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Mouse and human nucleotide sequences were aligned using Clustal W software. Cis-acting elements conserved between the human and murine SerpinB2 promoters are boxed and labeled. AP-1 =  activator protein 1; C/EBP =  CCAAT enhancer binding protein; CRE = cAMP response element; Oct1 =  octamer transcription factor 1/POU2F1; PU.1 =  purine box binding protein 1. The putative transcription initiation site (tis) is indicated and exon 1 is presented in uppercase. The location of the 5' ends of the −539, −189 and −87 reporter constructs are also shown."}

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Figure 3 Potential cis-acting regulatory elements in the LPS responsive region of the murine SerpinB2 promoter\n−563/−1. Mouse and human nucleotide sequences were aligned using Clustal W software. Cis-acting elements conserved between the human and murine SerpinB2 promoters are boxed and labeled. AP-1 =  activator protein 1; C/EBP =  CCAAT enhancer binding protein; CRE = cAMP response element; Oct1 =  octamer transcription factor 1/POU2F1; PU.1 =  purine box binding protein 1. The putative transcription initiation site (tis) is indicated and exon 1 is presented in uppercase. The location of the 5' ends of the −539, −189 and −87 reporter constructs are also shown."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T23418","span":{"begin":486,"end":514},"obj":"Protein"},{"id":"T23417","span":{"begin":478,"end":482},"obj":"Protein"},{"id":"T23416","span":{"begin":470,"end":476},"obj":"Protein"},{"id":"T23415","span":{"begin":439,"end":469},"obj":"Protein"},{"id":"T23414","span":{"begin":431,"end":435},"obj":"Protein"},{"id":"T23413","span":{"begin":290,"end":298},"obj":"Protein"},{"id":"T23412","span":{"begin":128,"end":136},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"10.1371/journal.pone.0057855.g003 Figure 3 Potential cis-acting regulatory elements in the LPS responsive region of the murine SerpinB2 promoter\n−563/−1. Mouse and human nucleotide sequences were aligned using Clustal W software. Cis-acting elements conserved between the human and murine SerpinB2 promoters are boxed and labeled. AP-1 =  activator protein 1; C/EBP =  CCAAT enhancer binding protein; CRE = cAMP response element; Oct1 =  octamer transcription factor 1/POU2F1; PU.1 =  purine box binding protein 1. The putative transcription initiation site (tis) is indicated and exon 1 is presented in uppercase. The location of the 5' ends of the −539, −189 and −87 reporter constructs are also shown."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T23561","span":{"begin":497,"end":514},"obj":"http://www.uniprot.org/uniprot/Q9UFW8"},{"id":"T23560","span":{"begin":497,"end":514},"obj":"http://www.uniprot.org/uniprot/Q13541"},{"id":"T23559","span":{"begin":497,"end":514},"obj":"http://www.uniprot.org/uniprot/Q86VP1"},{"id":"T23558","span":{"begin":497,"end":514},"obj":"http://www.uniprot.org/uniprot/O00560"},{"id":"T23557","span":{"begin":478,"end":482},"obj":"http://www.uniprot.org/uniprot/P17947"},{"id":"T23556","span":{"begin":335,"end":357},"obj":"http://www.uniprot.org/uniprot/P10145"},{"id":"T23555","span":{"begin":335,"end":357},"obj":"http://www.uniprot.org/uniprot/P05412"},{"id":"T23554","span":{"begin":290,"end":298},"obj":"http://www.uniprot.org/uniprot/P05120"},{"id":"T23553","span":{"begin":128,"end":136},"obj":"http://www.uniprot.org/uniprot/P05120"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"10.1371/journal.pone.0057855.g003 Figure 3 Potential cis-acting regulatory elements in the LPS responsive region of the murine SerpinB2 promoter\n−563/−1. Mouse and human nucleotide sequences were aligned using Clustal W software. Cis-acting elements conserved between the human and murine SerpinB2 promoters are boxed and labeled. AP-1 =  activator protein 1; C/EBP =  CCAAT enhancer binding protein; CRE = cAMP response element; Oct1 =  octamer transcription factor 1/POU2F1; PU.1 =  purine box binding protein 1. The putative transcription initiation site (tis) is indicated and exon 1 is presented in uppercase. The location of the 5' ends of the −539, −189 and −87 reporter constructs are also shown."}

