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{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T18787","span":{"begin":410,"end":418},"obj":"Protein"},{"id":"T18786","span":{"begin":289,"end":297},"obj":"Protein"},{"id":"T18785","span":{"begin":160,"end":168},"obj":"Protein"},{"id":"T18784","span":{"begin":75,"end":83},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"In summary, our studies show that the C/EBP site (−203/−195) in the murine SerpinB2 proximal promoter is necessary to support both constitutive and LPS-induced SerpinB2 gene expression. Importantly, we were able to uncover a previously unknown role for C/EBP-βS64 in negatively regulating SerpinB2 promoter activity. Taken together these data provide new insight into the regulation of inflammation-associated SerpinB2 gene expression."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T20241","span":{"begin":289,"end":297},"obj":"http://www.uniprot.org/uniprot/P05120"},{"id":"T20240","span":{"begin":160,"end":168},"obj":"http://www.uniprot.org/uniprot/P05120"},{"id":"T20239","span":{"begin":75,"end":83},"obj":"http://www.uniprot.org/uniprot/P05120"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"In summary, our studies show that the C/EBP site (−203/−195) in the murine SerpinB2 proximal promoter is necessary to support both constitutive and LPS-induced SerpinB2 gene expression. Importantly, we were able to uncover a previously unknown role for C/EBP-βS64 in negatively regulating SerpinB2 promoter activity. Taken together these data provide new insight into the regulation of inflammation-associated SerpinB2 gene expression."}

{"project":"GO-BP","denotations":[{"id":"T18829","span":{"begin":372,"end":382},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T18824","span":{"begin":386,"end":398},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T18818","span":{"begin":419,"end":434},"obj":"http://purl.obolibrary.org/obo/GO_0010467"},{"id":"T18817","span":{"begin":169,"end":184},"obj":"http://purl.obolibrary.org/obo/GO_0010467"}],"text":"In summary, our studies show that the C/EBP site (−203/−195) in the murine SerpinB2 proximal promoter is necessary to support both constitutive and LPS-induced SerpinB2 gene expression. Importantly, we were able to uncover a previously unknown role for C/EBP-βS64 in negatively regulating SerpinB2 promoter activity. Taken together these data provide new insight into the regulation of inflammation-associated SerpinB2 gene expression."}

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{"project":"simple1","denotations":[{"id":"T18924","span":{"begin":410,"end":418},"obj":"Protein"},{"id":"T18923","span":{"begin":289,"end":297},"obj":"Protein"},{"id":"T18922","span":{"begin":160,"end":168},"obj":"Protein"},{"id":"T18921","span":{"begin":75,"end":83},"obj":"Protein"}],"text":"In summary, our studies show that the C/EBP site (−203/−195) in the murine SerpinB2 proximal promoter is necessary to support both constitutive and LPS-induced SerpinB2 gene expression. Importantly, we were able to uncover a previously unknown role for C/EBP-βS64 in negatively regulating SerpinB2 promoter activity. Taken together these data provide new insight into the regulation of inflammation-associated SerpinB2 gene expression."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T20207","span":{"begin":372,"end":382},"obj":"Regulation"},{"id":"T20206","span":{"begin":424,"end":434},"obj":"Gene_expression"},{"id":"T20205","span":{"begin":386,"end":409},"obj":"Positive_regulation"},{"id":"T20204","span":{"begin":278,"end":288},"obj":"Regulation"},{"id":"T20203","span":{"begin":244,"end":248},"obj":"Regulation"},{"id":"T20202","span":{"begin":105,"end":114},"obj":"Positive_regulation"},{"id":"T20201","span":{"begin":148,"end":159},"obj":"Positive_regulation"},{"id":"T20200","span":{"begin":174,"end":184},"obj":"Gene_expression"},{"id":"T20132","span":{"begin":410,"end":418},"obj":"Protein"},{"id":"T20131","span":{"begin":289,"end":297},"obj":"Protein"},{"id":"T20130","span":{"begin":160,"end":168},"obj":"Protein"},{"id":"T20129","span":{"begin":75,"end":83},"obj":"Protein"}],"relations":[{"id":"R14569","pred":"themeOf","subj":"T20129","obj":"T20202"},{"id":"R14570","pred":"themeOf","subj":"T20130","obj":"T20200"},{"id":"R14571","pred":"themeOf","subj":"T20131","obj":"T20203"},{"id":"R14572","pred":"themeOf","subj":"T20131","obj":"T20204"},{"id":"R14573","pred":"themeOf","subj":"T20132","obj":"T20206"},{"id":"R14611","pred":"themeOf","subj":"T20200","obj":"T20201"},{"id":"R14612","pred":"themeOf","subj":"T20206","obj":"T20207"},{"id":"R14613","pred":"themeOf","subj":"T20206","obj":"T20205"}],"text":"In summary, our studies show that the C/EBP site (−203/−195) in the murine SerpinB2 proximal promoter is necessary to support both constitutive and LPS-induced SerpinB2 gene expression. Importantly, we were able to uncover a previously unknown role for C/EBP-βS64 in negatively regulating SerpinB2 promoter activity. Taken together these data provide new insight into the regulation of inflammation-associated SerpinB2 gene expression."}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T20643","span":{"begin":372,"end":382},"obj":"Regulation"},{"id":"T20642","span":{"begin":386,"end":409},"obj":"Positive_regulation"},{"id":"T20641","span":{"begin":424,"end":434},"obj":"Gene_expression"},{"id":"T20640","span":{"begin":174,"end":184},"obj":"Gene_expression"},{"id":"T20639","span":{"begin":148,"end":159},"obj":"Positive_regulation"},{"id":"T20582","span":{"begin":410,"end":418},"obj":"Protein"},{"id":"T20581","span":{"begin":289,"end":297},"obj":"Protein"},{"id":"T20580","span":{"begin":160,"end":168},"obj":"Protein"},{"id":"T20579","span":{"begin":75,"end":83},"obj":"Protein"}],"relations":[{"id":"R14778","pred":"themeOf","subj":"T20580","obj":"T20640"},{"id":"R14779","pred":"themeOf","subj":"T20582","obj":"T20641"},{"id":"R14801","pred":"themeOf","subj":"T20640","obj":"T20639"},{"id":"R14802","pred":"themeOf","subj":"T20641","obj":"T20643"},{"id":"R14803","pred":"themeOf","subj":"T20641","obj":"T20642"}],"text":"In summary, our studies show that the C/EBP site (−203/−195) in the murine SerpinB2 proximal promoter is necessary to support both constitutive and LPS-induced SerpinB2 gene expression. Importantly, we were able to uncover a previously unknown role for C/EBP-βS64 in negatively regulating SerpinB2 promoter activity. Taken together these data provide new insight into the regulation of inflammation-associated SerpinB2 gene expression."}

