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PMC:3589482 / 3829-4116
Annnotations
bionlp-st-ge-2016-spacy-parsed
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2919 | 286-287 | . | denotes | . |
T2918 | 285-286 | NNP | denotes | ] |
T2917 | 283-285 | CD | denotes | 33 |
T2916 | 282-283 | NNP | denotes | [ |
T2915 | 273-281 | NNS | denotes | pathways |
T2914 | 266-272 | NN | denotes | kinase |
T2913 | 265-266 | : | denotes | - |
T2912 | 264-265 | -RRB- | denotes | ) |
T2911 | 261-264 | NN | denotes | PI3 |
T2910 | 260-261 | -LRB- | denotes | ( |
T2909 | 259-260 | CD | denotes | 3 |
T2908 | 242-258 | NN | denotes | phosphoinositide |
T2907 | 235-241 | CC | denotes | and/or |
T2906 | 233-234 | -RRB- | denotes | ) |
T2905 | 229-233 | NNP | denotes | MAPK |
T2904 | 228-229 | -LRB- | denotes | ( |
T2903 | 221-227 | NN | denotes | kinase |
T2902 | 213-220 | NN | denotes | protein |
T2901 | 195-212 | JJ | denotes | mitogen-activated |
T2900 | 193-194 | , | denotes | , |
T2899 | 192-193 | -RRB- | denotes | ) |
T2898 | 187-192 | NNP | denotes | NF-κB |
T2897 | 186-187 | -LRB- | denotes | ( |
T2896 | 176-185 | NNP | denotes | factor-κB |
T2895 | 168-175 | JJ | denotes | nuclear |
T2894 | 164-167 | DT | denotes | the |
T2893 | 161-163 | TO | denotes | to |
T2892 | 153-160 | NNS | denotes | signals |
T2891 | 142-152 | VBG | denotes | generating |
T2890 | 140-141 | , | denotes | , |
T2889 | 133-140 | NNS | denotes | kinases |
T2888 | 125-132 | NN | denotes | protein |
T2887 | 122-124 | IN | denotes | of |
T2886 | 111-121 | NN | denotes | activation |
T2885 | 107-110 | DT | denotes | the |
T2884 | 103-106 | CC | denotes | and |
T2883 | 93-102 | NNS | denotes | molecules |
T2882 | 85-92 | NN | denotes | adaptor |
T2881 | 82-84 | IN | denotes | of |
T2880 | 70-81 | NN | denotes | recruitment |
T2879 | 66-69 | DT | denotes | the |
T2878 | 63-65 | TO | denotes | to |
T2877 | 57-62 | VBZ | denotes | leads |
T2876 | 45-56 | NNS | denotes | macrophages |
T2875 | 42-44 | IN | denotes | of |
T2874 | 34-41 | NN | denotes | surface |
T2873 | 30-33 | DT | denotes | the |
T2872 | 27-29 | IN | denotes | on |
T2871 | 22-26 | CD | denotes | TLR4 |
T2870 | 19-21 | TO | denotes | to |
T2869 | 15-18 | NNP | denotes | LPS |
T2868 | 12-14 | IN | denotes | of |
T2867 | 4-11 | JJ | denotes | binding |
T2866 | 0-3 | DT | denotes | The |
R1970 | T2866 | T2867 | det | The,binding |
R1972 | T2867 | T2877 | nsubj | binding,leads |
R1974 | T2868 | T2867 | prep | of,binding |
R1976 | T2869 | T2868 | pobj | LPS,of |
R1977 | T2870 | T2867 | prep | to,binding |
R1978 | T2871 | T2870 | pobj | TLR4,to |
R1980 | T2872 | T2867 | prep | on,binding |
R1981 | T2873 | T2874 | det | the,surface |
R1982 | T2874 | T2872 | pobj | surface,on |
R1984 | T2875 | T2874 | prep | of,surface |
R1985 | T2876 | T2875 | pobj | macrophages,of |
R1986 | T2877 | T2877 | ROOT | leads,leads |
R1987 | T2878 | T2877 | prep | to,leads |
R1989 | T2879 | T2880 | det | the,recruitment |
R1990 | T2880 | T2878 | pobj | recruitment,to |
R1991 | T2881 | T2880 | prep | of,recruitment |
R1993 | T2882 | T2883 | compound | adaptor,molecules |
