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Schematic representation of the −539/+92 region of the murine SerpinB2 promoter with the location of candidate cis-acting regulatory elements indicated with boxes. 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{"project":"simple1","denotations":[{"id":"T23814","span":{"begin":601,"end":611},"obj":"Protein"},{"id":"T23813","span":{"begin":458,"end":495},"obj":"Protein"},{"id":"T23812","span":{"begin":277,"end":285},"obj":"Protein"},{"id":"T23811","span":{"begin":66,"end":74},"obj":"Protein"}],"text":"(A) Schematic representation of the −539/+92 region of the murine SerpinB2 promoter with the location of candidate cis-acting regulatory elements indicated with boxes. The location of the 5′ ends of the −539, −189 and −87 reporter constructs is also shown. Positions of murine SerpinB2 proximal promoter-specific primers, 338/−315 and −5/+19 used in ChIP assays are indicated. (B) RAW 264.7 macrophages were transiently transfected with the indicated murine SerpinB2 promoter-luciferase reporter constructs and either left untreated or treated with 100 ng/ml LPS for 16 hrs. The results show relative luciferase activity following LPS treatment and represent the mean and SEM of 4–7 independent experiments. "}

{"project":"BioNLP16_DUT","denotations":[{"id":"T23946","span":{"begin":601,"end":611},"obj":"Protein"},{"id":"T23945","span":{"begin":458,"end":495},"obj":"Protein"},{"id":"T23944","span":{"begin":277,"end":285},"obj":"Protein"},{"id":"T23943","span":{"begin":66,"end":74},"obj":"Protein"}],"text":"(A) Schematic representation of the −539/+92 region of the murine SerpinB2 promoter with the location of candidate cis-acting regulatory elements indicated with boxes. The location of the 5′ ends of the −539, −189 and −87 reporter constructs is also shown. Positions of murine SerpinB2 proximal promoter-specific primers, 338/−315 and −5/+19 used in ChIP assays are indicated. (B) RAW 264.7 macrophages were transiently transfected with the indicated murine SerpinB2 promoter-luciferase reporter constructs and either left untreated or treated with 100 ng/ml LPS for 16 hrs. The results show relative luciferase activity following LPS treatment and represent the mean and SEM of 4–7 independent experiments. "}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T23970","span":{"begin":420,"end":431},"obj":"Gene_expression"},{"id":"T23969","span":{"begin":601,"end":611},"obj":"Protein"},{"id":"T23968","span":{"begin":458,"end":495},"obj":"Protein"},{"id":"T23967","span":{"begin":277,"end":285},"obj":"Protein"},{"id":"T23966","span":{"begin":66,"end":74},"obj":"Protein"}],"relations":[{"id":"R17237","pred":"themeOf","subj":"T23968","obj":"T23970"}],"text":"(A) Schematic representation of the −539/+92 region of the murine SerpinB2 promoter with the location of candidate cis-acting regulatory elements indicated with boxes. The location of the 5′ ends of the −539, −189 and −87 reporter constructs is also shown. Positions of murine SerpinB2 proximal promoter-specific primers, 338/−315 and −5/+19 used in ChIP assays are indicated. (B) RAW 264.7 macrophages were transiently transfected with the indicated murine SerpinB2 promoter-luciferase reporter constructs and either left untreated or treated with 100 ng/ml LPS for 16 hrs. The results show relative luciferase activity following LPS treatment and represent the mean and SEM of 4–7 independent experiments. "}

{"project":"DLUT931","denotations":[{"id":"T23959","span":{"begin":601,"end":611},"obj":"Protein"},{"id":"T23958","span":{"begin":458,"end":495},"obj":"Protein"},{"id":"T23957","span":{"begin":277,"end":285},"obj":"Protein"},{"id":"T23956","span":{"begin":66,"end":74},"obj":"Protein"}],"text":"(A) Schematic representation of the −539/+92 region of the murine SerpinB2 promoter with the location of candidate cis-acting regulatory elements indicated with boxes. The location of the 5′ ends of the −539, −189 and −87 reporter constructs is also shown. Positions of murine SerpinB2 proximal promoter-specific primers, 338/−315 and −5/+19 used in ChIP assays are indicated. (B) RAW 264.7 macrophages were transiently transfected with the indicated murine SerpinB2 promoter-luciferase reporter constructs and either left untreated or treated with 100 ng/ml LPS for 16 hrs. The results show relative luciferase activity following LPS treatment and represent the mean and SEM of 4–7 independent experiments. "}