{"project":"DLUT931","denotations":[{"id":"T20426","span":{"begin":372,"end":382},"obj":"Regulation"},{"id":"T20425","span":{"begin":386,"end":409},"obj":"Positive_regulation"},{"id":"T20424","span":{"begin":424,"end":434},"obj":"Gene_expression"},{"id":"T20423","span":{"begin":244,"end":248},"obj":"Regulation"},{"id":"T20422","span":{"begin":278,"end":288},"obj":"Regulation"},{"id":"T20421","span":{"begin":148,"end":159},"obj":"Positive_regulation"},{"id":"T20420","span":{"begin":131,"end":143},"obj":"Positive_regulation"},{"id":"T20419","span":{"begin":174,"end":184},"obj":"Gene_expression"},{"id":"T20356","span":{"begin":410,"end":418},"obj":"Protein"},{"id":"T20355","span":{"begin":289,"end":297},"obj":"Protein"},{"id":"T20354","span":{"begin":160,"end":168},"obj":"Protein"},{"id":"T20353","span":{"begin":75,"end":83},"obj":"Protein"}],"relations":[{"id":"R14664","pred":"themeOf","subj":"T20354","obj":"T20419"},{"id":"R14665","pred":"themeOf","subj":"T20355","obj":"T20422"},{"id":"R14666","pred":"themeOf","subj":"T20356","obj":"T20424"},{"id":"R14699","pred":"themeOf","subj":"T20419","obj":"T20420"},{"id":"R14700","pred":"themeOf","subj":"T20419","obj":"T20421"},{"id":"R14701","pred":"themeOf","subj":"T20422","obj":"T20423"},{"id":"R14702","pred":"themeOf","subj":"T20424","obj":"T20425"},{"id":"R14703","pred":"themeOf","subj":"T20425","obj":"T20426"}],"text":"In summary, our studies show that the C/EBP site (−203/−195) in the murine SerpinB2 proximal promoter is necessary to support both constitutive and LPS-induced SerpinB2 gene expression. Importantly, we were able to uncover a previously unknown role for C/EBP-βS64 in negatively regulating SerpinB2 promoter activity. Taken together these data provide new insight into the regulation of inflammation-associated SerpinB2 gene expression."}

