"subj":"T721","pred":"source","obj":"NEUROSES"},{"subj":"T722","pred":"source","obj":"NEUROSES"},{"subj":"T723","pred":"source","obj":"NEUROSES"},{"subj":"T726","pred":"source","obj":"NEUROSES"},{"subj":"T727","pred":"source","obj":"NEUROSES"},{"subj":"T728","pred":"source","obj":"NEUROSES"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93b2ec","default":true},{"id":"NEUROSES","color":"#cdec93"}]}]}}