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murine SerpinB2 proximal promoter region between nucleotides -539 and +92 mediated both PMA- and LPS-inducible gene transcription, with induction by PMA being less intense and more transient than that by LPS. Inspection of the murine SerpinB2 proximal promoter sequence shows that a CRE and two AP-1-like elements, demonstrated to mediate PMA-stimulated transcription of the human SERPINB2 gene [37], also are present in the murine SerpinB2 proximal promoter between nucleotides −189 and −87. These sites may therefore also play a role in mediating PMA-inducible transcription of the murine SerpinB2 gene. In contrast to the pattern of incremental increases in PMA-induced transcriptional activity conferred by regions of the murine SerpinB2 promoter containing these sites, most of the LPS-inducible response is dependent upon cis-acting regulatory sequences in the region between nucleotides −189 and −539. LPS responsiveness absolutely required the C/EBP binding site located in the region between nucleotides −189 and −539, with the downstream CRE and AP-1-like elements also being critical. Of note, there are previous reports of combinatorial interactions between C/EBP-β and CRE binding proteins (CREB) and AP-1 [63], and C/EBP-β has been reported to physically interact with AP-1, and NF-κB to promote gene expression of inflammatory mediators [63]; [66]. Additionally, CREB has been shown to control transcription of the C/EBP-β gene [67]."}

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murine SerpinB2 proximal promoter region between nucleotides -539 and +92 mediated both PMA- and LPS-inducible gene transcription, with induction by PMA being less intense and more transient than that by LPS. Inspection of the murine SerpinB2 proximal promoter sequence shows that a CRE and two AP-1-like elements, demonstrated to mediate PMA-stimulated transcription of the human SERPINB2 gene [37], also are present in the murine SerpinB2 proximal promoter between nucleotides −189 and −87. These sites may therefore also play a role in mediating PMA-inducible transcription of the murine SerpinB2 gene. In contrast to the pattern of incremental increases in PMA-induced transcriptional activity conferred by regions of the murine SerpinB2 promoter containing these sites, most of the LPS-inducible response is dependent upon cis-acting regulatory sequences in the region between nucleotides −189 and −539. LPS responsiveness absolutely required the C/EBP binding site located in the region between nucleotides −189 and −539, with the downstream CRE and AP-1-like elements also being critical. Of note, there are previous reports of combinatorial interactions between C/EBP-β and CRE binding proteins (CREB) and AP-1 [63], and C/EBP-β has been reported to physically interact with AP-1, and NF-κB to promote gene expression of inflammatory mediators [63]; [66]. Additionally, CREB has been shown to control transcription of the C/EBP-β gene [67]."}

{"project":"bionlp-st-ge-2016-coref","denotations":[{"id":"T18710","span":{"begin":105,"end":114},"obj":"Antecedent"},{"id":"T18709","span":{"begin":787,"end":813},"obj":"Anaphor"}],"relations":[{"id":"R13381","pred":"boundBy","subj":"T18709","obj":"T18710"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"The murine SerpinB2 proximal promoter region between nucleotides -539 and +92 mediated both PMA- and LPS-inducible gene transcription, with induction by PMA being less intense and more transient than that by LPS. Inspection of the murine SerpinB2 proximal promoter sequence shows that a CRE and two AP-1-like elements, demonstrated to mediate PMA-stimulated transcription of the human SERPINB2 gene [37], also are present in the murine SerpinB2 proximal promoter between nucleotides −189 and −87. These sites may therefore also play a