PMC:3660126 / 46299-48961
Annnotations
NEUROSES
{"project":"NEUROSES","denotations":[{"id":"T1995","span":{"begin":47,"end":55},"obj":"CHEBI_23888"},{"id":"T1996","span":{"begin":743,"end":751},"obj":"CHEBI_23888"},{"id":"T1997","span":{"begin":1218,"end":1226},"obj":"CHEBI_23888"},{"id":"T1998","span":{"begin":2509,"end":2517},"obj":"CHEBI_23888"},{"id":"T1999","span":{"begin":2619,"end":2627},"obj":"CHEBI_23888"},{"id":"T2000","span":{"begin":70,"end":77},"obj":"PATO_0000219"},{"id":"T2001","span":{"begin":308,"end":316},"obj":"CHEBI_33250"},{"id":"T2002","span":{"begin":352,"end":357},"obj":"CHEBI_15377"},{"id":"T2003","span":{"begin":352,"end":357},"obj":"CHEBI_46629"},{"id":"T2004","span":{"begin":359,"end":362},"obj":"CHEBI_28843"},{"id":"T2005","span":{"begin":443,"end":451},"obj":"PATO_0000070"},{"id":"T2006","span":{"begin":455,"end":462},"obj":"PATO_0000462"},{"id":"T2007","span":{"begin":468,"end":476},"obj":"PATO_0000757"},{"id":"T2008","span":{"begin":533,"end":547},"obj":"PATO_0001318"},{"id":"T2009","span":{"begin":691,"end":697},"obj":"CHEBI_7772"},{"id":"T2010","span":{"begin":709,"end":716},"obj":"CHEBI_3612"},{"id":"T2011","span":{"begin":794,"end":801},"obj":"CHEBI_3612"},{"id":"T2012","span":{"begin":1804,"end":1811},"obj":"CHEBI_3612"},{"id":"T2013","span":{"begin":709,"end":716},"obj":"PATO_0000185"},{"id":"T2014","span":{"begin":794,"end":801},"obj":"PATO_0000185"},{"id":"T2015","span":{"begin":1804,"end":1811},"obj":"PATO_0000185"},{"id":"T2016","span":{"begin":1075,"end":1090},"obj":"CHEBI_35469"},{"id":"T2017","span":{"begin":1259,"end":1267},"obj":"PATO_0002118"},{"id":"T2018","span":{"begin":1433,"end":1437},"obj":"PATO_0000304"},{"id":"T2019","span":{"begin":1480,"end":1484},"obj":"PATO_0001026"},{"id":"T2020","span":{"begin":1552,"end":1562},"obj":"PATO_0000990"},{"id":"T2021","span":{"begin":1870,"end":1877},"obj":"PATO_0001504"},{"id":"T2022","span":{"begin":2041,"end":2046},"obj":"PATO_0000587"},{"id":"T2023","span":{"begin":2427,"end":2436},"obj":"CHEBI_16118"},{"id":"T2024","span":{"begin":2452,"end":2460},"obj":"CHEBI_22315"},{"id":"T2025","span":{"begin":2076,"end":2086},"obj":"PM3425"},{"id":"T2026","span":{"begin":2330,"end":2340},"obj":"PM3425"},{"id":"T2027","span":{"begin":2412,"end":2422},"obj":"PM3425"},{"id":"T2028","span":{"begin":2542,"end":2552},"obj":"PM3425"},{"id":"T2029","span":{"begin":2648,"end":2658},"obj":"PM3425"},{"id":"T2030","span":{"begin":2076,"end":2086},"obj":"PM3425"},{"id":"T2031","span":{"begin":2330,"end":2340},"obj":"PM3425"},{"id":"T2032","span":{"begin":2412,"end":2422},"obj":"PM3425"},{"id":"T2033","span":{"begin":2542,"end":2552},"obj":"PM3425"},{"id":"T2034","span":{"begin":2648,"end":2658},"obj":"PM3425"}],"text":"Ayurvedic medicine in mood disorders\nAyurvedic medicine is an ancient healing system used in India, which is now practiced worldwide.161 Ayurveda denotes longevity. The theory of Ayurveda is based on balancing the individual’s three constitutional “doshas”, ie, vata, pitta, and kappa, which arise from five elements of ancient philosophy, being fire, water, air, earth, and space.162–163 It is believed that health or sickness depends on the presence or absence of a balanced state. Both intrinsic and extrinsic factors, such as an indiscriminate diet, undesirable habits, not observing the rules of healthy living, seasonal abnormalities, lack of exercise, and misuse of body and mind can result in lack of balance in the body.164 Ayurvedic medicine includes several treatment options, which balance three disturbed doshas (Table 3). Diagnosis is based on a comprehensive history, detailed physical examination, measurement of vital signs including pulse, and relevant laboratory tests.30 Ashwagandha, along with combinations of herbs, such as Amrit kalash and mentat, and antidepressants can be used in depressed patients.30,165–168\nThere has been difficulty in conducting randomized controlled trials in Ayurvedic medicine because most treatments involve multiple herbs, changes in diet and lifestyle, and treatments are individualized and target the entire person.169 Further, the effects of Ayurvedic herbs tend to be mild and slow in onset. Most Ayurvedic herbs do tend to work gradually and with increasing efficacy as the system habituates to consistent dosing. This is often true of herbs that are prescribed for mood disorders. However, the effect of Ayurvedic herbs is not always mild. With accurate tailoring of herbal preparations, herbal therapy can be powerful in effecting