{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T21108","span":{"begin":368,"end":434},"obj":"Regulation"},{"id":"T21107","span":{"begin":267,"end":315},"obj":"Regulation"},{"id":"T21104","span":{"begin":160,"end":184},"obj":"Gene_expression"},{"id":"T21100","span":{"begin":383,"end":434},"obj":"Gene_expression"},{"id":"T21075","span":{"begin":410,"end":418},"obj":"Protein"},{"id":"T21063","span":{"begin":38,"end":43},"obj":"Protein"},{"id":"T21053","span":{"begin":148,"end":159},"obj":"Entity"},{"id":"T21042","span":{"begin":34,"end":48},"obj":"Entity"},{"id":"T20966","span":{"begin":160,"end":168},"obj":"Protein"},{"id":"T20961","span":{"begin":160,"end":184},"obj":"Protein"},{"id":"T20960","span":{"begin":289,"end":306},"obj":"Entity"},{"id":"T20945","span":{"begin":289,"end":297},"obj":"Protein"},{"id":"T20914","span":{"begin":75,"end":83},"obj":"Protein"},{"id":"T20910","span":{"begin":75,"end":101},"obj":"Entity"}],"relations":[{"id":"R14948","pred":"themeOf","subj":"T20966","obj":"T21104"},{"id":"R14971","pred":"themeOf","subj":"T21075","obj":"T21100"},{"id":"R14977","pred":"themeOf","subj":"T21100","obj":"T21108"}],"text":"In summary, our studies show that the C/EBP site (−203/−195) in the murine SerpinB2 proximal promoter is necessary to support both constitutive and LPS-induced SerpinB2 gene expression. Importantly, we were able to uncover a previously unknown role for C/EBP-βS64 in negatively regulating SerpinB2 promoter activity. Taken together these data provide new insight into the regulation of inflammation-associated SerpinB2 gene expression."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T20772","span":{"begin":289,"end":306},"obj":"Protein"},{"id":"T20771","span":{"begin":253,"end":263},"obj":"Protein"},{"id":"T20770","span":{"begin":148,"end":159},"obj":"Positive_regulation"},{"id":"T20769","span":{"begin":174,"end":184},"obj":"Gene_expression"},{"id":"T20768","span":{"begin":160,"end":173},"obj":"Protein"},{"id":"T20767","span":{"begin":68,"end":101},"obj":"Protein"},{"id":"T20766","span":{"begin":38,"end":48},"obj":"Protein"}],"relations":[{"id":"R14866","pred":"themeOf","subj":"T20768","obj":"T20769"},{"id":"R14867","pred":"themeOf","subj":"T20769","obj":"T20770"}],"text":"In summary, our studies show that the C/EBP site (−203/−195) in the murine SerpinB2 proximal promoter is necessary to support both constitutive and LPS-induced SerpinB2 gene expression. Importantly, we were able to uncover a previously unknown role for C/EBP-βS64 in negatively regulating SerpinB2 promoter activity. Taken together these data provide new insight into the regulation of inflammation-associated SerpinB2 gene expression."}

{"project":"testone","denotations":[{"id":"T18281","span":{"begin":372,"end":382},"obj":"Regulation"},{"id":"T18280","span":{"begin":152,"end":159},"obj":"Positive_regulation"},{"id":"T18279","span":{"begin":105,"end":114},"obj":"Positive_regulation"},{"id":"T18235","span":{"begin":410,"end":418},"obj":"Protein"},{"id":"T18234","span":{"begin":289,"end":297},"obj":"Protein"},{"id":"T18233","span":{"begin":160,"end":168},"obj":"Protein"},{"id":"T18232","span":{"begin":75,"end":83},"obj":"Protein"}],"relations":[{"id":"R13157","pred":"themeOf","subj":"T18280","obj":"T18279"}],"text":"In summary, our studies show that the C/EBP site (−203/−195) in the murine SerpinB2 proximal promoter is necessary to support both constitutive and LPS-induced SerpinB2 gene expression. Importantly, we were able to uncover a previously unknown role for C/EBP-βS64 in negatively regulating SerpinB2 promoter activity. Taken together these data provide new insight into the regulation of inflammation-associated SerpinB2 gene expression."}

{"project":"test3","denotations":[{"id":"T18479","span":{"begin":410,"end":418},"obj":"Protein"},{"id":"T18478","span":{"begin":289,"end":297},"obj":"Protein"},{"id":"T18477","span":{"begin":278,"end":288},"obj":"Regulation"},{"id":"T18476","span":{"begin":174,"end":184},"obj":"Gene_expression"},{"id":"T18475","span":{"begin":160,"end":168},"obj":"Protein"},{"id":"T18474","span":{"begin":152,"end":159},"obj":"Positive_regulation"},{"id":"T18473","span":{"begin":75,"end":83},"obj":"Protein"},{"id":"T18352","span":{"begin":410,"end":418},"obj":"Protein"},{"id":"T18351","span":{"begin":289,"end":297},"obj":"Protein"},{"id":"T18350","span":{"begin":160,"end":168},"obj":"Protein"},{"id":"T18349","span":{"begin":75,"end":83},"obj":"Protein"}],"relations":[{"id":"R13221","pred":"themeOf","subj":"T18475","obj":"T18476"},{"id":"R13222","pred":"themeOf","subj":"T18476","obj":"T18474"}],"text":"In summary, our studies show that the C/EBP site (−203/−195) in the murine SerpinB2 proximal promoter is necessary to support both constitutive and LPS-induced SerpinB2 gene expression. Importantly, we were able to uncover a previously unknown role for C/EBP-βS64 in negatively regulating SerpinB2 promoter activity. Taken together these data provide new insight into the regulation of inflammation-associated SerpinB2 gene expression."}