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Transcription Factor C/EBP-β Mediates Constitutive and LPS-Inducible Transcription of Murine SerpinB2\nC/EBP-β Mediates SerpinB2 Transcription\n\nAbstract\nSerpinB2 or plasminogen activator inhibitor type 2 (PAI-2) is highly induced in macrophages in response to inflammatory stimuli and is linked to the modulation of innate immunity, macrophage survival, and inhibition of plasminogen activators. Lipopolysaccharide (LPS), a potent bacterial endotoxin, can induce SerpinB2 expression via the toll-like receptor 4 (TLR4) by ∼1000-fold over a period of 24 hrs in murine macrophages. To map the LPS-regulated SerpinB2 promoter regions, we transfected reporter constructs driven by the ∼5 kb 5'-f"}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T157","span":{"begin":25,"end":32},"obj":"Protein"},{"id":"T158","span":{"begin":97,"end":105},"obj":"Protein"},{"id":"T159","span":{"begin":156,"end":164},"obj":"Protein"},{"id":"T160","span":{"begin":168,"end":206},"obj":"Protein"},{"id":"T161","span":{"begin":208,"end":213},"obj":"Protein"},{"id":"T162","span":{"begin":466,"end":474},"obj":"Protein"},{"id":"T163","span":{"begin":494,"end":514},"obj":"Protein"},{"id":"T164","span":{"begin":516,"end":520},"obj":"Protein"},{"id":"T165","span":{"begin":608,"end":616},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"The Transcription Factor C/EBP-β Mediates Constitutive and LPS-Inducible Transcription of Murine SerpinB2\nC/EBP-β Mediates SerpinB2 Transcription\n\nAbstract\nSerpinB2 or plasminogen activator inhibitor type 2 (PAI-2) is highly induced in macrophages in response to inflammatory stimuli and is linked to the modulation of innate immunity, macrophage survival, and inhibition of plasminogen activators. Lipopolysaccharide (LPS), a potent bacterial endotoxin, can induce SerpinB2 expression via the toll-like receptor 4 (TLR4) by ∼1000-fold over a period of 24 hrs in murine macrophages. To map the LPS-regulated SerpinB2 promoter regions, we transfected reporter constructs driven by the ∼5 kb 5'-f"}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T539","span":{"begin":516,"end":520},"obj":"http://www.uniprot.org/uniprot/O00206"},{"id":"T530","span":{"begin":156,"end":164},"obj":"http://www.uniprot.org/uniprot/P05120"},{"id":"T531","span":{"begin":466,"end":474},"obj":"http://www.uniprot.org/uniprot/P05120"},{"id":"T532","span":{"begin":608,"end":616},"obj":"http://www.uniprot.org/uniprot/P05120"},{"id":"T537","span":{"begin":205,"end":211},"obj":"http://www.uniprot.org/uniprot/P05120"},{"id":"T524","span":{"begin":25,"end":32},"obj":"http://www.uniprot.org/uniprot/P28033"},{"id":"T529","span":{"begin":97,"end":105},"obj":"http://www.uniprot.org/uniprot/P05120"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"The Transcription Factor C/EBP-β Mediates Constitutive and LPS-Inducible Transcription of Murine SerpinB2\nC/EBP-β Mediates SerpinB2 Transcription\n\nAbstract\nSerpinB2 or plasminogen activator inhibitor type 2 (PAI-2) is highly induced in macrophages in response to inflammatory stimuli and is linked to the modulation of innate immunity, macrophage survival, and inhibition of plasminogen activators. Lipopolysaccharide (LPS), a potent bacterial endotoxin, can induce SerpinB2 expression via the toll-like receptor 4 (TLR4) by ∼1000-fold over a period of 24 hrs in murine macrophages. To map the LPS-regulated SerpinB2 promoter regions, we transfected reporter constructs driven by the ∼5 kb 5'-f"}