role in mediating PMA-inducible transcription of the murine SerpinB2 gene. In contrast to the pattern of incremental increases in PMA-induced transcriptional activity conferred by regions of the murine SerpinB2 promoter containing these sites, most of the LPS-inducible response is dependent upon cis-acting regulatory sequences in the region between nucleotides −189 and −539. LPS responsiveness absolutely required the C/EBP binding site located in the region between nucleotides −189 and −539, with the downstream CRE and AP-1-like elements also being critical. Of note, there are previous reports of combinatorial interactions between C/EBP-β and CRE binding proteins (CREB) and AP-1 [63], and C/EBP-β has been reported to physically interact with AP-1, and NF-κB to promote gene expression of inflammatory mediators [63]; [66]. Additionally, CREB has been shown to control transcription of the C/EBP-β gene [67]."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T18735","span":{"begin":1434,"end":1441},"obj":"Protein"},{"id":"T18734","span":{"begin":1233,"end":1240},"obj":"Protein"},{"id":"T18733","span":{"begin":1174,"end":1181},"obj":"Protein"},{"id":"T18732","span":{"begin":737,"end":745},"obj":"Protein"},{"id":"T18731","span":{"begin":595,"end":603},"obj":"Protein"},{"id":"T18730","span":{"begin":436,"end":444},"obj":"Protein"},{"id":"T18729","span":{"begin":385,"end":393},"obj":"Protein"},{"id":"T18728","span":{"begin":238,"end":246},"obj":"Protein"},{"id":"T18727","span":{"begin":11,"end":19},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"The murine SerpinB2 proximal promoter region between nucleotides -539 and +92 mediated both PMA- and LPS-inducible gene transcription, with induction by PMA being less intense and more transient than that by LPS. Inspection of the murine SerpinB2 proximal promoter sequence shows that a CRE and two AP-1-like elements, demonstrated to mediate PMA-stimulated transcription of the human SERPINB2 gene [37], also are present in the murine SerpinB2 proximal promoter between nucleotides −189 and −87. These sites may therefore also play a role in mediating PMA-inducible transcription of the murine SerpinB2 gene. In contrast to the pattern of incremental increases in PMA-induced transcriptional activity conferred by regions of the murine SerpinB2 promoter containing these sites, most of the LPS-inducible response is dependent upon cis-acting regulatory sequences in the region between nucleotides −189 and −539. LPS responsiveness absolutely required the C/EBP binding site located in the region between nucleotides −189 and −539, with the downstream CRE and AP-1-like elements also being critical. Of note, there are previous reports of combinatorial interactions between C/EBP-β and CRE binding proteins (CREB) and AP-1 [63], and C/EBP-β has been reported to physically interact with AP-1, and NF-κB to promote gene expression of inflammatory mediators [63]; [66]. Additionally, CREB has been shown to control transcription of the C/EBP-β gene [67]."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T20285","span":{"begin":1382,"end":1386},"obj":"http://www.uniprot.org/uniprot/Q02930"},{"id":"T20284","span":{"begin":1208,"end":1212},"obj":"http://www.uniprot.org/uniprot/Q02930"},{"id":"T20269","span":{"begin":299,"end":303},"obj":"http://www.uniprot.org/uniprot/P05412"},{"id":"T20249","span":{"begin":1434,"end":1441},"obj":"http://www.uniprot.org/uniprot/P28033"},{"id":"T20248","span":{"begin":1233,"end":1240},"obj":"http://www.uniprot.org/uniprot/P28033"},{"id":"T20247","span":{"begin":1174,"end":1181},"obj":"http://www.uniprot.org/uniprot/P28033"},{"id":"T20242","span":{"begin":385,"end":393},"obj":"http://www.uniprot.org/uniprot/P05120"},{"id":"T20218","span":{"begin":737,"end":745},"obj":"http://www.uniprot.org/uniprot/P05120"},{"id":"T20217","span":{"begin":595,