Rebound or regrowth of haemangioma, defined as increase in size, change in colour or both, can occur after discontinuation of treatment. Studies showed that stopping propranolol before the age of 1 year increases the risk of rebound growth. In deeper haemangiomas, the proliferative phase could be longer and hence stopping the treatment early may be a risk factor for rebound growth.[42] In a recent retrospective analysis, the authors found that 2 of the 68 (3%) children in whom propranolol was started at 3 months and discontinued at 10 months, had relapsed.[42] In an another study, 2 of 32 cases had relapsed after stopping the drug before 1 year of age.[28] Menezes et al. in their meta-analysis found that 14 of 64 children who had treatment for a mean period of 5.1 months had a relapse.[26] Table 2 shows the summary of propranolol treatment in infantile hemangioma. In these cases, propranolol was stopped at a mean age of 7.2 months.[26] Relapse after cessation of propranolol after 1 year of age has also been reported.[42] In a recent meta-analysis, it has been reported in 17% of children who received propranolol for an average of 6.4 months.[27] Relapsed haemangiomas have been effectively re-treated with propranolol.[42] They can also be treated with adjunctive systemic steroids.[44]