PMC:3792591 / 1167-2005 JSONTXT

{"project":"2_test","denotations":[{"id":"24109195-17765636-26175407","span":{"begin":741,"end":742},"obj":"17765636"}],"text":"Introduction\nAmiodarone is a benzofuran class III antiarrhythmic drug used to treat a wide spectrum of ventricular and supraventricular tachyarrhythmias. The mechanism of action is complex. It involves antagonism of the delayed rectifier potassium channels, in particular the rapid component, thereby increasing membrane refractoriness. This agent also affects inactivated sodium channels (Phase 0), sympathetic activity, and calcium channels (L-type).1 Long-term therapy is associated with various adverse effects due to accumulation of the drug in tissue. The intravenous (IV) preparation of amiodarone has been linked to adverse hepatic reactions such as hypotension, cardiac arrest, bradycardia, heart failure, and hepatic abnormalities.2 We report an unusual case of acute hepatitis immediately after the initiation of IV amiodarone."}