PMC:3649690 / 30987-32353
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3649690","sourcedb":"PMC","sourceid":"3649690","source_url":"http://www.ncbi.nlm.nih.gov/pmc/3649690","text":"13. Effects of Experimental Manipulation on Neural Plasticity\nMany of the studies examining a reduction in neurogenesis have used viral vectors, irradiation, or the cytostatic agent, methylazoxymethanol. It is important to note that the experimental manipulation of neurogenesis also likely produces downstream effects on neural plasticity in a much broader sense, including the expression of cell adhesion molecules (including PSA-NCAM), synaptic proteins, and BDNF. As such, it is difficult to know for sure whether the attenuation of antidepressant efficacy via reductions in neurogenesis is due to changes in neurogenesis levels or other aspects of neural plasticity. For instance, radiation levels as low as 2.5 Gy significantly reduce the density of BDNF-expressing neurons [179] and the expression of PSA-NCAM in the hippocampus [180]. This is important as a 10 Gy dose of radiation is typically used to inhibit neurogenesis in studies assessing attenuated neurogenesis [21, 96, 181], suggesting BDNF and PSA-NCAM expression will also be affected. This suggests that the effects of radiation affect proteins associated with neural remodelling and synaptic plasticity as well as neurogenesis [180]. It is important to address these caveats in future research to further elucidate the role of neurogenesis and neural plasticity in depression and its treatment.\n","divisions":[{"label":"Title","span":{"begin":0,"end":61}}],"tracks":[{"project":"2_test","denotations":[{"id":"23691371-9020400-75337750","span":{"begin":781,"end":784},"obj":"9020400"},{"id":"23691371-15763403-75337751","span":{"begin":837,"end":840},"obj":"15763403"},{"id":"23691371-12907793-75337752","span":{"begin":978,"end":980},"obj":"12907793"},{"id":"23691371-21814201-75337753","span":{"begin":982,"end":984},"obj":"21814201"},{"id":"23691371-19923282-75337754","span":{"begin":986,"end":989},"obj":"19923282"},{"id":"23691371-15763403-75337755","span":{"begin":1199,"end":1202},"obj":"15763403"}],"attributes":[{"subj":"23691371-9020400-75337750","pred":"source","obj":"2_test"},{"subj":"23691371-15763403-75337751","pred":"source","obj":"2_test"},{"subj":"23691371-12907793-75337752","pred":"source","obj":"2_test"},{"subj":"23691371-21814201-75337753","pred":"source","obj":"2_test"},{"subj":"23691371-19923282-75337754","pred":"source","obj":"2_test"},{"subj":"23691371-15763403-75337755","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#d093ec","default":true}]}]}}