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{"project":"sentences","denotations":[{"id":"T99","span":{"begin":0,"end":105},"obj":"Sentence"},{"id":"T100","span":{"begin":156,"end":398},"obj":"Sentence"},{"id":"T101","span":{"begin":399,"end":582},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":105},"obj":"Sentence"},{"id":"T2","span":{"begin":106,"end":145},"obj":"Sentence"},{"id":"T3","span":{"begin":147,"end":155},"obj":"Sentence"},{"id":"T4","span":{"begin":156,"end":398},"obj":"Sentence"},{"id":"T5","span":{"begin":399,"end":582},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The Transcription Factor C/EBP-β Mediates Constitutive and LPS-Inducible Transcription of Murine SerpinB2\nC/EBP-β Mediates SerpinB2 Transcription\n\nAbstract\nSerpinB2 or plasminogen activator inhibitor type 2 (PAI-2) is highly induced in macrophages in response to inflammatory stimuli and is linked to the modulation of innate immunity, macrophage survival, and inhibition of plasminogen activators. Lipopolysaccharide (LPS), a potent bacterial endotoxin, can induce SerpinB2 expression via the toll-like receptor 4 (TLR4) by ∼1000-fold over a period of 24 hrs in murine macrophages. To map the LPS-regulated SerpinB2 promoter regions, we transfected reporter constructs driven by the ∼5 kb 5'-f"}

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{"project":"DLUT931","denotations":[{"id":"T567","span":{"begin":25,"end":32},"obj":"Protein"},{"id":"T568","span":{"begin":97,"end":105},"obj":"Protein"},{"id":"T586","span":{"begin":73,"end":86},"obj":"Transcription"},{"id":"T587","span":{"begin":33,"end":41},"obj":"Positive_regulation"},{"id":"T588","span":{"begin":59,"end":72},"obj":"Positive_regulation"},{"id":"T569","span":{"begin":156,"end":164},"obj":"Protein"},{"id":"T570","span":{"begin":168,"end":206},"obj":"Protein"},{"id":"T571","span":{"begin":208,"end":213},"obj":"Protein"},{"id":"T572","span":{"begin":466,"end":474},"obj":"Protein"},{"id":"T573","span":{"begin":494,"end":514},"obj":"Protein"},{"id":"T574","span":{"begin":516,"end":520},"obj":"Protein"},{"id":"T576","span":{"begin":608,"end":616},"obj":"Protein"},{"id":"T589","span":{"begin":225,"end":232},"obj":"Positive_regulation"},{"id":"T590","span":{"begin":475,"end":485},"obj":"Gene_expression"},{"id":"T591","span":{"begin":459,"end":465},"obj":"Positive_regulation"}],"relations":[{"id":"R684","pred":"themeOf","subj":"T570","obj":"T589"},{"id":"R681","pred":"causeOf","subj":"T567","obj":"T587"},{"id":"R682","pred":"themeOf","subj":"T568","obj":"T586"},{"id":"R683","pred":"themeOf","subj":"T569","obj":"T589"},{"id":"R685","pred":"themeOf","subj":"T572","obj":"T590"},{"id":"R686","pred":"causeOf","subj":"T573","obj":"T591"},{"id":"R691","pred":"themeOf","subj":"T586","obj":"T587"},{"id":"R692","pred":"themeOf","subj":"T586","obj":"T588"},{"id":"R693","pred":"themeOf","subj":"T590","obj":"T591"}],"text":"The Transcription Factor C/EBP-β Mediates Constitutive and LPS-Inducible Transcription of Murine SerpinB2\nC/EBP-β Mediates SerpinB2 Transcription\n\nAbstract\nSerpinB2 or plasminogen activator inhibitor type 2 (PAI-2) is highly induced in macrophages in response to inflammatory stimuli and is linked to the modulation of innate immunity, macrophage survival, and inhibition of plasminogen activators. Lipopolysaccharide (LPS), a potent bacterial endotoxin, can induce SerpinB2 expression via the toll-like receptor 4 (TLR4) by ∼1000-fold over a period of 24 hrs in murine macrophages. To map the LPS-regulated SerpinB2 promoter regions, we transfected reporter constructs driven by the ∼5 kb 5'-f"}