"end":603},"obj":"http://www.uniprot.org/uniprot/P05120"},{"id":"T20216","span":{"begin":436,"end":444},"obj":"http://www.uniprot.org/uniprot/P05120"},{"id":"T20215","span":{"begin":238,"end":246},"obj":"http://www.uniprot.org/uniprot/P05120"},{"id":"T20214","span":{"begin":11,"end":19},"obj":"http://www.uniprot.org/uniprot/P05120"},{"id":"T20283","span":{"begin":1382,"end":1386},"obj":"http://www.uniprot.org/uniprot/P15336"},{"id":"T20282","span":{"begin":1208,"end":1212},"obj":"http://www.uniprot.org/uniprot/P15336"},{"id":"T20281","span":{"begin":1382,"end":1386},"obj":"http://www.uniprot.org/uniprot/O43889"},{"id":"T20280","span":{"begin":1208,"end":1212},"obj":"http://www.uniprot.org/uniprot/O43889"},{"id":"T20279","span":{"begin":1382,"end":1386},"obj":"http://www.uniprot.org/uniprot/P16220"},{"id":"T20278","span":{"begin":1208,"end":1212},"obj":"http://www.uniprot.org/uniprot/P16220"},{"id":"T20277","span":{"begin":1382,"end":1386},"obj":"http://www.uniprot.org/uniprot/Q8TEY5"},{"id":"T20276","span":{"begin":1208,"end":1212},"obj":"http://www.uniprot.org/uniprot/Q8TEY5"},{"id":"T20275","span":{"begin":1382,"end":1386},"obj":"http://www.uniprot.org/uniprot/P18848"},{"id":"T20274","span":{"begin":1208,"end":1212},"obj":"http://www.uniprot.org/uniprot/P18848"},{"id":"T20273","span":{"begin":1190,"end":1212},"obj":"http://www.uniprot.org/uniprot/Q92793"},{"id":"T20272","span":{"begin":1287,"end":1291},"obj":"http://www.uniprot.org/uniprot/P05412"},{"id":"T20271","span":{"begin":1218,"end":1222},"obj":"http://www.uniprot.org/uniprot/P05412"},{"id":"T20270","span":{"begin":1060,"end":1064},"obj":"http://www.uniprot.org/uniprot/P05412"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"The murine SerpinB2 proximal promoter region between nucleotides -539 and +92 mediated both PMA- and LPS-inducible gene transcription, with induction by PMA being less intense and more transient than that by LPS. Inspection of the murine SerpinB2 proximal promoter sequence shows that a CRE and two AP-1-like elements, demonstrated to mediate PMA-stimulated transcription of the human SERPINB2 gene [37], also are present in the murine SerpinB2 proximal promoter between nucleotides −189 and −87. These sites may therefore also play a role in mediating PMA-inducible transcription of the murine SerpinB2 gene. In contrast to the pattern of incremental increases in PMA-induced transcriptional activity conferred by regions of the murine SerpinB2 promoter containing these sites, most of the LPS-inducible response is dependent upon cis-acting regulatory sequences in the region between nucleotides −189 and −539. LPS responsiveness absolutely required the C/EBP binding site located in the region between nucleotides −189 and −539, with the downstream CRE and AP-1-like elements also being critical. Of note, there are previous reports of combinatorial interactions between C/EBP-β and CRE binding proteins (CREB) and AP-1 [63], and C/EBP-β has been reported to physically interact with AP-1, and NF-κB to promote gene expression of inflammatory mediators [63]; [66]. Additionally, CREB has been shown to control transcription of the C/EBP-β gene [67]."}

{"project":"GO-BP","denotations":[{"id":"T18819","span":{"begin":1405,"end":1426},"obj":"http://purl.obolibrary.org/obo/GO_0006355"},{"id":"T18813","span":{"begin":1314,"end":1329},"obj":"http://purl.obolibrary.org/obo/GO_0010467"},{"id":"T18802","span":{"begin":1413,"end":1426},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T18801","span":{"begin":567,"end":580},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T18800","span":{"begin":358,"end":371},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T18799","span":{"begin":120,"end":133},"obj":"http://purl.obolibrary.org/obo/GO_0006351"}],"text":"The murine SerpinB2 proximal promoter region between nucleotides -539 