{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T23997","span":{"begin":52,"end":83},"obj":"Entity"},{"id":"T23996","span":{"begin":277,"end":285},"obj":"Protein"},{"id":"T23995","span":{"begin":601,"end":611},"obj":"Protein"},{"id":"T23994","span":{"begin":350,"end":361},"obj":"Entity"},{"id":"T23993","span":{"begin":161,"end":166},"obj":"Entity"},{"id":"T23992","span":{"begin":567,"end":573},"obj":"Protein"},{"id":"T23990","span":{"begin":267,"end":361},"obj":"Entity"},{"id":"T23988","span":{"begin":267,"end":361},"obj":"Entity"},{"id":"T23987","span":{"begin":115,"end":118},"obj":"Protein"},{"id":"T23986","span":{"begin":381,"end":402},"obj":"Entity"},{"id":"T23985","span":{"begin":553,"end":573},"obj":"Entity"},{"id":"T23984","span":{"begin":66,"end":74},"obj":"Protein"},{"id":"T23982","span":{"begin":631,"end":634},"obj":"Entity"},{"id":"T23981","span":{"begin":451,"end":506},"obj":"Protein"}],"relations":[{"id":"R17239","pred":"partOf","subj":"T23997","obj":"T23984"}],"text":"(A) Schematic representation of the −539/+92 region of the murine SerpinB2 promoter with the location of candidate cis-acting regulatory elements indicated with boxes. The location of the 5′ ends of the −539, −189 and −87 reporter constructs is also shown. Positions of murine SerpinB2 proximal promoter-specific primers, 338/−315 and −5/+19 used in ChIP assays are indicated. (B) RAW 264.7 macrophages were transiently transfected with the indicated murine SerpinB2 promoter-luciferase reporter constructs and either left untreated or treated with 100 ng/ml LPS for 16 hrs. The results show relative luciferase activity following LPS treatment and represent the mean and SEM of 4–7 independent experiments. "}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T23975","span":{"begin":601,"end":611},"obj":"Protein"},{"id":"T23974","span":{"begin":476,"end":486},"obj":"Protein"},{"id":"T23973","span":{"begin":451,"end":475},"obj":"Protein"},{"id":"T23972","span":{"begin":59,"end":83},"obj":"Protein"}],"text":"(A) Schematic representation of the −539/+92 region of the murine SerpinB2 promoter with the location of candidate cis-acting regulatory elements indicated with boxes. The location of the 5′ ends of the −539, −189 and −87 reporter constructs is also shown. Positions of murine SerpinB2 proximal promoter-specific primers, 338/−315 and −5/+19 used in ChIP assays are indicated. (B) RAW 264.7 macrophages were transiently transfected with the indicated murine SerpinB2 promoter-luciferase reporter constructs and either left untreated or treated with 100 ng/ml LPS for 16 hrs. The results show relative luciferase activity following LPS treatment and represent the mean and SEM of 4–7 independent experiments. "}

{"project":"testone","denotations":[{"id":"T23769","span":{"begin":601,"end":611},"obj":"Protein"},{"id":"T23768","span":{"begin":458,"end":495},"obj":"Protein"},{"id":"T23767","span":{"begin":277,"end":285},"obj":"Protein"},{"id":"T23766","span":{"begin":66,"end":74},"obj":"Protein"}],"text":"(A) Schematic representation of the −539/+92 region of the murine SerpinB2 promoter with the location of candidate cis-acting regulatory elements indicated with boxes. The location of the 5′ ends of the −539, −189 and −87 reporter constructs is also shown. Positions of murine SerpinB2 proximal promoter-specific primers, 338/−315 and −5/+19 used in ChIP assays are indicated. (B) RAW 264.7 macrophages were transiently transfected with the indicated murine SerpinB2 promoter-luciferase reporter constructs and either left untreated or treated with 100 ng/ml LPS for 16 hrs. The results show relative luciferase activity following LPS treatment and represent the mean and SEM of 4–7 independent experiments. "}

{"project":"test3","denotations":[{"id":"T23780","span":{"begin":621,"end":630},"obj":"Positive_regulation"},{"id":"T23779","span":{"begin":601,"end":611},"obj":"Protein"},{"id":"T23778","span":{"begin":458,"end":495},"obj":"Protein"},{"id":"T23777","span":{"begin":277,"end":285},"obj":"Protein"},{"id":"T23776","span":{"begin":66,"end":74},"obj":"Protein"},{"id":"T23774","span":{"begin":601,"end":611},"obj":"Protein"},{"id":"T23773","span":{"begin":458,"end":495},"obj":"Protein"},{"id":"T23772","span":{"begin":277,"end":285},"obj":"Protein"},{"id":"T23771","span":{"begin":66,"end":74},"obj":"Protein"}],"relations":[{"id":"R17106","pred":"themeOf","subj":"T23779","obj":"T23780"}],"text":"(A) Schematic representation of the −539/+92 region of the murine SerpinB2 promoter with the location of candidate cis-acting regulatory elements indicated with boxes. The location of the 5′ ends of the −539, −189 and −87 reporter constructs is also shown. Positions of murine SerpinB2 proximal promoter-specific primers, 338/−315 and −5/+19 used in ChIP assays are indicated. (B) RAW 264.7 macrophages were transiently transfected with the indicated murine SerpinB2 promoter-luciferase reporter constructs and either left untreated or treated with 100 ng/ml LPS for 16 hrs. The results show relative luciferase activity following LPS treatment and represent the mean and SEM of 4–7 independent experiments. "}