{"project":"UBERON-AE","denotations":[{"id":"T23397","span":{"begin":487,"end":493},"obj":"http://purl.obolibrary.org/obo/UBERON_0001088"},{"id":"T23396","span":{"begin":284,"end":290},"obj":"http://purl.obolibrary.org/obo/UBERON_0001088"}],"text":"10.1371/journal.pone.0057855.g003 Figure 3 Potential cis-acting regulatory elements in the LPS responsive region of the murine SerpinB2 promoter\n−563/−1. Mouse and human nucleotide sequences were aligned using Clustal W software. Cis-acting elements conserved between the human and murine SerpinB2 promoters are boxed and labeled. AP-1 =  activator protein 1; C/EBP =  CCAAT enhancer binding protein; CRE = cAMP response element; Oct1 =  octamer transcription factor 1/POU2F1; PU.1 =  purine box binding protein 1. The putative transcription initiation site (tis) is indicated and exon 1 is presented in uppercase. The location of the 5' ends of the −539, −189 and −87 reporter constructs are also shown."}

{"project":"GO-BP","denotations":[{"id":"T23421","span":{"begin":529,"end":542},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T23420","span":{"begin":447,"end":460},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T23419","span":{"begin":408,"end":421},"obj":"http://purl.obolibrary.org/obo/GO_0051591"}],"text":"10.1371/journal.pone.0057855.g003 Figure 3 Potential cis-acting regulatory elements in the LPS responsive region of the murine SerpinB2 promoter\n−563/−1. Mouse and human nucleotide sequences were aligned using Clustal W software. Cis-acting elements conserved between the human and murine SerpinB2 promoters are boxed and labeled. AP-1 =  activator protein 1; C/EBP =  CCAAT enhancer binding protein; CRE = cAMP response element; Oct1 =  octamer transcription factor 1/POU2F1; PU.1 =  purine box binding protein 1. The putative transcription initiation site (tis) is indicated and exon 1 is presented in uppercase. The location of the 5' ends of the −539, −189 and −87 reporter constructs are also shown."}

{"project":"GO-MF","denotations":[{"id":"T23427","span":{"begin":497,"end":514},"obj":"http://purl.obolibrary.org/obo/GO_0008157"},{"id":"T23426","span":{"begin":497,"end":512},"obj":"http://purl.obolibrary.org/obo/GO_0005515"},{"id":"T23425","span":{"begin":385,"end":400},"obj":"http://purl.obolibrary.org/obo/GO_0005515"},{"id":"T23424","span":{"begin":497,"end":504},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T23423","span":{"begin":385,"end":392},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T23422","span":{"begin":376,"end":392},"obj":"http://purl.obolibrary.org/obo/GO_0035326"}],"text":"10.1371/journal.pone.0057855.g003 Figure 3 Potential cis-acting regulatory elements in the LPS responsive region of the murine SerpinB2 promoter\n−563/−1. Mouse and human nucleotide sequences were aligned using Clustal W software. Cis-acting elements conserved between the human and murine SerpinB2 promoters are boxed and labeled. AP-1 =  activator protein 1; C/EBP =  CCAAT enhancer binding protein; CRE = cAMP response element; Oct1 =  octamer transcription factor 1/POU2F1; PU.1 =  purine box binding protein 1. The putative transcription initiation site (tis) is indicated and exon 1 is presented in uppercase. The location of the 5' ends of the −539, −189 and −87 reporter constructs are also shown."}

{"project":"GO-CC","denotations":[{"id":"T23428","span":{"begin":335,"end":357},"obj":"http://purl.obolibrary.org/obo/GO_0035976"}],"text":"10.1371/journal.pone.0057855.g003 Figure 3 Potential cis-acting regulatory elements in the LPS responsive region of the murine SerpinB2 promoter\n−563/−1. Mouse and human nucleotide sequences were aligned using Clustal W software. Cis-acting elements conserved between the human and murine SerpinB2 promoters are boxed and labeled. AP-1 =  activator protein 1; C/EBP =  CCAAT enhancer binding protein; CRE = cAMP response element; Oct1 =  octamer transcription factor 1/POU2F1; PU.1 =  purine box binding protein 1. The putative transcription initiation site (tis) is indicated and exon 1 is presented in uppercase. The location of the 5' ends of the −539, −189 and −87 reporter constructs are also shown."}

