PMC:4129407 / 32340-33732 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4129407","sourcedb":"PMC","sourceid":"4129407","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4129407","text":"Table 1 Association Results of the HLA Variants for Overall PsV Risk in Multivariate Regression Model\nHLA Variant Frequency PsV-Affected versus Control Individuals\nPsV Control OR (95% CI) a p a\nClassical HLA-C Alleles\nHLA-C∗06:02 0.23 0.093 3.26 (3.02–3.52) 2.1 × 10−201\nHLA-C∗12:03 0.073 0.056 1.38 (1.26–1.52) 6.5 × 10−12\nOther four-digit HLA-C alleles 0.70 0.85 reference reference\nHLA-B Amino Acid Position 67\nCys 0.16 0.12 1.56 (1.45–1.67) 6.0 × 10−35\nMet 0.12 0.046 1.44 (1.30–1.58) 2.6 × 10−13\nTyr 0.12 0.16 1.00 (0.93–1.07) 0.93\nPhe 0.21 0.26 1.00 (0.93–1.08) 0.99\nSer 0.39 0.42 reference reference\nHLA-B Amino Acid Position 9\nAsp 0.096 0.11 1.33 (1.21–1.45) 1.6 × 10−9\nTyr 0.70 0.67 reference reference\nHis 0.20 0.22 0.87 (0.82–0.92) 1.6 × 10−6\nHLA-A Amino Acid Position 95\nVal 0.34 0.29 1.31 (1.25–1.38) 4.7 × 10−28\nIle 0.56 0.59 reference reference\nLeu 0.099 0.12 0.89 (0.83–0.95) 7.0 × 10−4\nHLA-DQα1 Amino Acid Position 53\nArg 0.37 0.29 1.07 (1.01–1.13) 0.016\nLys 0.39 0.43 reference reference\nGln 0.25 0.29 0.91 (0.86–0.96) 9.3 × 10−4\nAbbreviations are as follows: CI, confidence interval; OR, odds ratio; and PsV, psoriasis vulgaris.\na Obtained from the multivariate full regression model including the HLA-C, HLA-B, HLA-A, and HLA-DQA1 risk variants identified by the stepwise regression 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