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{"project":"DLUT931","denotations":[{"id":"T569","span":{"begin":4,"end":12},"obj":"Protein"},{"id":"T570","span":{"begin":16,"end":54},"obj":"Protein"},{"id":"T571","span":{"begin":56,"end":61},"obj":"Protein"},{"id":"T572","span":{"begin":314,"end":322},"obj":"Protein"},{"id":"T573","span":{"begin":342,"end":362},"obj":"Protein"},{"id":"T574","span":{"begin":364,"end":368},"obj":"Protein"},{"id":"T575","span":{"begin":571,"end":579},"obj":"Protein"},{"id":"T576","span":{"begin":456,"end":464},"obj":"Protein"},{"id":"T589","span":{"begin":73,"end":80},"obj":"Positive_regulation"},{"id":"T590","span":{"begin":323,"end":333},"obj":"Gene_expression"},{"id":"T591","span":{"begin":307,"end":313},"obj":"Positive_regulation"}],"relations":[{"id":"R684","pred":"themeOf","subj":"T570","obj":"T589"},{"id":"R683","pred":"themeOf","subj":"T569","obj":"T589"},{"id":"R685","pred":"themeOf","subj":"T572","obj":"T590"},{"id":"R686","pred":"causeOf","subj":"T573","obj":"T591"},{"id":"R693","pred":"themeOf","subj":"T590","obj":"T591"}],"text":"act\nSerpinB2 or plasminogen activator inhibitor type 2 (PAI-2) is highly induced in macrophages in response to inflammatory stimuli and is linked to the modulation of innate immunity, macrophage survival, and inhibition of plasminogen activators. Lipopolysaccharide (LPS), a potent bacterial endotoxin, can induce SerpinB2 expression via the toll-like receptor 4 (TLR4) by ∼1000-fold over a period of 24 hrs in murine macrophages. To map the LPS-regulated SerpinB2 promoter regions, we transfected reporter constructs driven by the ∼5 kb 5'-flanking region of the murine SerpinB2 gene and several deletion mutants into murine macrophages. In addition, we compared the DNA sequence of the murine"}

{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T760","span":{"begin":401,"end":429},"obj":"Localization"},{"id":"T759","span":{"begin":314,"end":333},"obj":"Gene_expression"},{"id":"T753","span":{"begin":571,"end":579},"obj":"Protein"},{"id":"T750","span":{"begin":267,"end":270},"obj":"Entity"},{"id":"T748","span":{"begin":314,"end":322},"obj":"Protein"},{"id":"T705","span":{"begin":184,"end":194},"obj":"Entity"},{"id":"T709","span":{"begin":247,"end":272},"obj":"Entity"},{"id":"T711","span":{"begin":292,"end":301},"obj":"Entity"},{"id":"T714","span":{"begin":338,"end":369},"obj":"Protein"},{"id":"T715","span":{"begin":364,"end":368},"obj":"Protein"},{"id":"T719","span":{"begin":401,"end":429},"obj":"Protein"},{"id":"T720","span":{"begin":456,"end":464},"obj":"Protein"},{"id":"T722","span":{"begin":668,"end":671},"obj":"Entity"},{"id":"T723","span":{"begin":84,"end":95},"obj":"Entity"},{"id":"T724","span":{"begin":411,"end":429},"obj":"Entity"},{"id":"T726","span":{"begin":619,"end":637},"obj":"Entity"},{"id":"T729","span":{"begin":438,"end":482},"obj":"Entity"},{"id":"T733","span":{"begin":220,"end":245},"obj":"Entity"},{"id":"T739","span":{"begin":56,"end":61},"obj":"Protein"},{"id":"T740","span":{"begin":4,"end":62},"obj":"Protein"},{"id":"T741","span":{"begin":442,"end":455},"obj":"Entity"},{"id":"T743","span":{"begin":557,"end":584},"obj":"Protein"},{"id":"T744","span":{"begin":16,"end":62},"obj":"Protein"},{"id":"T745","span":{"begin":223,"end":234},"obj":"Protein"}],"relations":[{"id":"R348","pred":"themeOf","subj":"T748","obj":"T759"},{"id":"R721","pred":"themeOf","subj":"T719","obj":"T760"},{"id":"R723","pred":"locationOf","subj":"T724","obj":"T760"}],"text":"act\nSerpinB2 