{"project":"sentences","denotations":[{"id":"T23404","span":{"begin":616,"end":705},"obj":"Sentence"},{"id":"T23403","span":{"begin":516,"end":615},"obj":"Sentence"},{"id":"T23402","span":{"begin":332,"end":515},"obj":"Sentence"},{"id":"T23401","span":{"begin":231,"end":331},"obj":"Sentence"},{"id":"T23400","span":{"begin":155,"end":230},"obj":"Sentence"},{"id":"T23399","span":{"begin":146,"end":154},"obj":"Sentence"},{"id":"T23398","span":{"begin":44,"end":145},"obj":"Sentence"},{"id":"T151","span":{"begin":0,"end":145},"obj":"Sentence"},{"id":"T152","span":{"begin":146,"end":154},"obj":"Sentence"},{"id":"T153","span":{"begin":155,"end":230},"obj":"Sentence"},{"id":"T154","span":{"begin":231,"end":331},"obj":"Sentence"},{"id":"T155","span":{"begin":332,"end":515},"obj":"Sentence"},{"id":"T156","span":{"begin":516,"end":615},"obj":"Sentence"},{"id":"T157","span":{"begin":616,"end":705},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"10.1371/journal.pone.0057855.g003 Figure 3 Potential cis-acting regulatory elements in the LPS responsive region of the murine SerpinB2 promoter\n−563/−1. Mouse and human nucleotide sequences were aligned using Clustal W software. Cis-acting elements conserved between the human and murine SerpinB2 promoters are boxed and labeled. AP-1 =  activator protein 1; C/EBP =  CCAAT enhancer binding protein; CRE = cAMP response element; Oct1 =  octamer transcription factor 1/POU2F1; PU.1 =  purine box binding protein 1. The putative transcription initiation site (tis) is indicated and exon 1 is presented in uppercase. The location of the 5' ends of the −539, −189 and −87 reporter constructs are also shown."}