and +92 mediated both PMA- and LPS-inducible gene transcription, with induction by PMA being less intense and more transient than that by LPS. Inspection of the murine SerpinB2 proximal promoter sequence shows that a CRE and two AP-1-like elements, demonstrated to mediate PMA-stimulated transcription of the human SERPINB2 gene [37], also are present in the murine SerpinB2 proximal promoter between nucleotides −189 and −87. These sites may therefore also play a role in mediating PMA-inducible transcription of the murine SerpinB2 gene. In contrast to the pattern of incremental increases in PMA-induced transcriptional activity conferred by regions of the murine SerpinB2 promoter containing these sites, most of the LPS-inducible response is dependent upon cis-acting regulatory sequences in the region between nucleotides −189 and −539. LPS responsiveness absolutely required the C/EBP binding site located in the region between nucleotides −189 and −539, with the downstream CRE and AP-1-like elements also being critical. Of note, there are previous reports of combinatorial interactions between C/EBP-β and CRE binding proteins (CREB) and AP-1 [63], and C/EBP-β has been reported to physically interact with AP-1, and NF-κB to promote gene expression of inflammatory mediators [63]; [66]. Additionally, CREB has been shown to control transcription of the C/EBP-β gene [67]."}

{"project":"GO-MF","denotations":[{"id":"T18848","span":{"begin":1190,"end":1206},"obj":"http://purl.obolibrary.org/obo/GO_0005515"},{"id":"T18847","span":{"begin":1186,"end":1197},"obj":"http://purl.obolibrary.org/obo/GO_0035497"},{"id":"T18846","span":{"begin":1190,"end":1197},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T18845","span":{"begin":962,"end":969},"obj":"http://purl.obolibrary.org/obo/GO_0005488"}],"text":"The murine SerpinB2 proximal promoter region between nucleotides -539 and +92 mediated both PMA- and LPS-inducible gene transcription, with induction by PMA being less intense and more transient than that by LPS. Inspection of the murine SerpinB2 proximal promoter sequence shows that a CRE and two AP-1-like elements, demonstrated to mediate PMA-stimulated transcription of the human SERPINB2 gene [37], also are present in the murine SerpinB2 proximal promoter between nucleotides −189 and −87. These sites may therefore also play a role in mediating PMA-inducible transcription of the murine SerpinB2 gene. In contrast to the pattern of incremental increases in PMA-induced transcriptional activity conferred by regions of the murine SerpinB2 promoter containing these sites, most of the LPS-inducible response is dependent upon cis-acting regulatory sequences in the region between nucleotides −189 and −539. LPS responsiveness absolutely required the C/EBP binding site located in the region between nucleotides −189 and −539, with the downstream CRE and AP-1-like elements also being critical. Of note, there are previous reports of combinatorial interactions between C/EBP-β and CRE binding proteins (CREB) and AP-1 [63], and C/EBP-β has been reported to physically interact with AP-1, and NF-κB to promote gene expression of inflammatory mediators [63]; [66]. Additionally, CREB has been shown to control transcription of the C/EBP-β gene [67]."}

{"project":"sentences","denotations":[{"id":"T18491","span":{"begin":1368,"end":1452},"obj":"Sentence"},{"id":"T18490","span":{"begin":1100,"end":1367},"obj":"Sentence"},{"id":"T18489","span":{"begin":913,"end":1099},"obj":"Sentence"},{"id":"T18488","span":{"begin":610,"end":912},"obj":"Sentence"},{"id":"T18487","span":{"begin":497,"end":609},"obj":"Sentence"},{"id":"T18486","span":{"begin":213,"end":496},"obj":"Sentence"},{"id":"T18485","span":{"begin":0,"end":212},"obj":"Sentence"},{"id":"T250","span":{"begin":0,"end":212},"obj":"Sentence"},{"id":"T251","span":{"begin":213,"end":496},"obj":"Sentence"},{"id":"T252","span":{"begin":497,"end":609},"obj":"Sentence"},{"id":"T253","span":{"begin":610,"end":912},"obj":"Sentence"},{"id":"T254","span":{"begin":913,"end":1099},"obj":"Sentence"},{"id":"T255","span":{"begin":1100,"end":1367},"obj":"Sentence"},{"id":"T256","span":{"begin":1368,"end":1452},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The