R1994 | T2883 | T2881 | pobj | molecules,of |
R1996 | T2884 | T2883 | cc | and,molecules |
R1997 | T2885 | T2886 | det | the,activation |
R1998 | T2886 | T2880 | conj | activation,recruitment |
R1999 | T2887 | T2886 | prep | of,activation |
R2001 | T2888 | T2889 | compound | protein,kinases |
R2002 | T2889 | T2887 | pobj | kinases,of |
R2004 | T2890 | T2877 | punct | ",",leads |
R2005 | T2891 | T2877 | advcl | generating,leads |
R2006 | T2892 | T2891 | dobj | signals,generating |
R2008 | T2893 | T2892 | prep | to,signals |
R2009 | T2894 | T2896 | det | the,factor-κB |
R2010 | T2895 | T2896 | amod | nuclear,factor-κB |
R2011 | T2896 | T2893 | pobj | factor-κB,to |
R2012 | T2897 | T2896 | punct | (,factor-κB |
R2013 | T2898 | T2896 | appos | NF-κB,factor-κB |
R2015 | T2899 | T2896 | punct | ),factor-κB |
R2016 | T2900 | T2896 | punct | ",",factor-κB |
R2017 | T2901 | T2902 | amod | mitogen-activated,protein |
R2018 | T2902 | T2903 | compound | protein,kinase |
R2020 | T2903 | T2915 | nmod | kinase,pathways |
R2021 | T2904 | T2903 | punct | (,kinase |
R2023 | T2905 | T2903 | appos | MAPK,kinase |
R2024 | T2906 | T2905 | punct | ),MAPK |
R2025 | T2907 | T2903 | cc | and/or,kinase |
R2027 | T2908 | T2903 | conj | phosphoinositide,kinase |
R2028 | T2909 | T2908 | nummod | 3,phosphoinositide |
R2029 | T2910 | T2908 | punct | (,phosphoinositide |
R2030 | T2911 | T2908 | appos | PI3,phosphoinositide |
R2032 | T2912 | T2908 | punct | ),phosphoinositide |
R2033 | T2913 | T2914 | punct | -,kinase |
R2034 | T2914 | T2915 | compound | kinase,pathways |
R2036 | T2915 | T2892 | appos | pathways,signals |
R2037 | T2916 | T2918 | nmod | [,] |
R2038 | T2917 | T2918 | nummod | 33,] |
R2040 | T2918 | T2915 | appos | ],pathways |
R2041 | T2919 | T2877 | punct | .,leads |
pmc-enju-pas
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1844 | 285-286 | -RRB- | denotes | ] |
T1843 | 283-285 | CD | denotes | 33 |
T1842 | 282-283 | -LRB- | denotes | [ |
T1841 | 273-281 | NN | denotes | pathways |
T1840 | 265-272 | NN | denotes | -kinase |
T1839 | 264-265 | -RRB- | denotes | ) |
T1838 | 261-264 | NN | denotes | PI3 |
T1837 | 260-261 | -LRB- | denotes | ( |
T1836 | 259-260 | CD | denotes | 3 |
T1835 | 242-258 | NN | denotes | phosphoinositide |
T1834 | 235-241 | CC | denotes | and/or |
T1833 | 233-234 | -RRB- | denotes | ) |
T1832 | 229-233 | NN | denotes | MAPK |
T1831 | 228-229 | -LRB- | denotes | ( |
T1830 | 221-227 | NN | denotes | kinase |
T1829 | 213-220 | NN | denotes | protein |
T1828 | 195-212 | JJ | denotes | mitogen-activated |
T1827 | 193-194 | -COMMA- | denotes | , |
T1826 | 192-193 | -RRB- | denotes | ) |
T1825 | 187-192 | NN | denotes | NF-κB |
T1824 | 186-187 | -LRB- | denotes | ( |
T1823 | 176-185 | NN | denotes | factor-κB |
T1822 | 168-175 | JJ | denotes | nuclear |
T1821 | 164-167 | DT | denotes | the |
T1820 | 161-163 | TO | denotes | to |
T1819 | 153-160 | NN | denotes | signals |
T1818 | 142-152 | VB | denotes | generating |
T1817 | 140-141 | -COMMA- | denotes | , |
T1816 | 133-140 | NN | denotes | kinases |
T1815 | 125-132 | NN | denotes | protein |