{"project":"simple1","denotations":[{"id":"T23435","span":{"begin":486,"end":514},"obj":"Protein"},{"id":"T23434","span":{"begin":478,"end":482},"obj":"Protein"},{"id":"T23433","span":{"begin":470,"end":476},"obj":"Protein"},{"id":"T23432","span":{"begin":439,"end":469},"obj":"Protein"},{"id":"T23431","span":{"begin":431,"end":435},"obj":"Protein"},{"id":"T23430","span":{"begin":290,"end":298},"obj":"Protein"},{"id":"T23429","span":{"begin":128,"end":136},"obj":"Protein"}],"text":"10.1371/journal.pone.0057855.g003 Figure 3 Potential cis-acting regulatory elements in the LPS responsive region of the murine SerpinB2 promoter\n−563/−1. Mouse and human nucleotide sequences were aligned using Clustal W software. Cis-acting elements conserved between the human and murine SerpinB2 promoters are boxed and labeled. AP-1 =  activator protein 1; C/EBP =  CCAAT enhancer binding protein; CRE = cAMP response element; Oct1 =  octamer transcription factor 1/POU2F1; PU.1 =  purine box binding protein 1. The putative transcription initiation site (tis) is indicated and exon 1 is presented in uppercase. The location of the 5' ends of the −539, −189 and −87 reporter constructs are also shown."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T23552","span":{"begin":486,"end":514},"obj":"Protein"},{"id":"T23551","span":{"begin":478,"end":482},"obj":"Protein"},{"id":"T23550","span":{"begin":470,"end":476},"obj":"Protein"},{"id":"T23549","span":{"begin":439,"end":469},"obj":"Protein"},{"id":"T23548","span":{"begin":431,"end":435},"obj":"Protein"},{"id":"T23547","span":{"begin":290,"end":298},"obj":"Protein"},{"id":"T23546","span":{"begin":128,"end":136},"obj":"Protein"}],"text":"10.1371/journal.pone.0057855.g003 Figure 3 Potential cis-acting regulatory elements in the LPS responsive region of the murine SerpinB2 promoter\n−563/−1. Mouse and human nucleotide sequences were aligned using Clustal W software. Cis-acting elements conserved between the human and murine SerpinB2 promoters are boxed and labeled. AP-1 =  activator protein 1; C/EBP =  CCAAT enhancer binding protein; CRE = cAMP response element; Oct1 =  octamer transcription factor 1/POU2F1; PU.1 =  purine box binding protein 1. The putative transcription initiation site (tis) is indicated and exon 1 is presented in uppercase. The location of the 5' ends of the −539, −189 and −87 reporter constructs are also shown."}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T23579","span":{"begin":431,"end":435},"obj":"Protein"},{"id":"T23578","span":{"begin":290,"end":298},"obj":"Protein"},{"id":"T23577","span":{"begin":128,"end":136},"obj":"Protein"},{"id":"T23583","span":{"begin":486,"end":514},"obj":"Protein"},{"id":"T23582","span":{"begin":478,"end":482},"obj":"Protein"},{"id":"T23581","span":{"begin":470,"end":476},"obj":"Protein"},{"id":"T23580","span":{"begin":439,"end":469},"obj":"Protein"}],"text":"10.1371/journal.pone.0057855.g003 Figure 3 Potential cis-acting regulatory elements in the LPS responsive region of the murine SerpinB2 promoter\n−563/−1. Mouse and human nucleotide sequences were aligned using Clustal W software. Cis-acting elements conserved between the human and murine SerpinB2 promoters are boxed and labeled. AP-1 =  activator protein 1; C/EBP =  CCAAT enhancer binding protein; CRE = cAMP response element; Oct1 =  octamer transcription factor 1/POU2F1; PU.1 =  purine box binding protein 1. The putative transcription initiation site (tis) is indicated and exon 1 is presented in uppercase. The location of the 5' ends of the −539, −189 and −87 reporter constructs are also shown."}

{"project":"DLUT931","denotations":[{"id":"T23569","span":{"begin":385,"end":392},"obj":"Binding"},{"id":"T23568","span":{"begin":486,"end":514},"obj":"Protein"},{"id":"T23567","span":{"begin":478,"end":482},"obj":"Protein"},{"id":"T23566","span":{"begin":470,"end":476},"obj":"Protein"},{"id":"T23565","span":{"begin":439,"end":469},"obj":"Protein"},{"id":"T23564","span":{"begin":431,"end":435},"obj":"Protein"},{"id":"T23563","span":{"begin":290,"end":298},"obj":"Protein"},{"id":"T23562","span":{"begin":128,"end":136},"obj":"Protein"}],"relations":[{"id":"R16967","pred":"themeOf","subj":"T23565","obj":"T23569"},{"id":"R16968","pred":"themeOf","subj":"T23565","obj":"T23569"},{"id":"R16969","pred":"themeOf","subj":"T23566","obj":"T23569"},{"id":"R16970","pred":"themeOf","subj":"T23566","obj":"T23569"},{"id":"R16971","pred":"themeOf","subj":"T23568","obj":"T23569"},{"id":"R16972","pred":"themeOf","subj":"T23568","obj":"T23569"}],"text":"10.1371/journal.pone.0057855.g003 Figure 3 Potential cis-acting regulatory elements in the LPS responsive region of the murine SerpinB2 promoter\n−563/−1. Mouse and human nucleotide sequences were aligned using Clustal W software. Cis-acting elements conserved between the human and murine SerpinB2 promoters are boxed and labeled. AP-1 =  activator protein 1; C/EBP =  CCAAT enhancer binding protein; CRE = cAMP response element; Oct1 =  octamer transcription factor 1/POU2F1; PU.1 =  purine box binding protein 1. The putative transcription initiation site (tis) is indicated and exon 1 is presented in uppercase. The location of the 5' ends of the −539, −189 and −87 reporter constructs are also shown."}