or plasminogen activator inhibitor type 2 (PAI-2) is highly induced in macrophages in response to inflammatory stimuli and is linked to the modulation of innate immunity, macrophage survival, and inhibition of plasminogen activators. Lipopolysaccharide (LPS), a potent bacterial endotoxin, can induce SerpinB2 expression via the toll-like receptor 4 (TLR4) by ∼1000-fold over a period of 24 hrs in murine macrophages. To map the LPS-regulated SerpinB2 promoter regions, we transfected reporter constructs driven by the ∼5 kb 5'-flanking region of the murine SerpinB2 gene and several deletion mutants into murine macrophages. In addition, we compared the DNA sequence of the murine"}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T649","span":{"begin":564,"end":584},"obj":"Protein"},{"id":"T648","span":{"begin":456,"end":473},"obj":"Protein"},{"id":"T647","span":{"begin":307,"end":313},"obj":"Positive_regulation"},{"id":"T646","span":{"begin":323,"end":333},"obj":"Gene_expression"},{"id":"T645","span":{"begin":314,"end":322},"obj":"Protein"},{"id":"T644","span":{"begin":209,"end":219},"obj":"Negative_regulation"},{"id":"T643","span":{"begin":73,"end":80},"obj":"Positive_regulation"},{"id":"T642","span":{"begin":73,"end":80},"obj":"Positive_regulation"},{"id":"T641","span":{"begin":223,"end":245},"obj":"Protein"},{"id":"T640","span":{"begin":56,"end":61},"obj":"Protein"},{"id":"T639","span":{"begin":16,"end":54},"obj":"Protein"}],"relations":[{"id":"R322","pred":"themeOf","subj":"T640","obj":"T643"},{"id":"R323","pred":"themeOf","subj":"T641","obj":"T644"},{"id":"R324","pred":"themeOf","subj":"T645","obj":"T646"},{"id":"R325","pred":"themeOf","subj":"T646","obj":"T647"},{"id":"R706","pred":"themeOf","subj":"T639","obj":"T642"}],"text":"act\nSerpinB2 or plasminogen activator inhibitor type 2 (PAI-2) is highly induced in macrophages in response to inflammatory stimuli and is linked to the modulation of innate immunity, macrophage survival, and inhibition of plasminogen activators. Lipopolysaccharide (LPS), a potent bacterial endotoxin, can induce SerpinB2 expression via the toll-like receptor 4 (TLR4) by ∼1000-fold over a period of 24 hrs in murine macrophages. To map the LPS-regulated SerpinB2 promoter regions, we transfected reporter constructs driven by the ∼5 kb 5'-flanking region of the murine SerpinB2 gene and several deletion mutants into murine macrophages. In addition, we compared the DNA sequence of the murine"}

{"project":"testone","denotations":[{"id":"T40","span":{"begin":323,"end":333},"obj":"Gene_expression"},{"id":"T39","span":{"begin":307,"end":313},"obj":"Positive_regulation"},{"id":"T29","span":{"begin":571,"end":579},"obj":"Protein"},{"id":"T28","span":{"begin":456,"end":464},"obj":"Protein"},{"id":"T27","span":{"begin":364,"end":368},"obj":"Protein"},{"id":"T26","span":{"begin":342,"end":362},"obj":"Protein"},{"id":"T25","span":{"begin":314,"end":322},"obj":"Protein"},{"id":"T24","span":{"begin":56,"end":61},"obj":"Protein"},{"id":"T23","span":{"begin":16,"end":54},"obj":"Protein"},{"id":"T22","span":{"begin":4,"end":12},"obj":"Protein"}],"relations":[{"id":"R3","pred":"equivalentTo","subj":"T27","obj":"T26"},{"id":"R8","pred":"themeOf","subj":"T40","obj":"T39"},{"id":"R1","pred":"equivalentTo","subj":"T24","obj":"T23"},{"id":"R2","pred":"themeOf","subj":"T25","obj":"T40"}],"text":"act\nSerpinB2 