murine SerpinB2 proximal promoter region between nucleotides -539 and +92 mediated both PMA- and LPS-inducible gene transcription, with induction by PMA being less intense and more transient than that by LPS. Inspection of the murine SerpinB2 proximal promoter sequence shows that a CRE and two AP-1-like elements, demonstrated to mediate PMA-stimulated transcription of the human SERPINB2 gene [37], also are present in the murine SerpinB2 proximal promoter between nucleotides −189 and −87. These sites may therefore also play a role in mediating PMA-inducible transcription of the murine SerpinB2 gene. In contrast to the pattern of incremental increases in PMA-induced transcriptional activity conferred by regions of the murine SerpinB2 promoter containing these sites, most of the LPS-inducible response is dependent upon cis-acting regulatory sequences in the region between nucleotides −189 and −539. LPS responsiveness absolutely required the C/EBP binding site located in the region between nucleotides −189 and −539, with the downstream CRE and AP-1-like elements also being critical. Of note, there are previous reports of combinatorial interactions between C/EBP-β and CRE binding proteins (CREB) and AP-1 [63], and C/EBP-β has been reported to physically interact with AP-1, and NF-κB to promote gene expression of inflammatory mediators [63]; [66]. Additionally, CREB has been shown to control transcription of the C/EBP-β gene [67]."}

{"project":"simple1","denotations":[{"id":"T18872","span":{"begin":1434,"end":1441},"obj":"Protein"},{"id":"T18871","span":{"begin":1233,"end":1240},"obj":"Protein"},{"id":"T18870","span":{"begin":1174,"end":1181},"obj":"Protein"},{"id":"T18869","span":{"begin":737,"end":745},"obj":"Protein"},{"id":"T18868","span":{"begin":595,"end":603},"obj":"Protein"},{"id":"T18867","span":{"begin":436,"end":444},"obj":"Protein"},{"id":"T18866","span":{"begin":385,"end":393},"obj":"Protein"},{"id":"T18865","span":{"begin":238,"end":246},"obj":"Protein"},{"id":"T18864","span":{"begin":11,"end":19},"obj":"Protein"}],"text":"The murine SerpinB2 proximal promoter region between nucleotides -539 and +92 mediated both PMA- and LPS-inducible gene transcription, with induction by PMA being less intense and more transient than that by LPS. Inspection of the murine SerpinB2 proximal promoter sequence shows that a CRE and two AP-1-like elements, demonstrated to mediate PMA-stimulated transcription of the human SERPINB2 gene [37], also are present in the murine SerpinB2 proximal promoter between nucleotides −189 and −87. These sites may therefore also play a role in mediating PMA-inducible transcription of the murine SerpinB2 gene. In contrast to the pattern of incremental increases in PMA-induced transcriptional activity conferred by regions of the murine SerpinB2 promoter containing these sites, most of the LPS-inducible response is dependent upon cis-acting regulatory sequences in the region between nucleotides −189 and −539. LPS responsiveness absolutely required the C/EBP binding site located in the region between nucleotides −189 and −539, with the downstream CRE and AP-1-like elements also being critical. Of note, there are previous reports of combinatorial interactions between C/EBP-β and CRE binding proteins (CREB) and AP-1 [63], and C/EBP-β has been reported to physically interact with AP-1, and NF-κB to promote gene expression of inflammatory mediators [63]; [66]. Additionally, CREB has been shown to control transcription of the C/EBP-β gene [67]."