PMC:3589482 / 36146-36874 JSONTXT

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    bionlp-st-ge-2016-spacy-parsed

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C/EBP-β binds to the SerpinB2 proximal promoter in an LPS-inducible manner both in vitro and in vivo, we wanted to address the question of whether C/EBP-β was an essential factor for driving transcription from the SerpinB2 promoter in cells in response to LPS. The ability of endogenous C/EBP-β to direct transcription from the SerpinB2 proximal promoter was examined by transfection of the pGLmP-539 murine SerpinB2 luciferase reporter construct into Cebpb+/+ and Cebpb−/− MEFs. We found that LPS-stimulated SerpinB2 promoter activity was significantly increased in Cebpb+/+ MEFs and abrogated in Cebpb−/− MEFs (Fig. 8A), indicating that endogenous C/EBP-β is required for LPS-induced SerpinB2 proximal promoter activity."}

    bionlp-st-ge-2016-test-proteins

    {"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T15768","span":{"begin":692,"end":700},"obj":"Protein"},{"id":"T15767","span":{"begin":656,"end":663},"obj":"Protein"},{"id":"T15766","span":{"begin":604,"end":609},"obj":"Protein"},{"id":"T15765","span":{"begin":573,"end":578},"obj":"Protein"},{"id":"T15764","span":{"begin":515,"end":523},"obj":"Protein"},{"id":"T15763","span":{"begin":471,"end":476},"obj":"Protein"},{"id":"T15762","span":{"begin":458,"end":463},"obj":"Protein"},{"id":"T15761","span":{"begin":414,"end":442},"obj":"Protein"},{"id":"T15760","span":{"begin":334,"end":342},"obj":"Protein"},{"id":"T15759","span":{"begin":293,"end":300},"obj":"Protein"},{"id":"T15758","span":{"begin":220,"end":228},"obj":"Protein"},{"id":"T15757","span":{"begin":153,"end":160},"obj":"Protein"},{"id":"T15756","span":{"begin":27,"end":35},"obj":"Protein"},{"id":"T15755","span":{"begin":6,"end":13},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Since C/EBP-β binds to the SerpinB2 proximal promoter in an LPS-inducible manner both in vitro and in vivo, we wanted to address the question of whether C/EBP-β was an essential factor for driving transcription from the SerpinB2 promoter in cells in response to LPS. The ability of endogenous C/EBP-β to direct transcription from the SerpinB2 proximal promoter was examined by transfection of the pGLmP-539 murine SerpinB2 luciferase reporter construct into Cebpb+/+ and Cebpb−/− MEFs. We found that LPS-stimulated SerpinB2 promoter activity was significantly increased in Cebpb+/+ MEFs and abrogated in Cebpb−/− MEFs (Fig. 8A), indicating that endogenous C/EBP-β is required for LPS-induced SerpinB2 proximal promoter activity."}

    bionlp-st-ge-2016-uniprot

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    GO-BP

    {"project":"GO-BP","denotations":[{"id":"T15771","span":{"begin":250,"end":265},"obj":"http://purl.obolibrary.org/obo/GO_0032496"},{"id":"T15770","span":{"begin":311,"end":324},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T15769","span":{"begin":197,"end":210},"obj":"http://purl.obolibrary.org/obo/GO_0006351"}],"text":"Since C/EBP-β binds to the SerpinB2 proximal promoter in an LPS-inducible manner both in vitro and in vivo, we wanted to address the question of whether C/EBP-β was an essential factor for driving transcription from the SerpinB2 promoter in cells in response to LPS. The ability of endogenous C/EBP-β to direct transcription from the SerpinB2 proximal promoter was examined by transfection of the pGLmP-539 murine SerpinB2 luciferase reporter construct into Cebpb+/+ and Cebpb−/− MEFs. We found that LPS-stimulated SerpinB2 promoter activity was significantly increased in Cebpb+/+ MEFs and abrogated in Cebpb−/− MEFs (Fig. 8A), indicating that endogenous C/EBP-β is required for LPS-induced SerpinB2 proximal promoter activity."}

