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{"project":"testone","denotations":[{"id":"T1124","span":{"begin":70,"end":81},"obj":"Binding"},{"id":"T1123","span":{"begin":4,"end":11},"obj":"Binding"},{"id":"T1105","span":{"begin":22,"end":26},"obj":"Protein"}],"relations":[{"id":"R747","pred":"themeOf","subj":"T1105","obj":"T1123"}],"text":"The binding of LPS to TLR4 on the surface of macrophages leads to the recruitment of adaptor molecules and the activation of protein kinases, generating signals to the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) and/or phosphoinositide 3(PI3)-kinase pathways [33]."}

{"project":"test3","denotations":[{"id":"T1174","span":{"begin":22,"end":26},"obj":"Protein"},{"id":"T1173","span":{"begin":4,"end":11},"obj":"Binding"},{"id":"T1146","span":{"begin":22,"end":26},"obj":"Protein"}],"relations":[{"id":"R758","pred":"themeOf","subj":"T1174","obj":"T1173"}],"text":"The binding of LPS to TLR4 on the surface of macrophages leads to the recruitment of adaptor molecules and the activation of protein kinases, generating signals to the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) and/or phosphoinositide 3(PI3)-kinase pathways [33]."}