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T20080","span":{"begin":1434,"end":1441},"obj":"Protein"},{"id":"T20079","span":{"begin":1233,"end":1240},"obj":"Protein"},{"id":"T20078","span":{"begin":1174,"end":1181},"obj":"Protein"},{"id":"T20077","span":{"begin":737,"end":745},"obj":"Protein"},{"id":"T20076","span":{"begin":595,"end":603},"obj":"Protein"},{"id":"T20075","span":{"begin":436,"end":444},"obj":"Protein"},{"id":"T20074","span":{"begin":385,"end":393},"obj":"Protein"},{"id":"T20073","span":{"begin":238,"end":246},"obj":"Protein"},{"id":"T20072","span":{"begin":11,"end":19},"obj":"Protein"},{"id":"T20157","span":{"begin":1405,"end":1412},"obj":"Regulation"},{"id":"T20156","span":{"begin":1413,"end":1426},"obj":"Transcription"},{"id":"T20155","span":{"begin":1273,"end":1281},"obj":"Binding"},{"id":"T20154","span":{"begin":1153,"end":1165},"obj":"Binding"},{"id":"T20153","span":{"begin":652,"end":661},"obj":"Positive_regulation"},{"id":"T20152","span":{"begin":543,"end":552},"obj":"Positive_regulation"},{"id":"T20151","span":{"begin":567,"end":580},"obj":"Transcription"},{"id":"T20150","span":{"begin":535,"end":539},"obj":"Regulation"},{"id":"T20149","span":{"begin":553,"end":566},"obj":"Positive_regulation"},{"id":"T20148","span":{"begin":414,"end":421},"obj":"Positive_regulation"},{"id":"T20147","span":{"begin":358,"end":371},"obj":"Transcription"},{"id":"T20146","span":{"begin":343,"end":357},"obj":"Positive_regulation"},{"id":"T20145","span":{"begin":335,"end":342},"obj":"Positive_regulation"},{"id":"T20144","span":{"begin":140,"end":149},"obj":"Positive_regulation"}],"relations":[{"id":"R14512","pred":"themeOf","subj":"T20072","obj":"T20144"},{"id":"R14513","pred":"themeOf","subj":"T20074","obj":"T20147"},{"id":"R14514","pred":"themeOf","subj":"T20075","obj":"T20148"},{"id":"R14515","pred":"themeOf","subj":"T20076","obj":"T20151"},{"id":"R14516","pred":"themeOf","subj":"T20077","obj":"T20153"},{"id":"R14517","pred":"themeOf","subj":"T20078","obj":"T20154"},{"id":"R14518","pred":"themeOf","subj":"T20079","obj":"T20155"},{"id":"R14519","pred":"themeOf","subj":"T20080","obj":"T20156"},{"id":"R14578","pred":"themeOf","subj":"T20147","obj":"T20145"},{"id":"R14579","pred":"themeOf","subj":"T20147","obj":"T20146"},{"id":"R14580","pred":"themeOf","subj":"T20151","obj":"T20152"},{"id":"R14581","pred":"themeOf","subj":"T20151","obj":"T20149"},{"id":"R14582","pred":"themeOf","subj":"T20152","obj":"T20150"},{"id":"R14583","pred":"themeOf","subj":"T20156","obj":"T20157"}],"text":"The murine SerpinB2 proximal promoter region between nucleotides -539 and +92 mediated both PMA- and LPS-inducible gene transcription, with induction by PMA being less intense and more transient than that by LPS. Inspection of the murine SerpinB2 proximal promoter sequence shows that a CRE and two AP-1-like elements, demonstrated to mediate PMA-stimulated transcription of the human SERPINB2 gene [37], also are present in the murine SerpinB2 proximal promoter between nucleotides −189 and −87. These sites may therefore also play a role in mediating PMA-inducible transcription of the murine SerpinB2 gene. In contrast to the pattern of incremental increases in PMA-induced transcriptional activity conferred by regions of the murine SerpinB2 promoter containing these sites, most of the LPS-inducible response is dependent upon cis-acting regulatory sequences in the region between nucleotides −189 and −539. LPS responsiveness absolutely required the C/EBP binding site located in the region between nucleotides −189 and −539, with the downstream CRE and AP-1-like elements also being critical. Of note, there are previous reports of combinatorial interactions between C/EBP-β and CRE binding proteins (CREB) and AP-1 [63], and C/EBP-β has been reported to physically interact with AP-1, and NF-κB to promote gene expression of inflammatory mediators [63]; [66]. Additionally, CREB has been shown to control transcription of the C/EBP-β gene [67]."