    GO-CC

    {"project":"GO-CC","denotations":[{"id":"T15772","span":{"begin":241,"end":246},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Since C/EBP-β binds to the SerpinB2 proximal promoter in an LPS-inducible manner both in vitro and in vivo, we wanted to address the question of whether C/EBP-β was an essential factor for driving transcription from the SerpinB2 promoter in cells in response to LPS. The ability of endogenous C/EBP-β to direct transcription from the SerpinB2 proximal promoter was examined by transfection of the pGLmP-539 murine SerpinB2 luciferase reporter construct into Cebpb+/+ and Cebpb−/− MEFs. We found that LPS-stimulated SerpinB2 promoter activity was significantly increased in Cebpb+/+ MEFs and abrogated in Cebpb−/− MEFs (Fig. 8A), indicating that endogenous C/EBP-β is required for LPS-induced SerpinB2 proximal promoter activity."}

    sentences

    {"project":"sentences","denotations":[{"id":"T15713","span":{"begin":486,"end":728},"obj":"Sentence"},{"id":"T15712","span":{"begin":267,"end":485},"obj":"Sentence"},{"id":"T15711","span":{"begin":0,"end":266},"obj":"Sentence"},{"id":"T220","span":{"begin":0,"end":266},"obj":"Sentence"},{"id":"T221","span":{"begin":267,"end":485},"obj":"Sentence"},{"id":"T222","span":{"begin":486,"end":728},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Since C/EBP-β binds to the SerpinB2 proximal promoter in an LPS-inducible manner both in vitro and in vivo, we wanted to address the question of whether C/EBP-β was an essential factor for driving transcription from the SerpinB2 promoter in cells in response to LPS. The ability of endogenous C/EBP-β to direct transcription from the SerpinB2 proximal promoter was examined by transfection of the pGLmP-539 murine SerpinB2 luciferase reporter construct into Cebpb+/+ and Cebpb−/− MEFs. We found that LPS-stimulated SerpinB2 promoter activity was significantly increased in Cebpb+/+ MEFs and abrogated in Cebpb−/− MEFs (Fig. 8A), indicating that endogenous C/EBP-β is required for LPS-induced SerpinB2 proximal promoter activity."}

    simple1

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    BioNLP16_DUT

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    BioNLP16_Messiy

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    DLUT931

    {"project":"DLUT931","denotations":[{"id":"T15985","span":{"begin":680,"end":691},"obj":"Positive_regulation"},{"id":"T15984","span":{"begin":591,"end":600},"obj":"Negative_regulation"},{"id":"T15983","span":{"begin":560,"end":569},"obj":"Positive_regulation"},{"id":"T15982","span":{"begin":168,"end":177},"obj":"Positive_regulation"},{"id":"T15981","span":{"begin":197,"end":210},"obj":"Transcription"},{"id":"T15980","span":{"begin":14,"end":19},"obj":"Binding"},{"id":"T15978","span":{"begin":692,"end":700},"obj":"Protein"},{"id":"T15977","span":{"begin":656,"end":663},"obj":"Protein"},{"id":"T15976","span":{"begin":604,"end":609},"obj":"Protein"},{"id":"T15975","span":{"begin":573,"end":578},"obj":"Protein"},{"id":"T15974","span":{"begin":515,"end":523},"obj":"Protein"},{"id":"T15973","span":{"begin":414,"end":442},"obj":"Protein"},{"id":"T15972","span":{"begin":334,"end":342},"obj":"Protein"},{"id":"T15971","span":{"begin":293,"end":300},"obj":"Protein"},{"id":"T15970","span":{"begin":471,"end":476},"obj":"Protein"},{"id":"T15969","span":{"begin":458,"end":463},"obj":"Protein"},{"id":"T15968","span":{"begin":220,"end":228},"obj":"Protein"},{"id":"T15967","span":{"begin":153,"end":160},"obj":"Protein"},{"id":"T15966","span":{"begin":27,"end":35},"obj":"Protein"},{"id":"T15965","span":{"begin":6,"end":13},"obj":"Protein"}],"relations":[{"id":"R11759","pred":"themeOf","subj":"T15965","obj":"T15980"},{"id":"R11760","pred":"themeOf","subj":"T15966","obj":"T15980"},{"id":"R11761","pred":"causeOf","subj":"T15967","obj":"T15982"},{"id":"R11762","pred":"themeOf","subj":"T15968","obj":"T15981"},{"id":"R11763","pred":"themeOf","subj":"T15974","obj":"T15983"},{"id":"R11764","pred":"themeOf","subj":"T15974","obj":"T15984"},{"id":"R11765","pred":"themeOf","subj":"T15978","obj":"T15985"},{"id":"R11766","pred":"themeOf","subj":"T15981","obj":"T15982"}],"text":"Since C/EBP-β binds to the SerpinB2 proximal promoter in an LPS-inducible manner both in vitro and in vivo, we wanted to address the question of whether C/EBP-β was an essential factor for driving transcription from the SerpinB2 promoter in cells in response to LPS. The ability of endogenous C/EBP-β to direct transcription from the SerpinB2 proximal promoter was examined by transfection of the pGLmP-539 murine SerpinB2 luciferase reporter construct into Cebpb+/+ and Cebpb−/− MEFs. We found that LPS-stimulated SerpinB2 promoter activity was significantly increased in Cebpb+/+ MEFs and abrogated in Cebpb−/− MEFs (Fig. 8A), indicating that endogenous C/EBP-β is required for LPS-induced SerpinB2 proximal promoter activity."}