or plasminogen activator inhibitor type 2 (PAI-2) is highly induced in macrophages in response to inflammatory stimuli and is linked to the modulation of innate immunity, macrophage survival, and inhibition of plasminogen activators. Lipopolysaccharide (LPS), a potent bacterial endotoxin, can induce SerpinB2 expression via the toll-like receptor 4 (TLR4) by ∼1000-fold over a period of 24 hrs in murine macrophages. To map the LPS-regulated SerpinB2 promoter regions, we transfected reporter constructs driven by the ∼5 kb 5'-flanking region of the murine SerpinB2 gene and several deletion mutants into murine macrophages. In addition, we compared the DNA sequence of the murine"}

{"project":"test3","denotations":[{"id":"T80","span":{"begin":571,"end":579},"obj":"Protein"},{"id":"T79","span":{"begin":456,"end":464},"obj":"Protein"},{"id":"T78","span":{"begin":364,"end":368},"obj":"Protein"},{"id":"T77","span":{"begin":342,"end":362},"obj":"Protein"},{"id":"T76","span":{"begin":323,"end":333},"obj":"Gene_expression"},{"id":"T75","span":{"begin":314,"end":322},"obj":"Protein"},{"id":"T74","span":{"begin":307,"end":313},"obj":"Positive_regulation"},{"id":"T73","span":{"begin":73,"end":80},"obj":"Positive_regulation"},{"id":"T72","span":{"begin":56,"end":61},"obj":"Protein"},{"id":"T71","span":{"begin":16,"end":54},"obj":"Protein"},{"id":"T70","span":{"begin":4,"end":12},"obj":"Protein"},{"id":"T58","span":{"begin":571,"end":579},"obj":"Protein"},{"id":"T57","span":{"begin":456,"end":464},"obj":"Protein"},{"id":"T56","span":{"begin":364,"end":368},"obj":"Protein"},{"id":"T55","span":{"begin":342,"end":362},"obj":"Protein"},{"id":"T54","span":{"begin":314,"end":322},"obj":"Protein"},{"id":"T53","span":{"begin":56,"end":61},"obj":"Protein"},{"id":"T52","span":{"begin":16,"end":54},"obj":"Protein"},{"id":"T51","span":{"begin":4,"end":12},"obj":"Protein"}],"relations":[{"id":"R15","pred":"themeOf","subj":"T71","obj":"T73"},{"id":"R16","pred":"equivalentTo","subj":"T72","obj":"T71"},{"id":"R17","pred":"themeOf","subj":"T75","obj":"T76"},{"id":"R18","pred":"themeOf","subj":"T76","obj":"T74"},{"id":"R19","pred":"equivalentTo","subj":"T78","obj":"T77"}],"text":"act\nSerpinB2 or plasminogen activator inhibitor type 2 (PAI-2) is highly induced in macrophages in response to inflammatory stimuli and is linked to the modulation of innate immunity, macrophage survival, and inhibition of plasminogen activators. Lipopolysaccharide (LPS), a potent bacterial endotoxin, can induce SerpinB2 expression via the toll-like receptor 4 (TLR4) by ∼1000-fold over a period of 24 hrs in murine macrophages. To map the LPS-regulated SerpinB2 promoter regions, we transfected reporter constructs driven by the ∼5 kb 5'-flanking region of the murine SerpinB2 gene and several deletion mutants into murine macrophages. In addition, we compared the DNA sequence of the murine"}