}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T20530","span":{"begin":1434,"end":1441},"obj":"Protein"},{"id":"T20529","span":{"begin":1233,"end":1240},"obj":"Protein"},{"id":"T20528","span":{"begin":1174,"end":1181},"obj":"Protein"},{"id":"T20527","span":{"begin":737,"end":745},"obj":"Protein"},{"id":"T20526","span":{"begin":595,"end":603},"obj":"Protein"},{"id":"T20525","span":{"begin":436,"end":444},"obj":"Protein"},{"id":"T20524","span":{"begin":385,"end":393},"obj":"Protein"},{"id":"T20523","span":{"begin":238,"end":246},"obj":"Protein"},{"id":"T20522","span":{"begin":11,"end":19},"obj":"Protein"},{"id":"T20593","span":{"begin":567,"end":580},"obj":"Transcription"},{"id":"T20592","span":{"begin":358,"end":371},"obj":"Transcription"},{"id":"T20598","span":{"begin":1413,"end":1426},"obj":"Transcription"},{"id":"T20597","span":{"begin":1273,"end":1281},"obj":"Binding"},{"id":"T20596","span":{"begin":1153,"end":1165},"obj":"Binding"},{"id":"T20595","span":{"begin":543,"end":552},"obj":"Positive_regulation"},{"id":"T20594","span":{"begin":553,"end":566},"obj":"Positive_regulation"}],"relations":[{"id":"R14737","pred":"themeOf","subj":"T20528","obj":"T20596"},{"id":"R14738","pred":"themeOf","subj":"T20529","obj":"T20597"},{"id":"R14739","pred":"themeOf","subj":"T20530","obj":"T20598"},{"id":"R14735","pred":"themeOf","subj":"T20524","obj":"T20592"},{"id":"R14736","pred":"themeOf","subj":"T20526","obj":"T20593"},{"id":"R14782","pred":"themeOf","subj":"T20593","obj":"T20595"},{"id":"R14783","pred":"themeOf","subj":"T20593","obj":"T20594"}],"text":"The murine SerpinB2 proximal promoter region between nucleotides -539 and +92 mediated both PMA- and LPS-inducible gene transcription, with induction by PMA being less intense and more transient than that by LPS. Inspection of the murine SerpinB2 proximal promoter sequence shows that a CRE and two AP-1-like elements, demonstrated to mediate PMA-stimulated transcription of the human SERPINB2 gene [37], also are present in the murine SerpinB2 proximal promoter between nucleotides −189 and −87. These sites may therefore also play a role in mediating PMA-inducible transcription of the murine SerpinB2 gene. In contrast to the pattern of incremental increases in PMA-induced transcriptional activity conferred by regions of the murine SerpinB2 promoter containing these sites, most of the LPS-inducible response is dependent upon cis-acting regulatory sequences in the region between nucleotides −189 and −539. LPS responsiveness absolutely required the C/EBP binding site located in the region between nucleotides −189 and −539, with the downstream CRE and AP-1-like elements also being critical. Of note, there are previous reports of combinatorial interactions between C/EBP-β and CRE binding proteins (CREB) and AP-1 [63], and C/EBP-β has been reported to physically interact with AP-1, and NF-κB to promote gene expression of inflammatory mediators [63]; [66]. Additionally, CREB has been shown to control transcription of the C/EBP-β gene [67]."}

{"project":"DLUT931","denotations":[{"id":"T20377","span":{"begin":1413,"end":1426},"obj":"Transcription"},{"id":"T20376","span":{"begin":1273,"end":1281},"obj":"Binding"},{"id":"T20375","span":{"begin":1153,"end":1165},"obj":"Binding"},{"id":"T20374","span":{"begin":553,"end":566},"obj":"Positive_regulation"},{"id":"T20373","span":{"begin":543,"end":552},"obj":"Positive_regulation"},{"id":"T20372","span":{"begin":567,"end":580},"obj":"Transcription"},{"id":"T20371","span":{"begin":358,"end":371},"obj":"Transcription"},{"id":"T20370","span":{"begin":78,"end":86},"obj":"Positive_regulation"},{"id":"T20304","span":{"begin":1434,"end":1441},"obj":