T1814 | 122-124 | IN | denotes | of |
T1813 | 111-121 | NN | denotes | activation |
T1812 | 107-110 | DT | denotes | the |
T1811 | 103-106 | CC | denotes | and |
T1810 | 93-102 | NN | denotes | molecules |
T1809 | 85-92 | NN | denotes | adaptor |
T1808 | 82-84 | IN | denotes | of |
T1807 | 70-81 | NN | denotes | recruitment |
T1806 | 66-69 | DT | denotes | the |
T1805 | 63-65 | TO | denotes | to |
T1804 | 57-62 | VB | denotes | leads |
T1803 | 45-56 | NN | denotes | macrophages |
T1802 | 42-44 | IN | denotes | of |
T1801 | 34-41 | NN | denotes | surface |
T1800 | 30-33 | DT | denotes | the |
T1799 | 27-29 | IN | denotes | on |
T1798 | 22-26 | NN | denotes | TLR4 |
T1797 | 19-21 | TO | denotes | to |
T1796 | 15-18 | NN | denotes | LPS |
T1795 | 12-14 | IN | denotes | of |
T1794 | 4-11 | NN | denotes | binding |
T1793 | 0-3 | DT | denotes | The |
R1199 | T1794 | T1793 | arg1Of | binding,The |
R1200 | T1794 | T1795 | arg1Of | binding,of |
R1201 | T1794 | T1797 | arg1Of | binding,to |
R1202 | T1794 | T1799 | arg1Of | binding,on |
R1203 | T1794 | T1804 | arg1Of | binding,leads |
R1204 | T1796 | T1795 | arg2Of | LPS,of |
R1205 | T1798 | T1797 | arg2Of | TLR4,to |
R1206 | T1801 | T1799 | arg2Of | surface,on |
R1207 | T1801 | T1800 | arg1Of | surface,the |
R1208 | T1801 | T1802 | arg1Of | surface,of |
R1209 | T1803 | T1802 | arg2Of | macrophages,of |
R1210 | T1804 | T1805 | arg1Of | leads,to |
R1211 | T1804 | T1842 | arg1Of | leads,[ |
R1212 | T1807 | T1806 | arg1Of | recruitment,the |
R1213 | T1807 | T1808 | arg1Of | recruitment,of |
R1214 | T1807 | T1811 | arg1Of | recruitment,and |
R1215 | T1810 | T1808 | arg2Of | molecules,of |
R1216 | T1810 | T1809 | arg1Of | molecules,adaptor |
R1217 | T1811 | T1827 | arg1Of | and,"," |
R1218 | T1813 | T1811 | arg2Of | activation,and |
R1219 | T1813 | T1812 | arg1Of | activation,the |
R1220 | T1813 | T1814 | arg1Of | activation,of |
R1221 | T1816 | T1814 | arg2Of | kinases,of |
R1222 | T1816 | T1815 | arg1Of | kinases,protein |
R1223 | T1816 | T1817 | arg1Of | kinases,"," |
R1224 | T1816 | T1818 | arg1Of | kinases,generating |
R1225 | T1818 | T1820 | arg1Of | generating,to |
R1226 | T1819 | T1818 | arg2Of | signals,generating |
R1227 | T1823 | T1820 | arg2Of | factor-κB,to |
R1228 | T1823 | T1821 | arg1Of | factor-κB,the |
R1229 | T1823 | T1822 | arg1Of | factor-κB,nuclear |
R1230 | T1823 | T1824 | arg1Of | factor-κB,( |
R1231 | T1825 | T1824 | arg2Of | NF-κB,( |
R1232 | T1826 | T1824 | arg3Of | ),( |
R1233 | T1827 | T1805 | arg2Of | ",",to |
R1234 | T1830 | T1828 | arg1Of | kinase,mitogen-activated |
R1235 | T1830 | T1829 | arg1Of | kinase,protein |
R1236 | T1830 | T1831 | arg1Of | kinase,( |
R1237 | T1830 | T1834 | arg1Of | kinase,and/or |
R1238 | T1832 | T1831 | arg2Of | MAPK,( |
R1239 | T1833 | T1831 | arg3Of | ),( |
R1240 | T1835 | T1834 | arg2Of | phosphoinositide,and/or |
R1241 | T1835 | T1836 | arg1Of | phosphoinositide,3 |
R1242 | T1838 | T1837 | arg2Of | PI3,( |
R1243 | T1839 | T1837 | arg3Of | ),( |
R1244 | T1841 | T1827 | arg2Of | pathways,"," |
R1245 | T1841 | T1830 | arg1Of | pathways,kinase |