{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T23629","span":{"begin":478,"end":514},"obj":"Protein"},{"id":"T23628","span":{"begin":332,"end":357},"obj":"Entity"},{"id":"T23627","span":{"begin":439,"end":476},"obj":"Protein"},{"id":"T23626","span":{"begin":439,"end":476},"obj":"Protein"},{"id":"T23625","span":{"begin":516,"end":564},"obj":"Entity"},{"id":"T23624","span":{"begin":128,"end":136},"obj":"Protein"},{"id":"T23623","span":{"begin":171,"end":181},"obj":"Entity"},{"id":"T23622","span":{"begin":478,"end":483},"obj":"Protein"},{"id":"T23621","span":{"begin":408,"end":412},"obj":"Protein"},{"id":"T23620","span":{"begin":283,"end":308},"obj":"Entity"},{"id":"T23619","span":{"begin":332,"end":357},"obj":"Protein"},{"id":"T23618","span":{"begin":470,"end":476},"obj":"Protein"},{"id":"T23617","span":{"begin":332,"end":337},"obj":"Protein"},{"id":"T23616","span":{"begin":402,"end":476},"obj":"Protein"},{"id":"T23615","span":{"begin":582,"end":588},"obj":"Entity"},{"id":"T23614","span":{"begin":231,"end":234},"obj":"Protein"},{"id":"T23613","span":{"begin":290,"end":298},"obj":"Protein"},{"id":"T23612","span":{"begin":402,"end":406},"obj":"Protein"},{"id":"T23611","span":{"begin":361,"end":367},"obj":"Protein"},{"id":"T23610","span":{"begin":211,"end":229},"obj":"Entity"},{"id":"T23609","span":{"begin":92,"end":95},"obj":"Entity"},{"id":"T23608","span":{"begin":114,"end":145},"obj":"Entity"}],"relations":[{"id":"R16981","pred":"partOf","subj":"T23608","obj":"T23624"},{"id":"R16982","pred":"partOf","subj":"T23620","obj":"T23613"}],"text":"10.1371/journal.pone.0057855.g003 Figure 3 Potential cis-acting regulatory elements in the LPS responsive region of the murine SerpinB2 promoter\n−563/−1. Mouse and human nucleotide sequences were aligned using Clustal W software. Cis-acting elements conserved between the human and murine SerpinB2 promoters are boxed and labeled. AP-1 =  activator protein 1; C/EBP =  CCAAT enhancer binding protein; CRE = cAMP response element; Oct1 =  octamer transcription factor 1/POU2F1; PU.1 =  purine box binding protein 1. The putative transcription initiation site (tis) is indicated and exon 1 is presented in uppercase. The location of the 5' ends of the −539, −189 and −87 reporter constructs are also shown."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T23595","span":{"begin":337,"end":338},"obj":"Negative_regulation"},{"id":"T23594","span":{"begin":478,"end":514},"obj":"Protein"},{"id":"T23593","span":{"begin":470,"end":476},"obj":"Protein"},{"id":"T23592","span":{"begin":431,"end":469},"obj":"Protein"},{"id":"T23591","span":{"begin":370,"end":400},"obj":"Protein"},{"id":"T23590","span":{"begin":361,"end":366},"obj":"Protein"},{"id":"T23589","span":{"begin":340,"end":359},"obj":"Protein"},{"id":"T23588","span":{"begin":332,"end":336},"obj":"Protein"},{"id":"T23587","span":{"begin":283,"end":308},"obj":"Protein"},{"id":"T23586","span":{"begin":96,"end":106},"obj":"Regulation"},{"id":"T23585","span":{"begin":107,"end":113},"obj":"Gene_expression"},{"id":"T23584","span":{"begin":121,"end":145},"obj":"Protein"}],"relations":[{"id":"R16973","pred":"themeOf","subj":"T23584","obj":"T23585"},{"id":"R16974","pred":"themeOf","subj":"T23585","obj":"T23586"},{"id":"R16975","pred":"causeOf","subj":"T23588","obj":"T23595"},{"id":"R16976","pred":"themeOf","subj":"T23589","obj":"T23595"}],"text":"10.1371/journal.pone.0057855.g003 Figure 3 Potential cis-acting regulatory elements in the LPS responsive region of the murine SerpinB2 promoter\n−563/−1. Mouse and human nucleotide sequences were aligned using Clustal W software. Cis-acting elements conserved between the human and murine SerpinB2 promoters are boxed and labeled. AP-1 =  activator protein 1; C/EBP =  CCAAT enhancer binding protein; CRE = cAMP response element; Oct1 =  octamer transcription factor 1/POU2F1; PU.1 =  purine box binding protein 1. The putative transcription initiation site (tis) is indicated and exon 1 is presented in uppercase. The location of the 5' ends of the −539, −189 and −87 reporter constructs are also shown."}