{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T749","span":{"begin":87,"end":105},"obj":"Protein"},{"id":"T758","span":{"begin":59,"end":105},"obj":"Transcription"},{"id":"T760","span":{"begin":553,"end":581},"obj":"Localization"},{"id":"T759","span":{"begin":466,"end":485},"obj":"Gene_expression"},{"id":"T750","span":{"begin":419,"end":422},"obj":"Entity"},{"id":"T748","span":{"begin":466,"end":474},"obj":"Protein"},{"id":"T731","span":{"begin":0,"end":32},"obj":"Protein"},{"id":"T705","span":{"begin":336,"end":346},"obj":"Entity"},{"id":"T709","span":{"begin":399,"end":424},"obj":"Entity"},{"id":"T711","span":{"begin":444,"end":453},"obj":"Entity"},{"id":"T714","span":{"begin":490,"end":521},"obj":"Protein"},{"id":"T715","span":{"begin":516,"end":520},"obj":"Protein"},{"id":"T719","span":{"begin":553,"end":581},"obj":"Protein"},{"id":"T720","span":{"begin":608,"end":616},"obj":"Protein"},{"id":"T723","span":{"begin":236,"end":247},"obj":"Entity"},{"id":"T724","span":{"begin":563,"end":581},"obj":"Entity"},{"id":"T729","span":{"begin":590,"end":634},"obj":"Entity"},{"id":"T733","span":{"begin":372,"end":397},"obj":"Entity"},{"id":"T739","span":{"begin":208,"end":213},"obj":"Protein"},{"id":"T740","span":{"begin":156,"end":214},"obj":"Protein"},{"id":"T741","span":{"begin":594,"end":607},"obj":"Entity"},{"id":"T744","span":{"begin":168,"end":214},"obj":"Protein"},{"id":"T745","span":{"begin":375,"end":386},"obj":"Protein"}],"relations":[{"id":"R348","pred":"themeOf","subj":"T748","obj":"T759"},{"id":"R349","pred":"themeOf","subj":"T749","obj":"T758"},{"id":"R721","pred":"themeOf","subj":"T719","obj":"T760"},{"id":"R723","pred":"locationOf","subj":"T724","obj":"T760"}],"text":"The Transcription Factor C/EBP-β Mediates Constitutive and LPS-Inducible Transcription of Murine SerpinB2\nC/EBP-β Mediates SerpinB2 Transcription\n\nAbstract\nSerpinB2 or plasminogen activator inhibitor type 2 (PAI-2) is highly induced in macrophages in response to inflammatory stimuli and is linked to the modulation of innate immunity, macrophage survival, and inhibition of plasminogen activators. Lipopolysaccharide (LPS), a potent bacterial endotoxin, can induce SerpinB2 expression via the toll-like receptor 4 (TLR4) by ∼1000-fold over a period of 24 hrs in murine macrophages. To map the LPS-regulated SerpinB2 promoter regions, we transfected reporter constructs driven by the ∼5 kb 5'-f"}

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{"project":"testone","denotations":[{"id":"T20","span":{"begin":25,"end":32},"obj":"Protein"},{"id":"T21","span":{"begin":97,"end":105},"obj":"Protein"},{"id":"T40","span":{"begin":475,"end":485},"obj":"Gene_expression"},{"id":"T39","span":{"begin":459,"end":465},"obj":"Positive_regulation"},{"id":"T28","span":{"begin":608,"end":616},"obj":"Protein"},{"id":"T27","span":{"begin":516,"end":520},"obj":"Protein"},{"id":"T26","span":{"begin":494,"end":514},"obj":"Protein"},{"id":"T25","span":{"begin":466,"end":474},"obj":"Protein"},{"id":"T24","span":{"begin":208,"end":213},"obj":"Protein"},{"id":"T23","span":{"begin":168,"end":206},"obj":"Protein"},{"id":"T22","span":{"begin":156,"end":164},"obj":"Protein"}],"relations":[{"id":"R3","pred":"equivalentTo","subj":"T27","obj":"T26"},{"id":"R8","pred":"themeOf","subj":"T40","obj":"T39"},{"id":"R1","pred":"equivalentTo","subj":"T24","obj":"T23"},{"id":"R2","pred":"themeOf","subj":"T25","obj":"T40"}],"text":"The