    bionlp-st-ge-2016-test-ihmc

    {"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T16105","span":{"begin":0,"end":106},"obj":"Binding"},{"id":"T16104","span":{"begin":500,"end":541},"obj":"Positive_regulation"},{"id":"T16103","span":{"begin":301,"end":351},"obj":"Regulation"},{"id":"T16101","span":{"begin":480,"end":484},"obj":"Protein"},{"id":"T16100","span":{"begin":153,"end":160},"obj":"Protein"},{"id":"T16099","span":{"begin":458,"end":463},"obj":"Protein"},{"id":"T16098","span":{"begin":330,"end":351},"obj":"Protein"},{"id":"T16097","span":{"begin":6,"end":13},"obj":"Protein"},{"id":"T16096","span":{"begin":241,"end":246},"obj":"Entity"},{"id":"T16095","span":{"begin":710,"end":718},"obj":"Entity"},{"id":"T16092","span":{"begin":352,"end":360},"obj":"Entity"},{"id":"T16091","span":{"begin":398,"end":402},"obj":"Protein"},{"id":"T16090","span":{"begin":582,"end":586},"obj":"Protein"},{"id":"T16089","span":{"begin":619,"end":622},"obj":"Protein"},{"id":"T16088","span":{"begin":216,"end":237},"obj":"Entity"},{"id":"T16087","span":{"begin":500,"end":514},"obj":"Entity"},{"id":"T16086","span":{"begin":515,"end":523},"obj":"Protein"},{"id":"T16085","span":{"begin":471,"end":477},"obj":"Protein"},{"id":"T16084","span":{"begin":640,"end":663},"obj":"Protein"},{"id":"T16083","span":{"begin":613,"end":617},"obj":"Protein"},{"id":"T16082","span":{"begin":220,"end":228},"obj":"Protein"},{"id":"T16081","span":{"begin":680,"end":727},"obj":"Protein"},{"id":"T16080","span":{"begin":279,"end":300},"obj":"Protein"},{"id":"T16079","span":{"begin":680,"end":691},"obj":"Entity"},{"id":"T16078","span":{"begin":27,"end":35},"obj":"Protein"},{"id":"T16077","span":{"begin":515,"end":532},"obj":"Entity"},{"id":"T16076","span":{"begin":604,"end":610},"obj":"Protein"},{"id":"T16075","span":{"begin":20,"end":53},"obj":"Entity"},{"id":"T16074","span":{"begin":262,"end":265},"obj":"Entity"},{"id":"T16072","span":{"begin":414,"end":442},"obj":"Protein"}],"relations":[{"id":"R11800","pred":"partOf","subj":"T16075","obj":"T16078"},{"id":"R11801","pred":"themeOf","subj":"T16075","obj":"T16105"},{"id":"R11802","pred":"partOf","subj":"T16077","obj":"T16086"},{"id":"R11803","pred":"causeOf","subj":"T16087","obj":"T16104"},{"id":"R11804","pred":"partOf","subj":"T16088","obj":"T16082"},{"id":"R11806","pred":"themeOf","subj":"T16097","obj":"T16105"}],"text":"Since C/EBP-β binds to the SerpinB2 proximal promoter in an LPS-inducible manner both in vitro and in vivo, we wanted to address the question of whether C/EBP-β was an essential factor for driving transcription from the SerpinB2 promoter in cells in response to LPS. The ability of endogenous C/EBP-β to direct transcription from the SerpinB2 proximal promoter was examined by transfection of the pGLmP-539 murine SerpinB2 luciferase reporter construct into Cebpb+/+ and Cebpb−/− MEFs. We found that LPS-stimulated SerpinB2 promoter activity was significantly increased in Cebpb+/+ MEFs and abrogated in Cebpb−/− MEFs (Fig. 8A), indicating that endogenous C/EBP-β is required for LPS-induced SerpinB2 proximal promoter activity."}