{"project":"testone","denotations":[{"id":"T23381","span":{"begin":486,"end":514},"obj":"Protein"},{"id":"T23380","span":{"begin":478,"end":482},"obj":"Protein"},{"id":"T23379","span":{"begin":470,"end":476},"obj":"Protein"},{"id":"T23378","span":{"begin":439,"end":469},"obj":"Protein"},{"id":"T23377","span":{"begin":431,"end":435},"obj":"Protein"},{"id":"T23376","span":{"begin":290,"end":298},"obj":"Protein"},{"id":"T23375","span":{"begin":128,"end":136},"obj":"Protein"}],"text":"10.1371/journal.pone.0057855.g003 Figure 3 Potential cis-acting regulatory elements in the LPS responsive region of the murine SerpinB2 promoter\n−563/−1. Mouse and human nucleotide sequences were aligned using Clustal W software. Cis-acting elements conserved between the human and murine SerpinB2 promoters are boxed and labeled. AP-1 =  activator protein 1; C/EBP =  CCAAT enhancer binding protein; CRE = cAMP response element; Oct1 =  octamer transcription factor 1/POU2F1; PU.1 =  purine box binding protein 1. The putative transcription initiation site (tis) is indicated and exon 1 is presented in uppercase. The location of the 5' ends of the −539, −189 and −87 reporter constructs are also shown."}

{"project":"test3","denotations":[{"id":"T23395","span":{"begin":486,"end":514},"obj":"Protein"},{"id":"T23394","span":{"begin":478,"end":485},"obj":"Protein"},{"id":"T23393","span":{"begin":470,"end":476},"obj":"Protein"},{"id":"T23392","span":{"begin":439,"end":469},"obj":"Protein"},{"id":"T23391","span":{"begin":431,"end":438},"obj":"Protein"},{"id":"T23390","span":{"begin":290,"end":298},"obj":"Protein"},{"id":"T23389","span":{"begin":128,"end":136},"obj":"Protein"},{"id":"T23388","span":{"begin":486,"end":514},"obj":"Protein"},{"id":"T23387","span":{"begin":478,"end":482},"obj":"Protein"},{"id":"T23386","span":{"begin":470,"end":476},"obj":"Protein"},{"id":"T23385","span":{"begin":439,"end":469},"obj":"Protein"},{"id":"T23384","span":{"begin":431,"end":435},"obj":"Protein"},{"id":"T23383","span":{"begin":290,"end":298},"obj":"Protein"},{"id":"T23382","span":{"begin":128,"end":136},"obj":"Protein"}],"relations":[{"id":"R16859","pred":"equivalentTo","subj":"T23393","obj":"T23392"}],"text":"10.1371/journal.pone.0057855.g003 Figure 3 Potential cis-acting regulatory elements in the LPS responsive region of the murine SerpinB2 promoter\n−563/−1. Mouse and human nucleotide sequences were aligned using Clustal W software. Cis-acting elements conserved between the human and murine SerpinB2 promoters are boxed and labeled. AP-1 =  activator protein 1; C/EBP =  CCAAT enhancer binding protein; CRE = cAMP response element; Oct1 =  octamer transcription factor 1/POU2F1; PU.1 =  purine box binding protein 1. The putative transcription initiation site (tis) is indicated and exon 1 is presented in uppercase. The location of the 5' ends of the −539, −189 and −87 reporter constructs are also shown."}