change in the balance of body and mind, eg, with mood disorders that often have complex multifactorial origins. Patients who are intolerant to prescription medications fare better with Ayurvedic interventions, including panchakarma detoxification.162 Small preliminary studies of major depression treated with herbs, herbal mixtures, and Rasayanas (a special branch of Ayurveda aiming to rejuvenate and nourish the body at all levels and comprises several products manufactured from a combination of herbs) have demonstrated improvement in depression scores.163 Sharma et al recommended larger controlled studies in major depression.163 Berberine, a traditional alkaloid plant used in Ayurvedic and traditional Chinese medicine, is reported to improve depression.170 Posmontier and Teitelbaum have discussed the use of Ayurvedic medicine to treat postpartum depression.171"}
2_test
{"project":"2_test","denotations":[{"id":"23700366-19123878-76000719","span":{"begin":133,"end":136},"obj":"19123878"},{"id":"23700366-18166127-76000720","span":{"begin":381,"end":384},"obj":"18166127"},{"id":"23700366-20528765-76000721","span":{"begin":729,"end":732},"obj":"20528765"},{"id":"23700366-17404115-76000722","span":{"begin":1128,"end":1131},"obj":"17404115"},{"id":"23700366-23016473-76000722","span":{"begin":1128,"end":1131},"obj":"23016473"},{"id":"23700366-11194174-76000722","span":{"begin":1128,"end":1131},"obj":"11194174"},{"id":"23700366-15253680-76000722","span":{"begin":1128,"end":1131},"obj":"15253680"},{"id":"23700366-22830972-76000723","span":{"begin":1369,"end":1372},"obj":"22830972"},{"id":"23700366-18166127-76000724","span":{"begin":2348,"end":2351},"obj":"18166127"},{"id":"23700366-18166127-76000725","span":{"begin":2423,"end":2426},"obj":"18166127"},{"id":"23700366-19574756-76000726","span":{"begin":2659,"end":2662},"obj":"19574756"}],"text":"Ayurvedic medicine in mood disorders\nAyurvedic medicine is an ancient healing system used in India, which is now practiced worldwide.161 Ayurveda denotes longevity. The theory of Ayurveda is based on balancing the individual’s three constitutional “doshas”, ie, vata, pitta, and kappa, which arise from five elements of ancient philosophy, being fire, water, air, earth, and space.162–163 It is believed that health or sickness depends on the presence or absence of a balanced state. Both intrinsic and extrinsic factors, such as an indiscriminate diet, undesirable habits, not observing the rules of healthy living, seasonal abnormalities, lack of exercise, and misuse of body and mind can result in lack of balance in the body.164 Ayurvedic medicine includes several treatment options, which balance three disturbed doshas (Table 3). Diagnosis is based on a comprehensive history, detailed physical examination, measurement of vital signs including pulse, and relevant laboratory tests.30 Ashwagandha, along with combinations of herbs, such as Amrit kalash and mentat, and antidepressants can be used in depressed patients.30,165–168\nThere has been difficulty in conducting randomized controlled trials in Ayurvedic medicine because most treatments involve multiple herbs, changes in diet and lifestyle, and treatments are individualized and target the entire person.169 Further, the effects of Ayurvedic herbs tend to be mild and slow in onset. Most Ayurvedic herbs do tend to work gradually and with increasing efficacy as the system habituates to consistent dosing. This is often true of herbs that are prescribed for mood disorders. However, the effect of Ayurvedic herbs is not always mild. With accurate tailoring of herbal preparations, herbal therapy can be powerful in effecting change in the balance of body and mind, eg, with mood disorders that often have complex multifactorial origins. Patients who are intolerant to prescription medications fare better with Ayurvedic interventions, including panchakarma detoxification.162 Small preliminary studies of major depression treated with herbs, herbal mixtures, and Rasayanas (a special branch of Ayurveda aiming to rejuvenate and nourish the body at all levels and comprises several products manufactured from a combination of herbs) have demonstrated improvement in depression scores.163 Sharma et al recommended larger controlled studies in major depression.163 Berberine, a traditional alkaloid plant used in Ayurvedic and traditional Chinese medicine, is reported to improve depression.170 Posmontier and Teitelbaum have discussed the use of Ayurvedic medicine to treat postpartum depression.171"}