    bionlp-st-ge-2016-test-tees

    {"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T16048","span":{"begin":667,"end":675},"obj":"Positive_regulation"},{"id":"T16047","span":{"begin":591,"end":600},"obj":"Negative_regulation"},{"id":"T16046","span":{"begin":560,"end":569},"obj":"Positive_regulation"},{"id":"T16045","span":{"begin":692,"end":718},"obj":"Protein"},{"id":"T16044","span":{"begin":656,"end":663},"obj":"Protein"},{"id":"T16043","span":{"begin":573,"end":586},"obj":"Protein"},{"id":"T16042","span":{"begin":515,"end":532},"obj":"Protein"},{"id":"T16041","span":{"begin":311,"end":324},"obj":"Transcription"},{"id":"T16040","span":{"begin":471,"end":484},"obj":"Protein"},{"id":"T16039","span":{"begin":458,"end":463},"obj":"Protein"},{"id":"T16038","span":{"begin":414,"end":433},"obj":"Protein"},{"id":"T16037","span":{"begin":334,"end":360},"obj":"Protein"},{"id":"T16036","span":{"begin":293,"end":300},"obj":"Protein"},{"id":"T16035","span":{"begin":197,"end":210},"obj":"Transcription"},{"id":"T16034","span":{"begin":14,"end":19},"obj":"Binding"},{"id":"T16033","span":{"begin":14,"end":19},"obj":"Binding"},{"id":"T16032","span":{"begin":220,"end":237},"obj":"Protein"},{"id":"T16031","span":{"begin":153,"end":160},"obj":"Protein"},{"id":"T16030","span":{"begin":27,"end":53},"obj":"Protein"},{"id":"T16029","span":{"begin":6,"end":13},"obj":"Protein"}],"relations":[{"id":"R11781","pred":"themeOf","subj":"T16029","obj":"T16033"},{"id":"R11782","pred":"themeOf","subj":"T16029","obj":"T16034"},{"id":"R11783","pred":"themeOf","subj":"T16030","obj":"T16034"},{"id":"R11784","pred":"themeOf","subj":"T16032","obj":"T16035"},{"id":"R11785","pred":"themeOf","subj":"T16037","obj":"T16041"},{"id":"R11786","pred":"themeOf","subj":"T16042","obj":"T16047"},{"id":"R11787","pred":"themeOf","subj":"T16043","obj":"T16046"},{"id":"R11788","pred":"causeOf","subj":"T16044","obj":"T16048"},{"id":"R11789","pred":"themeOf","subj":"T16045","obj":"T16048"}],"text":"Since C/EBP-β binds to the SerpinB2 proximal promoter in an LPS-inducible manner both in vitro and in vivo, we wanted to address the question of whether C/EBP-β was an essential factor for driving transcription from the SerpinB2 promoter in cells in response to LPS. The ability of endogenous C/EBP-β to direct transcription from the SerpinB2 proximal promoter was examined by transfection of the pGLmP-539 murine SerpinB2 luciferase reporter construct into Cebpb+/+ and Cebpb−/− MEFs. We found that LPS-stimulated SerpinB2 promoter activity was significantly increased in Cebpb+/+ MEFs and abrogated in Cebpb−/− MEFs (Fig. 8A), indicating that endogenous C/EBP-β is required for LPS-induced SerpinB2 proximal promoter activity."}