R1246 | T1841 | T1835 | arg1Of | pathways,phosphoinositide |
R1247 | T1841 | T1837 | arg1Of | pathways,( |
R1248 | T1841 | T1840 | arg1Of | pathways,-kinase |
R1249 | T1843 | T1842 | arg2Of | 33,[ |
R1250 | T1844 | T1842 | arg3Of | ],[ |
bionlp-st-ge-2016-test-proteins
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1310 | 22-26 | Protein | denotes | TLR4 |
bionlp-st-ge-2016-uniprot
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2122 | 22-26 | http://www.uniprot.org/uniprot/O00206 | denotes | TLR4 |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1367 | 111-140 | http://purl.obolibrary.org/obo/GO_0032111 | denotes | activation of protein kinases |
T1366 | 203-227 | http://purl.obolibrary.org/obo/GO_0030295 | denotes | activated protein kinase |
T1365 | 111-140 | http://purl.obolibrary.org/obo/GO_0030295 | denotes | activation of protein kinases |
T1364 | 203-227 | http://purl.obolibrary.org/obo/GO_0032147 | denotes | activated protein kinase |
T1363 | 111-140 | http://purl.obolibrary.org/obo/GO_0032147 | denotes | activation of protein kinases |
T1362 | 203-227 | http://purl.obolibrary.org/obo/GO_0034199 | denotes | activated protein kinase |
T1361 | 111-140 | http://purl.obolibrary.org/obo/GO_0034199 | denotes | activation of protein kinases |
T1355 | 153-160 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signals |
T1369 | 229-233 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | MAPK |
T1368 | 203-227 | http://purl.obolibrary.org/obo/GO_0032111 | denotes | activated protein kinase |
GO-MF
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1384 | 229-233 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | MAPK |
T1383 | 203-227 | http://purl.obolibrary.org/obo/GO_0030295 | denotes | activated protein kinase |
T1382 | 111-140 | http://purl.obolibrary.org/obo/GO_0030295 | denotes | activation of protein kinases |
T1381 | 4-18 | http://purl.obolibrary.org/obo/GO_0001530 | denotes | binding of LPS |
T1379 | 4-11 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1216 | 0-287 | Sentence | denotes | The binding of LPS to TLR4 on the surface of macrophages leads to the recruitment of adaptor molecules and the activation of protein kinases, generating signals to the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) and/or phosphoinositide 3(PI3)-kinase pathways [33]. |
T26 | 0-287 | Sentence | denotes | The binding of LPS to TLR4 on the surface of macrophages leads to the recruitment of adaptor molecules and the activation of protein kinases, generating signals to the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) and/or phosphoinositide 3(PI3)-kinase pathways [33]. |
simple1
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1408 | 22-26 | Protein | denotes | TLR4 |
BioNLP16_DUT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2066 | 22-26 | Protein | denotes | TLR4 |
T2087 | 57-62 | Positive_regulation | denotes | leads |
T2086 | 4-11 | Binding | denotes | binding |
R1454 | T2066 | T2086 | themeOf | TLR4,binding |
R1468 | T2086 | T2087 | themeOf | binding,leads |
BioNLP16_Messiy
