PMC:4277126 / 21912-22612
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4277126","sourcedb":"PMC","sourceid":"4277126","source_url":"http://www.ncbi.nlm.nih.gov/pmc/4277126","text":"Summary of the anti-aging and antioxidative effectsof LBPs\nIn summary, LBPs have shown potent anti-aging and antioxidant activities (Figure 3). They increase SOD, GPx, CAT, and GR activities, thereby inhibiting oxidative stress-induced damage. LBPs ameliorate oxidative stress-induced cellular apoptosis. They can delay angiotensin II-induced aging of HUVECs by downregulating the expression of p53 and p16. In the ischemia/reperfusion (I/R) injuries to heart, LBPs significantly decreased the myocardium lactate dehydrogenase (LDH) level and increased Na+/K+-ATPase and Ca2+-ATPase activities. LBPs ameliorate oxidative stress-induced cellular apoptosis by downregulating Bax and upregulating Bcl-2.","divisions":[{"label":"Title","span":{"begin":0,"end":58}}],"tracks":[{"project":"NEUROSES","denotations":[{"id":"T505","span":{"begin":109,"end":120},"obj":"CHEBI_22586"},{"id":"T506","span":{"begin":168,"end":171},"obj":"CHEBI_32402"},{"id":"T507","span":{"begin":236,"end":242},"obj":"PATO_0001020"},{"id":"T508","span":{"begin":480,"end":489},"obj":"PATO_0001997"},{"id":"T509","span":{"begin":505,"end":512},"obj":"CHEBI_24996"},{"id":"T510","span":{"begin":543,"end":552},"obj":"PATO_0000470"},{"id":"T511","span":{"begin":553,"end":556},"obj":"CHEBI_29101"},{"id":"T512","span":{"begin":571,"end":575},"obj":"CHEBI_29108"}],"attributes":[{"subj":"T505","pred":"source","obj":"NEUROSES"},{"subj":"T506","pred":"source","obj":"NEUROSES"},{"subj":"T507","pred":"source","obj":"NEUROSES"},{"subj":"T508","pred":"source","obj":"NEUROSES"},{"subj":"T509","pred":"source","obj":"NEUROSES"},{"subj":"T510","pred":"source","obj":"NEUROSES"},{"subj":"T511","pred":"source","obj":"NEUROSES"},{"subj":"T512","pred":"source","obj":"NEUROSES"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"NEUROSES","color":"#93baec","default":true}]}]}}