Transcription Factor C/EBP-β Mediates Constitutive and LPS-Inducible Transcription of Murine SerpinB2\nC/EBP-β Mediates SerpinB2 Transcription\n\nAbstract\nSerpinB2 or plasminogen activator inhibitor type 2 (PAI-2) is highly induced in macrophages in response to inflammatory stimuli and is linked to the modulation of innate immunity, macrophage survival, and inhibition of plasminogen activators. Lipopolysaccharide (LPS), a potent bacterial endotoxin, can induce SerpinB2 expression via the toll-like receptor 4 (TLR4) by ∼1000-fold over a period of 24 hrs in murine macrophages. To map the LPS-regulated SerpinB2 promoter regions, we transfected reporter constructs driven by the ∼5 kb 5'-f"}

{"project":"test3","denotations":[{"id":"T49","span":{"begin":25,"end":32},"obj":"Protein"},{"id":"T50","span":{"begin":97,"end":105},"obj":"Protein"},{"id":"T68","span":{"begin":25,"end":32},"obj":"Protein"},{"id":"T69","span":{"begin":97,"end":105},"obj":"Protein"},{"id":"T79","span":{"begin":608,"end":616},"obj":"Protein"},{"id":"T78","span":{"begin":516,"end":520},"obj":"Protein"},{"id":"T77","span":{"begin":494,"end":514},"obj":"Protein"},{"id":"T76","span":{"begin":475,"end":485},"obj":"Gene_expression"},{"id":"T75","span":{"begin":466,"end":474},"obj":"Protein"},{"id":"T74","span":{"begin":459,"end":465},"obj":"Positive_regulation"},{"id":"T73","span":{"begin":225,"end":232},"obj":"Positive_regulation"},{"id":"T72","span":{"begin":208,"end":213},"obj":"Protein"},{"id":"T71","span":{"begin":168,"end":206},"obj":"Protein"},{"id":"T70","span":{"begin":156,"end":164},"obj":"Protein"},{"id":"T57","span":{"begin":608,"end":616},"obj":"Protein"},{"id":"T56","span":{"begin":516,"end":520},"obj":"Protein"},{"id":"T55","span":{"begin":494,"end":514},"obj":"Protein"},{"id":"T54","span":{"begin":466,"end":474},"obj":"Protein"},{"id":"T53","span":{"begin":208,"end":213},"obj":"Protein"},{"id":"T52","span":{"begin":168,"end":206},"obj":"Protein"},{"id":"T51","span":{"begin":156,"end":164},"obj":"Protein"}],"relations":[{"id":"R15","pred":"themeOf","subj":"T71","obj":"T73"},{"id":"R16","pred":"equivalentTo","subj":"T72","obj":"T71"},{"id":"R17","pred":"themeOf","subj":"T75","obj":"T76"},{"id":"R18","pred":"themeOf","subj":"T76","obj":"T74"},{"id":"R19","pred":"equivalentTo","subj":"T78","obj":"T77"}],"text":"The Transcription Factor C/EBP-β Mediates Constitutive and LPS-Inducible Transcription of Murine SerpinB2\nC/EBP-β Mediates SerpinB2 Transcription\n\nAbstract\nSerpinB2 or plasminogen activator inhibitor type 2 (PAI-2) is highly induced in macrophages in response to inflammatory stimuli and is linked to the modulation of innate immunity, macrophage survival, and inhibition of plasminogen activators. Lipopolysaccharide (LPS), a potent bacterial endotoxin, can induce SerpinB2 expression via the toll-like receptor 4 (TLR4) by ∼1000-fold over a period of 24 hrs in murine macrophages. To map the LPS-regulated SerpinB2 promoter regions, we transfected reporter constructs driven by the ∼5 kb 5'-f"}