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2225 | 22-26 | Protein | denotes | TLR4 |
T2246 | 57-62 | Positive_regulation | denotes | leads |
T2245 | 4-11 | Binding | denotes | binding |
R1515 | T2225 | T2245 | themeOf | TLR4,binding |
R1542 | T2245 | T2246 | themeOf | binding,leads |
DLUT931
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2166 | 57-62 | Positive_regulation | denotes | leads |
T2165 | 4-11 | Binding | denotes | binding |
T2144 | 22-26 | Protein | denotes | TLR4 |
R1482 | T2144 | T2165 | themeOf | TLR4,binding |
R1494 | T2165 | T2166 | themeOf | binding,leads |
bionlp-st-ge-2016-test-ihmc
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2477 | 195-234 | Positive_regulation | denotes | mitogen-activated protein kinase (MAPK) |
T2474 | 66-102 | Binding | denotes | the recruitment of adaptor molecules |
T2473 | 0-56 | Binding | denotes | The binding of LPS to TLR4 on the surface of macrophages |
T2466 | 107-140 | Positive_regulation | denotes | the activation of protein kinases |
T2460 | 19-26 | Protein | denotes | to TLR4 |
T2459 | 213-234 | Protein | denotes | protein kinase (MAPK) |
T2457 | 42-56 | Entity | denotes | of macrophages |
T2451 | 122-140 | Protein | denotes | of protein kinases |
T2435 | 195-202 | Entity | denotes | mitogen |
T2426 | 242-272 | Entity | denotes | phosphoinositide 3(PI3)-kinase |
T2424 | 261-264 | Protein | denotes | PI3 |
T2403 | 82-102 | Entity | denotes | of adaptor molecules |
T2391 | 242-272 | Protein | denotes | phosphoinositide 3(PI3)-kinase |
T2385 | 12-18 | Entity | denotes | of LPS |
T2372 | 187-192 | Protein | denotes | NF-κB |
T2370 | 229-233 | Protein | denotes | MAPK |
R1649 | T2459 | T2477 | themeOf | protein kinase (MAPK),mitogen-activated protein kinase (MAPK) |
R1651 | T2460 | T2473 | themeOf | to TLR4,The binding of LPS to TLR4 on the surface of macrophages |
R1606 | T2385 | T2473 | themeOf | of LPS,The binding of LPS to TLR4 on the surface of macrophages |
R1611 | T2403 | T2474 | themeOf | of adaptor molecules,the recruitment of adaptor molecules |
R1634 | T2435 | T2477 | causeOf | mitogen,mitogen-activated protein kinase (MAPK) |
R1644 | T2451 | T2466 | themeOf | of protein kinases,the activation of protein kinases |
bionlp-st-ge-2016-test-tees
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2284 | 4-11 | Binding | denotes | binding |
T2283 | 229-233 | Protein | denotes | MAPK |
T2282 | 195-227 | Protein | denotes | mitogen-activated protein kinase |
T2281 | 187-192 | Protein | denotes | NF-κB |
T2280 | 168-185 | Protein | denotes | nuclear factor-κB |
T2279 | 22-26 | Protein | denotes | TLR4 |
R1543 | T2279 | T2284 | themeOf | TLR4,binding |
testone
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1124 | 70-81 | Binding | denotes | recruitment |
T1123 | 4-11 | Binding | denotes | binding |
T1105 | 22-26 | Protein | denotes | TLR4 |
R747 | T1105 | T1123 | themeOf | TLR4,binding |
test3
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1174 | 22-26 | Protein | denotes | TLR4 |
T1173 | 4-11 | Binding | denotes | binding |
T1146 | 22-26 | Protein | denotes | TLR4 |
R758 | T1174 | T1173 | themeOf | TLR4,binding |