    testone

    {"project":"testone","denotations":[{"id":"T15670","span":{"begin":591,"end":600},"obj":"Negative_regulation"},{"id":"T15669","span":{"begin":377,"end":389},"obj":"Gene_expression"},{"id":"T15668","span":{"begin":352,"end":360},"obj":"Entity"},{"id":"T15667","span":{"begin":311,"end":324},"obj":"Transcription"},{"id":"T15666","span":{"begin":45,"end":53},"obj":"Entity"},{"id":"T15665","span":{"begin":36,"end":44},"obj":"Entity"},{"id":"T15664","span":{"begin":14,"end":19},"obj":"Binding"},{"id":"T15663","span":{"begin":692,"end":700},"obj":"Protein"},{"id":"T15662","span":{"begin":656,"end":663},"obj":"Protein"},{"id":"T15661","span":{"begin":604,"end":609},"obj":"Protein"},{"id":"T15660","span":{"begin":573,"end":578},"obj":"Protein"},{"id":"T15659","span":{"begin":515,"end":523},"obj":"Protein"},{"id":"T15658","span":{"begin":471,"end":476},"obj":"Protein"},{"id":"T15657","span":{"begin":458,"end":463},"obj":"Protein"},{"id":"T15656","span":{"begin":414,"end":442},"obj":"Protein"},{"id":"T15655","span":{"begin":334,"end":342},"obj":"Protein"},{"id":"T15654","span":{"begin":293,"end":300},"obj":"Protein"},{"id":"T15653","span":{"begin":220,"end":228},"obj":"Protein"},{"id":"T15652","span":{"begin":153,"end":160},"obj":"Protein"},{"id":"T15651","span":{"begin":27,"end":35},"obj":"Protein"},{"id":"T15650","span":{"begin":6,"end":13},"obj":"Protein"}],"relations":[{"id":"R11580","pred":"themeOf","subj":"T15650","obj":"T15664"},{"id":"R11581","pred":"themeOf","subj":"T15654","obj":"T15667"},{"id":"R11582","pred":"themeOf","subj":"T15656","obj":"T15669"},{"id":"R11583","pred":"themeOf","subj":"T15666","obj":"T15664"},{"id":"R11584","pred":"themeOf","subj":"T15668","obj":"T15667"}],"text":"Since C/EBP-β binds to the SerpinB2 proximal promoter in an LPS-inducible manner both in vitro and in vivo, we wanted to address the question of whether C/EBP-β was an essential factor for driving transcription from the SerpinB2 promoter in cells in response to LPS. The ability of endogenous C/EBP-β to direct transcription from the SerpinB2 proximal promoter was examined by transfection of the pGLmP-539 murine SerpinB2 luciferase reporter construct into Cebpb+/+ and Cebpb−/− MEFs. We found that LPS-stimulated SerpinB2 promoter activity was significantly increased in Cebpb+/+ MEFs and abrogated in Cebpb−/− MEFs (Fig. 8A), indicating that endogenous C/EBP-β is required for LPS-induced SerpinB2 proximal promoter activity."}

