PMC:3589482 / 38-660 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3589482","sourcedb":"PMC","sourceid":"3589482","source_url":"http://www.ncbi.nlm.nih.gov/pmc/3589482","text":"tes Constitutive and LPS-Inducible Transcription of Murine SerpinB2\nC/EBP-β Mediates SerpinB2 Transcription\n\nAbstract\nSerpinB2 or plasminogen activator inhibitor type 2 (PAI-2) is highly induced in macrophages in response to inflammatory stimuli and is linked to the modulation of innate immunity, macrophage survival, and inhibition of plasminogen activators. Lipopolysaccharide (LPS), a potent bacterial endotoxin, can induce SerpinB2 expression via the toll-like receptor 4 (TLR4) by ∼1000-fold over a period of 24 hrs in murine macrophages. 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