"Protein"},{"id":"T20303","span":{"begin":1233,"end":1240},"obj":"Protein"},{"id":"T20302","span":{"begin":1174,"end":1181},"obj":"Protein"},{"id":"T20301","span":{"begin":737,"end":745},"obj":"Protein"},{"id":"T20300","span":{"begin":595,"end":603},"obj":"Protein"},{"id":"T20299","span":{"begin":436,"end":444},"obj":"Protein"},{"id":"T20298","span":{"begin":385,"end":393},"obj":"Protein"},{"id":"T20297","span":{"begin":238,"end":246},"obj":"Protein"},{"id":"T20296","span":{"begin":11,"end":19},"obj":"Protein"}],"relations":[{"id":"R14623","pred":"themeOf","subj":"T20296","obj":"T20370"},{"id":"R14624","pred":"themeOf","subj":"T20298","obj":"T20371"},{"id":"R14625","pred":"themeOf","subj":"T20300","obj":"T20372"},{"id":"R14626","pred":"themeOf","subj":"T20302","obj":"T20375"},{"id":"R14627","pred":"themeOf","subj":"T20303","obj":"T20376"},{"id":"R14628","pred":"themeOf","subj":"T20304","obj":"T20377"},{"id":"R14674","pred":"themeOf","subj":"T20372","obj":"T20373"},{"id":"R14675","pred":"themeOf","subj":"T20372","obj":"T20374"}],"text":"The murine SerpinB2 proximal promoter region between nucleotides -539 and +92 mediated both PMA- and LPS-inducible gene transcription, with induction by PMA being less intense and more transient than that by LPS. Inspection of the murine SerpinB2 proximal promoter sequence shows that a CRE and two AP-1-like elements, demonstrated to mediate PMA-stimulated transcription of the human SERPINB2 gene [37], also are present in the murine SerpinB2 proximal promoter between nucleotides −189 and −87. These sites may therefore also play a role in mediating PMA-inducible transcription of the murine SerpinB2 gene. In contrast to the pattern of incremental increases in PMA-induced transcriptional activity conferred by regions of the murine SerpinB2 promoter containing these sites, most of the LPS-inducible response is dependent upon cis-acting regulatory sequences in the region between nucleotides −189 and −539. LPS responsiveness absolutely required the C/EBP binding site located in the region between nucleotides −189 and −539, with the downstream CRE and AP-1-like elements also being critical. Of note, there are previous reports of combinatorial interactions between C/EBP-β and CRE binding proteins (CREB) and AP-1 [63], and C/EBP-β has been reported to physically interact with AP-1, and NF-κB to promote gene expression of inflammatory mediators [63]; [66]. Additionally, CREB has been shown to control transcription of the C/EBP-β gene [67]."}

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Inspection of the murine SerpinB2 proximal promoter sequence shows that a CRE and two AP-1-like elements, demonstrated to mediate PMA-stimulated transcription of the human SERPINB2 gene [37], also are present in the murine SerpinB2 proximal promoter between nucleotides −189 and −87. These sites may therefore also play a role in mediating PMA-inducible transcription of the murine SerpinB2 gene. In contrast to the pattern of incremental increases in PMA-induced transcriptional activity conferred by regions of the murine SerpinB2 promoter containing these sites, most of the LPS-inducible response is dependent upon cis-acting regulatory sequences in the region between nucleotides −189 and −539. LPS responsiveness absolutely required the C/EBP binding site located in the region between nucleotides −189 and −539, with the downstream CRE and AP-1-like elements also being critical. Of note, there are previous reports of combinatorial interactions between C/EBP-β and CRE binding proteins (CREB) and AP-1 [63], and C/EBP-β has been reported to physically interact with AP-1, and NF-κB to promote gene expression of inflammatory mediators [63]; [66]. Additionally, CREB has been shown to control transcription of the C/EBP-β gene [67]."}

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