    test3

    {"project":"test3","denotations":[{"id":"T15693","span":{"begin":153,"end":160},"obj":"Protein"},{"id":"T15692","span":{"begin":45,"end":53},"obj":"Entity"},{"id":"T15691","span":{"begin":27,"end":35},"obj":"Protein"},{"id":"T15690","span":{"begin":14,"end":19},"obj":"Binding"},{"id":"T15689","span":{"begin":6,"end":13},"obj":"Protein"},{"id":"T15686","span":{"begin":692,"end":700},"obj":"Protein"},{"id":"T15685","span":{"begin":656,"end":663},"obj":"Protein"},{"id":"T15684","span":{"begin":604,"end":609},"obj":"Protein"},{"id":"T15683","span":{"begin":573,"end":578},"obj":"Protein"},{"id":"T15682","span":{"begin":515,"end":523},"obj":"Protein"},{"id":"T15681","span":{"begin":471,"end":476},"obj":"Protein"},{"id":"T15680","span":{"begin":458,"end":463},"obj":"Protein"},{"id":"T15679","span":{"begin":414,"end":442},"obj":"Protein"},{"id":"T15678","span":{"begin":334,"end":342},"obj":"Protein"},{"id":"T15677","span":{"begin":293,"end":300},"obj":"Protein"},{"id":"T15676","span":{"begin":220,"end":228},"obj":"Protein"},{"id":"T15675","span":{"begin":153,"end":160},"obj":"Protein"},{"id":"T15674","span":{"begin":27,"end":35},"obj":"Protein"},{"id":"T15673","span":{"begin":6,"end":13},"obj":"Protein"},{"id":"T15709","span":{"begin":692,"end":700},"obj":"Protein"},{"id":"T15708","span":{"begin":684,"end":691},"obj":"Positive_regulation"},{"id":"T15707","span":{"begin":656,"end":663},"obj":"Protein"},{"id":"T15706","span":{"begin":604,"end":609},"obj":"Protein"},{"id":"T15705","span":{"begin":573,"end":578},"obj":"Protein"},{"id":"T15704","span":{"begin":515,"end":523},"obj":"Protein"},{"id":"T15703","span":{"begin":504,"end":514},"obj":"Positive_regulation"},{"id":"T15702","span":{"begin":471,"end":476},"obj":"Protein"},{"id":"T15701","span":{"begin":458,"end":463},"obj":"Protein"},{"id":"T15700","span":{"begin":414,"end":442},"obj":"Protein"},{"id":"T15699","span":{"begin":334,"end":342},"obj":"Protein"},{"id":"T15698","span":{"begin":311,"end":324},"obj":"Transcription"},{"id":"T15697","span":{"begin":293,"end":300},"obj":"Protein"},{"id":"T15696","span":{"begin":250,"end":258},"obj":"Positive_regulation"},{"id":"T15695","span":{"begin":220,"end":228},"obj":"Protein"},{"id":"T15694","span":{"begin":197,"end":210},"obj":"Transcription"}],"relations":[{"id":"R11585","pred":"themeOf","subj":"T15689","obj":"T15690"},{"id":"R11586","pred":"themeOf","subj":"T15691","obj":"T15690"},{"id":"R11587","pred":"themeOf","subj":"T15692","obj":"T15690"},{"id":"R11588","pred":"themeOf","subj":"T15695","obj":"T15694"},{"id":"R11589","pred":"themeOf","subj":"T15699","obj":"T15698"}],"text":"Since C/EBP-β binds to the SerpinB2 proximal promoter in an LPS-inducible manner both in vitro and in vivo, we wanted to address the question of whether C/EBP-β was an essential factor for driving transcription from the SerpinB2 promoter in cells in response to LPS. The ability of endogenous C/EBP-β to direct transcription from the SerpinB2 proximal promoter was examined by transfection of the pGLmP-539 murine SerpinB2 luciferase reporter construct into Cebpb+/+ and Cebpb−/− MEFs. We found that LPS-stimulated SerpinB2 promoter activity was significantly increased in Cebpb+/+ MEFs and abrogated in Cebpb−/− MEFs (Fig. 8A), indicating that endogenous C/EBP-β is required for LPS-induced SerpinB2 proximal promoter activity."}