PMC:4134656 / 21048-22351
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4134656","sourcedb":"PMC","sourceid":"4134656","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4134656","text":"Rebound or regrowth of haemangioma, defined as increase in size, change in colour or both, can occur after discontinuation of treatment. Studies showed that stopping propranolol before the age of 1 year increases the risk of rebound growth. In deeper haemangiomas, the proliferative phase could be longer and hence stopping the treatment early may be a risk factor for rebound growth.[42] In a recent retrospective analysis, the authors found that 2 of the 68 (3%) children in whom propranolol was started at 3 months and discontinued at 10 months, had relapsed.[42] In an another study, 2 of 32 cases had relapsed after stopping the drug before 1 year of age.[28] Menezes et al. in their meta-analysis found that 14 of 64 children who had treatment for a mean period of 5.1 months had a relapse.[26] Table 2 shows the summary of propranolol treatment in infantile hemangioma. In these cases, propranolol was stopped at a mean age of 7.2 months.[26] Relapse after cessation of propranolol after 1 year of age has also been reported.[42] In a recent meta-analysis, it has been reported in 17% of children who received propranolol for an average of 6.4 months.[27] Relapsed haemangiomas have been effectively re-treated with propranolol.[42] They can also be treated with adjunctive systemic steroids.[44]","tracks":[{"project":"2_test","denotations":[{"id":"25136206-21844428-58659589","span":{"begin":385,"end":387},"obj":"21844428"},{"id":"25136206-21844428-58659590","span":{"begin":563,"end":565},"obj":"21844428"},{"id":"25136206-21261702-58659591","span":{"begin":661,"end":663},"obj":"21261702"},{"id":"25136206-22097156-58659592","span":{"begin":797,"end":799},"obj":"22097156"},{"id":"25136206-22097156-58659593","span":{"begin":946,"end":948},"obj":"22097156"},{"id":"25136206-21844428-58659594","span":{"begin":1033,"end":1035},"obj":"21844428"},{"id":"25136206-23405852-58659595","span":{"begin":1159,"end":1161},"obj":"23405852"},{"id":"25136206-21844428-58659596","span":{"begin":1236,"end":1238},"obj":"21844428"},{"id":"25136206-23659587-58659597","span":{"begin":1300,"end":1302},"obj":"23659587"}],"attributes":[{"subj":"25136206-21844428-58659589","pred":"source","obj":"2_test"},{"subj":"25136206-21844428-58659590","pred":"source","obj":"2_test"},{"subj":"25136206-21261702-58659591","pred":"source","obj":"2_test"},{"subj":"25136206-22097156-58659592","pred":"source","obj":"2_test"},{"subj":"25136206-22097156-58659593","pred":"source","obj":"2_test"},{"subj":"25136206-21844428-58659594","pred":"source","obj":"2_test"},{"subj":"25136206-23405852-58659595","pred":"source","obj":"2_test"},{"subj":"25136206-21844428-58659596","pred":"source","obj":"2_test"},{"subj":"25136206-23659587-58659597","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ecae93","default":true}]}]}}